AMPK Signaling Pathway: Regulation and Downstream Effects

Medical/Biochemistry lesson on energy sensing AMP-activated protein kinase (AMPK) signaling, regulation and downstream effects.
Hey guys! In this video I talk about the AMPK pathway, regulation of the pathway, and various downstream effects. AMPK is a potent negative regulator of mTOR in order to reduce cellular energy expenditure while promoting energy production.
Please let me know what you think, and if you have any questions/concerns. Please feel free to comment or ask any questions! I'll try my best to help you :)
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@MatthiasKlees]

short, clear, enlightenig, i am happy, to just have found your channel

[@F_Y_82]

Great Video!! Thank you a lot. This AMPK signaling gave me a lot help.

[@schuggy4408]

Best explanation on KZbin.

[@brookemissfit6236]

Thank you so so so much for this video! It is so helpful! Better than any of my textbooks or lectures!

[@bionautas8667]

Very nice video! Sometimes this kind of videos helps much more than reading 4 papers :)

[@theclassroomdoc]

Great stuff many thinks! Good teachers are rare.

[@upholstery1995]

Man this is top-notch stuff! Love it

[@gspence8327]

Thanks very much for making this info available in an easiy understandable presentation.

[@mariociencia12]

Very nice video! Unfortunately, I missed the gluconeogenesis inhibition by AMPK. By the way, this is one of the main mechanism of metformin (an indirect activator of AMPK) in avoiding hyperglycemia

[@kamilantwin1]

Very good conclusion! Thats exactly how i think it should be done!

[@jjmedicine]

Thanks for the comment! Glad you liked it :)

[@Yuchunyuchunyuchun]

Its really helpful and clear!! Appreciated!!

[@JAISANTHOSHKRISHNANKRISHNASAMY]

AMPK aids in the synthesis of Nitric Oxide as well, which exerts anti contractile activity.

[@mariananutrideas1020]

thank you so much this was so helpful !!!!!!

[@michelleelizabeth9956]

Better than my professor

[@guybrown9422]

Great summary vid! There's also the calcium ion-dependant (Ca2+) pathway for AMPK activation, separate to but not as significant as the LKB1 pathway

[@vincentmoses8204]

i know im asking randomly but does someone know a trick to log back into an instagram account?? I somehow lost my password. I would appreciate any help you can give me.

[@gavingibson7471]

@Vincent Moses Instablaster :)

[@vincentmoses8204]

@Gavin Gibson thanks so much for your reply. I got to the site thru google and Im in the hacking process now. I see it takes a while so I will reply here later when my account password hopefully is recovered.

[@vincentmoses8204]

@Gavin Gibson it did the trick and I finally got access to my account again. I'm so happy! Thank you so much you saved my account!

[@gavingibson7471]

@Vincent Moses No problem :D

[@ericamoonrose9053]

Very clear and helpful ! thankyouuuuu

[@deborahcohen4045]

Great video thank you! It would be amazing if you did a 2 minute medical correlation with the method of action of metformin (and the MOA of its side effect of lactic acidosis)

[@Randibaaj_sala]

I need this. Did you find any videos about metformin?

[@AnaMusat89]

@@Randibaaj_sala Check David Sinclair on Huberman Lab podcast, or his new podcast Lifespan

[@3000Jeffrey]

Awesome... I feel like I've stayed at a Holiday Inn Express!

[@alemshawul]

please can you tell me how it increase both FAO and glycolysis..seems like it contradict with randle cycle

[@adrianadibua7980]

This was a great summary; helped so much!

[@bodycareforhealth8656]

very very well done, thank you so much for making this simple and clear, I agree with all the comments below keep up the good work

[@tipimebak7105]

Thank you so much from Zonguldak/Turkey

[@ths1158]

Thank you a really helpful summary.

