Answering Your Questions on Longevity | 37 - Ask Matt Anything #2

[@jdogi1]

I was shocked that you're only at 5k. Keep grinding it out. You do a great show.

[@optispan]

Thank you so much for your support @jdogi1. - Tara

[@jerrywest7068]

I've noticed good websites go up very slowly at first then seem to increase almost logarithmically before leveling off.

[@kaceeboxers3580]

Around minute 41, discussion on how to approach primary care doctor about possible use of rapamycin. Generally, my visits consist of bloodwork results so there is time to discuss other topics. I have asked my doctor about rapamycin and even metformin and he ordered an insulin resistance panel. The rapamycin discussion occurred twice and I will bring it up again in a week. I also purchased a book for him and am sure he is researching the current data on rapamycin. I will not let up and thankfully he is open to these discussions. I am almost 70, female, probably do not have insulin resistance, carry an A1C that makes my doctor uncomfortable (I only have this one doctor), have controlled Hashimotos, but - I can see and feel the aging process occurring and want to see if rapamycin could halt or slow these processes. No doubt having diabetes is a huge factor even though it is well controlled. I don’t do well with Berberine for some reason. I also wrote down several podcasters for my doctor to listen to. Optispan was at the top of the list. He does listen to Peter Attia, so know he will enjoy Matt’s shows. Thanks for sharing your common sense thoughts and knowledge.

[@optispan]

That's great that you've found a primary care doc who is so open to these discussions. And thanks for recommending us! - Tara

[@SilverFan21k]

Congrats on 5k subs

[@espinosalexis]

Make a video about TRIIM! Interview Dr. Fahy! The recovery of thymus function indeed seems to be a great target for anti-aging! Right? I mean, I heard you saying that "aging is an autoimmune disease".

[@andreasrydstrom9112]

My take on energy restriction benefits is that we all have a range of intake that will lead to stable weight, normally a range of like 400kcal per day. You can be in the higher end of the range without gaining weight and you can be in the lower range without losing weight. And I interpret the research as being in favor of staying in the lower range for example to reduce chronic inflammation. That's not hypocaloric, but a energy restriction without weight loss.

[@rogehnimunoz4327]

You deserve more than 5k!!! More to come!

[@espinosalexis]

ITP project is flawed. It's a shame! Just as your comment for the short-lived controls, here the controls are being metabolically-sickened by the ad-libitum feeding (too much food) and the chow (processed food diet). So, at the end, ITP is just finding medicine to fight against these two insults, rather than broad spectrum anti-aging molecules. ITP project should use all 1-year money to address these issues and produce a decent whole food omnivore diet with a decent amount. Then measure extent in health- and life-spans with respect to decent controls and not with respect to on-purpose-sickened controls.

[@kamanashisroy]

also they should test drugs in different time of day. probably some intervention is good in the fasted state others are fed state.

[@espinosalexis]

I heard you saying on Inka Land podcast that you think that "aging is indeed an autoimmune disease". Can you make a video expanding this concept?

[@ZeitgeistHomer]

Thank you for answering my question! Appreciate it very much!

[@optispan]

Feel free to ask more, we'll do more of these! -Tara

[@jakubchrobry3701]

