Action Potential | Graded Potentials

In this video, Dr Mike explains everything you need to know about how neurons send signals via action potentials!
He also discusses different types of graded potentials including;
- excitatory postsynaptic potentials (EPSPs)
- inhibitory postsynaptic potentials (IPSPs)
And what role neurotransmitters like glutamate and GABA play!
Follow on:
Instagram: @drmiketodorovic
TikTok: dr_mike_todorovic
Twitter: @drmiketodorovic

[@marziarangel654]

You have no idea how much your videos helped me. I'm a slow learner and need repetition, and your methods make everything so clear. I can rewatch your videos and get confident in knowledge. I graduated my program with a 4.0 and I think largely thanks to having access to your videos. Thanks SO much.

[@wikkedJ12]

your teaching style is unmatched - superb content!

[@mikeb2644]

I noticed that KZbin is featuring this video. Normally I wouldn't care............ .................BUT............"Action Potential" is probably Drs Matt and Mike's best video. Action potential is almost never explained clearly. I've watched many videos on it, and they're almost always bewildering. I was bewildered by action potential........until I watched this INCREDIBLE VIDEO. Made me a fan forever.

[@alexcross3286]

This video saved my life and my grade. Action Potentials used to be my least favorite subject in intro psych and biology classes. could never keep up with all the components when it was being lectured for some reason. “Ligand gated this, voltage gated that, sodium, potassium, ATP, etc” it was overwhelming. I watched this video to help me prepare for a neuroscience exam tho and my mind was blown when I could finally understand the whole process. Not just that but realizing the WHY each part mattered. WHY the sodium-potassium pump is soooo important. That it resets the cell so action potentials can keep firing is amazing to me

[@DrMattDrMike]

I hope you did well in the exam! 😊

[@reirei6464]

I was so confsued about this concept, but holy crap this changed my whole view of electrical signaling subject, Thanks for the great video!!

[@DrMattDrMike]

Glad it helped!

[@sommandal8597]

After reading from my book i can't understand....but after watching your explanation finally i have a clear cut thoughts about this topic Thanks 😊 Only the students like me fell how much worth your video😊😊😊

[@thelmangoma7070]

And just like that I feel confident to answer any question related to action potential.. Thank you ❤

[@user-di2im5tr3w]

I was so confused by lecture notes and was sad, suddenly I noticed this video first and watched it. This video literally cleared my doubts and Big THANKS TO DR MIKE FOR MAKING OUR DAYS BETTER.

[@CharlesLacarin]

Another amazing video. Reviewing content for my paramedic exam and this helped so much !

[@HasanAli-pm6jg]

Thanks you dr mike, from today I am one your students. I want to say, you are the best person to explain and teach someone like me. I understand very well. Thanks you please keep more🎉

[@user-bb5cd4tr2i]

Honestly I just subscribed right after watching only 2 videos, this is real high quality content & this is really better than some paid contents available. Huge thanks for such great content Doc. U r doing great, keep it up. 👏👏👏

[@DrMattDrMike]

Thank you! 😊

[@animeeditz649]

Me too

[@anaisrodriguez4420]

The best explanation yet! Thank you so much for your videos!

[@belindaalderson7209]

Thanks Dr Mike great to see an Aussie leading the way in this type of type of education - shame your not teaching at University of Newcastle, NSW but truly thanks for all your help it goes a long way. 🇦🇺

[@RagingSymphony]

Yet again high quality content. Thanks!

[@sophieekhegfejwgk]

I have a test on the nervous system today, thanks for the very well-timed refresher video

[@braviousbundundoko278]

Thank you so much Dr. Matt. This video helps a lot with my studies.

[@akpoilihoghenekome8567]

You've just gained a subscriber after watching 2videos.. thank you Dr matt. Your teachings are very helpful and easy to understand 🥰🥰

[@Brandonwalsh18]

Crazy, you hit all the marks! Definitely got another subscriber just now!

[@kimberleyseon6412]

So well done. Thank you!

[@Neuromorphin2]

Thank you Dr Mike ❤❤

[@ishasoyza]

Please make a video for propagate of action potential and solitary conduction

[@Randomguy-ru7fn]

Thank you so much. I had trouble understanding with some of my diagrams but this one made it really clear. Thank you for your efforts.

[@mikeyslaps]

yo Dr. Mike you lowkey saved my anat and phys grade so thanks for that but also you’re actually jacked please drop the routine

[@raga5812]

Hii sir I'm from India 🇮🇳 and your lectures are really helping me a lot in my highschool studies 🙏🏻 thanks a lot

[@YuvrajParmar-cl8lf]

Appreciate your work sir❤ i was having so many doubts related to this topic but after this video my doubts are cleared . Thanks a lot sir❤

[@shyannakeesy8686]

Thank YOu! i have online anatomy and i had no idea how to figure this out. YOu explained it so clearly. thank you.

