31. Immunology 2 - Memory, T cells, & Autoimmunity

MIT 7.016 Introductory Biology, Fall 2018
Instructor: Adam Martin
View the complete course: ocw.mit.edu/7-...
KZbin Playlist: • MIT 7.016 Introductory...
Continuing the topic of immunity, Professor Martin talks about how immune cells are able to see within a cell in order to address an infection in the body. He focuses on the processes of antigen presentation, isotype switching, and autoimmunity.
License: Creative Commons BY-NC-SA
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[@jakeeutis5035]

I believe information should be free. I am so thankful that MIT feels the same

[@shivangirai4154]

You are right.

[@ianmatthewkline8279]

I've been studying immunology for years now and I never get bored with hearing this story :) Always fun to hear it taught by different instructors too.

[@GeorgiosAndreasIoannou]

We need to cure cancer

[@ianmatthewkline8279]

@@GeorgiosAndreasIoannou Im a viroliogist and not a cancer biologist by training, but I can tell you that "curing cancer" in one blanket move isnt possible. There are many mechanistic ways cancer develops and each may require a different drug to stop oncogenic transformation. A loose analogy is saying, "we need to stop crime". There are MANY causes of crime and each would require a unique approach, although some overlap might exist in how we deal with each. Hope that makes sense. And yes, I agree. I have Crohn's and am high risk Colon cancer bec of that. ITotally with you on this but it's just not a simple thing like, "why havent we cured cancer yet"

[@GeorgiosAndreasIoannou]

@ianmatthewkline8279 I am pretty sure we haven't cured cancer yet is because the technologies are not here yet, a drug will not do much, a chemo? Even worse, we have to find better and more targeted ways to kill cancer, the best approach I've seen so far is immunotherapy and extreme plant based diet with a lot of fruits and vegetables, we must find a way to give strong power to the healthy cells and not only kill the bad ones, surely Artificial Super Intelligence will beat us on curing cancer also aging, I hope I helped you with one of these approaches, I am currently studying biology to be accepted on a university in Athens University in Greece, MY mission is to make everyone be alive forever and make me be alive forever, and like you said we need logic that's why we must also Believe in Jesus Christ and Follow God's will forever, The problem is Death, Immortality or Nothing, Don’t Die and by all means we need to stop death, death is the root cause of all evil

[@mkirtikoushik8471]

Im from odisha (a tribal state of india ) A huge 🙏 to MIT for making these lecture absolutely for free, this would really help a lot like me who just cant afford this kind high quality education even in their dreams .....

[@mohamedismail6273]

Are preparing neet download byjus😂😂

[@Ronaldo71543]

Absolutely

[@tranna1503]

🎉

[@mkirtikoushik8471]

@@tranna1503 🙏🏼

[@think3rofficial]

I love how he uses seemingly useless objects to demonstrate biology. He’s a great lecturer. Those students are lucky to have an instructor so passionate about what he does.

[@mohitjesani2797]

46:36, one of the mechanisms can be degeneration of the lymphoid organ (say, thymus, which reduces in size at puberty) to prevent self immunity.

[@shehzadali7609]

Excellent lecture series I work in the Tranplant field and this is so relevant to our field and patients Great work and Thank You

[@nathanielbutler3378]

"I endocytosed my chalk, I need to get it back" LOL

[@tillyfreeman5192]

Like others have mentioned, this is an excellent lecture. I have been trying to tie in together the knowledge I gained from different institutions and place immunology at the center of all the information to learn how to create the vaccines and I have gotten so much more from this lecture. I went back to school to learn this. I wanted a specific career path where I’m able to make vaccines or help my scientific community drive drug discovery and this lecture is one of the best I have ever came across. It supplements my biochemistry and love that the instructor had to show the anatomy of the Ag receptors for B and T-cells!!! Excellently done. And for this reason alone, I am even considering visiting MIT as a scholar.

[@arwasayed846]

you returned my interest and passion ,thank you 🤩

[@doctors_of_medicine]

really enjoyed this lecture

[@janetanna8542]

Excellent lecture! Explanation was so precise and to the point! Thank you MIT😊

[@leemack8163]

Amazing!

[@priyanganiegunathilake3540]

Best teacher ever wow explanation is crystal clear god bless him🙏🙏🙏🙏 And thank you MIT

[@georgereese2066]

I loved the lecture , He is a very entertaining lecturer!

[@cynthiad_]

Thank You for sharing this 💯❤I learn so so much from your lectures 🤗💯

[@icshahid]

Thank you professor . We want complete lectures here please .