37:48 I don't understand how the idea that _"people who adopt a low-protein diet look sickly and frail"_ makes a high protein diet optimal for longevity. I define a low-protein diet as less than 1.0 g/kg (Longo, Greger) and a high protein diet as at least greater than 1.6 g/kg, but more "optimally" around 2.2 g/kg as Peter Attia and others recommend. You don't need 2.2 g/kg of protein to build muscle, even in old age. You need weight training. Shouldn't exercise always be part of a longevity protocol? I'm not sure that too many older adults (>50) are wanting to maximize muscle ASAP to compete in bodybuilding. So preventing sarcopenia is not a reason to eat 2.2 g/kg. What other health benefits are there for this amount of protein? Satiety? There are none that I have found. Until more research comes out, 1.2 to 1.6 g/kg seems to be a "natural" amount for people who exercise one hour per day. By "natural" I mean people eating a balanced diet (not extreme like keto or 80-10-10). Choose closer 1.2 g/kg if you want to maintain muscle (most typical) and closer 1.6 g/kg if you're trying to add muscle (e.g. after an illness, less typical). Even eating only plants, I find it difficult to get out of this range. I eat 3,000 calories per day of only plants and I'm around 1.5 g/kg of protein. If I opted for more lower protein foods, the volume of food would be too much and I would begin having issues with bloating and acid reflux. This actually makes Michael Greger's Daily Dozen impossible to eat to meet his protein target of 0.8 g/kg. If I lowered my protein down to 0.8 g/kg, protein would be less than 9% of my calories. You have to eat a lot of fruit to get your protein this low, not the the Daily Dozen (for example beans are nearly 25% of calories from protein). Of course, this requires exercise, which is part of the Greger's Daily Dozen. I could become sedentary and lower my calorie requirements, but I don't think anyone is recommending that.

[@hristosstrihas4010]

Thanks for the amazing video! The question/answer idea is great! I personally think that improving germinal niches is probably a great intervention for longevity. So I wonder if senolytics drugs can rejuvenate aged stem cells niches. If this is indeed the case how long does the effect last, i.e. could this mean reversal of aging or just improved health?

[@60-Is-The-New-30]

Hi Nick! I would love for Mr. Kaeberlein to do a video on the loss of motor units in healthy aging and if it is an unknown hallmark of aging. Loss of motor units is irreversible. Once people lose them there is no getting them back. This is what initiates the loss of fast twitch fibers, dynapenia and sarcopenia, and indirectly affects every organ in the body.

[@Krunch2020]

What’s a motor unit?

[@nicholasarapis]

Hey! Great suggestion, we will cover it soon. Hope you're well,

[@nicholasarapis]

@@Krunch2020 A motor unit is the basic functional unit of skeletal muscle, made up of a motor neuron and all of the muscle fibers it innervates. When a motor unit is activated, all of its fibers contract to produce force.

[@60-Is-The-New-30]

@@nicholasarapis hi Nick. Thank you for your response. I am making a video on this very shortly, but I really would love to hear what Mr. Kaeberlein can share about it. I'll be waiting. Thank you and have a great day

[@kaceeboxers3580]

I do believe metabolism and genetics are a factor in whether caffeine affects a person negatively, IE, poor sleep, anxiousness. My liquid diet consists of water, coffee and some coconut milk. I have a fast metabolism and can literally fall asleep with a cup of coffee in my hand, at 10 in the evening. My husband can only drink coffee in the morning or it will affect his sleep pattern.

[@mitchellgould2053]

Ryan Smith of Trudiagnostics has mentioned epitalon a few times. IIRC he did not see any evidence of telomere lengthening but did mention there were some organ specific benefits. He also did some biological click testing for the clinical trial on neutral plasma exchange that Dobri Kiperov ran in conjunction with the Conboy lab. I’d love to see a conversation between him and Matt both on biological clocks and peptides/HRT on them.

[@SilverFan21k]

Dr. Kaeberlein: do you feel like exponential growth is possible in the entire worldwide longevity field? Aka at a compound rate upwards. Or.... Is the future so so unpredictable and many possibilities

[@ats89117]

The Journal of Irreproducible Results is one of my favorites...

[@briann8911]

Great video. Rapam has helped me to some degree with Crohn's. It's most obvious when I take rapa-vacation.

[@Samanthael1234]

Hello! New subscriber. I have celiac, food allergies that come and go, cold urticaria, endometriosis, heat allergies etc etc. Possible histamine and/or oxalate problem. Mold or pesticides maybe. My doctor doesnt know, so I dont know. What is the best diet for autoimmune when you react to everything? Carnivore surprisingly worked. I do not think it is a long term solution and I have gone back to eating regularly. Are there supplements you recommend supported by the data. How about Rhodiola and L-theonine for stress? Difference between magnesium glycinate and magnesium threonate. Can you take both at the same time.