[@lakshmidumpa]

Thank you so much for explaining well.

[@kevinmontoya43]

This is amazing

[@Random-wc4ob]

Brilliant explanation!

[@Akselhtoo]

I'M WAITING!!!😍😍😍

[@jabirlokhandwala1390]

Me too

[@Akselhtoo]

@@jabirlokhandwala1390 🤗🤗🤗

[@mmenadine9222]

Perfect explanation👍🥇

[@jacobwn3965]

You are my fav Dr, you helped me so much and I hope you keep up the great work

[@shellythalliburton7559]

Wow!!! Thanks Doc

[@chris-mj8792]

wow thank you so much !!!

[@carlanderson6845]

Great video

[@doctorsaoodwithacamera]

You're exceptional 👏

[@mmmlolo6722]

Best dr.♥️♥️

[@jeromenimer1612]

This is completely mind blowing. I love your videos😍

[@MulugetaSolomon-bo3jy]

I don't think that is mind blowing

[@ytzpro]

Great explanation. I wish I watched this before my final Anatomy exam loll I would have ended the class with an A!

[@appiahrichard5921]

I never understood this In class I'll stop attending lectures and watch you videos instead

[@stevejones3662]

Excellent work! Loved this lesson; brilliantly structured explanation. 1 question: Do positive sodium or potassium ions get attracted towards negative areas due to opposing charges or move away from each other by same change repulsion? Same outcome but subtely different reason? And I read somewhere that only small numbers of ions need to move to cause these charge changes?

[@LTIMES-cw5tw]

GOAT 🐐👍🏼

[@gabrielaelias6276]

great video !!

[@DrMattDrMike]

Thank you!

[@sadeemAbdullah1]

🫡🫡🫡🫡🫡 اقوى استاذ اتحدااااك يالاستاذ البطل والله شرحك يجنن

[@easymedicose]

V r w8ing sir 🙌♥️

[@julianfischer4207]

you may have just saved me from having to drop a and p and having to do a 6th year of undergrad

[@jacquelineterrazas3343]

THANK YOUUU

[@DrMattDrMike]

You're welcome!!

[@laughedagain904]

Hello Dr.Mike..please do the special senses

[@amiraali818]

Hey are you guys not doing podcasts anymore?

[@billymeeks845]

🙌🏼🙌🏼🙌🏼

[@Startpixie12]

Did you make a mistake when you said na/k pump restores hyper polarization back to resting membrane potential? That’s not possible because if anything, nak pump will make the inside more negative right.?… what actually restores hyper polarization back to resting membrane potential is the inward rectifier potassium leaky channels , nak pump will help to bring back the ionic concentration gradient.. please correct me if I’m wrong 😊

[@blairbeebebee8763]

Which Na channels have inactivation gate?

[@baseleldeep5368]

How much EPSP take ?? And how mucjh AP take ??? I heard from my leacturer that EPOS ×10 than AP

[@oldschoolwaverider]

I thought they went across the synapse in a vesicle rather than diffused. That’s confused me a bit 😅 formative exam on Monday. Summative 16 days later

[@noonereallyknows6643]

Vesicles containing the neurotransmitters actually fuse with the membrane of presynaptic neuron and "dump" the neurotransmitters outside into the synaptic cleft, and that's how they diffuse across, until they reach postsynaptic receptors. I know you are long finished with your exam but hopefully this response can help someone else. FYI ... vesicles can't leave the membrane which is why it's considered exocytosis - "exo" - outside, "cytosis" - cell

[@sumaiyajhinuk8637]

1.for 3Na Out +2 k in-- causing negativity inside-ok.2.excitation - works on Na+ Ca channel. 3.inhibitory - acts on K channel.2.excitation and inhibition always work on in same time????.pl.sir. Give ans.

[@rachell4576]

I am not sure about any rare cases. However, based on the definition, if AP occur, it should be a depolarizing period before the AP can occur and it means the cell is being experienced EPSP. If it strong enough, the summation of these Graded potential (EPSP) such as the appearance of Glutamate then enough positive so become AP. Otherwise, if there is the appearance of GABA, the neutron is experienced IPSP, it means the cell becoming more negative and far away from threshold to be depolarizer so AP cannot occur. And AP characteristic is “all or non”, which means fired or not fired. You question about if EPSP AND IPSP can happens at same time or not, I believe the same time if EPSP and IPSP is during the summation of GRADED Potential, if 2 EPSP OCCUR WITH 2IPSP, then it will be canceled out and no AP occur! This is my opinion based on what I understand! If you have more idea about it, please correct me!

[@fuggully]

stoppp😂 why the thumbnail HSHAJAJ

[@MarcusWolford]

Tall and Hard .. Thank You

[@DrMattDrMike]

Hahahahaha

[@peterjohn8625]

Voltometer lol. Think you meant voltmeter.