In this episode we discuss: 00:00:00 - Intro 00:00:10 - Steve’s background and unusual childhood 00:07:19 - Steve’s adventures driving a cab in New York City 00:12:11 - How Steve drove to LA and accidentally became a lion tamer 00:22:18 - How Steve’s early graduate school experiences led him to study longevity 00:30:35 - The challenges and limitations of working with lab mice 00:43:49 - The connection between caloric restriction and lifespan 00:52:30 - Mice vs. rats and rodent aging experiments 00:57:32 - The impact of dietary composition and the harm of sucrose: Comparing two caloric-restriction studies in monkeys 01:12:22 - Challenges of studying animals due to major differences in the lab animal vs. wild animals 01:28:22 - Human studies of calorie restriction 01:37:18 - Better dietary protocols for humans: Alternatives to long-term caloric restriction 01:42:12 - The protective effect of fasting 01:50:53 - Reflecting on the sex differences in human lifespan, and why women have more neurodegenerative diseases 02:10:17 - The importance of identifying longevity biomarkers and which ones show the potential to change the landscape of longevity research 02:21:35 - Molecules showing the most promise as longevity agents
@NunoCordeiroPT2 жыл бұрын
1:57 "There are many that get no X chromossome. They get two Ys." Lack of X chromosome is incompatible with life. There are several variants like XYY... maybe that's what you meant.
@Beginnerarttutorials3 жыл бұрын
Wow! That story with the lion and his youth in general would make a great movie!
@ItsBlissfulAcres3 жыл бұрын
The movie is called "Roar"
@patrickwhelan26563 жыл бұрын
This is very good. When you have a cursory knowledge of a subject, like I have, it’s easy to get swayed by a superficial read of an abstract or watch a podcast by a scientist perhaps with a book to sell or a project to push - no names mentioned, but we can all think of a few - whereas these two gentlemen give a non-biased deep dive into the subject matter.
@Nando_lifts20213 жыл бұрын
This guy had some stories to tell. Man ! Great podcast
@espinosalexis3 жыл бұрын
Well said Dr. Steve! The same thing I said about the Richard Miller's "gold standard tests for longevity": they are finding that diabetes drugs extend life of mice in their experiments. I say: of course, if they give them a diabetes-producing diet to the mice, then yes, those drugs of course will help. But the control group should be eating a much better diet than the chow they give them. Then, from there, longevity drugs should be tested. So, yes, it is very important to find the ideal diets (and life style) for the lab mice and rats to start with.
@scottgilliland20613 жыл бұрын
Ouch, as a 5’7” person, I was saddened to hear I’m not normal 😝 Great video, as always! Thank you for sharing these great conversations with us, I always learn a lot.
@mary_puffin3 жыл бұрын
Haha. I laughed at that too. I don't think Peter is much taller, so you're in good company. :)
@iss85042 жыл бұрын
5'9" is average height for guys ie Peter's height. I think he is also including weight in his discussion. Steve was really short and light before...5'4' is small for a guy.
@elizabethk32382 жыл бұрын
You just didn't want to know...
@richardlawson6787 Жыл бұрын
Cheer up....studies show tall people don't live as long as short people
@awnzotheman Жыл бұрын
5'7 perfect.
@jackiebardsley99463 жыл бұрын
Thank you - another great interview. I always learn so much.
@lucretiasulimay1968 Жыл бұрын
My best friend, Diane, and I were just talking about how we can't believe we are still alive!! We are 64 , after all the crazy things we did in our early 20ies !!!! Thank you for the laughs and great conversation and information !!
@markveen13733 жыл бұрын
I've seen a woman in pristine condition at age 103. Could still walk without any help. Clear voice and hold long conversations. Hardly any wrinkles. Looked like a healthy 75 year old. Doctor checkups every season. Everything seemed more then fine for her age. One summer day however she took a midday nap and was gone. With a smile on her face. Family told nothing strange was going on the day before. I would imagine at those extreme ages. You would need to have a very strong will to live, and still have goals. If you're happy and content. Did everything you wanted to do. The body just gives up I think, eventhough it could go on for longer. Ultimately, the mind controls the body.
@knowledgelibrary11413 жыл бұрын
At any age, purpose is what fuels human life. Hence why most people "die" very early in life. They navigate the world without purpose and live cookie-cutter lives until they reach old age and then pass away. I would argue that the elderly person you speak of live ten lives relative to others as clearly something kept her going for many decades beyond average human life span.
@iss85042 жыл бұрын
Absolutely you are right. My father in law was a spry 85 year old, living independently and he had an accident that resulted in a leg injury that ended his independence. He had to live in a nursing home. He couldn't drive or cook or do amything without help. He lasted a year. Refused to leave his room. He was a social guy. He just gave up on life.
