Why is Alzheimer’s disease so difficult to treat? - Krishna Sudhir

[@ThrillSeeker3524]

This is why we support medical research.

[@ScarySkele]

Exactly. There are no miracle cures / snake oil. We have medical research for a reason. I hope to see an Alzheimers prevention treatment in my lifetime so, no one has to suffer the way current older generations suffer.

[@user-221i]

Conservatives don't actually.

[@ScarySkele]

@@user-221i Correction, idiots don’t actually. I have known conservatives who don’t buy into moronic babblings of the Culture Wars

[@thisisntallowed9560]

Companies paying scientists to make studies with questionable conclusions in order to sell their products are wasting scientist's potential.

[@Just_som_Ottur]

Even AI Technology that can (potentially) identify the onset symptoms of similar illnesses?

[@timmisrael]

This disease really makes you think about who we really are as humans. It leaves only the shell, shedding away everything inside you. Very unsettling

[@KhoiruunisaRF]

It's part of human's fate, to forget things they learned before eventually die, as if they are going back to their initial state before they even learn anything.

[@Watch-0w1]

It really shedding or more blocking part of your head?

[@TheFalseShepphard]

​@@Watch-0w1 More so destructive since the neurons that literally hold who you are die as the disease progresses

[@Tiger-789]

​@@KhoiruunisaRFNot everyone goes through that though

[@ammaranwar5343]

I know it's absolutely awful. It's basically like dying from the inside out.

[@Asaelus]

The graph at 5:17 was really creative

[@Sudip_the_god]

yes, they used the neuron as the curve of the graph

[@L17_8]

Jesus loves you so soooo much ❤️

[@firelow]

​@@L17_8why are you using your gods name in vain?

[@Electroblade360]

They knew what they were doing

[@justenoughrandomness8989]

@@firelow not god's name but still good

[@kanellita]

I got back from caring for my grandma with Alzheimer's for a week, and it was very challenging. She doesn't remember me. It was most difficult when she imagined I was stealing from her, that really hurt my feelings.

[@randomskills5231]

It's a hard thing to go through, slowly "losing" a family member over time. Do the best you can to be patient with them, and do the best you can to cope and process. Support groups and MH counselors can be a great resource, if you're open to them.

[@tomney4460]

There are many people willing to help! My grandmother died of Alzheimer’s several years ago and seeing the toll that caring for her took on my aunt was heartbreaking. Counseling can be a great resource.

[@-AyushSaha]

I had a friend whose grandma forgot even her son due to Alzheimer... and this seems devasting even to listen that something like this happens!

[@Shafin15]

My father with Alzheimer's cannot remember my name. I realized this after asking him one day and found him struggling.

[@-AyushSaha]

@@Shafin15 Bro that's really sad to hear... must've been hurtful for your loved ones to forget you.... hope they soon find a cure

[@KhoiruunisaRF]

At least her son still remember her as his mother.

[@jolness1]

My great grandma had Alzheimer’s and I always worried my grandma (who had the biggest impact on me of any person save my parents; maybe even more than my dad due to how much he traveled) would develop Alzheimer’s. As a kid I wanted to go into some sort of medical research because I so badly wanted to be able to hold on to her for longer. Long story short; she developed it much too early for me to be able to even start college. Watching someone I loved so much slip away for over a decade was so hard. I thought that when she died it wouldn’t be so bad because I had been grieving her for so long. It was bad. I know hereditary links for Alzheimer’s is pretty flimsy but I worry that my mother will develop it too. Every study, every potential medication to slow the progression, every test that gives us a better shot at detecting it early.. gives me hope. All this to say.. it’s such a horrible disease and I feel for anyone going through that. My paternal grandmother has been diagnosed with probably Alzheimer’s disease as well and while I feel “prepared” I guess.. I know that despite not being nearly as close it will be painful and dredge up all sorts of painful memories.

[@sarab2834]

My grandmother has Alzheimer. And it is difficult to deal with her. It's been a year now she gets worse day by day. She's taking medicines yet it doesn't ease her condition at all. Everyday is a hastle with her and she's illiterate, stubborn and she sometimes speaks in her native language which only her daughters understand. She wets her bed and refuses to confess to it, and sneaks into the toilet because she doesn't want anyone to see her go number1 or 2. She stays in one of the rooms of the house and thinks we're her neighbours once we step in on her. She makes up names to call us and talks about things that never happened and says that she spoke to people who are already dead. Sometimes if she is feeling worse, she claims that she is the cleaning lady at our house and that it's time for her to leave and go home, mind you she never worked a day in her life.

