Insulin Signaling Cascade and Downstream Effects - Biochemistry Lesson

Learn the insulin signaling transduction cascade/pathway in this biochemistry powerpoint-style lecture!
Hey guys! Here is a new video where I teach the insulin signaling pathway in a new powerpoint style lecture format. Please let me know if you guys like this format of learning, and I will make more videos using this teaching method! I hope you all find it informative and please like and subscribe if you found the video helpful! All feedback is appreciated :) JJ
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***EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and are intended for educational/teaching purposes only.***
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@benjy1898]

This is brilliant! Having animations and a voiceover is so much easier to understand than static diagrams and walls of text. Thank you!

[@jjmedicine]

You're very welcome!

[@bensukacamak3466]

This video is amazing. Very informative and clear explanations. Thank you so much!

[@Flugeo]

This tremendously helped me to understand insulin resistance pathogenesis. Many thanks, that’s a gold content!!

[@professor9883]

I like your videos you explanation is quite simple and easy to remember thank you so much for such a great work

[@RomajaneAbrenio]

Thank you so much. You made this topic easier!

[@brunocirillo7072]

Thank you very much. Extremely well-done explanations.

[@Abdullah_DS]

Thanks a lot, I love your explainations. One of my favorite channels⚘️.

[@juliecloutier3929]

I love your videos and how you make sense of all the detailed information in the end! I also love the tool you use to draw your very comprehensive pathways, if you don't mind telling us what software you are using, i would like to use it for my own pathways. Thank you very much!

[@spencergreen6772]

Great video. Helped tremendously!

[@aleidam2485]

this video literally helped me understand a whole subtopic of my biochem project. thank you so much!!

[@hrishabhupadhyay751]

Aleida M what project did you make?

[@aleidam2485]

@@hrishabhupadhyay751 it was about insulin but i didnt really understood how the signaling cascade was explained in my coursework and this vid really helped

[@xaviergomez2175]

Great video! Huge help learning cell signaling pathways and cancer cascades

[@Zetsuke4]

The best ever teaching style soo good!

[@ivanpvai5221]

this helped me alot, thanks JJ medicine!!

[@peptoid1]

Thank you for very clear presentation.

[@m.raismustafa8546]

Thanks for the simplistic explanation

[@yasee9771]

Thank you so much for this video!

[@user-yq8pj4xz3i]

Very good explaining and fully understanding

[@hassibatiachadine9322]

Thank you so much ..really it is so helpful

[@garimahanz7346]

It was really helpful ,thank you sir

[@Siher86]

You just saved my life!

[@Otaku2803]

I just gave my cell signaling final exam yesterday and struggled with an essay question about insulin signaling. Today I discovered this helpful video. You can imagine my frustration.

[@mostafadiab1224]

This is PERFECT

[@KalpanaKumari140203]

looove your videos !

[@phsal5182]

Very helpful, thank you!

[@PatrickLoobs]

Thank you!! Very clearly explained. I now understand what GLUT4 translocation means. :)

[@ronaldobadrinauth123]

Very good explanation!

[@zenovier7689]

Thank you so much for this

[@manjupathak1643]

very clear and good one

[@KK-yt3iy]

great video!

[@abdullahsabr5657]

Helpful video many thanks sir

[@reemal-dhaywi1854]

very helpful 😍thank you.

[@mardenidres]

Thank you 🌸🌸

[@Greanestbean]

Thank you!

[@aj6283]

Thank you so much 👏🏻

[@hannihalabi4560]

Great video!

[@noovement1436]

Wonderful!

[@josephchong783]

GOOD JOB Thank you

[@mistriarup]

Excellent presentation. Could you please tell the book you followed to make this presentation ? It would be very very helpful for me.

[@maibarak1921]

You are the best

[@susanredna688]

great, thanks!

[@beautyblossoms1879]

Wowwww thanks!!!

[@jomanaazab3166]

This has been very helpful. Can u please share your reference? (P.S I wish I can cite your video but I need a book or a paper for an educational project). thank you

[@sophiewitherspoon4435]

thank you !!

[@lucasl.5479]

What about the pathway that activates protein phosphatase 1 tho? I was waiting for you to comment on this very enzyme : (.

[@BRUSHPK_]

Thank you

[@yogayantra]

thank you

[@Zetsuke4]

I SUBSCRIBED!

[@SunSunSunn]

prior to phosphorylation, don't they need to dimerize? I thought that was the conformational change that occurs as a result of insulin binding

[@hazemabdalhadi3061]

thank u

[@joeimama]

So understanding insulin resistance, I've been trying to find research on this, insulin is just don't trigger the cascade at the insulin receptor site? or it triggers but connects and doesn't trigger the AKT to inhibit the AS16 so GLUT 4 is unable to open the channel for glucose uptake. Is it autoimmune, is the body creating antibodies that latch onto the insulin to make is less effective?