@elizabethk32382 жыл бұрын
At 74 the only goal I have is doing what it takes to remain healthy. Some need GOALS (usually those who have not yet begun to examine their lives), those of us who have done self examination just enjoy living in the present.
@gloriasaliba3395 Жыл бұрын
@@elizabethk3238 agreed - I’ve contributed much to my family work friends and the community I live in - it’s now my time to focus on me - walking Pilates strength training reading books from cover to cover being mindful and relaxed when cooking spending time with friends long lunches the cinema opera ballet spending quality time with the second generation in my family and treasured sleep ins - when people ask me how I spend my day I just smile
@kirstinstrand6292 Жыл бұрын
I've heard it said that we can choose when to die; my mother did. ❤
@elbay23 жыл бұрын
Fascinating discussion… thank you!
@craigm72403 жыл бұрын
I cannot believe how educational this was.
@HkFinn83 Жыл бұрын
59:02 Squirrel monkeys, my spirit animal
@focusedvegetable36552 жыл бұрын
Loved his background and overall perspective. I am not sure I would known him to be such an exciting scientist from his papers.
@bottymcbotface0073 жыл бұрын
"But you're a normal sized person, its not as if you are 5'7 now, so where did the growth spurt come from?" 5'7 man crying here :'( Thanks Peter! Made my day!
@kirstinstrand6292 Жыл бұрын
Got a growth hormone injection during childhood.
@nadernayo3 жыл бұрын
wow.. Lots of knowledge.. Thanks peter for making this knowledge available to us..
@happynjoyousnfree Жыл бұрын
OMG how were you not laughing HYSTERICALLY at the lion story??? I would have been rolling on the floor 🤣🤣🤣🤣🤣
@melisasurprisebox99782 жыл бұрын
This is the best episode that i’ve ever had on yours for fun. I heard this one third time and I still laugh about the lion.
@khaledzurikat7190 Жыл бұрын
Genius person with unlimited humility!
@tablecork3 жыл бұрын
I think we would all would like to know what they injected him with in high school, could've used some myself! LOL
@cryptomusician40393 жыл бұрын
At the age of 72, I am at 20 a year low point at 239 lbs. It is now 30:00 of an extremely interesting KZbin and I am on a calorie restricted nutritious diet. Will continue to watch and report...
@kirstinstrand6292 Жыл бұрын
What's your height?
@HkFinn83 Жыл бұрын
As a person who is natural...weight gainer, fasting is one of the only things that works for me, good luck:) Edit, comments a year old, hope it’s going well😂
@IvicaOS3 жыл бұрын
what a great guest, as always…🤗 what a great pod, as always…👊🏻
@anthonylawrence58423 жыл бұрын
I have a personalised story and n of 1 but I seem to have established an interesting effect. I am aged 69. I have worked out for the last 45 years 3 times per week HIIT and HIRT for 1 hour. The last 5 years fairly strict Keto diet, almost no sugar and starch and only complex carbs. (no nuts I'm allergic) I weigh 70kg at 5'10" height. I take a daily, limited but strict, daily supplement stack daily. I use IF only, eating within a 6 hour window twice per day between 1pm and 7pm. I have recently had a GlycanAge Test for biological age. It came back at 32 (they've never seen this out of 150,000 subjects). Interestingly, I have recently increased my calorie intake by at least 400 calories using natural yoghurt, double cream, pure Whey protein powder and a few blueberries. In a month it has made no difference to my baseline weight. Anyway, seems to be interesting so far?
@LTPottenger3 жыл бұрын
Great! You are getting the result everyone hopes is possible. Do you do any longer fasts?
@anthonylawrence58423 жыл бұрын
@@LTPottenger No, just the daily 6 hour window 1pm to 7pm. Small daily supplement stack. Multi B complex with C, Calcium AKG, Vit E (only Tocotrienol) Omega3 (only DHA) Seaweed caps, Adaptogens, Pottasium and slow release Magnesium, K2 (special formulation) CoQ10 with Resveratrol, Phospholipid complex, mixed Japanese mushroom complex.
@oolala532 жыл бұрын
@@anthonylawrence5842 May I ask what you spend on a monthly basis on supplements? You have ahd good results, though you are doing so many things that it could be hard to determine if something wasn't actually optimal. Longevity researcher Valter Longo has said that the only daily fasting window that has not shown any issues is 12 hours. Also, what do you mean by complex carb? I thought it was pretty hard to have what I think of as complex carb at all on keto. In any case, you have found a lifestyle that gets you what you want!
