CRISPR System and CRISPR CAS9 Technique, The full principle (Part 1)

This video is a full explanation of the CRISPR system and the utilization of this system in gene engineering (Part 1).
The link of part 2:
• CRISPR CAS9 Gene Editi...

[@merttantari5473]

finally someone who explains this topic very clear and also detailed enough :) thank you , it was really helpful !!

[@priyamvadam4928]

really good. much more detailed than most videos available on the same topic.thanks.

[@lembuhota]

True

[@anushabs6599]

Exactly!!

[@chemistrymattersgetit4161]

Very well done, great for both undergraduates and the more advanced. I found especially useful the way you distinguished between the 3 different systems, which is often not clear to those who are first learning about the system.

[@aaryashashi173]

This is one of the best detailed video on CRISPR i have seen in KZbin

[@VijaySingh-tg1be]

So far the best video on CRISPR basics. Easy to understand in layman's langauge...

[@lucasalopez-jirau4714]

Thank you!!! Excellent for undergrads having trouble with the primary sources; it really helped me. * thumbs up *

[@RealJulWhite]

Great Video! Have suggested the channel to my professor so he can recommend throughout the next years

[@NookKana]

Thank you so much. This is so helpful. Great video and great explanation :) I can understand about CRISPR system better in just twenty minutes. Thank you

[@biomedicalandbiologicalsci4989]

Thank you for your comment :)

[@lukengai4956]

tysm this was what i was looking for for so long ;-;

[@chuti_vanila]

Thanks​ you​ so much, you​ explained clearly for​ this​ topic.​

[@ahmedmohamed-iu2fj]

Wow I’ve watched this couple times and u explained it very well. Thank you

[@mirzamudassir3937]

Thank you so much for this vedio I exactly understand how crispr work

[@lethaltrix316]

GOAT CRISPR Video

[@RomanKenzie]

Amazing, thank you for taking the time to make this- really helpful!

[@eddiewampande5107]

This was fantastic, i can now apply the technique of crispr in my research

[@OrlandoRodriguezHK]

Many thanks for the video, it is very clear. Well done.

[@IbuWdesta]

Really nice presentation, much more detailed. Wait for your next presentations

[@desuranus7349]

At 9:15, cas6e/cas6f cut at the junction of ssRNA and dsRNA. The graph is not correct. It should stop at the end of hairpin loop. But this is minor detail. Many thanks for the videos. This is the only CRISPR video in English I can find on youtube that teaches type I, II, and III. Thanks!

[@kathleenranihagen9256]

This was great! Now I finally understand. Thank you!

[@biomedicalandbiologicalsci4989]

you are welcome :)

[@nika_cm]

thank you, this was very clear and easy to understand, it helped me out a lot!

[@maximilianfischer9198]

Great video, just a minor suggestion: I would give a short general overview (basically the summary that you give at the end of the video) of what the system does and the goal at the beginning of the video and then go in detail.

[@DhobyVic]

Thank you for a very helpful explanation. It's not an easy topic and I will need to watch the video again a few times for it all to sink in but, essentially, and for the first time, I feel I do understand.

[@nataliyamelnyk5904]

Thank you for the great explanation of the great system work!

[@animeshhb]

so nicely explained ! A big thanyou for making me understand the whole process in a easy way !

[@StepsHardcore]

This is so generous and clear. Thank you so much.

[@danielholley2495]

Excellent video. Thank you so much!

[@inshaishrat4371]

The best of all videos. Thank you 💕

[@rababeleit5317]

Wonderful explanation!!!

[@70194tanner]

At 8:12 you refer to the lower strand as the coding strand. I believe that this strand is actually the template strand because the newly synthesized strand would have the same sequence as the top strand. That would make the top strand the coding strand and the bottom strand the template strand.

[@mohinitalwar2888]

You are right the coding strand is actually the Non template strand as it contains the SAME nucleotides as that of mRNA while the template strand contains the COMPLEMENTARY nucleotides

[@fagusformigordusfagordumfl1798]

yeah right

[@LKVPAWAR_ycmou]

Exactly right.. bottom strand is template ..