[@nerdlingeeksly5192]

I know she's your mother and everything, but I feel that it would be best for you and your family to admit her to a nursing home for people with dementia.

[@trimthee4863]

I know what you are going through. My grandmother has similar symptoms. I hope you are alright! Wishing the best for you and your grandma.

[@borislee2920]

@@nerdlingeeksly5192 nursing homes (especially good quality ones) can be incredibly expensive, and there are usually waiting lists to enter these places. It can also be incredibly heartbreaking for families to admit they need to take this step/option. For some people nursing homes may simply not be an option.

[@LilySmith90]

I understand that this can be a very trying time for you and your family. It can feel like your loved one is sitting right there but the mind is different. One important thing to remember, your grandma is waking up every day in a body that is too old for what she remembers and surrounded by strangers who want to claim kinship and watch her do private things. She is struggling to exist. That is not to say that your frustration and pain are not valid. They most certainly are. Just putting out into the universe what the other side can be going through.

[@johnnywatson4629]

I had acute and severe appendicitis when I was around 9 years old. Doctor said if the surgery had been an hour late, there would be no way for me to survive. So, I’m very grateful for modern medicine.

[@MrKento111221]

Same for me. My appendix burst. I was in queue for the surgical bed and the girl before me had almost identical diagnosis; she didnt make it.

[@johnnywatson4629]

@@MrKento111221 sad.

[@NITHINS]

Solution: Excercise Learn new skills So, basically be active and cheerful

[@Somejaun]

More so use it or lose it

[@bookwormweeb]

My grandma dies of Alzheimer's, the fact that she forgot everything and everyone till the phase where she were like a baby and dies will be always carried in my mind. If I test positive of Alzheimer's I will like to sign up for assistive death because i have no brother, i choose not to have kids cause i don't want to be a burden to them. If i ever had Alzheimer's i will like to signed up for assistive death, I'm not gonna be a burden to society.

[@lararabbit]

You are going to live a long , healthy life, do not worry about it. have a good day!

[@hussein5367]

​​@@lararabbitjesus its you😮

[@aminaelo]

Was your grandma a burden to you and your family?

[@bookwormweeb]

@@aminaelo no, but her case was different from mine. She have three children which my mom her older daughter put me in charge to take care for her. No it wasn't a burden to me, I loved my grandma, but it hurts me remember how she forgot things as the disease progress and I don't want that to happened to me, especially for a stranger that probably might thing that I'm a bother.

[@tulipeofficial5595]

You are not a burden to anyone, U deserve to be looked after , God bless You

[@mugurekimani1380]

In her book, Hellen Brain's character who is about 10 or 12 thinks Alzheimer's is called OldTimer's disease. I thought that was a good one.

[@amg.72]

ngl, this is what I thought it was called until I was a senior in high school o__0

[@Somejaun]

@@amg.72oh wow

[@BaiLong45]

Oh wow, didn't think I was the only one. Exactly, thought that it was called OldTimer's disease as well for a long time.

[@yuzu54o]

Im trying to forget about my fear of dementia after listening too many EATEOT and now this video show up in my recommendation...

[@AnthonyDentinger]

If a video that you don’t want to get recommended shows up in your KZbin home page, there is an option to say that you’re not interested in this kind of video. On the KZbin app’s home page, click on the little "three dots" button of the video you’re not interested in, then select "Not interested". Also, sorry to hear about this kind of fear!

[@yuzu54o]

@@AnthonyDentinger Thanks, but I'm not that scared and I like to study about this kind of thing to better understand it lol.

[@randomskills5231]

Keeping active physically, socially, and mentally are great aids as we age. Just something "easy" everyone can do to help keep the body and mind strong.

[@indahbudiani4773]

C'est Fini

[@eddieperalta2496]

May God Bless all the Familys that are going through this

[@jonathanandro1736]

I'd like to congratulate the director and the editor for the great animations. Some of the translations in scenes are delightfully creative, like drawing the graph with the neuron's dentrites at 5:16. Thank you for the great work!

[@icantchooseaname6903]

I wishthe government funded medical research instead of pety wars

[@charleychristie4260]

So true

[@Sunflowersarepretty]

I wish we can find cures to Cancers, Alzheimers and Insomnia. I have insomnia and im afraid I'm gonna have either of these two one day. It's scary.

[@jadeltrickery]

oh! and rabies!

[@SonnyDarvishzadeh]

and malaria and HIV?

[@Darsh0606]

Nah, cancer

[@EdinoRemerido]

Depends on your definition of cure, as a actual cure to cancer would be genegic modification.

