Norepinephrine Your Get Up and Go

[@linagarcia1887]

Omg, I’m 35, my whole life no doctor could ever tell me what my problem was, the postural hypotension, restless leg, sleep disorder, AdHD, bad memory, feeling cold and unable to warm up, depression, my muscles were chronically 24/7 tensed up , etc , were always causing me so many issues and i could never find answers. You have no idea how much this video has blessed me and how much it explains and liberates me !!! Thank you immensely, only God can pay you for this

[@DocSnipes]

Most Welcome. Thanks for watching.

[@rosierose7059]

Holy cow. I’ve never even bothered to try and deal with those things but I have them. Thank you

[@Danichoit]

Were you able to do anything to help it?

[@rumls4drinkin]

Doc Snipes should be overhauling the entire industry. Most doctors seem to be doing guesswork rather than looking at how specific symptoms are uniquely tied to these balances. We can get people on the right drugs with fewer negative side effects with a proper diagnosis based on this methodology. I've been reading about it for years but never quiet heard it vocalized so well, and I've yet to see it used at 95% of practices....

[@DocSnipes]

So kind of you. I appreciate it!

[@sciencenotstigma9534]

I absolutely agree! I think we should be hooked up to diagnostics, like cars, periodically, to measure our chemical balance. Then, balanced accordingly! Doc Snipes will make it happen! ❤

[@ElaineBurke-mw1ol]

Totally agree. Most Doctors don't seem to study the neurotransmitters patients are on. They seem to pick a med & try it out. I actually have been talking to my Doc about the different neurotransmitters & I've been tracking them myself. Excellent video, Very informative.... Thank you ❤

[@kristendavies5220]

I'm going for an adult ADHD assessment this month. This is really informative and well presented, thank you. Interestingly, bradycardia, postural hypotension and migraines run in my family.

[@DocSnipes]

Thanks for watching. Wishing you peace, health, and happiness.

[@calderonjd30]

Hope all is well. I’m also going to a test this month for ADHD but my psychiatrist already started me on Strattera from his evaluation

[@kianabrown6631]

Doc Snipes, you are saving my life and I'm so grateful to you! Thank you. Thank you so much for providing and sharing your work on this platform with everyone.

[@shirleyvigus8938]

Terrific info by a wise woman. I liked your tone and pace of delivery truly excellent and so professional. Thank you lady.

[@DocSnipes]

You are so welcome!

[@miagifodder5599]

HA funny how much her being a lady matters to you :D

[@RyanDaMannn]

@@miagifodder5599 sounds like English is their second language, sometimes people put emphasis on things that is seen typical in their first language that isn’t typical in ours. Just let them be, you didn’t need to call that out.

[@sciencenotstigma9534]

@@miagifodder5599I didn’t get that impression.

[@CodyFIHS]

Very informative video. I take Zoloft 100mg and Wellbutrin XL 150mg. Info on plasticity was phenomenal. I’ve been with counselors for years and could not tip the tides, so to say.

[@ExNihlo]

What a fantastic, informative video!! Thank you for taking the time to prepare and present this information so clearly.

[@DocSnipes]

You are so welcome! Thanks for watching the video

[@linagarcia1887]

Thanks!

[@DocSnipes]

Thanks so much for the tip!!

[@andrewlewiscameras]

This is excellent. So informative and clearly explained. Thank you 😊

[@DocSnipes]

You are so welcome!

[@teresadarden-behr9219]

I love this ongoing educational webinar!

[@DocSnipes]

Thanks for watching.

[@SanchoGracie]

Having a GeneSight was the game changer for me. No more tossing RXs at the wall & see what sticks. Also identified I have several polymorphisms. You can clearly see in my genes ADHD & bipolar tendencies. Also empowered me to learn about MTHFR & my slow COMT met/met. Pristiq & lamactil were identified as a result of the testing. I've had 9 great months of stability.....and that's coming from a rapid cycler.

[@DocSnipes]

Thanks for watching the video and for sharing

[@lautarogarciasalgado3003]

Wow ! thank you so much for this explanation so well done and clear. I am greatfull.

[@DocSnipes]

Welcome

[@jejskskbshehe7210]

I have been looking everywhere for lecture about noradrenaline , tysm for such an informative video

[@DocSnipes]

You're so welcome!

