AMPK Signaling Pathway: Regulation and Downstream Effects

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JJ Medicine

JJ Medicine

Күн бұрын

Пікірлер: 96
@mariociencia12
@mariociencia12 3 жыл бұрын
Very nice video! Unfortunately, I missed the gluconeogenesis inhibition by AMPK. By the way, this is one of the main mechanism of metformin (an indirect activator of AMPK) in avoiding hyperglycemia
@MatthiasKlees
@MatthiasKlees 5 жыл бұрын
short, clear, enlightenig, i am happy, to just have found your channel
@deborahcohen4045
@deborahcohen4045 5 жыл бұрын
Great video thank you! It would be amazing if you did a 2 minute medical correlation with the method of action of metformin (and the MOA of its side effect of lactic acidosis)
@Randibaaj_sala
@Randibaaj_sala 3 жыл бұрын
I need this. Did you find any videos about metformin?
@AnaMusat89
@AnaMusat89 2 жыл бұрын
@@Randibaaj_sala Check David Sinclair on Huberman Lab podcast, or his new podcast Lifespan
@guybrown9422
@guybrown9422 5 жыл бұрын
Great summary vid! There's also the calcium ion-dependant (Ca2+) pathway for AMPK activation, separate to but not as significant as the LKB1 pathway
@vincentmoses8204
@vincentmoses8204 3 жыл бұрын
i know im asking randomly but does someone know a trick to log back into an instagram account?? I somehow lost my password. I would appreciate any help you can give me.
@gavingibson7471
@gavingibson7471 3 жыл бұрын
@Vincent Moses Instablaster :)
@vincentmoses8204
@vincentmoses8204 3 жыл бұрын
@Gavin Gibson thanks so much for your reply. I got to the site thru google and Im in the hacking process now. I see it takes a while so I will reply here later when my account password hopefully is recovered.
@vincentmoses8204
@vincentmoses8204 3 жыл бұрын
@Gavin Gibson it did the trick and I finally got access to my account again. I'm so happy! Thank you so much you saved my account!
@gavingibson7471
@gavingibson7471 3 жыл бұрын
@Vincent Moses No problem :D
@bionautas8667
@bionautas8667 4 жыл бұрын
Very nice video! Sometimes this kind of videos helps much more than reading 4 papers :)
@brookemissfit6236
@brookemissfit6236 7 жыл бұрын
Thank you so so so much for this video! It is so helpful! Better than any of my textbooks or lectures!
@kamilantwin1
@kamilantwin1 4 жыл бұрын
Very good conclusion! Thats exactly how i think it should be done!
@jjmedicine
@jjmedicine 4 жыл бұрын
Thanks for the comment! Glad you liked it :)
@theclassroomdoc
@theclassroomdoc 5 жыл бұрын
Great stuff many thinks! Good teachers are rare.
@gspence8327
@gspence8327 3 жыл бұрын
Thanks very much for making this info available in an easiy understandable presentation.
@schuggy4408
@schuggy4408 3 жыл бұрын
Best explanation on KZbin.
@upholstery1995
@upholstery1995 2 жыл бұрын
Man this is top-notch stuff! Love it
@tipimebak7105
@tipimebak7105 Жыл бұрын
Thank you so much from Zonguldak/Turkey
@mariananutrideas1020
@mariananutrideas1020 7 жыл бұрын
thank you so much this was so helpful !!!!!!
@michelleelizabeth9956
@michelleelizabeth9956 6 ай бұрын
Better than my professor
@loveliamunoz5210
@loveliamunoz5210 4 жыл бұрын
Alittle technical and elevated, but extremely informative and interesting. I am diabetic and am going to study this and practice it. Thank you so much. Have logged in for your Tesday research. Lovelia Munoz
@Yuchunyuchunyuchun
@Yuchunyuchunyuchun 4 жыл бұрын
Its really helpful and clear!! Appreciated!!
@ThyroidVsKeto
@ThyroidVsKeto 5 жыл бұрын
if something was to Activate the AMPK by inhibiting Complex I in the mitochondria how would this impact in the supposed increase in fatty acid oxidation since there would be if anything a lack of Oxygen maybe suggesting Anaerobic Glicolisys as the main source of fuel?
@3000Jeffrey
@3000Jeffrey 6 жыл бұрын
Awesome... I feel like I've stayed at a Holiday Inn Express!
@alemshawul
@alemshawul Жыл бұрын
please can you tell me how it increase both FAO and glycolysis..seems like it contradict with randle cycle
@scoobyandscrappy1
@scoobyandscrappy1 3 жыл бұрын
This is a little out of my comfort zone...so should we be taking this product??
@ericamoonrose9053
@ericamoonrose9053 5 жыл бұрын
Very clear and helpful ! thankyouuuuu
@adrianadibua7980
@adrianadibua7980 5 жыл бұрын
This was a great summary; helped so much!
@ths1158
@ths1158 4 жыл бұрын
Thank you a really helpful summary.
