ADE | What is Antibody Dependent Enhancement

Many people are wondering what is Antibody Dependent Enhancement or ADE. Antibody Dependent Enhancement (ADE) is a second key for a virus to enter your immune cells. Viruses have spike proteins that allow it to enter one or two types of cells like lung cells or neurons. That is the first key. If antibodies bind to a virus in a non-neutralizing way, the virus can enter immune cells called macrophages. This is the second key. Having an antibody bind in a non-helpful, non-neutralizing way allows the virus to enter macrophages and gives the virus an advantage. ADE happens naturally during dengue virus infections. It has also happened during RSV vaccine trials. However, there is no evidence that ADE is happening now with COVID-19.

[@friendlyneighborhoodimmuno7192]

Please forgive the audio glitches. I fought with Premiere Pro for a week and decided to just post it.

[@thomasmccullough1557]

They probably don't like the content.

[@Chris-xd4kb]

thank you. appreciate all you do.

[@hurtmanp5803]

Jeremiah 17:5 King James Version 5 Thus saith the Lord; Cursed be the man that trusteth in man, and maketh flesh his arm, and whose heart departeth from the Lord. God's Kingdom is perfect and can be trusted. Man's Kingdom is literaly filled with liars and the bones of dead men.... Jesus is Lord of Lords!!!!

[@hurtmanp5803]

I was hoping to have an itelligent conversation on the matter at hand. Where did you go Dr.?

[@hurtmanp5803]

DO NOT LISTEN TO ANY REPORTS OR DOCTORS. DO NOT FILL YOUR BLOOD WITH GARBAGE! Proverbs 3:5-6 KJV. Trust in the Lord with all thine heart; and lean not unto thine own understanding. In all thy ways acknowledge him, and he shall direct thy paths.

[@daviddavidson1090]

Correct me if I'm wrong: "Enhancement" refers to the enhancement of the virus, as in heightening its ability to spread; and "Antibody-Dependent" describes this particular method to achieve that Enhancement which relies on antibodies malfunctioning in this way.

[@matthewnicholls5496]

Enjoyed the video, even with the hiccups. One question - in Germany now half the hospitalisations are vaccinated, as for much of UK and Europe. The belief is that it is caused by the waning effectiveness of the vax but is it possible that ADE may also be a factor, especially as T cells should be working ( if the vax is truly a vax)?

[@3rdGenRX7TT]

Yes I was looking at this as well..especially when you look at what happened in Israel

[@whatstrue8936]

Very good question. One doctor said they have about 60 percent vaccinated people with covid over all. Some even got their boosters already. 🤔

[@BrokerBarbara119]

The same thing is happening in much of the U.S. too!

[@marekb1556]

The reason why you see so many hospitalized vaxxed people is because those are the states with massive vaccination rates. (Germany is around 70 I think) That means you are pulling data from a disproportionate pool. Whats more, these countries prioritized 60+ demographic, which is the most vulnerable to the virus overal and thus will be overrepresented in hospitals no matter what (in Germany over 89% of people over 60 are vaccinated!!). The really best piece of data you can look at is average age of hospitalised vaccinated vs unvaccinated people, where you are taking in account all of the variables mentioned above. Its no surprise that the average age of hospitalised unvaxxed people is much lower than the vaxxed ones.

[@Xc31]

"Results of the study: COVID-19 vaccines designed to elicit neutralising antibodies may sensitise vaccine recipients to more severe disease than if they were not vaccinated. Vaccines for SARS, MERS and RSV have never been approved, and the data generated in the development and testing of these vaccines suggest a serious mechanistic concern: that vaccines designed empirically using the traditional approach (consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies), be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID-19 disease via antibody-dependent enhancement (ADE). This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID-19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials." pubmed.ncbi.nlm.nih.gov/33113270/

[@zubaer73]

First of all, thank you for explaining ADE in a nutshell. Video content & quality nearly or completely offsets the audio glitch. What led me to your video is a bit tortuous; I'm from Bangladesh where dengue is still rampant seasonally; I was searching about why second exposure to DENV is more dangerous than the first and this ultimately led to your video.

