Adrenergic Drugs (Part 02)| Alfa and Beta Receptors with Their Location and Functions | Adrenergic

Adrenergic system or Adrenergic nervous system (ANS) is a group of organs and nerves in which adrenaline (epinephrine) and/or noradrenaline (norepinephrine) act as neurotransmitters. ANS is counted as one of the main neurohormonal systems that regulate cardiovascular function, including smooth muscle tone.
There are several key things to understand about the adrenergic system. The first is that the nerve fibres that release norepinephrine as their main neurotransmitter are called adrenergic neurons. The receptors stimulated by either norepinephrine or epinephrine are called adrenergic receptors or adrenoceptors. The drug that activates the adrenergic receptors is called sympathomimetics. On the other hand, drugs that block the activation of these same receptors are known as sympatholytics.
Epinephrine is both a naturally occurring biochemical in the body and it is synthetically produced for medical purposes. Norepinephrine is also used medically but far less so than epinephrine. Primarily, adrenergic neurons (nerve cells) release norepinephrine as their neurotransmitter. Adrenergic neurons can be found in the central nervous system (the brain and spinal cord), as well as the sympathetic nervous system. The receptors these adrenergic neurons stimulate are called alpha 1, alpha 2, beta 1, beta 2, and beta 3. Some of these can be further subdivided into more receptor subtypes, but this is beyond this lesson's scope.
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If possible. Then explain adevese effect. Contraindication .

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Sir, Alpha 1 receptor gland k secretion ko increase krta h ya decrease krta h??

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See all the adrenergic receptor which has number 1 they are stimulatory receptor and which has number 2 they are inhibitory receptor like in bronchi it has beta 2 Receptor that's why brochi will dilate. Hope u understand 😊

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@@jaypatel2343 beta 2 receptor is not inhibitory it is stimulatory but bronchodilation is cause due to presence of smooth muscle in bronchi

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Sir Beta1 receptor blockers are safe in asthmatic patient, only non selective beta blockers are contraindicated like propranolol.

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If the Aplha 2 receptor receptor decrease . How can it be? Pls sir explain

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Clonidine causes vasodilation or vasoconstricion? I think it is former. Please clearify.

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How alpha receptors act as excitatory ?? beta - inhibitory????????????? nature

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In which sence ?

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@@solutionpharmacy that is what i m asking......in which sesnse....it is written in my medchem book

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Due to activate the big condutance potassium channels these are activated by the calcium signalling and voltage sensing.

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Sir alpha 2 receptor present on trabecular meshwork also?? In some article say that activation of alpha 2 receptor cause decreased in aqueous secretion present on ciliary process and increased outflow which is present on trabecular meshwork. ????????? Sir pls answer this question coz on google information about this is not much available pls 2) ICI 11 8551 has 100 time higher affinity for beta 2 as compare to beta 1 so why its show in beta3

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Sir there are D1to D5 receptors also present ... please explain them too sir ...

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If Alfha 2 receptors cause decreased neurotransmitter release then who does it caused Vasoconstriction... Plzz explain this

[@solutionpharmacy]

Vasocontriction is not always dependent on neurotransmitter

[@easymedicinebyshahnawaziqb8901]

@@solutionpharmacy but the alpha receptor is only specific for Catecholamines so it only reacts to Catecholamines.... What can be the other cause of Vasocostruction?

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sir i have a question for alpha 2 receptor if alpha 2 receptor cause vasoconstriction then why we are giving clonidine as a agonist u said agonist are those which shows positive effect then m still confused about clonidine and alpha methyl dopa pls clear my doubt

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Please explain contraindications

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Sir ek question hai ki agonist KB dete h or antagonist KB dete h

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Jab aap signal aur receptor ke binding se advantage lena chahe to agonist aur unko rokna chahe to antagonist.

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sir beta2 shows vasodilation or vasoconstriction

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Sir, alpha methyl propranolol selective beta antagonist hota h ya non selective??

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I think sir wanted to say alpha methy dopa. (It’s a cvs drug for hypertension especially for pregnant womens)

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Sir can you please explain why alpha1 receptors increase bp while alpha2 decrease bp

[@solutionpharmacy]

Its because of their vasodilator n constrictor activity

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@@solutionpharmacy Sir but you have written on both alpha 1 and alpha 2 vasoconstriction...?

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Different neurotransmitters and hormones

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But Sir . B1- agonist drugs dobutamine have some affinity for Alfa receptor ... So how is it pure bitA agonist ?

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Dobutamine, has predominantly β-adrenergic effects with minimal α-adrenergic effects. Its efficasy is not as high as beta recp.

[@shaik.karimullagullapalli7867]

It's pure beta 1 receptor agonist .for example if we take isoprenaline it is a non selective for beta 1 and also it works on beta 2 receptor both are quite different mechanism.Alpha 1 receptor exogenous agonist is phenylephrine

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Sabka nahi hota pdf. Baki kuch alag se notes hain. Ye dekhiye. How to Download PDF from Solution Pharmacy Facebook Group Using Mobile kzbin.info/www/bejne/pKXdiX6fZ9V0a7c Please download WPS office from play store after downloading that, download these documents.once the download is complete open through WPS office the problem will be solved it will be easily available play.google.com/store/apps/details?id=cn.wps.moffice_eng

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Sir ek baat smjh m nhi aai..! Ki suppose hamne agr Adrenergic drug diya toh kya vo drug jaakr alpha aur beta receptor pr jaake bind hoga apna reaction show krne k liye?? Agonist aur antagonist ka role kya hoga iss condition m?

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Jo agonist hai wo bind hoga aur jo antagonist hai wo signal molecule ko bind hone nahi dega

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@@solutionpharmacy toh sir vo drug apna action kaise show krega jb Antagonist signal ko bind hi hone nhi dega toh...

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07:54 Adrenaline se barabar yaa phir Adrenaline se kam* hona chaiyetha.... aapne Adrenaline se jyada boldiya

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Why ß1 blockers are not given to asthma patients? I suppose non- selective ß blockers are not given to asthama patients and ß1 blockers should not cause any harm because on bronchioles ß2 receptors are present not ß1 receptors.

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Shrishti Shandily Beta receptor or so cruel they are also used in hypertensive and as well as in asthma so if these are non-selective they may home both present accordingly

[@hrithikchatterjee1773]

@@solutionpharmacy sir can u tell it in details beta 1 blocker should not cause any harm to asthma as it present in heart beta 2 blocker can cause harm to asthma patient as it wil do bronchoconstriction.so why i say beat 1 blocker cant be given to asthma patient

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Great content!! But why does he pronounce it "RECEP-TAAAAR"

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Sorry that was my personal mistake because of my language. I have now improved that.

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Antagonist which is not recognized yet so uskaa code h ye

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I think beta 2 mein vasodilation hota hai

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Block karne se

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B2 doesnt constrict... As far i know.

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Sorry. Yes tez to hai but itna bhi nahi