Cyclooxygenase-1 & Cyclooxygenase-2 (COX 1, COX 2) - All You Need To Know - Pharmacology

[@MedicosisPerfectionalis]

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where is microbiology.cardio-diseases,respiratory disease

[@MedicosisPerfectionalis]

On their way

[@gratitude5740]

Medicosis Perfectionalis Where can I get COX2? I’m going to have a surgery in October. Don’t want to take NSAIDS . Thank you you !

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@Alexis Ernesto Lately I have been using FlixZone. Just google for it =)

[@ronakroshan7878]

An absolute boon to us med students. My professor taught this once and took an hour for this. I can revise the same pathway in less than 15 mins, with diagrams, mnemonics, concepts and clinical correlations as well. Thank you, good sir!!!

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Time will come when education will b like this....its actually interesting, its simple, very logical, fun to watch, keeps attention and without noticing u just learned everything till the ending of the video!! Great stuff, Thanks man, You are really awesome!!.... hitting something that 99,9% of the professors r unable to do....

[@MedicosisPerfectionalis]

Thank you ☺️

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i didn't know that i can laugh so hard watching a pharmacology video....

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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You made pharmacology fun to me !! Thanks

[@MedicosisPerfectionalis]

I'm so glad!

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

Thank you so much 😊

[@humairaakter739]

I'll never understand how you can teach complex things, that even professors find difficult, so easily. Thank you so much sirrr❤

[@islamsaleh4697]

After 2 days of digging in the COX mode of action, none of the article was easy to read....found this video that made my life easy...Amazing job done boy

[@MedicosisPerfectionalis]

Thank you so much 😊

[@islamsaleh4697]

@@MedicosisPerfectionalis I have only one question if you please. In 5:39 you said, now you know why inhaled steroids are used to treat asthmatics. This is because they block the pathway leading to production of Thromboxane A2 and so no vasoconstriction?

[@MedicosisPerfectionalis]

No, it’s because inhaled steroids block the PLA2 and therefore decrease the level of arachidonic acid. This will, subsequently, decrease the level of leukotriens which make the life of an asthma patient hell!

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[@MedicosisPerfectionalis]

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These are the best videos! Man, I am just a regular person with no medical education just an interest. You make it understandable and entertaining.

[@MedicosisPerfectionalis]

Thank you 😊

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Thank u for saving those of us struggling in biochem

[@MedicosisPerfectionalis]

My pleasure!

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Bro love the video, the sarcasm is great. It's funny, the way you talk is the same way I talk to myself when I'm studying. Thanks for making this!

[@MedicosisPerfectionalis]

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This video is pure gold. Funny and informative!! Concepts well explained

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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Sir u have great sense of humor

[@MedicosisPerfectionalis]

Thank you ☺️

[@emilyf6325]

When you linked it to real clinical scenarios, it felt like it clicked! Thank you! Also, I am from Australia and I am worried there are differences in the naming of certain things. Should I be worried about any differences that you know of?

[@MedicosisPerfectionalis]

Hey 👋 Emily...Thank you so much for your kind words...Brand names differ between countries, but what really helps is knowing the generic name by heart.

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I never comment on KZbin videos, but your channel is one of the best things I've ever found on the Internet. Everything is so well explained and you're so damn funny. A huuuge thank you ❤️

[@MedicosisPerfectionalis]

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great presentation thank you from a non academic studying herbs!

[@MedicosisPerfectionalis]

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Informative and humorous.... as always... a winning combo.

[@MedicosisPerfectionalis]

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I'm subscribing purely for your laugh. The personality in this video makes me actually enjoy pharmacology

[@MedicosisPerfectionalis]

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I didn't know when clicking on this video I'd laugh, let alone how much I did. Amazing work ahahhaa

[@MedicosisPerfectionalis]

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This video is great! Thank you! I understood everything! 🎉

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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U got a nice way of teaching...keep it up...good job man...i like ur style

[@MedicosisPerfectionalis]

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oh how I wish you were my pharmacology professor. This makes so much more sense now!

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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Awesome video. I am currently writing an article about this subject, and it was really informative and entertaining. Keep it up.