[@MatthewAshworth]

But what about the natural immune response to SARS-CoV-2, which is known to target all 4 of the surface proteins (S, M, N, and E)? If ADE was happening through targeting of the M-protein, then surely people who have recovered naturally would all be experiencing ADE upon repeat exposure to the virus and its new variants. I personally think targeting only the S-protein with vaccines is a bad idea, because S-protein changes very rapidly in new variants, so vaccine effectiveness drops quickly, which is why we're seeing the need for boosters and a much lower effectiveness against delta variant. The body's natural immune response has been targeting all 4 proteins over the past 2 years (if not more) and in majority of people it's provided a lasting protection better than all the current vaccines (at least according to numerous science publications). Another thing with ADE, doesn't it normally happen upon exposure to new strains and variants and not always to the same one? With dengue fever for example, it was an enhanced reaction to a different strain of the virus. Would be great to see some future videos on IgA antibodies and also on somatic hypermutation of immune cells and how they adapt to tackle the ever-changing threat from the pathogens. I think people really need to know about these.

[@MatthewAshworth]

As far as I know, according to one of the science publications, antibodies targeting S- and N-proteins of SARS-CoV-2 can also potentially attack body's own tissues. They've found that this effect was largely concentration-dependent.

[@lanceg6828]

You are correct. The vaccines are causing the variants. They aimed only at one Spike protein. The wild virus is 26 spike proteins. When someone has antibodies along with T and B cell memory, the virus naturally can’t evolve easily. If faced with someone with the vaccine, the virus only has to adapt one spike protein.

[@MatthewAshworth]

@@lanceg6828 Thanks for the comment, Lance G. Well summarized. This kind of information should be common knowledge among those who are in the biomedical professions. If the vaccine only targets one area of the virus, then it's easy for the virus to quickly evolve to change that area and make it unrecognizable. It enforces the natural selection among the variants, and so vaccine-resistant variants quickly outcompete the ones that aren't resistant.

[@WellBeing999]

@@MatthewAshworth they know. They just want to divide and conquer by blaming the unvaccinated for the variants so that the vaccinated will be ok with their freedoms and the freedoms of others (the unvaccinated) being stolen from them slowly but surely.

[@MatthewAshworth]

@@WellBeing999 Yeah, it's all ending up in segregation and control. I don't think they even care about the vaccinated and what happens to these people after receiving their dose, otherwise they wouldn't have liability protection and wouldn't censor doctors and scientists who ask inconvenient questions about vaccines. The idea of informed consent has been completely thrown out the window.

[@Copyright822]

Hmm recent hospitalizations numbers are showing higher percentage of patients are fully vaccinated. Omicron’s massive mutations along the RBD and S1 subunit are causing vaccine induced antibodies to not fully bind correctly. Plus, antibodies created by spike protein along with other areas on the virus like the membrane, envelope and nucleoproteins have a high number of molecular similarities to other proteins found throughout the body and could cause autoimmune diseases since the mimicry is massive. Repeated vaccines that produce massive amounts of spike will can continuously trick your immune system into attacking your own body.

[@erikahachiko104]

Thank you, I’m a novice with this and loving your videos. The glitches did made it difficult for me to truly follow. If it is possible to fix that, that would be super 😊 thank you again!

[@friendlyneighborhoodimmuno7192]

Thanks you and sorry again. I’m afraid there will be some audio issues until I can upgrade my laptop. It’s 8 years old. 😅

[@petermunro]

@@friendlyneighborhoodimmuno7192 If you want to re-record the audio or send me the unglitchy audio file, I’d be happy to edit it together with the video for you so you have an unblemished version you can upload.

[@C2yourself]

Great info but hard to follow with audio crackling and glitches. Please re-upload

[@ML-qt8hr]

Such a pandemic. More vaccine, more cases. Why you say no ADE in this COVID vaccine?

[@backyardgroceriesgmail6926]

I think it must've been the timing of when this was made and published.

