#27 - David Sinclair, Ph.D.: Slowing aging - sirtuins, NAD, and the epigenetics of aging

[@damarischiquete8084]

Congratulations for the best interview to David Sinclair PhD... shows that the interviewer is well educated in the field to do a deep talking about science. Thank u so much to both!! You are awesome guys!

[@chrisportislander2458]

"I assure you the listeners are still with us." YES! I am!

[@mixedandmashed]

Two of my favorites. Thanks for this!

[@seabound1350]

I whish Peter wouldnt interupt so much when David is trying to explain things. It takes away so much.

[@thinkandquestion5156]

I look at it as a discussion, conversation, not a strict Q & A session.

[@jellybeanvinkler4878]

I was happy that he did, because it was going over my head til Peter veered David into lay person's understanding.

[@elvay6847]

Typically I am fine with Peter interrupting, as these podcasts are discussions and not lectures. But Peter was particularly annoying in this one. He completely derailed David many times.

[@filipporivalta]

thanks from Italy for sharing precious information in this practical way... it's part of my graduation thesis.

[@stefanlucchesi7789]

Si puo davere mettere indietro il tempo biologicamente di una persona o e' una cosa solo delle industrie farmaceutiche

[@filipporivalta]

stefan lucchesi andare contro natura non si può. Accompagnare al meglio un percorso biologico è possibile, la parole d’ordine però è rispetto e totalità di azione... movimento, alimentazione, riposo. Yin e Yang è la regola. Quando si va oltre succede il danno, sul breve o sul lungo. Peter Attia è un medico che da molta importanza alla sfera mentale e fisica anche

[@salardz]

Great, great video. Very interesting points were coverd.

[@sciencekid]

More people need to listen to this!

[@LilianaGrueber]

Both of you guys are AMAZING!!!!! I love it! Super interesting and useful! Way to go Peter Attia!

[@rossbarker3362]

I'm confused by this nicotinamide, David was explaining it and you interrupted him and Said "OH!, I get it" I'm glad you get it so U can explain to me, it seems the MNM/NAD excites the Sirtuins and this is a good thing as they can make repairs and do there thing, but the nicotinamide, B3, inhibits the Sirtuins, U said something about a feedback loop, how can both statements be true?

[@allurbase]

there are several chemicals, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR) and nicotinamide (NAM or vitamin B3). NR is converted to NMN and depending on conditions sometimes NMN is converted back to NR. NMN is mainly converted to NAD+ that is what we want, because NAD+ is necesary for the Sirtuins activity. And if I'm not mistaken after using the NAD+ you are left with NAM (aka vitamin B3). When you have too much NAM this Sirtuins activity is inhibited and thats your negative feedback, convert NAD+ to NAM until there is too much NAM.

[@scottk1525]

Yeah I didn't understand a word of this.

[@kanahn7402]

I didn't get the bit about the synergy between alternate day fasting and resveratrol. Where they saying it's better to skip the resveratrol when fasting. Or was the resveratrol the same on fasting and feeding days?

[@leonardodamico9344]

Could you do a video on parkinson disease

[@edisonclaro5363]

hi I follow your work and it is really amazing.David told us what he takes. and what about you . Do you take NMN or other like that?

[@NavidNathoo]

This might be bias, but here's an overview of the NMN vs NR and why Elysium uses NR. TL;DR = NMN is bigger, NR is smaller = NR [likely] has better cell absorption rates but hasn't been tested side by side yet. --> www.elysiumhealth.com/en-us/knowledge/science-101/nmn-and-nr-how-these-nad-precursors-measure-up

[@SquatFull]

I would appreciate a response to Dr. Charles Brenner's Article "Sirtuins are not conserved longevity genes" Life Metabolism, Volume 1, Issue 2, October 2022, Pages 122-133.

[@cholakicha]

59:00

[@lizaalexeeva7009]

I want peter attia merch

[@FatherGorgony]

Thank you, Peter for your English. It would be nice if you translate😂 or just repeat what David says in Australian.

[@rui-9-cs315]

💕

[@janelopez5988]

The overjoyed himalayan intrinsically hate because maid utrastructurally admire across a wide-eyed word. soggy, cheerful wave