[@MedicosisPerfectionalis]

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[@bismarck5503]

thank you u got a new follower , im pharmacy student and this is way better thanhow my professor explain

[@MedicosisPerfectionalis]

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You are absolutely the best at explaining things in a way I understand! And you're so funny, my 14 year old watches you with me just to hear you're jokes

[@musicbeachdance]

I love the prostacyclins keep the blood "cyclin" that helps me actually recall PGI2 function!

[@MedicosisPerfectionalis]

Thank you 😊

[@bruryrosally]

2:31 in the name of God The most merciful بسم الله الرحمن الرحيم

[@pharmacist2125]

💜

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I found you just before our exam! I feel so lucky. Sending love! Thank you for the fun-niest learning💚

[@MedicosisPerfectionalis]

Thanks a million, dear :) I truly appreciate it. If you have time, can you please help me by sharing?

[@hamnaiqbal230]

what an explanation man😍😍😍.....thank you for making it easier and funny👍🏻👍🏻

[@MedicosisPerfectionalis]

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I was not bored for a single miN lol thanku! really helpful

[@MedicosisPerfectionalis]

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you are better than my uni teacher

[@MedicosisPerfectionalis]

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YOU ARE FREAKIN FUNNY. I love it. Learned so much.

[@MedicosisPerfectionalis]

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Thank you very much I always love watching your video Your video help me alot ❤

[@MedicosisPerfectionalis]

I am honored, Mary!

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thank you! you just saved my LIFE

[@MedicosisPerfectionalis]

My pleasure 😇

[@accountnew6474]

Why was only Rofecoxib removed and not other COX 2 selective NSAIDs? Don't they all increase the risk of blood clotting because like you said at 9:44?

[@MedicosisPerfectionalis]

Theoretically you are correct, but in the real world, there seem to be a difference.

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[@MedicosisPerfectionalis]

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I like the "just kidding" at the end, implying that there's so much spite he wouldn't tell Merck & Co. about the biopathway even for a billion dollars. That's the kind of top-tier spite I can get behind.

[@qixiantang1311]

great video...just curious about how does the NSAID drug inhibits the cyclocygenase? like the functional groups present within the binding site etc....

[@563051]

It was great. So simple and easy to remember way of teaching

[@MedicosisPerfectionalis]

Thank you so much 😊

[@563051]

@@MedicosisPerfectionalis may you make a lecture about antipsychotics?

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

Thank you 😊

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The best lectures!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@EylulTurksever]

One might have tought: maybe if you inhibit COX1, since COX2 still works and can't make TXA2, it can make more PGI2 when not racing against COX1 for PGH2 thus decreasing the risk of clotting more than non-selective COX inhibitors?

[@kandy7803]

Cyclooxygenase 1 and 2 begins at 6:15 for those that only need that information.

[@KeaJei]

Got curious about cox 1 and cox 2 because celebrex only inhibits the latter and I'm wondering why I'm still in pain compared from when I took ibuprofen before getting prescribed celebrex. I have otitis externa. From what I understood, I shouldn't be in pain. This is coming from a non-pharmacy student. Thank you very much by the way for having this lecture free for everyone to learn. :)

[@MedicosisPerfectionalis]

My pleasure 😇 I am sorry for your pain, but I really don’t know...Please talk to your doctor.

[@ricardobaroni1714]

Everithing looks clear now! Awesome vid, thanks...

[@MedicosisPerfectionalis]

You’re very welcome, bro!

[@Teezar22]

Can't thank you enough for this content.

[@MedicosisPerfectionalis]

My pleasure 😇

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Amazing Video, Thank You for sharing your Knowledge with us.

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[@MedicosisPerfectionalis]

Thanks a million 😎

[@nishchit9035]

how is PGI2 decreasing in COX 2 inhibition? It should be promoted with TXA2 right? and there can be balance. Isnt PGI2 coming under COX1 control? please help thanks :)))

[@MedicosisPerfectionalis]

PGI2 is via COX-2

[@oshalab1816]

I assumed PGI2 comes under COX 1 coz COX2 selective inhibition allows COX1 function to occur unopposed..

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You are amazing. Thank you for your videos♡♡♡

[@MedicosisPerfectionalis]

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Brilliant video!!

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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Great teaching..... Bless up

[@MedicosisPerfectionalis]

Thanks 🙏 Can you please help me by sharing?

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Thankyou so much🙌

[@MedicosisPerfectionalis]

My pleasure!