[@kelvintrollol]

​@backyardgroceriesgmail6926 the video doesn't cite its sources for the so called unvaccinated hospitalizations. The devil is in the details. With covid, one is not considered fully vaccinated until 14+ days after second shot. So people who get killed by vaccine before 14 days after second shot are considered unvaccinated. This is misleading.

[@smokecurl9437]

Great ❤️. I wish you could re-record the audio

[@pittschapelfarm2844]

The glitches seems to clear up, so it's all good! I can't help but wonder tho - how long does it take to cut out all those little antibodies?

[@friendlyneighborhoodimmuno7192]

Lol not too long. Maybe 5 minutes? My crafting skills are still pretty good.

[@MK-ih6wp]

@@friendlyneighborhoodimmuno7192 this is my new favorite channel!! Thank you

[@josemilian4167]

some good info but video audio cracks certain spots and makes cc not work well.

[@hurtmanp5803]

Isaiah 55:6-7 King James Version 6 Seek ye the Lord while he may be found, call ye upon him while he is near: 7 Let the wicked forsake his way, and the unrighteous man his thoughts: and let him return unto the Lord, and he will have mercy upon him; and to our God, for he will abundantly pardon. In Mighty Jesus name.

[@friendlyneighborhoodimmuno7192]

Thanks for the verse. I can tell your faith is important to you. Did you know that the Pope has asked Christians and Catholics to get vaccinated? www.reuters.com/world/europe/pope-francis-urges-everyone-get-covid-19-vaccines-good-all-2021-08-18/

[@thomasmccullough1557]

A lot of Catholics are really questioning this Pope.

[@MrOlaboss]

In 1980 I had my spleen removed after it was ruptured. The surgeon explained that I had a small organ that he left there and he though it could be a small second spleen that possibly could grow when my spleen was removed. I have no idea if I now as an adult have a healthy spleen or not. Is there any reliable test which could tell me if I have a functional spleen?

[@tgifford4]

What glitches? Another brilliant lesson! I'm looking forward to the next one. 🧠

[@friendlyneighborhoodimmuno7192]

Thank you!

[@hurtmanp5803]

Jeremiah 17:5 King James Version 5 Thus saith the Lord; Cursed be the man that trusteth in man, and maketh flesh his arm, and whose heart departeth from the Lord. God's Kingdom is perfect and can be trusted. Man's Kingdom is literaly filled with liars and the bones of dead men.... Jesus is Lord of Lords!!!!

[@vg7735]

I briefly watched another lady with a phD I think in Immunology or something else say that if we have the vaccines a few years in a row we could end up sicker than if we have no vaccine. She said that this is the case with the flu vaccine. What are your thoughts about that? Thanks

[@friendlyneighborhoodimmuno7192]

That's a very interesting question. I looked it up on Pubmed which is where peer-reviewed scientific papers are available. There are only 6 papers on this topic. Most papers say that yearly vaccination is good for the immune system. One paper said that yearly vaccination might change the way your antibodies bind to influenza which was better to catch A type influenza but not B type influenza. However, none of the research papers proved that immune exhaustion was happening. As far as I know, immune exhaustion can only happen when you have a chronic condition where your immune system fights ever single day like HIV infection and cancer.

[@vg7735]

@@friendlyneighborhoodimmuno7192 After reading a little more I think she was talking about antibody dependent enhancement.

[@MK-ih6wp]

@@friendlyneighborhoodimmuno7192 I think that's what Christina Parks (PhD) references in her testimony here: kzbin.info/www/bejne/mZyTeGxqi5Jnd7sm40s

[@MK-ih6wp]

@@vg7735 Is this the lady you are thinking of? kzbin.info/www/bejne/mZyTeGxqi5Jnd7sm40s

[@TaiganTundra]

@@friendlyneighborhoodimmuno7192 Is immune exhaustion the same as high zone tollerance?

[@MatthewKGarr]

Didn’t know any of this, thank you!

[@user-bp1dd8fg2y]

thanks alot, really appreciate it is super helpful!!!

[@babylittleness]

The audio glitches are unfortunate. I wonder why they didn't want to fix the problem by replacing it with another take.