@anthonylawrence58422 жыл бұрын
@@oolala53 Hi - I spend in the region of £150 per month on supplements. I workout 3 to 4 times a week - 15 minutes HIIT and 45min to one hour with weights. At now 70, maintaining muscle mass is more important than aerobics. I can drop the weight and increase the reps. I'm not too religious about keto but the complex carbs are usually cruciferous vegetables, avocados, avacado and selective nuts. (not cashews or peanuts) I only use avacado and coconut oil. No fruit at all - I use fermented veg and Inulin for fibre. (awesome!) BTW I can still bench press at world championship level for my age and weight!
@oolala532 жыл бұрын
@@anthonylawrence5842 Goodness! You have to admit that is quite a big budget for supplements, though obviously worth it to you. I thought to maintain muscle a person would want to keep weight high. I guess you buy inulin separately. I eat about a half a cup of fermented veg a day. That doesn't amount to much fiber, but magnesium helps as well as some greens. Do you eat mostly fatty meats for the core of your calories? I don't mean to be disrespectful but in first post you said you had a fairly strict keto diet but later said you are not too religious about it. I guess that just means you don't have a hard-and-fast limit, but know from experience where you land with your plant intake. Fair enough! Your consistent exercise regimen sure keeps you in the elite! Reminds me of a former Crossfit champion who changed his sights and dropped way back in training. His former life, though resulting in a strong body, also wore him out. What he does now he says he can continue for decades. I believe his name is Marcus Filley. Maybe he should be featuring you in a video!
@y.g.1313 Жыл бұрын
2:11:08 - NIA (National institute of aging) in 1990 rec'd $100M for biomarkers of aging and got nothing. - probably the most valuable statement in the whole interview.
@tonynoonan37233 жыл бұрын
Thanks Dr Attia, Great Podcast,whats your view on giving metformin to an asymptomatic patient with 35% generalized coronary artery plaque deposits with a view to stabilising the disease process..
@Dan-jo8py3 жыл бұрын
"As rats they're fatter, more diseased, reach puberty quicker, have too many kids" ...sounds the perfect model for human research to me.
@aquamarine999113 жыл бұрын
tl/dr We still don't know anything, because we don't yet have the appropriate biomarkers for judging the efficacy of rapamycin, metformin, fasting, NAD enhancer or whatever. But still an excellent conversation.
@spek25542 жыл бұрын
I have listened to many talks on this subject of calorie restriction and it seems that the message is the more that your body struggles to stay alive by not starving to death, the longer you do stay alive. Dietary hormesis. As though it is mutating everything to achieve that goal. SAD dieters are telling their bodies “hey, I am satisfied, it’s a great time to die.”
@sciencesimplified38903 жыл бұрын
im starting to really agree that methylation clocks are just a big effort to find a signal in a bunch of noise.. but its mostly just noise or different proxys for different things depending on the clock.. like im sorry if a certain lifestyle reverses clock by 6 years, does that mean that lifestyle will make you age in reverse in live forever? of course not.. of course its all more nuanced different clocks are measuring different things but it is starting to feel like hype
@bernhardwalther2 жыл бұрын
Great content! Thanks for being so accurate. I heard the way is long to go for people over 40. Let's hope to be lucky on rapamycine very soon...
@jakobw135 Жыл бұрын
So which has a more positive effect overall on your health: caloric restriction, or time restricted eating?
@ES-qe1nh Жыл бұрын
CR irrespective of timing is what matters. TRF makes CR easier for some people. Unclear if TRF by definition has additional benefits over CR
@pavelchorda84252 жыл бұрын
Great interview. As a biologist, I was always interested in longevity, my thirst of knowledge brought me to Studie Taoism (I was doing martial arts since I was 4), I went deep into the topic and in the practice, the point here is, in men the shortering of life span comes directly from the loss of jingchi, directly associated to the loss of sperm, Of course as animals we need to pass on our genetics to the next generation, improving if it's possible 😉, This could be the relationship between sexual hormones, longevity. It's a long topic
@digantasarma77273 жыл бұрын
I think we should also observe people around us. I have seen many who eat less and active and are healthy in their seventies.
@armandsriekstins76463 жыл бұрын
This was really good!
@carlaharmon45522 жыл бұрын
This is AMAZING!
@loginusers58122 жыл бұрын
I would want to be part of calorific or dietary restriction studies and I promise to follow them diligently.
@espinosalexis3 жыл бұрын
As my past 12 comments: Everytime you touch this topic I wonder when are you going to invite Prof. Longo to your show? Or, put in other way, I wonder if you guys don't like each other? It appears incredible to me that Longo has not been yet in "The drive"!