@jenna-r1428
@jenna-r1428 3 жыл бұрын
Thank you so much for this video! I read my biochem textbook on this concept and felt pretty confused. This REALLY helped so much! Thank you, thank you, thank you!
@bodycareforhealth8656
@bodycareforhealth8656 5 жыл бұрын
very very well done, thank you so much for making this simple and clear, I agree with all the comments below keep up the good work
@TheTruthResearchers
@TheTruthResearchers 8 күн бұрын
Many Thanks! Can you please do a Lesson on Chronic Severe Dehydration (as a direct result of acute Rhabdomyolysis which lasted so long that it literally dissolved more than 50% of all body Muscle! (All of this occured in a perfectly healthy & fit body that had a sun-stroke from 2nd degree sunburn which lead to the Rhabdo which lead to acute kidney failure (all of which was UNTREATED by the Doctor!!) Oral Hydration has failed consistantly as the cells will not let any water inside! The thirst mechanism in the brain has even been switched-off. And even after the kidneys finally healed, the blood-work always shows normal electrolyte levels, but the most severe dehydration persists and the skin is shriveled up to the texture of crinkles and the skin can be pulled up from the bone and remain in a squeezed shape like sculpted puddy (worse than the aged skin of 100 year old individual). In addition, this severe Dehydration has caused relentless Chronic Fatigue and a complete loss of all "feelings of self". A constant overall feeling of deadness. Literally always feeling like THE LIFE has been drained out. The only thing that has helped was IV Hydration at the ER. So we tried "In Home" IV Hydration with a Home Care Service through a Pharmacy and the therapy became near fatal as a result of their "unsterile" IV Solution! So, now, there is stunting fear of returning to any IV Therapy. PLEASE help us to understand what is going on and any alternate REHYDRATION methods that can repair and recover the loss of brain function, an inability of intracellular hydration, loss of ATP production, etc, and loss of all cellular Signaling mechanisms!!! Thus far, all of the 35 Medical Specialists from (Nephrologists to Neurologists) have either failed to resolve the problems, or just refused any "effort to research" and find (or create) any solutions for recovery. You are so bright & knowledgeable. Any of your thoughts or teachings would be most greatly appreciated. Thank you.
@toughsuga2
@toughsuga2 7 жыл бұрын
Awesome, two thumbs up
@abvmoose87
@abvmoose87 5 жыл бұрын
I would like some clarificatuons on ampk vs mtor in relation to exercise. Is there a specific type of exercise that upregulates ampk or just any kind? Heavy, intense exercise with compound weights increase igf-1 which upregulates mtor which upregulates protein synthesis. Since it has been proven that you have increased protein synthesis a couple of hours after that kind of exercise it must mean that mtors upregulating effect of protein synthesis beats ampk's downregulating effect.
@conorellisfitness
@conorellisfitness 4 жыл бұрын
coffey et al., 2009 - consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle
@Mindsetsandreps
@Mindsetsandreps 4 жыл бұрын
I believe ampk is more so upregulated in long duration cardio rather than heavy lifting. With heavy lifting you would have breaks in between sets to replenish fuel so I don't think you would get the high AMP ATP ratio. This is just a guess though.
@misterman6369
@misterman6369 4 жыл бұрын
@@Mindsetsandreps compare long distance runners to sprinters. high intensity v low intensity.
@dottiedean3149
@dottiedean3149 4 жыл бұрын
Do you have any articles on AMPKs downstream cellular pathway? More specifically the histones it interacts with ?
@kefirmomo1570
@kefirmomo1570 4 жыл бұрын
I also would like these articles... If you find some, pleeeasse let me know! Thank you
@randallhesse5011
@randallhesse5011 Жыл бұрын
Research: methylene blue!
@brunocirillo7072
@brunocirillo7072 4 жыл бұрын
Great explanation as always. From an exercise physiology point of view, I was wondering how AMPK and mTOR are then fighting between each other to prevail certain training adaptations. For example, since AMPK blocks the mTOR activation and therefore protein synthesis, how come concurrent training (CrossFit style workouts) still produces effects on hypertrophy? Thanks
@Overcrook65
@Overcrook65 4 жыл бұрын
AMPK blocks mTOR only as long as its activators (like exercise, coldness, calory restriction, energy deficit) push the button. AMPK activation increases the amount or size of mitochondria. When you eat after exercise, you produce an energy excess, glucose blocks AMPK, insulin and amino acid activate mTOR and it will start to support the regeneration, growth and supercompensation processes, proliferation and protein synthesis.
@digantasarma7727
@digantasarma7727 4 жыл бұрын
I agree. Hypertrophy occurs in the feeding state with activation of mTOR not during the exercise per say because exercise itself is a catabolic state. When you eat after exercise mTOR is activated and you raech an anabolic state. This cycle continues.
@bigdansfitnesscomchannel6729
@bigdansfitnesscomchannel6729 5 ай бұрын
Very good work!
@toniop93
@toniop93 3 жыл бұрын
Thanks a lot from Italy!