[@ManinderSingh-di8ul]

save this reply for future, please try inner engineering by sadhguru, just try with open mine, don't believe anything, after completing and practicing for one month, reply me back and share your experience, we want to know because we have seen so many people benefit from it in so many ways

[@TheJProducti0ns]

Thank you for this post! Just recently got hired to be one of the statisticians for a giant clinical trial in Alzheimer's. Always wanted to be part of the frontier that studies this disease. Is there a reference page where we can see the sources used in this video?

[@Jackie_YG]

Thank you for this beautiful illustration, for the animation , the nice music, the calm voice of the speaker, for the info , everything...Great work 🙏🌹

[@sarahlevine776]

They are also looking into a protein called Reelin, which they think might help to detangle tau.

[@MrFunnyPenny]

Basically, DON'T BE LAZY! Keep it moving! And keep on learning!

[@Coquettepink0]

This is really scary when I have always been teased for being severely absent minded

[@FlynnMegaTensei]

My grandmother passed away over a decade before I was ever born, so I really hope medicine can evolve to the point of completely curing the disease.

[@ChrisKhani]

My grandmother had Alzheimer. It was such a devastating disease. It rob my grandmother her golden years and me and my family a loved one. 😢

[@ajaygopal2208]

Fantastic art and narration as always!

[@dejesusrussell]

SLP here. Great video! I'd love to see one on Parkinsons

[@kavithabr5824]

All we can do is better the life we already have. It's a fact that we can't change the inevitable. We just have to learn to go along.😇👍

[@L17_8]

Jesus loves you soooo much ❤️

[@kavithabr5824]

@@L17_8 yeah, right. And everyone.

[@Superdeath25]

My grandfather on my mom's side developed Alzheimer's during his last few years. I remember Granddad becoming very loopy and telling weird stories blurring reality and fiction. He had to be moved out of his home in mid 2012 after he went over to Grandmom and said "Hey nice lady, will you take me home?" He forgot everything by the time of his death in 2013

[@kesler4982]

made me wanna rewatch the movie Father 2020, with Anthony Hopkins and Olivia Colman. Great drama!

[@Deluluou]

Yesterday we were driving the car with my family and my brother asked us what dementia is because he thought he had it as he forgets to make his bag for school (he is 9😅) .It is amazing that this video was uploaded the day after explaining something that i did not know clearly

[@aperson432]

There is a huge difference between Dementia and Forgetfulness. I guess your Brother doesn’t know the difference.

[@LilFoxyCosplay]

My nan has dementia she remembers my mum and me forgot my sister (after she went to uni) its like she knows her but doesn't know who she is and often forgets her son (my dad) She will occasionally call me by my sisters name but everyone confuses us despite the big age gap I believe she's on meds that are slowing it I was in denial for years but have now accepted it i dont feel sad anymore i feel nothing Its one of my biggest fears that ill develop this myself as two of my relatives have had it (the other was a great aunt i met once) I just pray we find prevention or a cure in the future

[@gailaltschwager7377]

Thank you!

[@null1ffy798]

I really hope a cure is made before I get old

[@decklanquow9709]

My mother has alzheimer's and in my care. It is not a easy journey. It is cruel especially for someone like her who was so independent. It requires a lot of patience to take care of her, which I admit I do run out sometimes. But I know it's hard for her to be told when to eat or take a bath or even when it's day or night. She sees reflection in the mirror as strangers looking at her. It really sucks.

[@Electrobuzz17]

If you could share us some tips on how you are taking care of your mother i think it will help me and others in future. My mom will son. Be 60 even if not Alzheimer's i am sure as she grows old dementia might turn up so just want to have a bit more knowledge and be ready.

[@erdvilla]

I've always wondered if all these "Brain supplements" we are bombarded with since the 1960s have something to do with the more cases. Even babies are given a ton of supplements in their formula, so "they grow smart, have better chances in life, their brains grow to their fullest potential...". Wouldn't this accelerated development of the brain have an impact later in life?

[@silvermica]

My mother passed away two years ago (in 2022). The first obvious signs of dementia came in 2014. I have no words.

[@shubhangichandanshive9806]

So sorry for your loss. May the departed soul rest in peace. Take care.

[@christiaancoetzee1696]

My greatest fear is that I or someone I love gets Alzheimer’s

[@noproblematallmate]

When is Meredith finishing her research?