@doctork17083 жыл бұрын
Lingo probably disagrees with his life philosophies.
@LTPottenger3 жыл бұрын
Where is longo though? That may be an issue
@oolala532 жыл бұрын
@@LTPottenger He works in Italy and Los Angeles. Yeah, he would have a lot of contradictory interpretations.
@LTPottenger3 жыл бұрын
Sounds like there is zero benefit to caloric restriction than not overeating and a lot of drawbacks. Now let's see fixed ad libitum compared to fixed healthy diet compared to 23:1 compared to fasting one day and eating ad libitum, fixed budget and or 23:1 on the eating day. Then maybe we will get some idea if the actual lifespan can be improved
@Chris_Kunce2 жыл бұрын
The story about the CR mice that were climbing the cage was interesting. Presumably they were devouring their food and incidentally eating OMAD. Could you pair feed two mice, both CR, but one OMAD and the other in a time-released schedule that mimicked meals and snacks? Would there different outcomes?
3 жыл бұрын
1:56:50 I don’t think a human embryo with a 46,YY karyotype would be viable (or a human embryo with any total monosomy other than 45,X).
@joetart99053 жыл бұрын
Would love a interview with Dr Ron Rosedale!
@lk-ky3rw3 жыл бұрын
I find it interesting that Dr Attia is chasing longevity and yet the activities he participates in are higher risk such as extreme swimming or car racing, quite the paradox... almost like he can't get rid of the thrill seeking aspect of his life
@iss85042 жыл бұрын
Forever consists of nows. You're better off having lived and experienced than just living a long time and avoiding risk. Life is an adventure !
@oolala532 жыл бұрын
I believe he has curtailed a lot of his extreme activities because of that very issue.
@cbbhvjc3 жыл бұрын
Dr. Attia, please activate KZbin's "Clip" feature.
@kirstinstrand6292 Жыл бұрын
After listening here, it seems that longevity studies are just getting started. Oddly, I always find myself agreeing with Dr. Attia's judgement.
@ES-qe1nh Жыл бұрын
Indeed! At least the rigorous, useful ones
@jeffrey45773 жыл бұрын
Which mice species does valter lingo use?
@scottk15253 жыл бұрын
I think the monkey studies prove one thing: excessive sugar is a death sentence.
@t.t.8878 Жыл бұрын
My mother ate large amount of sugar all her life. She never exercised ,& never took any meds or vitamins. She liver to be 89 & died in her bed reading the bible.
@scottk1525 Жыл бұрын
@@t.t.8878 Oh well in that case, we should all stop exercising and eating healthy because it clearly doesn't matter. Nice work. Make sure to call Attia. I think he still believes that exercise is healthy and sugar is harmful. Crazy, I know.
@BubbaBeast321Go3 жыл бұрын
Is that a picture of Richard Feynman in Peter's office?
@peterz533 жыл бұрын
Yes
@LTPottenger3 жыл бұрын
good eye
@AllWordsAreDust2 ай бұрын
"Virtually all captive animals are obese" - wow, it makes sense when you think about it, but I never realised this could be the case. Says a lot about the nature of obesity and the modern human condition.
@iss85042 жыл бұрын
@10:40 NYC is back to the 70s. I used to live in NYC , glad i am not there now. The stabbings and random attacks...its back to Batman's Gotham.
@peterz533 жыл бұрын
Keeping monkeys caged for decades, alone in small cages, was extremely inhumane. Brutal. Don't understand how this could be allowed.
@HkFinn83 Жыл бұрын
We still do it to humans
@elvay68473 жыл бұрын
02:24:45 LOL guess he hasn't turned on a television in a year.
@johnditraglia83453 жыл бұрын
Dr. Austad that's called constitutional short stature (that also runs in families like familial short stature) where you go through puberty later and finally wind up more average height. 0
@BigPictureYT Жыл бұрын
Not only are the lab mice genetically bizarre, their environment is totally weird. Wild mice are nocturnal. They forage. They interact with other mice. They are not locked in prisons and feed balanced meals without exerting any effort.
@korchansan2 жыл бұрын
Wow this guy took an arrow to the knee and lived to tell the tale
@RanAmitay3 жыл бұрын
1:25:50 is a small Easter egg. Loved this discussion!
@AlexEats Жыл бұрын
I’ll volunteer
@Nando_lifts20213 жыл бұрын
Right away hearing about the kidney blood restriction test on mice seems cruel to me. Like we are nazis and other species are the test subjects
@junepagan87152 жыл бұрын
Profilings offered a calorie restricted program at 1200 calories.
@moontrack46253 жыл бұрын
Concerning that all lab research with these meices may have almost no real scientific applications r/t humans!
