Acetylcholine

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Video by Dr. Dawn Elise Snipes on integrative behavioral health approaches including counseling techniques and skills for improving mental health and reducing mental illness.
Acetylcholine
Objectives
- Review the function of Acetylcholine
- Identify mood and behavioral disorders associated with acetylcholine imbalance
- Explore interaction between acetylcholine and other neurotransmitters and hormones
Function of Acetylcholine
- Stimulating skeletal muscles, smooth muscles dilation of blood vessels, slowed heart rate, increased body secretions
- Memory and Learning
- Attention
- Cognition
- Motivation
- Arousal
- Promoting REM sleep
- The central nervous system undergoes several dynamic changes during sleep, which are mediated by norepinephrine, serotonin, and acetylcholine.
- Sleep contributes to memory and brain plasticity and triggers overnight learning
- Immunity: During infection this immune-derived ACh is necessary for the T cells to migrate into infected tissues
Implication in Mood and Behavioral Disorders
- Alzheimer’s patients have low acetylcholine levels
- Parkinson’s
- Delirium: Caused by acetylcholine deficiency and dopamine excess, relative to each other
- Anxiety: In excess compared to other NTs, acetylcholine increases anxiety
- nAChR agonists
- Can improve mood and cognitive performance in depressed individuals
- regulate mood, anxiety, and aggression related behavioral states
Symptoms
- Excess
- Increases hypervigilance
- Increases fear learning
- Increases anxiety
- Increases CB1 receptors promoting eating
- Contributes to rumination and reduced psychological flexibility
- Can cause delirium, confusion, headache, or drowsiness
- Increased body temperature and flushing
- Increased blood pressure
- Increases the release of gastric acid
Acetylcholine and Mood
- Unipolar Depression
- AChEI: Worsened depression (induced in controls)
- mAChR agonist: Worsened depression (induced in controls w/ cannabis and with Alzheimer’s)
- Antimuscarinic: Antidepressant
- nAChR agonist: Antidepressant in non-smokers
- Bipolar depression
- AChEi: Worsened depression
- AChR agonist: Worsened depression
- Antimuscarinic: Antidepressant
- Bipolar mania
- AChEI: Reduced mania
- AChR agonist: Reduced mania
Summary
- Acetylcholine is not often talked about but is a necessary excitatory neurotransmitter
- Acetylcholine interacts with gonadal hormones, thyroid hormones and several neurotransmitters
- Acetylcholine is important for energy, memory, attention, regulation of muscle contraction and much more.
- Choline is necessary to make acetylcholine
- Tyrosine is necessary to make acetylcholine
- Too much acetylcholine contributes to anxiety and irritability, too little contributes to anhedonia
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[@jennirmz2381]

This was excellent information. Thank you.

[@DocSnipes]

Very welcome. Thanks for watching

[@sabincioflec8413]

My 2 cents. Acetylcholine is increased through xenoestrogens (in women, higher estrogen more focus, earlier puberty n such ) but is decreased in men. Maybe the ratio of testosterone to estrogen becomes imbalanced and makes men not as focused and mood becomes lower. If testosterone is lower when acetyl choline is higher then why is testosterone really important, for men, for motivation and a lot of good stuff that targets acetylcholine too.

[@Big-Pimp-Esquire]

Excellent milestone for understanding the relationship between acetylcholine and diabetes insipidus. Thank you :)

[@DocSnipes]

Thanks for watching.

[@thegreatgatsby5493]

Another great video that is underrated.

[@DocSnipes]

Thanks for watching the video. What did you find most useful from it?

[@thegreatgatsby5493]

@@DocSnipes See, for an example, clarifying the distinctions between activating and inhibiting the nicotinic and muscarinic receptors with symptoms and medications without putting jargons into it, is a really nice thing to do. We all can find the information in books but in order to absorb all that we first have to get the simple ideas and then later on dive into the intricacies gradually. So, to start with Neurotransmitters, this video is certainly helpful.

[@mazedmarky]

Very Glad You Talk about it

[@SharonLByrd]

All your presentations are interesting to me.. as a 61 yo female, many useful tidbits, I'm someone that needs more acetylcholine..I feel like all my neurotransmitters are flatlining, but near the end 2 things caught my attention, one, I'm on hrt w additional progesterone..supposed to be good for my sleep which I struggle with and two, I've been taking ZQuil to help me get a good night's rest.. maybe these 2 things are actually sabotaging my acetylcholine which might explain my absolute loss of energy or motivation lately.. I'll speak w my doc to see what she suggests regarding this.