[@friendlyneighborhoodimmuno7192]

I tried 8 takes and got fed up. I will watch a lot of videos on audio before I make my next video.

[@celestialfix]

Thanks very much. Super interesting.

[@friendlyneighborhoodimmuno7192]

Thanks for watching!

[@freespeech4all723]

New subscriber Thank you...very interesting!

[@thilinakasthuriarachchi9374]

Please please change the audio track.. It's really disturbing to the important explanation..

[@claireabailey]

Thank you so much!

[@graw777]

I "Liked" the video regardless... but gave up at 3:17. Too glitchy!. FIX IT PLEASE!... PLEASE! So much potential.

[@bobman929]

She is using a new recording program and was unable to fix it after several recordings. She asked her followers and they requested they she post it anyway. I'm sure she feels crap about having to post it but just do your best to follow along.

[@dammitol25mg19]

Thumbs up for your effort, thumbs down on the technical sabotage. Been there many times.

[@friendlyneighborhoodimmuno7192]

Thanks! I think I may need to replace my 8 year old laptop. It just can't handle Premiere Pro. It takes 4-8 hours to covert one video. 😅

[@dammitol25mg19]

@@friendlyneighborhoodimmuno7192 I think the industry imposes planned quiescence.

[@laurasophie3059]

thanks for the info! Pretty sure it's time to do an update regarding ADE and the vax...

[@friendlyneighborhoodimmuno7192]

Yes that is true. Things have changed with omicron.

[@blittleing]

@@friendlyneighborhoodimmuno7192 I would love an update too. You described ADE real well. Thank you.

[@paulorufalco]

the sound is very low, what a pity

[@jaspersilver1055]

Your incredible. I guess you think it’s ok to activate complement cascades and yield thrombi

[@vg7735]

You said in another video that it isn't known if the Covid19 vaccinations will have long term affects. If the mRNA only lasts 30mins to 24 hours what could the possible long term effect be?

[@babylittleness]

I think when people say we don't know if there will be any long term side effects of something (even something that is in our body for a very short time) is because there are some things that cause long term side effects from short time exposures. One example is radiation poisoning. If you get exposed to even just a single dose of high dose radiation even for just a few seconds it's already too late. The damage has already been done. In addition to the scary short term side effects radiation poisoning can cause long term side effects like cancer and cardiovascular disease several years later. With radiation poisoning you should remove clothing and take a shower to remove any radioactive material to try to minimize any damage. Radiation poisoning is not the same as a vaccine. It's just an example of a short term exposire causing a long term effect. We won't know if or what the long term side effects a vaccine will have until enough time passes (several years go by) and people start to develop things. Maybe there won't be any long term side effects. We just won't know until we see if nothing happens or something happens.

[@lesseirgpapers9245]

Because they capped the mRNA with nucleotides that make them last up to 6 months.

[@vg7735]

@@lesseirgpapers9245 The Lady who runs this channel said the mRNA only lasts less than 24 hours.

[@lesseirgpapers9245]

@@vg7735 Normally correct. A peer reviewed paper boast how they made it last longer by putting nucleotide caps on it. Dr Flemming also reported this. Other report shows reactions up to 3-4 months later. This is about the time that scamccines no longer work at all. I fact they seem to attack the lymphocytes as the count after vaccination stays below 50% months after the vaccination.

[@vg7735]

@@lesseirgpapers9245 Do you have any links and what is Dr Flemming's first name?

[@MK-ih6wp]

I am confused about the differences between: -original antigenic sin (OAS) -pathogenic priming -antibody dependent enhancement (ADE) My (limited!) understanding of OAS = your body develops a preference for the first type of challenge it encounters? So if you get the virus initially, your body seems more calibrated towards responding to similar viruses in the future. But what happens if you get the vaccine first, successfully make antibodies, but then get infected w the virus later? Is your body less likely to respond adequately, since you were "primed" by vaccine? And then how is that any different from pathogenic priming or ADE? I am just a stay-at-home mom so I apologize if I botched the question, I hope you get the gist of what I am asking, lol. We are all learning so much from your videos, thank you!!!