[@hongwinglee3073]

Thank you, great podcast. I have a small question regarding caloric restriction. Dr Kaeberlein quotes 40% extension of mice lifespan as the gold standard interventions should be measured against. Should Dr Kaeberlein be more skeptical of that 40% figure? If ITP were to repeat caloric restriction experiments, would they be able to reproduce 40% lifespan extension?

[@RobertNaik]

Well done!

[@user-lv4ni2fp3i]

I would like to ask a question about protein. Which is more important when you get older, frailty vs increasing mTor.

[@saliksayyar9793]

The human equivalent dose for taurine is very large. You have not read the paper . Cats cannot make taurine, so dietary deficiency in kitten results in blindness

[@susymay7831]

Cafine from say green tea is usually good in the morning and bad late in the day because of possible sleep problems! ❤

[@orion9k]

Green tea makes me sleep better.

[@saliksayyar9793]

‘ Don’t fully understand the mechanism of metformin’. Is the mechanism fully understood of any drug or nutraceutical?

[@Roberto-cg2gr]

Any research on GKI that will improve longevity?

[@MichaelMerritt]

There's a fun reddit post by user telomerotica in the peptides subreddit who as a 49yo male through the use of 500mg worth of Epitalon over 12 weeks took his 55 year old telomeres to that of a 10 year old boy! So there seems to be some effect there, not sure how safe any of it, esp with crazy high dosages like that.

[@TheBroSplit]

Nice, let's call it drip lol

[@Roberto-cg2gr]

Which is better Metformin or Fasting on AMPK?

[@anirecapped.]

Can't you guys test out this Epitalon and methylene blue??

[@bigbear7567]

I was taking between 5 and 6 grams of taurine and every day and noticed that when I didn't take it I would have withdrawal symptoms in the form of not being able to sleep for an entire night so I reduced it to 6 then 5 days a week and I would still have those withdrawals and so I stopped taking taurine and when I did I noticed my very recently diagnosed lower back arthritis started rapidly and significantly disappearing and I'm hoping it will completely disappear. People should be very careful about taking taurine.

[@bigbear7567]

When I stop multiple times and the same thing happens only a fool wouldn't notice the connection.

[@gridwanderer]

​@@bigbear7567 Have been taking 5g taurine daily for the last year and have noticed lower back weakness in the morning lately - have you looked further since then to see if there was a scientific explanation?

[@peterezzell3865]

On Diet: suggest work of long term (decades) diet researchers Gary Fraser and Walter Willet PhDs. Both have presentations and interviews available on KZbin, and studies in PubMed.

[@dharma__3]

Had to stop mine. Took 6mg every 10 days but felt too fatigued to exercise for at least 3 of them.

[@Thenachobear101]

What do you think about starting rapamycin early? Is there any study on rapa’s effect on a specimen post early post sexual maturity across a lifetime?

[@rm6857]

For longevity best to eat is not to eat :)

[@balanv7327]

1. I am 65 year old male, 65Kg.weight, 40 minutes weight exercises, 40 minutes

[@balanv7327]

Jogging I do ... diet maximum calorie should I take? All vitamin included mea

[@balanv7327]

Meal a day? What are they?

[@lucycooper55]

Does serrapeptase actually work? Any usefulness for longevity?

[@Krunch2020]

Are most Americans deficient in iodine and is the optimal intake many times higher than the RDA?

[@aky2k10]

Is improving health is NOT improving biological aging...then what else is,!!?

[@adcaptandumvulgus4252]

You should look at that guy who injects small doses of many different snake venom he seems to be super young even though he's old, so what about that?

[@MichaelEdwardWright1]

“Quality diet”… “lots of vegetables.” What is your scientific basis for this of your statements? I have deleted all vegetables and all carbs after over 1000 hours of study of nutrition.

[@rusne167]

Hi there! I wanted to contact you through your email address regarding some business offer... It seems like there is no email address associated with your account - I would appreciate it if you could share the correct email address with me. Your videos are just great! 🤩