[@mitchnidey2453]

Holy Basil

[@t.cchuah5463]

Great lecture. Thanks, Doc.

[@DocSnipes]

Thanks for watching!

[@patrickhanson712]

Interesting. The sub cortisol in some PTSD people I saw yesterday made sense, probably a dissociation that helps stay calm maybe (or so seems)

[@SirYobble]

I’m confused. At 38.05 you start talking about acetylcholinesterase (which breaks down acetylcholine) and then you switch to talking about increasing/decreasing acetylcholine.

[@hikmatullahammar]

Acetylcholinesterase is enzyme that breaks the Acetylcholine into Choline and Acetate now if the action of Acetylcholinesterase is inhibited, no more Acetylcholine will convert into Choline and Acetate which will eventually cause accumulation and increase level of Acetylcholine at Synaptic cleft

[@luisgerardollamasgutierrez9726]

14:36 but it seems we make acetylcholinesterase endogenosly, as an enzyme. So if it gets bogged down it won't produce its effect of breaking down acetylcholine making it accumulate and GO UP

[@irmaflores8166]

What kind do you suggest is good. Thank you!

[@DocSnipes]

I appreciate you watching. Sadly, I can’t recommend medication.

[@lovesgibson]

I’m kind of confused. I have panic disorder and heard that the body will stop the autonomic nervous system panic response by activating the parasympathetic nervous system, and I heard that it does this with acetylcholine. So I was thinking that raising my acetylcholine levels would help preventing the body from going into a panic response. But on here you say that acetylcholine increases memory associated fear - which is kind of a big factor of panic disorder. Didn’t watch the rest of the video yet, but curious if acetylcholine would be something positive or negative regarding panic attacks, or if it’s basically a non factor. Hopefully there’s more clarity as I go through the rest of the video

[@DocSnipes]

Anytime you modify the level of one neurotransmitter, it impacts the levels of other neurotransmitters. Here is a good article. www.ncbi.nlm.nih.gov/pmc/articles/PMC3466476/

[@Robertsmith-un5cu]

magic mushrooms will help

[@jenniferheath4844]

Check out Hawthorn Berry, Dr. Christopher!

[@tims1561]

Receptors: At min 31:12 Dawn says that dopamine and acetylcholine are low in people with RLS and parkinsons. I think she means that the receptors are low and not the dopamine and acetylcholine themselves.

[@DocSnipes]

Not necessarily. The dysfunction in neurotransmitter levels can come from insufficient axons, insufficient dendrites, insufficient production or even imbalance in other neurotransmitters or hormones causing low levels of dopamine or dysfunction.

[@acacianorison]

Thank you so much . Please talk about dopamine. God bless

[@DocSnipes]

Bless you as well. I also have another KZbin Channel: Good Orderly Direction | Practical Bible Study kzbin.info/door/YYJCD94NU3_qdbkSEyHLrg Please consider liking and subscribing.

[@DocSnipes]

Bless you. I also have another KZbin Channel, I just started: Good Orderly Direction | Practical Bible Study kzbin.info/door/YYJCD94NU3_qdbkSEyHLrg Please consider liking and subscribing.

[@absbi0000]

Acetylcholine is underrated! And unfortunately less well known than Dopamine as a neurotransmitter and neuromodulator.

[@DocSnipes]

You're absolutely right! Acetylcholine, often overshadowed by its more popular counterpart dopamine, plays a crucial role in cognitive functions and muscle control. It's like the unsung hero of neurotransmitters, quietly doing its job to keep our brains and bodies in sync.

[@jenniferheath4844]

@@DocSnipes Hence why they used this in Trauma Based Mind Control! Thank you so much for this presentation! Blessings!

[@jenniferheath4844]

@@DocSnipes FYI Hawthorn Berry has Acetylcholine! Check out Dr. Christopher!