[@loveliamunoz5210]

Alittle technical and elevated, but extremely informative and interesting. I am diabetic and am going to study this and practice it. Thank you so much. Have logged in for your Tesday research. Lovelia Munoz

[@mindofzyzz8805]

So easy to understand! Subscribed

[@toughsuga2]

Awesome, two thumbs up

[@scoobyandscrappy1]

This is a little out of my comfort zone...so should we be taking this product??

[@ThyroidVsKeto]

if something was to Activate the AMPK by inhibiting Complex I in the mitochondria how would this impact in the supposed increase in fatty acid oxidation since there would be if anything a lack of Oxygen maybe suggesting Anaerobic Glicolisys as the main source of fuel?

[@joeq111]

Very clear and helpful, 🙏

[@dottiedean3149]

Do you have any articles on AMPKs downstream cellular pathway? More specifically the histones it interacts with ?

[@kefirmomo1570]

I also would like these articles... If you find some, pleeeasse let me know! Thank you

[@randallhesse5011]

Research: methylene blue!

[@bigdansfitnesscomchannel6729]

Very good work!

[@abvmoose87]

I would like some clarificatuons on ampk vs mtor in relation to exercise. Is there a specific type of exercise that upregulates ampk or just any kind? Heavy, intense exercise with compound weights increase igf-1 which upregulates mtor which upregulates protein synthesis. Since it has been proven that you have increased protein synthesis a couple of hours after that kind of exercise it must mean that mtors upregulating effect of protein synthesis beats ampk's downregulating effect.

[@conorellisfitness]

coffey et al., 2009 - consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle

[@Mindsetsandreps]

I believe ampk is more so upregulated in long duration cardio rather than heavy lifting. With heavy lifting you would have breaks in between sets to replenish fuel so I don't think you would get the high AMP ATP ratio. This is just a guess though.

[@misterman6369]

@@Mindsetsandreps compare long distance runners to sprinters. high intensity v low intensity.

[@sidmichael1158]

So berberine, metformin and fasting activate ampk?

[@toniop93]

Thanks a lot from Italy!

[@mehrezharmaoui5473]

Thanks a lot ,a great summary and helpful .

[@Kukatoo]

this is fantastic, thanks so much

[@yiuume]

this is great, thank you!!

[@HollywoodWestern]

Thanks for the breakdown!

[@casperbeukema371]

Great vid, thanks man!

[@jonathanlawler6482]

Which program do you use to make the cell pathway programs?

[@TheTruthResearchers]

Many Thanks! Can you please do a Lesson on Chronic Severe Dehydration (as a direct result of acute Rhabdomyolysis which lasted so long that it literally dissolved more than 50% of all body Muscle! (All of this occured in a perfectly healthy & fit body that had a sun-stroke from 2nd degree sunburn which lead to the Rhabdo which lead to acute kidney failure (all of which was UNTREATED by the Doctor!!) Oral Hydration has failed consistantly as the cells will not let any water inside! The thirst mechanism in the brain has even been switched-off. And even after the kidneys finally healed, the blood-work always shows normal electrolyte levels, but the most severe dehydration persists and the skin is shriveled up to the texture of crinkles and the skin can be pulled up from the bone and remain in a squeezed shape like sculpted puddy (worse than the aged skin of 100 year old individual). In addition, this severe Dehydration has caused relentless Chronic Fatigue and a complete loss of all "feelings of self". A constant overall feeling of deadness. Literally always feeling like THE LIFE has been drained out. The only thing that has helped was IV Hydration at the ER. So we tried "In Home" IV Hydration with a Home Care Service through a Pharmacy and the therapy became near fatal as a result of their "unsterile" IV Solution! So, now, there is stunting fear of returning to any IV Therapy. PLEASE help us to understand what is going on and any alternate REHYDRATION methods that can repair and recover the loss of brain function, an inability of intracellular hydration, loss of ATP production, etc, and loss of all cellular Signaling mechanisms!!! Thus far, all of the 35 Medical Specialists from (Nephrologists to Neurologists) have either failed to resolve the problems, or just refused any "effort to research" and find (or create) any solutions for recovery. You are so bright & knowledgeable. Any of your thoughts or teachings would be most greatly appreciated. Thank you.