[@MatthewAshworth]

Hi. Perhaps I'll be able to clear up some differences between these. - Original Antigenic Sin (OAS) is how our immune system gets primed to a specific shape of an antigen when dealing with an infection. It can be a good thing, because if another similar pathogen attacks later with some parts of surface proteins being similar to what immune system was exposed to before, then it will respond quicker to it. But it can be a bad thing too, because if it gets strongly primed towards a specific shape, it might not respond quite as effectively to something entirely different. It essentially narrows the scope of the response (like a tunnel vision). However, when we get a natural infection, the immune system responds to every surface protein on the surface of the pathogen, not just the spike protein. That way, if the spike protein changes, the immune system can still recognize other parts which haven't changed and still provide protection. But if we artificially prime it to only recognize the spike protein (like with the immunization shots), it wouldn't have received any exposure to other surface proteins and so the protection is not broad. This allows a very easy immune evasion in the virus. - Pathogenic Priming is when a pathogen has some surface protein which has a very similar shape to proteins on our own cells. So, when an immune system responds and attacks the pathogen, it gets primed to recognize that type of protein as something carried by an enemy, so when it comes across similarly-shaped proteins on our own cells, it launches an attack against them too, leading to an auto-immune condition. - Antibody-Dependent Enhancement (ADE) is when the antibodies that we produce in response to a pathogen can end up making the situation worse. This is usually the case when later we come across another strain of the same pathogen (so like antibodies managed to suppress the first strain, but not the second strain). In those situations, the antibody still binds to the virus (the second strain) but fails to neutralise it like before and instead gives the virus an easier entry into our cells, which results in worse symptoms.

[@sophia8482]

@@MatthewAshworth You've provided a really thorough explanation. Do you have an opinion on why there is little concern about the possibility of the virus mutating to evade the spike? At the end of this video she seemed so certain that the virus would not be able to mutate enough to do that. The key analogy makes sense to me if there are many elements to the spike protein that would all have to fit together to open the lock but I don't know if that's the case.

[@MatthewAshworth]

@@sophia8482 Honestly, I am not sure why the authorities have decided to go about it this way. It seems rather counterintuitive, because if the vaccines target only one protein, then the virus variants that can evade vaccine defence will out-survive those that do not, and over time vaccines will become ineffective, which is what we're seeing now with the delta and other variants. By comparison, when we're exposed to the virus naturally, our immune system is exposed to the entirety of the virus and launches an immune response against all the surface proteins, so even if one of them mutates and changes, the immune system will still recognize the others. There's not that high a chance for all the surface proteins to change shape. It would require too many mutations. Now of course it's true that the spike protein has to be a certain shape to be able to fit the lock, but there is some leeway room. Receptors and spike proteins are an interesting thing and oftentimes their shape changes upon the binding with each other, so, so long as the mechanism can still work, it's fair game. Another possibility - if the spike protein changes sufficiently enough, it might not be able to bind to the receptors on its target cells, but it might instead be able to bind to receptors on other cells and in time there could be new strains that would be able to infect another tissue type. A lot is possible. The viruses get mutations all the time when they reproduce. They have millions of chances to throw the dice, and it doesn't matter if most of those mutations do nothing or are harmful to them. If at least a few are beneficial, then those virus particles will survive and drive the genetic shift, so those variants become dominant. I personally think the best thing we can do is to not do actions that would provide selective pressure and favour the survival and dominance of problematic variants (faster-spreading, vaccine-resistant, etc). But this is exactly what happens with heavy-handed blanket approaches. At least real-life data has shown that over the past couple of years, the variants have mutated enough to be able to resist the vaccines, to infect vaccinated individuals with more success, and to inflict heavier symptoms once again. My favourite data as of recently is from Gibraltar. It's the most vaccinated place in Europe, with virtually every adult vaccinated (118% vaccination rate according to them, which includes not only the citizens but also the Spaniards that cross the border every day for work!), and in the past few days, they've been getting a surge of infections. How would this be possible if the vaccines were effective at curbing the spread?