[@johnathanabrams8434]

Mechanisms of Myofascial Pain M. Saleet Jafri "This nonquantal spontaneous acetylcholine release at the motor end plate as a result of CGRP is termed as acetylcholine leakage" The psychological stress after a physical injury can interfere with mitochondrial biogenesis and the leakage of acetylcholine at the neuromuscular junction. How can this be mediated or modulated with breathing or nutrition? HOW CAN ACETYLCHOLINESTERASE BE DISINHIBITTED ?

[@JonathanWirth-cu7sw]

Production ideas have a goodnight 😀

[@DocSnipes]

Thanks for watching

[@matthewjr1982]

Greetings, I'm exposed to a specific organophosphate at work that can cause "irreversible inhibition of acetylcholinesterase" and I believe it's at least contributing to some issues I'm having. While this video has been more helpful than any other single resource I've found so far, I still have questions. Basically, all these studies about tricresyl phosphate mention "irreversible inhibition of acetycholinesterase" but none of them describe what is meant by "irreversible". Does your body make a finite supply of this enzyme? For example, if this enzyme becomes a new AChe-Organophosphate molecule, are you out of luck in producing new enzyme that is not affected? I'm also wondering if the body can clear this compromised molecule. While it's a big topic in my industry right now, it's not well known outside the industry and it's tough to get help. I'm also trying to help some of my coworkers who have been affected more than me and are extremely unwell and having trouble getting help. It's not about going after anyone and placing blame, but about figuring out how to get better and providing helpful information to our healthcare providers. Any information is helpful

[@ChristopherGray00]

that makes complete sense as when i would quit nicotine and experience the withdrawal effects my mood would be extremely terrible, i would be in a very irritable state of mind, so much so that i would have to advise people around me before i even have any interaction with them. i do wonder if this has to do with the fact that nAChR agonists (such as nicotine) regulates mood, and the withdrawal of that constant agonism results in mood dysregulation.

[@sabyasachisen5351]

Yes, same thing has happened to me after quitting smoking 7 yrs ago. Brain not normalising,without nicotine. Starting soon on choline supplements.

[@christopherdockstader16]

Sorry to bother you so much recently. Am very interested in the subjects of your talks. Slide twelve, which is titled Acetlycholinesterase, has a subtitle called "Reduces" and then diphenydramine as one that reduces it. And I emphasize "it" because I got kinda confused. If I am not wrong, diphenhydramine reduces acetylcholine, not acetylcholinesterase. I kept looking back at the title.

[@dustin9893]

I was diagnosed with an autoimmune disease 1 year ago. My legs are currently paralyzed from it. Do you think acetylcholine would be good for my motor nerves?

[@CorinaChirilaArtist]

Can CHRNA3 and CHRNA5 mutations affect you is you are not a smoker and you never smoked?

[@billiejomcquistan278]

What is the connection between plavix and onset of cussing and mania thought maybe it was the adenosine break on the dopamine inhibited also have aggressiveness that lose by any type or any amount of hydrocodone as a painkiller for major surgery what's the neural modulator neurotransmitter connection between the outburst the hypervigilance the aggressiveness almost tourette's like cussing from plavix and the damn near going postal connection with hydrocodone in a person who doesn't drink doesn't use doesn't smoke and eats healthy to where you can't take those medications

[@jenniferheath4844]

Check out Hawthorn Berry by Dr. Christopher

[@ryanp7822]

Sugar and salt.... CBD VS THC Ratio Mix 😅 I think abt it all da time 😂

[@DocSnipes]

Thanks for watching

[@user-gd6rp5cqp]

Does marijuana block acetylcholine?

[@DocSnipes]

Yes, marijuana can impact acetylcholine levels in the brain. It's believed to have both inhibitory and stimulatory effects on acetylcholine release, which could contribute to various physiological and cognitive effects experienced when using marijuana. However, the exact mechanisms are complex and not fully understood.

[@jenniferheath4844]

@@DocSnipes That totally makes since! Thank you!

[@mitchnidey2453]

God bless you and your family and friends forever in Jesus name Jesus Christ is the Lord 🙏 Acts 2:38

[@DocSnipes]

Thanks for watching.

[@Brownnproud91]

Hello doc. I deleted acetylcholine from brain and I'm delaying with rhythmic muscle movement. I depleted it from years of daily masterbation. I quit my addiction 2 years ago. Can the brain heal of burned out acetylcholine receptors and low acetylcholine? Please tell me can the brain recover on its own?

[@bobdylan9117]

Great!