@LTPottenger3 жыл бұрын
I don't think that's true. Being homogenous has a lot of benefits.
@Thomas-kx5nj Жыл бұрын
Vous avez bon cœur et nous vous sommes reconnaissants pour tout ce que vous faites Dr akhande Merci de nous avoir fourni le traitement contre l'herpès 1:28.
@mightbefire2 жыл бұрын
1:43:00 Who are these monsters? This is the path to Josef Mengele. You can do whatever you want, and feel justified, as long as you decide something’s pain, suffering, or even life, doesn’t matter.
@zack_1202 жыл бұрын
20:20, 34:45, 1:57:35
@nonononononono0003 жыл бұрын
Good overall but the conversation about the origins of risk-taking behaviors in young men vs. women veered off in a real non-scientific and clueless direction
@QueOndaWhey3 жыл бұрын
Clearly haven't been to #NYC recently....
@LTPottenger3 жыл бұрын
heh
@riddlescom2 жыл бұрын
I'm glad I'm not a mouse.
@AlexEats Жыл бұрын
I balance my 5 days of 1k calories with two days of 5-7k days. Get yo weight up 💪😂
@trismegistus34613 жыл бұрын
tl;dr what can we (humans) do to increase longevity?
@ES-qe1nh Жыл бұрын
Exercise, have friends, avoid saturated fat, ingest DHA/EPA, get your APOE alleles and Lp(a)+ApoB checked
@Ayrad1602 жыл бұрын
How can you be on a calorie deficit your whole life without losing all your fat
@neilpbullock1572 жыл бұрын
Almost half way thru and no specific health, medical or research data beneficial toward aging. These basic approaches & insights could have been covered in 10 min or less.
@kirstinstrand6292 Жыл бұрын
I eventually skipped ahead. lol
@user-po7te6hn2s3 жыл бұрын
talk to programmer who improves code of "blind programmer" like Nature is
@kicknadeadcat3 жыл бұрын
Labs are now getting away from rats and have settled on lawyers. For 2 reasons…..lab technicians do not get as attached to the lawyers and lawyers will do things the rats won’t. Robin Williams……
@bugsbunny23573 жыл бұрын
Somehow the idiocy of men I do not find surprising. LOL I have no doubt the difference is testosterone (but, then again, it's not my job to prove it).
@elvay68473 жыл бұрын
Idiotic yet better at just about everything ♂
@mary_puffin3 жыл бұрын
@@elvay6847 Better at caretaking and childbearing too? LOL. What a sexist comment! Men and women contribute differently - you don't have to put women down to say men are good at something.
@csn5838 ай бұрын
"CO2 is highly sedating", Peter?! Sure you're not thinking of CO? For obvious reasons, CO2 buildup is the MOST guaranteed fear-inducing environment across all sorts of air-breathing lifeforms. Dragging that on longer could maybe have a frog-in-boiling-water effect; that could be the logic to the new methodology. But while 5 seconds may not be long to suffer it, that is a final shot of adrenaline as sure as a bag over the head. Surprising flaw in thinking in what was otherwise impressive diligence in fighting bias. Perhaps what it takes to internally justify exterminating hundreds of thousands of animals as a career is a bit of a blind spot. Doubt me? Try it. Bring a friend so you don't kill yourself.
@brookstorm9789 Жыл бұрын
Such an entitled attitude about torturing animals for things that could be easily known through common sense and anecdotal evidence. It seems just that the main torturer dies of a violent injury himself. "I don't think the animal research tells us that much about people". He admits it. These people are not wise or compassionate. The animals also have the mind of God, the full spectrum of feeling and suffer greatly. Look at the researcher's face and hear his broken voice. Nothing he has done has benefited him or anyone The human population is being used as lab rats as well and how has that worked out?
@ES-qe1nh Жыл бұрын
What?
@mikefinlayson99072 жыл бұрын
Why is it a “problem” that women live longer? Other than an intellectual perspective?
@johnbaker87423 жыл бұрын
Haha
@MikeG-js1jt2 жыл бұрын
Stupid behavior like swimming the Catalina channel?................. stuff like that?
@user-po7te6hn2s3 жыл бұрын
just for the record: in this episode Peter is dead-wrong on epi-genomic info for longevity-science.
@pimvisser38743 жыл бұрын
Elaborate?
@user-po7te6hn2s3 жыл бұрын
@@pimvisser3874 will do once paper released
@pimvisser38743 жыл бұрын
@@user-po7te6hn2s ETA :D
@quantumuniverse57713 жыл бұрын
X longevity is way big area, you need to be a bit specific when you're saying smt like that!