[@Xc31]

@@MatthewAshworth UKHSA has observed a noticably lower level of Roche N antigen in double vaccinated after infection and I have a hard time finding a proper awnser what that might imply. Some say it could be a sign of a lobsided immune system response and others say its a sign the vaccines are working great, wich seems doubtfull seeing the infection rates in countries with a very high vaccination rate. What is your opinion on that matter?

[@MatthewAshworth]

@@Xc31 Is this less of the antigen detected in the bloodstream or in the nose/mouth? If it's in the bloodstream, it could mean there's less of the virus circulating in the blood. But then we also know that this virus mainly affects lung tissue and is expelled through coughs and sneezes, so how much of it in the blood doesn't tell us how infectious the person is. It's more important how well the mucosal immunity reacts to the virus.

[@alialmosawy6255]

Thank you for this video.

[@whoami252]

Thank you for this video!

[@friendlyneighborhoodimmuno7192]

Thanks for watching!

[@francisbertolini2538]

Audio problems!! Make this again please

[@friendlyneighborhoodimmuno7192]

Sorry I know it’s bad. I have Adobe Pro Premiere and no graphics card and I don’t think my old laptop can handle it. I am working on alternative video software.

[@sanjumhoudi9601]

got the gist of it thanks. In spite of the sound.

[@gurpchirp]

unwatchable due to audio glitches. reupload the goods, dawg!

[@vg7735]

My other question is, why do people who have had Covid19 have to have the vaccine? Why isn't natural immunity enough?

[@friendlyneighborhoodimmuno7192]

That’s a great question. The recommended for people who recovered from COVID to get vaccinated is because of some antibody data. About a year ago some researchers showed that people who get COVID and recover only have antibodies for 3-6 months and they will have high levels of antibodies for over a year if they get vaccinated. Some people may be fine with their natural levels of antibodies but other people may not.

[@MatthewAshworth]

This is something that has bugged me and is one of the main reasons why I'm so skeptical nowadays of the recommendations given by the mainstream sources regarding COVID-19 vaccinations. Denial of natural immunity last autumn was a turning point for me. It's an outright denial of science. By then, there was already some evidence showing effective T-cell responses against SARS-CoV-2 (and since then, there has been a lot more evidence in countless science papers), and yet authorities and media ignored it and focused solely on waning antibody levels in some people, something that happens naturally anyway during any infection. Antibody levels don't need to be high permanently, because that will simply make the blood too thick if this was happening for every infection we come across. The important aspect of long-lasting immunity is not whether the antibodies stay at high level, but whether the immune system retains memory of the exposure to the pathogen, usually in a form of memory B- and T-cells.

[@friendlyneighborhoodimmuno7192]

@@MatthewAshworth that’s a fair point but not the whole picture. Having antibodies ahead of time is critical during COVID to neutralize it before it can replicate in your cells. People with high antibody levels are less likely to spread COVID to others. So yes memory T cells are essential to protect an individual long term. However, high levels of antibodies protects the person and the community.

[@friendlyneighborhoodimmuno7192]

@David Goodtime yes that’s is critical. The exact time a person is protected from COVID does seem to be less than a year which is super frustrating. I’ll do some research on Pubmed and get back to you.

[@MatthewAshworth]

@@friendlyneighborhoodimmuno7192 Ok. However, their levels wane with time with virtually every illness, so it's not like this is an exception with COVID-19, and they also wane from vaccine-induced immunity. And that level doesn't really drop to zero. Rather it just lowers to more appropriate levels in the absence of a pathogen, so there's still some instant protection. And also, something that we're not always aware of - when it comes to respiratory illnesses, IgA antibodies play a bigger role as they're usually found on mucosal surfaces such as the airways and are the first point of contact with such viruses. IgG antibodies only really come into effect if the virus manages to get into the bloodstream. So, aren't we measuring the wrong thing and making wrong assumptions about someone's level of protection against SARS-CoV-2?

[@myanis007]

i think the audio has got the ADE...