[@thelovechildofautumn]

True

[@Lorkdemper]

My maternal grandma and paternal great-grandma both had Alzheimer's. I didn't really see my great-grandma's progression with the disease, but my grandma deteriorated fast after turning 90. In hindsight, she showed symptoms before then - forgetfulness and negative mood shifts - but we thought that was just kind of normal for people as they aged.

[@AssanaliSaidikarimov]

As always, incredible video

[@Sam-nd7sl]

Fellas, do you know the socials of the artist? I really like the art and would like see more of it.

[@dominikkvesic6158]

Hello, you have awesome videos, which program you use for animation? 😁

[@DavidLukoson-om7rl]

Thanks.

[@luis-in1ch8yw1r]

good one

[@zacturtleback]

I Havnt seen this video but the bars red for some reason? Guess ill just watch it.

[@GameyGaming]

I agree

[@KICK839]

I feel like i will get it in future

[@alfrancisbuada2591]

Well, that is hard to explain

[@love_orangestar]

Thanks for amazing vedio.

[@_emmz]

Ohh I was confused thanks!

[@tasneem547]

I think medical information is fun when you understand it, but when it's not, it's complicated and like you're in a battle.

[@maahipaliwal4210]

the animations are amazing

[@chiendo5265]

As it may not important for the video creator, but for me, the inheritance risk of Alzheimer should also be factored in.

[@la_papillon]

I love watching these

[@bearlogg7974]

We have to stop forgetting how to treat it

[@poulomi__hari]

My grandma had alzhimers. It was very very disturbing to watch her lose her sanity over time.

[@HakuCell]

not offering the option of euthanasia to alzheimer patients is inhumane.

[@Shafin15]

That's a terrible thing to do

[@HakuCell]

@@Shafin15 no, forcing patients to experience alzheimer is a terrible thing to do. i didn't say "kill everyone who has alzheimer", i said "give them the option".

[@reyne2077]

Terminal patients are not able to really answer for themselves and make concious decisions, and I really doubt giving such an option to relatives is a good idea. And even if disease is only starting... You never really know how fast or slow it will progress, you may have still lived relatively normally if you didnt get scared and took a way out. Also imagine taking euthanasia a day before the cure arrives.

[@wolfferoni]

@@reyne2077 It is true that patients who are terminal can have difficulties making decisions for themselves but I think it should still be an option. Ideally relatives would know what the wishes of the patient is. If the disease is in its early stages then the patient has the ability to make the decision then. Why is it so bad that someone took a way out because they were scared? It's their life. The whole point is that the person gets to decide for themselves how they want to go out. Living longer isn't always better or what the patient wants. If they want to go when they're at their best then so be it.

[@rf2632_]

Agree!

[@nicobambino191]

Early onset dementia/altzheimers run in my family. I know if I live long enough, that’s my future. So I’m working on a contingency plan

[@valentinacarreno1254]

a few months ago i did some research for university and its very likely that anxiety and depression are a factor in the development of dementia and alzheimer´s. There´s still a lot of doubts and more data is needed, but it really makes you wonder just how much your mental health will affect you in almost every single aspect

[@nerdlingeeksly5192]

Without inconsistent plaques are I doubt it is a significant contributor to alzheimer's if at all

[@smyrnamarauder1328]

I'm 26 but due to psuedo dementia caused by depression I have almost same syptoms. You cant imagine how embrassing and saddening it is. i would give everything to fix it. I used many antidepressants and CES but sadly they didnt work on me....

[@andieallison6792]

That's not a thing

[@MalonMateria]

@@andieallison6792 it is. Depression can lead to severe cognitive disfunctions

[@Filan.Fistekuuu]

hope it all gets better for you buddy

[@millionmelonmint]

I love this voice❤

[@Pitchoo973]

Do we have a way to diagnostic those plaques ?

[@MJR_ATX]

When you research Alzheimer’s symptoms but the links are all purple

[@itachi-hf3kv]

😮

[@lifewiyannaa]

My grandma passed in June from dementia I wish there was a cure 😢

[@shortsking6471]

Plz make a video on how to do medical research

[@Lexyvil]

My grandmother has it. :( It sucks.

[@MR.LEGOBRICKD2]

Everywhere at the end of time meaning

[@Sabrinasvids]

Why did they say expect it to double in the future?

[@CharlotteXMoon]

What if they try and find a way to get rid of the stickiness that is messing with the brain or give the patients the bodily chemicals they've lost when they were I'm their youth

[@un_tip_obisnuit]

It's like your body lives but it's not you anymore. Terrifying

[@Filan.Fistekuuu]

Nothing's worse than dying can still being alive

[@salasbilbou3166]

اللهم عافنا 💔

[@KhoiruunisaRF]

It's part of human's fate, to forget things they learned before eventually die, as if they are going back to their initial state before they even learn anything.