[@Adultsodas]

Hi, thank you for this video! I thought Effexor is a SNRI not a SNDRI 36:34 Can you please clarify.

[@lydieuhh]

CBd and gabba have been a godsend for me while struggling with anxiety. I take both in a powder form which I add to water and just drink morning and night. My muscle tension, panick attacks, muscle spasms, and ruminating decrease significantly when I take it.

[@miagifodder5599]

I just have two drops of cbd before bed and get hella sleep

[@miagifodder5599]

i only just found out about this so it's good to hear how important it is. i only knew about seritonin and dophamine really

[@sciencenotstigma9534]

Yes, I used to always forget norepinephrine!

[@tejasparikh6610]

very nice information, please make VIDEO ON FASTING EFFECT ON NOREPINEPHRINE.

[@darla8786]

Would love to see a video on how to lower norepinephrine levels in people with comorbid autism/anxiety that doesn't respond to even benzodiazepines to diminish their symptoms

[@e.vanderwel7911]

But what is the difference between ssri and Clomipramine?

[@Finkeldinken]

This was really great. Thank you. I was wondering: Is there any knowledge on what makes some depressives eat less and get hyposomnia and other eat more and get hypersomnia? Could that be a serotonine v norepinephrine thing?

[@DocSnipes]

Due to time constraints, I am just not able to answer all questions here. I have options at DocSnipes.com to schedule a cognitive behavioral education appointment, or submit a contact form for a detailed response. Thanks for understanding. I appreciate all my viewers and the interaction! 😀

[@B3arAbl3]

Thank you for this.

[@DocSnipes]

You’re so welcome. Thanks for watching

[@quenyasansel]

Hey Doc! Thank you so much for a great video! It cleared up a lot. I have a request, if you don’t mind. I am trying to understand the specific neuroscience of antagonists, specifically the D2, A2A relationship, and how adenosine affects other neurotransmitters, but I can’t find any video material that explains it in a way that a biology and chemistry inept individual like myself would understand. For context: I have ADHD, and I was trying to find out why caffeine makes me tired, and it makes sense now that I know that adenosine messes with the neurotransmitters you’re talking about here. I just don’t know HOW it does it. One video I found seemed to suggest that it blocks the release of dopamine into the synaptic cleft, but another talked about how the dopamine and adenosine receptors are close to each other, and neither explains the relationship between the two, and they also don’t explain how this affects seratonin, norepinephrine etc. (although you explaining the relationship between dopamine and norepinephrine in this video helped with at least part of that). If at all possible, could you do a video on this?

[@DocSnipes]

I understand your interest in the neuroscience behind the D2 and A2A receptors and how adenosine affects neurotransmitters like dopamine, serotonin, and norepinephrine. It's a complex topic, but I'll do my best to explain it in a way that's accessible. The D2 receptor is a type of dopamine receptor that has a role in many neurological processes, including motor control, motivation, and the reward system. Antagonists of the D2 receptor, such as certain antipsychotics, can reduce dopamine activity, which is relevant in conditions like schizophrenia. Adenosine is a neuromodulator that can inhibit the release of neurotransmitters, including dopamine. It does this by binding to its own receptors, such as the A2A receptor. Caffeine's stimulating effects come from its ability to block adenosine receptors, which in turn can increase the release of neurotransmitters like dopamine and norepinephrine. The relationship between dopamine and norepinephrine is particularly interesting. Dopamine is a precursor to norepinephrine, and alterations in dopamine levels can affect norepinephrine as well. This interplay is important for mood regulation and stress responses. As for serotonin, it's another neurotransmitter that's involved in mood, digestion, and sleep, among other things. Serotonin receptors, like the 5-HT2A receptor, can influence dopamine activity. For example, certain drugs that act as antagonists at the 5-HT2A receptor can modulate dopamine levels, which may be useful in treating conditions like psychosis or substance dependence. Given your interest in a video that explains these concepts, until I can film another video, I can recommend a few resources from my channel that delve into the role of neurotransmitters and their interactions: Dopamine: It is more than a pleasure chemical kzbin.info/www/bejne/rGGxgp-IhMithJI Neurobiology: Understanding the Big 6 Neurotransmitters kzbin.info/www/bejne/pYeYfYeFhbRqqMU Neurobiology of Addiction | Quickstart Guide kzbin.info/www/bejne/e3-TlYR6aplpjM0 The Brain, Vagus Nerve, HP Axes, and Neurotransmitters Continuing Education Training kzbin.info/www/bejne/fKCvcnWvbJydrpo Post Acute Withdrawal Syndrome (PAWS) in Addiction Recovery kzbin.info/www/bejne/Z2fKi4aoZq2Yo9k These videos should provide you with a clearer understanding of how neurotransmitters work and interact with each other. If you have any more questions or need further clarification, feel free to ask. Also, you can use my AI for free: allceus.com/DocSnipes-AI