[@LKVPAWAR_ycmou]

@@mohinitalwar2888 I didn't got the Non template strand concept please explain what u said in didn't understand it please

[@mohinitalwar2888]

@@LKVPAWAR_ycmou as you know there are two strands, template and non template. And because template strand has the complimentary sequences with that of mRNA (the complementary rule) that means the another DNA strand (non template strand)has the same sequence as that of the mRNA (except T in place of U) that's it is called as conding sequence as it has THE SAME CODES as that of mRNA.

[@ximenaze8242]

Great video! Thanks for sharing

[@utsavvaghasiya]

very detailed and easy to understand this complicated mess. thank you

[@dennisalego6548]

Thanks so much, exactly what I have been looking for 🙏

[@garyraab9132]

Informative content, with simple and useful animation. Having produced hundreds of science videos and animations, some simple suggestions for the sound track. First, write out a clear concise script. Do a second edit on the script. When recording the script, speak each line clearly, leaving a long pause in between each comment. Avoid ummms and awes! With audio editing software it’s easy to adjust the length of the audio to match the animation. With the audio editing software, it’s easy to recognize and find, ummms and awe waveforms and replace audio distractions with silence.

[@mdshahidulislam6805]

Yes, it was very good to understand easily. Thanx.

[@farhanabbas2728]

Very helpful video about CRISPR.... Thanks alot for guiding

[@BeUWinteer]

Thank for sharing this video. It very greatful.

[@CropScienceyt]

Detail information in simple language with presentation

[@lembuhota]

So simply explained with details... And also very simple and nice animation.... Great work... Keep explaining topics like this.... Your video helped me a lot... Thank you 😊😊👏👏

[@giuliarossetti197]

Thank you very much! It saved my lifeeeee! :D

[@martingitonga5436]

Wow, very help basics! Thank you

[@gcris9927]

Thank you, very useful!

[@arvindgond4149]

Very well explain I think 1st (this video) is essential to create base to understand CRISPR . Thank you for breakdown it and explain it in the simplest way 🙂

[@debashreedas9897]

Well explained. It helped me a lot! Thank you so much!

[@juandavidolayacelis2626]

Great video. Thanks!

[@kianakhz4558]

Very helpful.Thank you

[@harunkimathi8515]

thank you! very clear

[@carloseduardoferreirapache9428]

Very well explained, thanks!

[@srishtisharma3200]

Amazing video !! You win it !!!

[@bdhome2010]

thank you. it was an awesome video.

[@sumantamohapatra6727]

Literally very informative mam

[@arkveth6921]

I believe that at 10:43 you wanted to say Cas6 homolog (as written in diagram) instead of Cas9.

[@qaisarshakoor09]

Thank you very much for the explaination

[@_MercyStephen_]

You made it so well

[@ryanhimawanwibowo6014]

Thank you so much!! well explained :)

[@medineadin4700]

Thanks, it is a very good explanation

[@tukombemuleya9689]

well well. this was so clear ma'am. i understand it well

[@IshitaJain10]

A great help...thanks

[@jacquelinelabovitz4613]

fabulous explanation. thank you

[@maomaotan8270]

YOU ARE AMAZING!

[@maiaralarissa8805]

Thank you very much! Excellente explanation!

[@biomedicalandbiologicalsci4989]

Welcome :)

[@suvethas1851]

Very well explained 👌

[@dimitragennimata89]

Excellent presentation. Ideal as an educational resource, for explaining how the system works in bacteria. Very well done, indeed.

[@biomedicalandbiologicalsci4989]

Thank you for the nice review ... stay tuned :)

[@AnkitKumar-nh5io]

Biomedical and Biological Sciences very good explanation

[@kofipapa2886]

​@@biomedicalandbiologicalsci4989 The nice reviews are nice but the not so nice reviews are also very necessary for growth and learning your self because you don't know it all. I love your video and the motivation to help people understand. I have learned by you. Thank you. But! It still remains that the mRNA transcripts isn't complementary to the coding strand( 5'-3'). It is always complementary to the 3'-5' strand ( anti sense/ template strand). And this should be viewed as nothing but a closed loop feedback. Nice reviews feel nice but the feeling aside it does nothing by way of promoting learning as ' not-so-nice' type of reviews do. Thanks for sharing your knowledge. I enjoyed your class very much.