[@nibussss]

Cd4 ....First latches on isotype switching.... Affinity maturation.. From weak to tight binding somantigen.. Igg Bacteria Ige Worms Effector cell Memory cells

[@MrRangerzz]

Amazing!

[@shaifalisoni8479]

Plz provide these type of lecture

[@mohitjesani2797]

clarity at roots👌

[@sekousesay9352]

Thanks MIT OpencourseWare; I really don't know if this is the fundamental for immunology or its an in-depth into immunology for those who wants to study Medicine. Thank you and I will be very interested to learn more, from Ghana.

[@lakshmananshunmugam7931]

Super

[@scottcoston7832]

Thanks!

[@nibussss]

Peptide Amino acid more Classs 1 .....cd8 Professor youn kim...Divic martin

[@bomama9169]

Where is lecture 3? 😊

[@mitocw]

kzbin.info/www/bejne/pYDckmaZe9J0g8U

[@shanawarplayz8236]

Amazing explaination... please upload complete lecture series'

[@mitocw]

Here is the full playlist:kzbin.info/aero/PLUl4u3cNGP63LmSVIVzy584-ZbjbJ-Y63. For course materials, see ocw.mit.edu/7-016F18. Best wishes on your studies!

[@priyanganiegunathilake3540]

@@mitocw OH MY GOD THANK YOU SO SO SO MUCH

[@nibussss]

Peptide....attracts Corecptor? Both....on in cell? T cell ...nucleus.... Cytosol....is Sol in cell?

[@GeorgiosAndreasIoannou]

We need to cure cancer

[@khgnew763]

great sir. one question when CD8 interact with MHC 1 can it be stimulated or it need help from CD4?

[@gogemusicimprov4421]

8:40 well there are so many different kinds of proteins in the cytoplasm made by the host itself, not just antigen! So why wouldn't these get loaded onto MHC1? And if they are loaded too, killing MHC1+peptide cells would be a terrible autoimmune idea. So no explanation on that??? And the students did not think of this when he asked whether CD8+ cells should kill?

[@M.u18]

10:28

[@nibussss]

If i ever be a professor ...man..tough job...but maybe not fear based?

[@nibussss]

Mhc molecule.....class two. Cd4

[@nibussss]

Genomicmlocue?

[@artemkondratyev2805]

Having made it all the way to this lecture, unfortunately, it feels to me that the explanations get worse and worse with every lecture. I guess all the people who actually liked this or other lectures are probably already familiar with the material presented here, so they can easily bridge gaps and connect things. But this is my very first time learning the subject and I am completely confused, and constantly find myself in need to google everything to patch the explanations and re-order them in more logical way. However, the claim made in the very first lecture was that no prerequisites were required (although I did finish MIT 5.111 Principles of Chemical Science before starting this course, so I consider myself reasonably prepared). The only lecture that I truly enjoyed was lecture #22 on neurons, the reason being that I already studied the Hodgkin-Huxley Model before (as part of MIT 9.40 Introduction to Neural Computation) and already knew the material one level deeper than what was explained. The lecture, in that case, was a breeze. What is missing most, in my opinion, is meta-explanations: explaining what you are explaining, how these things connect and the sense of direction: where is this explanation going. You cannot simply jump from rather high-level overview of immunity into formation of MHC Class I peptide complex without any warning, so to speak. You need to explain why we are suddenly going into such level of details and bridge it properly with the previous explanations. I often find the order, the context and the proper connections missing. Nevertheless, I am very thankful for being able to access these recordings online and for free, so I hope MIT continues to publish these materials. All the best and hope you take this as a useful feedback rather than a rant :D

[@leemack8163]

Very good. Just please drop that battery flashpoint. It is really annoying.

[@seymanurozkan9150]

is there third lesson ?

[@mitocw]

There is not a third lesson on immunology. See the course materials for details: ocw.mit.edu/courses/biology/7-016-introductory-biology-fall-2018/calendar/. Best wishes on your studies!

[@nibussss]

Locus...?

[@nibussss]

Antigen...is like marker Antibody destroyer

[@nibussss]

Antigen produCing cells...two origins

[@nibussss]

T cell has two chains alpha and beta..

[@fadygorgy7266]

I miss chalkboards

[@AshishPatel-qo9xl]

Hell no🔪

[@nibussss]

I think I'm only one....only child syndrome....

[@nibussss]

Can be irritating? But me feling special causes others to look at me?