[@MrH103]

If Alzheimer had a theme song, it would probably be The Caretaker - It's just a burning memory.

[@عبدالعزيزألأزرق-و5ي]

My bad

[@NoShameSpeakYour_Mind]

My grandmother casually shat on the floor as if it were nothing when living at our house and accused of me and my mom of stealing her money. Later on she died of the vascular dementia type (I heard it was pretty bad)

[@NoShameSpeakYour_Mind]

I also have one copy of the gene for Alzheimer’s (APOE4)

[@midnighttrain-jz2my]

this is great!

[@785jrtasanG]

If you are watching this video...read "Time Shelter" by Georgi Gospodinov. Its a booker prize winning novel

[@thermalnuclearwar]

Alzheimer's scares me so bad

[@personaslates]

When i was little i thought it was called "Oldtimers disease"

[@aperson432]

I can’t believe a Roblox KZbinr I watch whose Grandma died of Dementia was made fun of. Those toxic kids were calling her “Biden 2.0” and stuff. Not only that but people were making rude jokes about Biden and his memory in the comments of a video and all I did was say that that was disrespect to the guy that’s literally running our country and some Minecraft kid replied to my comment saying my life was an insult. People don’t take stuff like Alzheimer’s and Dementia seriously until they actually end up getting it themselves in the future.

[@hanve]

❤❤❤

[@quynhanhtranle1242]

Toll, clinical trial, dementia, broader term, mild memory,agitation,unfold, pinpoint, trigger bằng active, cleave,plaques, accumulate, tau scaffold, reinforce, clump, dysfunction, cascade, hold the promise of

[@atklm1]

May, maybe, likely, possibly, could be, is linked to… Yeah, that’s the result of decades worth of research.

[@Arasaw]

Huh I feel like I've already seen this one before

[@DVDCJW]

2:40 whats the difference

[@ParvinderSinghSaini]

Wondering the same!

[@sketchyskies8531]

The fact that I got a notification from The Onion about Alzheimer’s at the same time as this video is some crazy coincidence

[@vinitvsankhe]

0:35 is so profound!!! A patient hiding oblivious in the corner of his brain and a doctor searching for him with a flashlight behind his neural curtain. Lovely creativity there animators. ❤

[@theshroomian2415]

This videos was great good job!

[@theshroomian2415]

I agree they did do a good job

[@theshroomian2415]

wait I don’t remember commenting this…

[@theshroomian2415]

Bro I think someone hacked my account

[@theshroomian2415]

Bro shut up nobody hacked your account

[@ZohaLatif_145]

Please also give English subtitles below It's more easy to understand

[@Bingojingo646]

You can switch on the captions

[@ZohaLatif_145]

@@Bingojingo646 how?

[@Bingojingo646]

@@ZohaLatif_145 please click the " cc" option at the top ..

[@ZohaLatif_145]

@@Bingojingo646 oookayy thankuu ❤️

[@blazer9547]

No, we need medication.

[@Jemiღ]

bros first

[@NatureSpeedatRoad7H]

Probiotics for the brain can help!

[@Blackjack09721]

Feels like tax dollars should be supporting research into this field instead of general tax breaks.

[@legitscoper3259]

Yeah, imma throw myself off something before becoming a vegetable if i would get a diagnosis and it confirmed by multiple docs.

[@lucianoosorio5942]

“This battle's been a blowout like that hemorrhage in your head!” Karl Marx Alice In Chains: California I’m fine, somebody check my brain! California’s alright, somebody my brain! Check my brain!

[@webfatigue]

I love when science has no clue.

[@UserAurKya]

😂

[@furonwarrior]

We do have a clue. It was stated in the video. We’re figure it out once we transition towards Quantum computers.

[@乾燥剤-u7o]

yeah,that’s where the fun begins.

[@vigboi345]

That horrible

[@derekw9724]

Yeah, this is the worst possible video to make that comment on@@vigboi345

[@Look_itsBroken]

Hi l am here 🎉🎉

[@Dirk-g2f]

What where am I who are you

[@circuloviciosamente]

Make people with dementia be aware they suffer dementia: the hardest thing in the world.

[@mriam9843]

Does blueberry really help with alzheimer????

[@Filan.Fistekuuu]

Exercise and learn new stuff , that helps Use it or lose it situation

[@samihan6661]

LOVE the hijabi researcher.