[@ayso2127]

Thanks

[@linaap2465]

please continue with Claire de lune ♡♡ we miss youu

[@medicalscience1528]

Isn't the PI3K present inside IRS ? Plz clear it out.

[@emmynuel1773]

Wow. So molecular

[@GodfreyMann]

REQUEST: could you please continue this video with an explanation of how insulin resistance occurs. Thanks.

[@kmcveigh100]

Anthony Mak, I second this request. Specifically how Diacylglycerol could interrupt this signaling cascade?

[@carolinaguerra6726]

Please how is insulina resistan ocurrs

[@MafiaMendel]

Brilliant and very helpful. Could have been a bit more smooth but wonderful explanation nonetheless.

[@jelleleeuwis4353]

Exactly How does increased pip3 recruit and activate pdk1/AKT?

[@drmudfi]

What app do u use to make this video ?

[@vaniasq78]

Great Video! What program did you use to make this?

[@LikeTheVik]

probably powerpoint

[@gamingrex2930]

Most likely powerpoint, but any drawing software can do the same. Just create shapes and colour them. Then group them together and drag them around.

[@johnathanrendon4933]

mTOR tore my brain

[@ferdinandofrandina3432]

Sorry, could you explain me the pathway of PKB?

[@johnathansmith6093]

So AKT is activated and glycogen synthesis is allowed to take place because AKT is stopping GSK3 from blocking GS, correct? This happens during the translocation of GLUT4?

[@johnathansmith6093]

Also, where is insulin resistance found in this? Is it a lack of receptors, lack of PDK1, IRS1/2, etc?

[@fran16justo]

Anyone could explain me the IRS4 signaling cascade?

[@lloyd1386]

Please can you give me the source of this information ?

[@hraqhraq]

You should have mentioned that P110 is the catalytic part of PI3K while p85 is the regulatory one of it

[@jamesgordon8867]

So how is this affected by insulin resistance?

[@nordiniadriana7966]

during 7.25 hesaid that AKT is inhibiting the inhibitor means you activate the glycogen synthesis. so it means AKT has two roles which are inhibiting and phosphorylates the GSK3 ? is it???

[@samanthal9114]

No, AKT is inhibiting GSK3, which results in GS being turned on. AKT (serine/threonine-specific protein kinase) phosphorylates GSK3 at the inhibitory residue at serine-9 in GSK-3β & serine-21 in GSK-3α and thus makes it more difficult for GS3K to bind it's substrate and therefore reduces catalytic activity. So, AKT (Which is a serine phosphatase), phosphorylates these residues and decreases GSK3 activity. Glycogen Synthase (GS) is directly regulated by GSK3. GSK3 phosphorylates GS at inhibitory residues and therefore inactivate GS and turn off glycogen synthesis. Because GSK3 is inhibited, and not there to turn off GS, GS becomes activated as a result. I know it’s really easy to think about phosphorylation as only being “on” but a lot of inhibitory sites are also activated. The easiest way I remember it is ON-OFF-ON for AKT-GSK3-GS. Its an on sandwich.

[@nordiniadriana7966]

@@samanthal9114 wow, cool. Thankss !!

[@jhances]

@8:00 is he saying "REB" proteins?

[@2391jessie]

What happens when a lectin sticks to the insulin receptor?

[@sunmathyk2360]

Akt inactivate AS160???

[@fernsader9261]

Once IRS1/2 is activated, you better have your taxes ready.

[@hraqhraq]

despite all these molecules the whole picture still is unknown how Insulin affect other cellular structures and cells. More discoveries are needed to understand it

[@brandonpeel9793]

Your description of the islets is true for mice, but not for humans. Humans there is a more even distribution of alpha and beta cells throughout the islet

[@kevinaviles9668]

Hi JJ, do you have a mail adress?? Thanks

[@claudiacitera500]

wait a minute so the protein as160 actually anhibits the transportation og GLUT4? i dont get it? i thought it was the opposite. plz can someone esplain me?

[@AjlaKameric]

Great video. Just one thing, if you could please try to talk somewhat a tiny bit more clearly, it would make everything perfect. :)

[@btudrus]

Insulin is much more than just controlling glucose. This is just ridiculous. What about MAPK pathway? What about de novo lipogenesis and fat storage?

[@JacindaRivera]

0:25

[@JacindaRivera]

3:14

[@JacindaRivera]

3:45

[@JacindaRivera]

4:30

[@JacindaRivera]

7:42

[@azazkhan4204]

you did not mention the role of PKB.

[@CGStep]

AKT is PKB

[@brandongarrison1005]

PKB actually IS Akt. I found that out too from my own question.

[@thegahd]

way to badly planned, very hard to follow along when you jump back and forth