@joeq111
@joeq111 2 жыл бұрын
Very clear and helpful, 🙏
@joecanti5944
@joecanti5944 2 жыл бұрын
Great video! ...thank you. So I've seen a few people saying that metformin will reduce CoQ10 synthesis. I couldn't find much data on it, but AMPK being an HMG CoA reductase inhibitor was the missing link! Do you know of any studies on that?
@pujithkumar5849
@pujithkumar5849 4 жыл бұрын
Soo good
@sidmichael1158
@sidmichael1158 4 жыл бұрын
So berberine, metformin and fasting activate ampk?
@yiuume
@yiuume 4 жыл бұрын
this is great, thank you!!
@HollywoodWestern
@HollywoodWestern 6 жыл бұрын
Thanks for the breakdown!
@mindofzyzz8805
@mindofzyzz8805 6 жыл бұрын
So easy to understand! Subscribed
@Kukatoo
@Kukatoo 2 жыл бұрын
this is fantastic, thanks so much
@dr_blueman
@dr_blueman 10 күн бұрын
Thank you ❤.
@cozzycave
@cozzycave 5 жыл бұрын
a million thumbs up
@jonen9494
@jonen9494 6 жыл бұрын
Great video. Maybe mention Adiponectin as an activator also?
@mehrezharmaoui5473
@mehrezharmaoui5473 3 жыл бұрын
Thanks a lot ,a great summary and helpful .
@casperbeukema371
@casperbeukema371 4 жыл бұрын
Great vid, thanks man!
@Chiewrt
@Chiewrt 6 жыл бұрын
Nice overview!
@Chiewrt
@Chiewrt 6 жыл бұрын
A little to much on the uhms tho
@jonathanlawler6482
@jonathanlawler6482 Жыл бұрын
Which program do you use to make the cell pathway programs?
@vibratehigher2441
@vibratehigher2441 Ай бұрын
Thanks
@messiah980
@messiah980 3 жыл бұрын
If you could share the graphics, would help a lot when trying to visualize the logic. Tnx!
@shubhanshujain9827
@shubhanshujain9827 2 жыл бұрын
Thanks.
@bobcocampo
@bobcocampo Жыл бұрын
Does it mean that even if MTOR is high if AMPK is activated MTOR will be down regulated?
@karimnaraki7376
@karimnaraki7376 5 жыл бұрын
thank u man for ur lesson
@immadisarojini2775
@immadisarojini2775 3 жыл бұрын
Super useful
@samnoah6019
@samnoah6019 6 жыл бұрын
Thank you so much 💜
@westfield90
@westfield90 Жыл бұрын
Metformin blocks this enzyme but how does metformin then increase insulin sensitivity by causing cells to uptake glucose from the blood?
@jioyu9180
@jioyu9180 6 жыл бұрын
Thank you it is so helpful
@christopherpalmer4243
@christopherpalmer4243 4 ай бұрын
ALA is good for AMPK, isn't it?
@慶弘王
@慶弘王 3 жыл бұрын
4:43 thank you, thumb up alraedy
@Peace597
@Peace597 6 жыл бұрын
Thank you
@mikepict9011
@mikepict9011 4 жыл бұрын
That made sense
@bobcocampo
@bobcocampo Жыл бұрын
What happens if you are on carnivore diet and not eating carbs?
@hannihalabi4560
@hannihalabi4560 5 жыл бұрын
Great!!!!!!
@pedrozuniga5581
@pedrozuniga5581 7 жыл бұрын
helpful
@sidmichael1158
@sidmichael1158 4 жыл бұрын
Fasting doesn't activate it?
@gmalabdulh6876
@gmalabdulh6876 2 жыл бұрын
Fastin increase the degradtion to the glycogen in the lever
@ali-f6b1t
@ali-f6b1t 3 күн бұрын
😍😍😍😍
@btudrus
@btudrus Жыл бұрын
HMG-CoA is not only cholesterol...
@ArghaSaha05
@ArghaSaha05 5 жыл бұрын
Decreases glycogen synthesis or glucose?
@gmalabdulh6876
@gmalabdulh6876 2 жыл бұрын
Glycogen not glucose
@AmitKumar-em3vz
@AmitKumar-em3vz 4 жыл бұрын
JJ you are lovely. Pls tell which Country you are from. I guess USA.....?
@jjmedicine
@jjmedicine 4 жыл бұрын
Hey Amit Kumar! Thanks so much :) I'm actually from Canada.
@AmitKumar-em3vz
@AmitKumar-em3vz 4 жыл бұрын
Oh Canada what a great country.
@ErickOberholtzer
@ErickOberholtzer 3 жыл бұрын
So... It makes you smaller
@madsm8337
@madsm8337 4 жыл бұрын
who s here for metformin
@gmalabdulh6876
@gmalabdulh6876 2 жыл бұрын
Metformin increase ampk
@daniaalma4846
@daniaalma4846 Жыл бұрын
Dudes just reading off pathways in a semi random order
@ayso2127
@ayso2127 5 жыл бұрын
Thanks
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