[@BurningsoulCZ]

Nice explanation bringing some light to this matter. But why are you considering ppl land in hospital? Why is not considered that you currently can have milder version of it, but instead you will be delivered to hospital, your troubles are just worse than without, maybe because of small gene differences against “mass population”? And therefore causing not such wild reactions but def worse then before?

[@earthstick]

Is the process of entering a macrophage one of the reasons why the vaccine reduces symptoms? Some viruses enter macrophages, where they are destroyed. And at the same time, the macrophages produce more, so you can still transmit the virus.

[@friendlyneighborhoodimmuno7192]

Good question. The main way the vaccine reduces symptoms is by creating antibodies that bind to the virus spike protein and stop the virus from ever entering your cells. The vaccine could help the macrophages destroy the virus as well.

[@friendlyneighborhoodimmuno7192]

It depends on a lot of factors, but most data indicates that if you are vaccinated you are less likely to be hospitalized due to COVID and less likely to transmit it to someone else.

[@earthstick]

@@friendlyneighborhoodimmuno7192 Another question then. As I understand, under normal conditions, a virus will evolve to live within the host without killing them. Because as a virus becomes more deadly, it kills the host quicker and spreads less. But if a vaccine is introduced that suppresses symptoms but not transmission, then deadlier viruses can evolve without killing the host and spread. So don't the vaccines promote deadlier strains of the virus? This is what happened with Marek's disease in chickens.

[@randomstranger2472]

Anybodies audio "glitchy"? Is this a new form of censorship?

[@friendlyneighborhoodimmuno7192]

Nope. I had an issue with my new Blue Yeti microphone and Adobe Premier Pro. I'm working on it. My other videos have better audio.

[@dean3338]

Cool!😎. Thanks!

[@friendlyneighborhoodimmuno7192]

Thanks for watching!

[@raggi1732]

To the point what I was looking for

[@jaspersilver1055]

I guess it’s ok that this spike protein binds no specifically to ace2 receptors on every organ system

[@davekeith7504]

The audio should be re done this makes it Very unprofessional .It's no good saying forgive me I took off the wrong leg.

[@MohammadBahiraei]

Love your videos 🌹❤️🌹

[@kirapalazzo3753]

If you'd like to skip the intro to antibodies, go to 4:04!

[@lesseirgpapers9245]

Singapore has 99% of the adult population vaccinated and with booster. The death rate is 10 x higher than it has ever been. An the unvaccinated kids are "still" healthy.....Same in Israel. except infections have slowed down because the westher now is were people are outside a lot.

[@KMStatsData]

Lmfao are you serious? The death rate in Singapore is higher than before covid of course bc the virus is circulating and getting to vulnerable ppl, but it's death rate is still orders of magnitude lower than unvaxxed areas. Even though my state has a million fewer people, we have a death count that is over 17 TIMES HIGHER, 14800 vs 830. We've had as many people die in my little county as they have in their entire nation.

[@kennyg1358]

@@KMStatsDatado you believe the published death rates?

[@KMStatsData]

@@kennyg1358 If it were China, there would be plenty reason to be skeptical, but Singapore is ranked as the 4th least corrupt country in the world and the most transparent in Asia. Even if it's higher death rate than published, they would have to do near impossible and countrywide cover up of hospital overload and deaths to get anywhere close to what's happened/happening where I live. Even in India for example, they already only capture a fraction of their deaths before they had mass casualties during their delta wave, but we know it was even larger than reported bc of constant reports of healthcare collapse around the country, and even family members of my colleagues who had died.

[@kennyg1358]

@@KMStatsData oh I think it's very much the other way around. These death numbers are inflated beyond all reason.

[@KMStatsData]

@@kennyg1358 Ha, well 800 total deaths in Singapore is definitely not inflated, and I know in my state every time a wave came through and people filled up my and my best friend's hospital in town, and we had to open up 4 extra covid units during the surges, and she took care of dying patients daily, and I we had 3 colleagues die in one weekend alone during delta, one of whom was pregnant, that if that is my direct experience, these surges have absolutely resulted in many more deaths. For this current surge that isn't happening yet though thank god!

