Risk Factors. Classically the common risk factors for gallstone disease are colloquially described as the "5 F's": Fat, Female, Fertile, Forty, and Family history.
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What causes gallstones? Gallstones may form if bile contains too much cholesterol, too much bilirubin, or not enough bile salts. Researchers do not fully understand why these changes in bile occur. Gallstones also may form if the gallbladder does not empty completely or often enough.