[@Wathiq199317]

thank you it was very clear and easy

[@v.ariabod5488]

excellent and very useful video and explanation

[@sydfarag3345]

Great work, thanks

[@oui1205]

Great Job, you helped me a lot

[@biomedicalandbiologicalsci4989]

This is my target :) thank you

[@zph1806]

Thank you so much for your very nice explanation it wa really very helpful ❤️

[@ahmedalfahad3866]

Thanks very useful

[@vaishnavibhike1586]

Well Explained!

[@ankushbajaj5764]

👏👏👏GREAT JOB. pls keep uploading videos on ur channel. 🤗🤞

[@Quotila0]

Loveeeedddd it. Very detailed.

[@lujainalnemr8983]

Thank you so much you are the best

[@lucho0849]

very good explanation am able to better understand the processes involved

[@hemastandard7649]

Great video I understood really nicely and loved the accent, very understandable (perhaps you can make an updated video on the subject).

[@wdyafw]

This video explanation is very helpful especially for a beginner like me. Could you please also explain how CRISPR/Cas9 disappear from the genome of an organism? Thanks.

[@mohammedtolba9886]

Great .. really Great

[@bharathreddy9337]

thank y very much and I like your video presentations. have y made any videos jumping genes(transposons)?

[@biomedicalandbiologicalsci4989]

Thank you for your comment, I will try to do it :)

[@amonoracheal9118]

impressive explanation:)

[@dikshashreedevi4568]

very usefull...plz make more videos.

[@rumasarkar1382]

Thank you very much...

[@Shadowdarknessone]

a really great video. I just dont understand one thing. where did you know where to cut. And how did crispr knew where its needs to cut and replace the dna/rna or modifie the dna/rna. As far as i understand it crispr splits the rna/dna up but where did know what you need to pick.

[@sandeepshinde8806]

Great attempt 👍

[@anshumathur7585]

Thanku mam to share this video Its good enough to understand the mechanism of crispr bt i hv a query regaring this as u told about crispr mechanism to bacteria protect from viral infection as immunity, bt there is also the lytic or lysogeny cycle where they protect from adverse conditions what about ds?

[@edthoreum7625]

4:09,3 steps 1-spacer acquisition,4:21 2-crRNA processing,7:30 3-interference,10:55

[@OzgeSonmezler]

Hi! Thx for the video, helps a lot. Is there any place i could find it as pdf or ppt?

[@familieaa1968]

شكرا جزيلا

[@sumerarajper8294]

Very informative

[@enerandmackon761]

great job

[@hiraateeq3186]

Best explanation very helpful

[@biomedicalandbiologicalsci4989]

Thank you for the nice comment :)

[@cagaditamiaditas6280]

Fuck you

[@toyito1]

Thanks!!!!!

[@sarmadElhassan]

Very helpful, however PAM position is on the non target strand 3’ to the protospacer

[@md.ridwanahmed1769]

Do you have this crispr 2 video as an article???

[@andreagoh6198]

thank u for teaching me what my teacher did not teach but wants to test T.T

[@bioinformaticforall]

very helpful tnx

[@rikkigupta9546]

thanks alot for easy explanations could u pls send me its refrences

[@questforenlightenment441]

I have to do a presentation about the CRISPR/Cas System and couldn't find any conclusive, highschooler-friendly texts. Thank you so much.

[@MatheusLimaMatias]

Well done

[@saintamaria5598]

Please i have question . How to explain having diffrent size of deletion by using the same two gRNA

[@mohammedhasanalmashat846]

Thank you ,it is very useful video . I have Q if virus invade a bacterial cell ,it will insert genome and use bacterial cell to produce compunents to produce new phage and finally, bacterial cell will lysis . the question is how can bacterial cell save piece of viral genome when it will be degredate after viral invading .

[@thurayaelbanna5773]

Sometimes the bacteria resist the phage so it can take a part of its genome, and pass this genome to the next generations.

[@jagannathswain5288]

WHERE TRACR RNA FORMED? HOW USE IN GENOME EDITING?