[@DarkAngel-cj6sx]

Is possible to fix HVA/MVA ratio when it is high? It was caused by clostridia ( HPHPA and 4 cresol). Is this situation permanent or it will balance with time?

[@mrsimo7144]

Please help. I have a blockage of DOPA to NE, hence my chronic fatigue. How can I unblock this conversion? I've had CFS for over 30 years. Thanks.

[@suburbanturnip2426]

Are norepinephrine spikes what causes the start of the hyperfocus periods those with ADHD experience?

[@kianabrown6631]

That's a really good and interesting question.

[@suburbanturnip2426]

@@kianabrown6631 from self experimentation, it ended up working for me. Aiming the hyperfocus was hard for a while, but it worked for me.

[@malishafuller364]

So if you have Addisons Disease, you need this? I struggle with learning, memory, alertness and am on steroids plus depressed.

[@thecheesegod2738]

Idk because I'm taking it for ADHD and it's used for ADHD so honestly ask your doctor

[@bellanoire2271]

@@thecheesegod2738 hey are you taking Strattera? I just started today and I had a good first day on it. I was nervous because I heard a lot of different reviews.

[@omgdflea]

how do micro plastics affect the brain? 😢 asking for a friend

[@kalaklah4848]

Thank you for this information.

[@DocSnipes]

Welcome.

[@fitlifeconrad]

What are some supplements people can use to help increase the epinephrine/nor epinheprine pathway... doctor put me on wellbutrirn and i littearly wanted to go to sleep all day after the first 2 days... any supplements i can take instead?

[@DocSnipes]

Thank you for watching the video. I am so sorry, I cannot recommend any supplements. Please talk to your doctor about your symptoms

[@kwesidarkwa5443]

I think the Norepinephrine Cortisol and HPA Axis are affecting my sleep...... I need help please....

[@DocSnipes]

I am sorry about that and I appreciate you watching the video. If you’re interested in videos on improving sleep, you can find them at: kzbin.infosearch?query=sleep

[@TheSubpremeState]

I was on tramadol for a year. I quit for a month and never got my "get up and go" back. I have to go back to work now and just had to go back on tramadol. This is very disappointing to me. Am I stuck on this for life?

[@thecheesegod2738]

No ask your doctor for an alternative and if not possible you might benefit from adderall or concerta

[@LisaS1]

So how do we get the Norepinephrin? Is the best way from food and what foods?

[@DocSnipes]

These video should help. They are different lengths. kzbin.infosearch?query=nutrition%20for%20mental%20health

[@DocSnipes]

Norepinephrine is only one of many potential issues. It could be dopamine, serotonin, thyroid or gonadal hormones, insufficient quality sleep (such as due to sleep apnea) or even inflammation which causes HPA-Axis dysregulation. My suggestion would be to get a complete physical done to rule out biochemical imbalances that can be tested for (Vitamin D, sex hormones, thyroid hormones) or ruled out like sleep apnea or inadequate nutrition.

[@kitdrawsalot]

Once I was started on Ritalin, on top of Wellbutrin, it spiked my stress hormones, wayyy too much. I had anxiety (I’ve always had anxiety since I was a kid) all night and into 6am. I wish I had been prescribed a bottle of beta blockers ahead of time considering my history but I did not know about them at the time. I stopped the Ritalin after day one and weened off of the Wellbutrin in a few days. Took me a week, and some Hydroxyzine to get my head right. I’m going to talk to my doctor today. During the week I took a GABA supplement, and L-thisine and probiotics to help me.