[@evolvingerinb]

To bad it's not going to be available in the USA this year. But else where, good to go. I just read that this morning.

[@megowens7084]

Your microphone was annoying. I could not hear all.

[@matthewbond8275]

Your information was good up to a point and then completely wrong. I suggest you take another look at the raw data.

[@jaspersilver1055]

I guess you never heard of immune induced myocarditis and pericarditis

[@neuspeed79]

terrible sound quality

[@jaspersilver1055]

Wrong. The antibody binds to Mac 2s

[@friendlyneighborhoodimmuno7192]

That's incorrect. Here is a Nature paper that explains ADE. www.nature.com/articles/s41564-020-00789-5

[@nextleader7543]

@@friendlyneighborhoodimmuno7192 This paper is outdated.

[@JonahLaining]

Nice audio glitches jesus christ

[@techroach6343]

Could I get your opinion on this paper please? "An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies. Yafei Liu" It clearly shows there are multiple epitopes on the ntd that are known to raise antibodies that hold the trimer in the open conformation. COV2 2490 and COV2 2660 being the most agregious. So we do have evidence that the transfection can cause ADE. Second the data IS starting to show transfected people are more likely to get severe covid and die. You can check the latest OFFICIAL UK numbers or Israel's data to see this. Good talk though. I'm starting to warm to your channel even if you're a bit biased towards the immunomythology narrative.

[@friendlyneighborhoodimmuno7192]

Thanks for sharing the paper with me. I am always up to read peer-reviewed science. This paper found a mechanism that is unusual and potentially dangerous. It is not classic ADE that would allow for infection of macrophages. So no on Key #2. However they did find that some (but by no means all) antibodies allowed for easier entry into ACE2 expressing cells. UK still has more unvaccinated people in the hospital than vaccinated, but yes the rate is much higher than in the US. I'm glad you are warming to the channel. I hope for the day we can talk about the immune system when the pandemic is over.

[@techroach6343]

@@friendlyneighborhoodimmuno7192 I'm losing my job, my children and both my homes due to the mandating of the transfection in Australia... so I'm not sure I'll actually make it out of this. I'd like to return to study and get my masters, focusing on sars-cov-2 respriratory immunology. Unfortunately Uni's here require the transfection. So even that path might be blocked for me. Great channel. Thanks again.

[@nicole8307]

@@techroach6343 keep hope and stay in prayer. I truly believe God is our only way out. I'm in the US, so not as bad here YET, but I know it's coming. Hold the line! I'm a nurse who resigned due to the mandates. I will ALWAYS choose morals, ethics and integrity over a career or money. I stand with you, and many other Americans do also.

[@LeukeGast]

Citokinestorm, where it's end.

[@user-jy5fz3mm5i]

Bad audio

[@theothercomicguy]

Well this didn't age well #dec2022

[@jarronhaleysorrell]

Caused by the needle

[@veritasomniavincit7]

Most.frustrating.audio. ever.

[@ronalddepesa6221]

SARS CoV2

[@jedadruled984]

Vaccin making Corona great again in tha coming winter

[@ML-qt8hr]

Actually variants enhance the ADE, in my opinion

[@jaspersilver1055]

I guess you never heard of myasthenia Travis or MS or transverse myelitis. Via non self antibody reactions. I guess you never heard of anti neutrophil antibodies with Fc specific binding via hypergammaglobulinemia

[@friendlyneighborhoodimmuno7192]

My mother had myasthenia gravis after she was laid off of work, and thankfully she is in remission. I have studied the immune system for 14 years, and I have grown macrophages, T cells, and astrocytes for over 9 years. So yes of course I have heard of these things. You are confusing multiple different immune pathways with ADE and then adding autoimmune disease which are NOT connected to ADE.

[@dan1204hc]

@@friendlyneighborhoodimmuno7192 I'm neither immunologist, nor psychologist. But my Dunning-Kruger effect tells me that Mr. Jasper Silver suffers from acute Dunning-Kruger effect. 😄

[@guitarwhisperer6262]

Think we are seeing it now

[@martynphipps9117]

This is all lies