[@dr_blueman]

Thank you ❤.

[@Chiewrt]

Nice overview!

[@Chiewrt]

A little to much on the uhms tho

[@bobcocampo]

Does it mean that even if MTOR is high if AMPK is activated MTOR will be down regulated?

[@westfield90]

Metformin blocks this enzyme but how does metformin then increase insulin sensitivity by causing cells to uptake glucose from the blood?

[@jenna-r1428]

Thank you so much for this video! I read my biochem textbook on this concept and felt pretty confused. This REALLY helped so much! Thank you, thank you, thank you!

[@karimnaraki7376]

thank u man for ur lesson

[@jonen9494]

Great video. Maybe mention Adiponectin as an activator also?

[@brunocirillo7072]

Great explanation as always. From an exercise physiology point of view, I was wondering how AMPK and mTOR are then fighting between each other to prevail certain training adaptations. For example, since AMPK blocks the mTOR activation and therefore protein synthesis, how come concurrent training (CrossFit style workouts) still produces effects on hypertrophy? Thanks

[@Overcrook65]

AMPK blocks mTOR only as long as its activators (like exercise, coldness, calory restriction, energy deficit) push the button. AMPK activation increases the amount or size of mitochondria. When you eat after exercise, you produce an energy excess, glucose blocks AMPK, insulin and amino acid activate mTOR and it will start to support the regeneration, growth and supercompensation processes, proliferation and protein synthesis.

[@digantasarma7727]

I agree. Hypertrophy occurs in the feeding state with activation of mTOR not during the exercise per say because exercise itself is a catabolic state. When you eat after exercise mTOR is activated and you raech an anabolic state. This cycle continues.

[@pujithkumar5849]

Soo good

[@samnoah6019]

Thank you so much 💜

[@jioyu9180]

Thank you it is so helpful

[@joecanti5944]

Great video! ...thank you. So I've seen a few people saying that metformin will reduce CoQ10 synthesis. I couldn't find much data on it, but AMPK being an HMG CoA reductase inhibitor was the missing link! Do you know of any studies on that?

[@immadisarojini2775]

Super useful

[@FocaFlix]

a million thumbs up

[@messiah980]

If you could share the graphics, would help a lot when trying to visualize the logic. Tnx!

[@christopherpalmer4243]

ALA is good for AMPK, isn't it?

[@ArghaSaha05]

Decreases glycogen synthesis or glucose?

[@gmalabdulh6876]

Glycogen not glucose

[@bobcocampo]

What happens if you are on carnivore diet and not eating carbs?

[@sidmichael1158]

Fasting doesn't activate it?

[@gmalabdulh6876]

Fastin increase the degradtion to the glycogen in the lever

[@shubhanshujain9827]

Thanks.

[@慶弘王]

4:43 thank you, thumb up alraedy

[@Peace597]

Thank you

[@ayso2127]

Thanks

[@mikepict9011]

That made sense

[@hannihalabi4560]

Great!!!!!!

[@pedrozuniga5581]

helpful

[@btudrus]

HMG-CoA is not only cholesterol...

[@AmitKumar-em3vz]

JJ you are lovely. Pls tell which Country you are from. I guess USA.....?

[@jjmedicine]

Hey Amit Kumar! Thanks so much :) I'm actually from Canada.

[@AmitKumar-em3vz]

Oh Canada what a great country.

[@ali-f6b1t]

😍😍😍😍

[@ErickOberholtzer]

So... It makes you smaller

[@madsm8337]

who s here for metformin

[@gmalabdulh6876]

Metformin increase ampk

[@daniaalma4846]

Dudes just reading off pathways in a semi random order

[@vibratehigher2441]

Thanks