[@kwesidarkwa5443]

Doc Snipes ,pls help with sleep issues

[@DocSnipes]

Thanks for watching the video. If you’re interested in videos on improving sleep, you can find them at: kzbin.infosearch?query=sleep

[@shawnrobertson9901]

Opiates at reduced levels also produce a stimulant effect. At least it does in me. I hate the way amphetamines or other stimulants make me feel but like opiates for the stimulant effects.

[@DocSnipes]

Thanks for watching.

[@thecheesegod2738]

Maybe you can benefit from strattera, it's a non stimulant ADHD medication that uses norepinephrine

[@saraivatoledo1842]

Welcome to the World of each and every Opiate addict .

[@shawnrobertson9901]

@@ImmovableM I'm currently on Suboxone 8/2 3 times a day for 7 years, 600 mg lithium, 450 mg lithium, 10 mg diazapam and 2 mg prozosin. I feel like crap constantly and have no will to do anything. It's like nothing makes me happy anymore. At least when I was using opiates I would have good days.

[@saraivatoledo1842]

@@ImmovableM Here´s the science behind it . precisely why some experiment , puke their guts out , proceed to gouch out for a few hours , and , at the end of it , ask the same idiotic question I must have heard 1 thousand times ? : " so , this is it , yeah ? Your idea of having a great time is through sleep ... a´ight ! a´ight ! " ( and never take opiates again in their lives ) " - how lucky they are - they will never know . Now there´s people like " us " ... from " recreational " and very " occasional " to literally having made deliberate choices where I favoured a powder over my family´s well being , over my health ...a lifeline if you will ... like some character trapped in a few of Dante´s circles of Hell ( how dramatic !!!! Feels like that once you´re truly there though ... caught up in the eye of the storm 😂 ) .

[@frutigermetroboomin]

Venlafaxine really helped me.

[@DocSnipes]

That’s awesome! Thank you for watching the video and for sharing. What did you find most useful from it?

[@frutigermetroboomin]

@@DocSnipes The parts where you explained what norepinephrine was, the symptoms of insufficiency and what one could do to increase it.

[@karenyoung5786]

Orthomolecular Psychiatry addresses disorders through diet and healing nutrient deficiencies.

[@sunny12341000]

Hello. Should a 51 year old woman seek out hormone replacement therapy or antidepressants for depressive symptoms and anxiety?.

[@DocSnipes]

You need to talk it over with your Doctor. Thanks for watching

[@jayton580]

Would 300mg of Effexor effective for social anxiety? Just been upped from 150 to 300 mg

[@DocSnipes]

You need to ask your medical doctor.

[@jayton580]

@@DocSnipes I would like your personal opinion I like your knowledge on the subject

[@zzzz546]

Hi Doc , Thanks for so much knowledge on these. Is it safe to take these because when I contact doctors for my OCD and anxiety they don't pull the trigger from SSRI to others . Are the side effects are life threatening even docs doesn't want to try because will be habit forming ? . I have a good response from SSRI but not complete or with some other negative thoughts and Rumination. I really not happy with psychiatrist in India who just doesn't listens you completely like they want to just know in what category you lie rather than tharough analysis on what you talks in the video . Expecting this level of treatment from them is impossible. Eventhough I may not afford you but you are worth .

[@DocSnipes]

I certainly would not start taking supplements if that is what you are saying because it could trigger serotonin syndrome

[@zzzz546]

@@DocSnipes Sorry I did not get you completely . If that can cause Serotonin syndrome they can slowly stop SSRI and try increasing SNRI or SNDRI . So is it worth gving try ? And also what I was saying is here psychiatristic assesment is mainly 15 to 30 min max where getting to know patient patterns and comorbids and psychoanalysis is out of practicality

[@andybreedlove]

Can I work with you pls? Bedridden a year, needing help (understatement).. crashed with cns dysregulation, I am so unwell - pls advise if we can work together. I’ve tried so hard to get to the roots of this - I know what issues I have but need some advice please.

