Centromeres | Centromeres and Kinetochores | Chromosomal organization

Centromeres | Centromeres and Kinetochores | Chromosomal organization | centromere function

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Күн бұрын

Пікірлер: 25

@studious_Ak 5 ай бұрын

I am grateful for this video, as it has helped me to understand some of the more difficult concepts of biology. I appreciate the lucid and succinct explanations of the concepts, which were easy to follow and understand. Thank you for your clear and concise explanations.

@animatedbiologywitharpan 5 ай бұрын

Please check out our molecular biology playlist. Believe me its better than any videos in KZbin. Please share with your friends

@ch.k4580 Жыл бұрын

Really nice done. I know how difficult it is to explain such topics, since I am actually doing my PhD in this field. Since you provide an overview it is well done. Just one thing: the point centromere is special to only S. cerevisiae and already at S. pombe we speak about a "simple" regional centromere. Moreover, other species such as D. melanogaster have a different centromere organization, which you did not mention. Moreover, CENP-A has different names in each organism (Cse4 in S. cerevisiae, CID in D. melanogaster and only called CENP-A in human). In addition, the centromere is defined by the (peri)centromeric heterochromatin structure which is unique to its self, since it contains histone marks (which you have shown) which can be found in Euchromatin or Heterochromatin. It is not as densly packed as seen in Heterochromatin, since it has been shown (and I am working on that too) that the centromeric chromatin has to be assessible for the kinetochore foundation proteins (CENP-B and CENP-C, CENP-N/L etc.) to build up the first layer and then the layers you have just mentioned. I am excited to see your video on Kinteochore. Maybe if you have time to mention it, you could show the current structure of the human Kinetochore bound to the alpha-satellite containing CENP-A Nucleosome (Yatskevich et.al 2022, Science). All the best and keep up this great work!

@animatedbiologywitharpan Жыл бұрын

Thanks a lot for the elaborate feedback, may be i will make a detailed video and incorporate your feedbacks. What is your opinion about it?

@ch.k4580 Жыл бұрын

@@animatedbiologywitharpan sounds great, but just keep in mind it might be to specialized if you do so. I hope your audience might like it more detailed. Your channel covers many great topics and I am really amazed by your dedication with all the nice figures you are making. If you need some advice regarding chromatin or centromere, please feel free to contact me. I am happy to help. Other then that, keep going, you are doing a fantastic job!

@gunterkandler5560 6 ай бұрын

Thank you so much. We can see you put a lot of effort into your videos and I can't be more grateful. I hope God blesses you in return with much more. Thank you

@animatedbiologywitharpan 6 ай бұрын

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@abeer8733 5 ай бұрын

Such a high quality and detailed video, amazing work!

@animatedbiologywitharpan 5 ай бұрын

refer to the molbio playlist kzbin.info/aero/PLKtiwIJ8Q7rppT2_xeMbIbrfTvAttgVcP&si=qPKV7Z7pt7mjC9LQ

@animatedbiologywitharpan 5 ай бұрын

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@abeer8733 5 ай бұрын

@@animatedbiologywitharpan Sure, will do so. But also give yourself some credit, you're doing really well with 251K subscribers!

@dilipsam4271 Жыл бұрын

Very nice explanation.

@animatedbiologywitharpan Жыл бұрын

Please share my channel link with your friends and help me to reach big audiance

@ShahadShahad-f9b 11 ай бұрын

Very good and nice explanation

@animatedbiologywitharpan 11 ай бұрын

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.