[@DocSnipes]

Thank you for watching the video! Please join me on Mondays at 10AM EDT for the Live Q&A and I will gladly answer your questions. You can also email me at: [e-mail]

[@lindacarol5982]

I just found your channel and I was placed on 50mg prestiq and I was wired and felt hyper 😅. But, I didn't like the shakes and nervousness. But I started 25 mgs still get nervousness so I'll just keep taking it because it's getting me off the couch from stewing In deep depression. Maybe I'll get use to it and the neervous shakes may go away after awhile 🤔 not sure yet. It's been a month now on it all together. Do you have any advice? I took Strattera for about a week and it made me so sleepy and tired. Weird how different medicine effects each individual

[@DocSnipes]

You need to talk to your medical doctor about it, or get a second opinion from another medical doctor.

[@bobchevallier8456]

Wellbutrin helped me get off the couch.

[@hanskraut2018]

Interessing talk I think people that smoke might also have lower baseline and might be self medicating that would perfectly explain the relapse difficulties and quitting AND * that for some genetic predispositions or low transmitter developmental delays its more likely to be a smoker and more difficulty quitting like adhd* Why would nature be fair - In the sense that everyone gets the same levels? Not sure

[@DocSnipes]

Thanks for watching the video

[@stefanweilhartner4415]

so, maybe instead of drinking every second coffee, drink water with 1g of tyrosine instead?

[@thecheesegod2738]

Uhh I used to do that and I dont reccomend either, get strattera instead it's a norepinephrine ADHD medication so you can even get it online but I hear its 400$ without insurance 😭 but online itll be much less than a prescription and if for some reason you wanna do it online without a doctor take 40 mg to start with once a day in the morning

[@LisaS1]

I feel such apathy and depression I can't even get myself to pick up around here.

[@thecheesegod2738]

Sounds like depression, thus medications is for ADHD as far as I know nothing more (I take it for that reason) so get it checked out cause the depression can be from ADHD but your probably wont be put be on strattera but adderall or concerta

[@LisaS1]

@@thecheesegod2738 Thanks Sabrina, I tried lots of different medications for depression in the past but they felt like a mask - you know? I wasn't able to get any really good medication for depression. I think I mostly need talk therapy and a better diet.

[@bobchevallier8456]

​@@LisaS1 Wellbutrin is awesome

[@LisaS1]

@@bobchevallier8456 Thanks Bob. I tried that before in the past.

[@dddamaged7501]

With fibromyalgia I tried a lot of SNRI's, the best was the original tricycle anti depressant amitriptyline. Go figure 🤷‍♂️

[@DocSnipes]

Thanks for watching.

[@Tinyteacher1111]

What is that?

[@dddamaged7501]

@@Tinyteacher1111 there is not much difference, both work on the same neurotransmitters. The tricycle was discontinued because of the side effects. With low a dose, I have no side effects. Is a good sleep aid.

[@jayton580]

@@dddamaged7501 amitriptyline is still being prescribed I was taking 75 mg

[@kitdrawsalot]

Nortyptyline?

[@EleauxPreeze]

What is “monkeying”????

[@DocSnipes]

In the video, "monkeying" refers to the act of altering or experimenting with specific neurotransmitter levels, such as serotonin and norepinephrine, to observe the effects on mood and depression. As you noticed, I discussed a study where they "monkeyed with" (i.e., manipulated) these neurotransmitter levels in healthy individuals and those with depression to assess how changes in these neurotransmitters impacted depressive symptoms. The experiment did not result in worsening depression, suggesting that the causes of depression are more complex than just imbalances in these neurotransmitters. I use the phrase "monkeying with" informally in the video to indicate tampering or tinkering with something, in this case, brain chemistry. I’d be grateful if you were to share what you found most useful from the video. Additionally, if you're interested in more tips on the topic or if you want to explore my video library, you can use my AI: allceus.com/AskDocSnipes.

[@tarunarachmad3976]

is adhd symptom. sleep deprivation show adhd symptom

[@DocSnipes]

Thanks for watching the video

[@TheSubpremeState]

19.10 you don't need to go to toilet during flight or fight hahaha. I wish

[@DocSnipes]

:)

[@omgdflea]

me and my AI girlfriend are watching this together lol 😂 she needs to know how to take care of her lil human pet 🐕

[@LisaRichards_123]

On second day, starving all day for no reason

[@TheContrariann]

49:30

[@DocSnipes]

Thanks for watching.