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Ahahha never enjoyed studying before thank you

[@MedicosisPerfectionalis]

My pleasure 😇

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Thanks for the video. I love it. 🙆🏻‍♀️❤️

[@MedicosisPerfectionalis]

My pleasure 😇

[@m.m.m.c.a.k.e]

You are great! I am beside myself angry with uneducated nurses shaming me for managing pain after a surgery without NSAID’s (asthmatic). I don’t know why in the hell I have to do all of this research myself as a patient. I have learned a lot but this is aggravating. Anesthesiologist understands it. What do I tell these people? Please help

[@MedicosisPerfectionalis]

Thank you 🙏 I appreciate your comment! I really admire your perseverance and the fact that you are doing all of this research even though you’re not a doctor! Hats off to you!

[@m.m.m.c.a.k.e]

@@MedicosisPerfectionalis well my friend, I’ve always had interest in the medical field…. being a seasoned IT veteran, many of those whom which I’ve helped have called me a doctor anyway, lol. Being an analytical thinker to begin with, they have some alignment. Anyway if anybody would be kind enough to provide their two cents I would love to hear it. Obviously it’s not going to be taken as any sort of medical advice I promise! More or less,, direction,, would be nice or references to material that I can study. Just trying to feel better as all. And I’m in such a small group of people apparently. Asthma exacerbation caused by classical NSAID’s with persistent nasal polyps and contact dermatologist. I’ve been called lucky in the past by several people. Evidently as my life continues I realize I am always gaining on that forefront LOL…

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Thank you soo much sir ❤

[@MedicosisPerfectionalis]

Most welcome!

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Thank you ❤😘

[@MedicosisPerfectionalis]

My pleasure 😇

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My GOAT🐐

[@MedicosisPerfectionalis]

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awesome video .got solid concepts!

[@MedicosisPerfectionalis]

Great 👍

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YOU ARE AMAAAAAAAAAZING...THANK YOOOOOU

[@MedicosisPerfectionalis]

My pleasure 😇

[@anikhalder187]

Very helpful and fun in learning.

[@MedicosisPerfectionalis]

Thanks a ton!

[@hungryasian9883]

hello, have an pharmacology text book "pharmacology for health professionals 5th ed, by B, Byrant & K, Knights, and it says that it is PGI2 with COX1 inhibition that causes gastric ulcers, not Thromboxane A2 and now im confused to know which is right. Could you please be able to explain why the text book may be saying this and why you have said otherwise? Thank you :)

[@MedicosisPerfectionalis]

I never said that inhibition of thromboxane A2 causes gastric ulcers.

[@hungryasian9883]

@@MedicosisPerfectionalisoops my bad, then what causes gastric ulcers more specifically other than just saying COX 1? I just want to learn thank you :)

[@MedicosisPerfectionalis]

There are some prostaglandins that protect the stomach...These prostaglandins are produced thanks to COX-1...When a drug inhibits COX-1 and COX-2, the protective mechanism is destroyed. However, when a drug selectively inhibits COX-2 only, the stomach is in good shape because COX-1 is uninhibited...Hope it helps!

[@hungryasian9883]

@@MedicosisPerfectionalis thank you very much :)

[@MedicosisPerfectionalis]

My pleasure 😇

[@shadawnhenderson9186]

Probably the funniest video I have ever seen.... lol

[@MedicosisPerfectionalis]

Thank you 🙏

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Stupid stuff you learnt in physiology 😂 you made my day , i enjoyed this lesson , thank you

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Soo professional 👌😎

[@MedicosisPerfectionalis]

Thanks, dear :) Please share my videos with others...It really helps!

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@@MedicosisPerfectionalis already did👍

[@MedicosisPerfectionalis]

Thanks a ton!

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You’re the BEST

[@MedicosisPerfectionalis]

Thank you 🙏

[@lilianaproenca6064]

Hello! I love this video, thank you! I would like to ask about the PGI2 - prostacyclin, its COX-1 and COX-2? At your "game" COX 2 OR COX 1 you left PGI2 out :)

[@vipereshon7041]

That was really gud , thank you

[@MedicosisPerfectionalis]

My pleasure 😇

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WOW... Just WOW :)

[@MedicosisPerfectionalis]

Thank you so much 😊

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You are very much inspiring.i want to be cool like u

[@MedicosisPerfectionalis]

I am humbled ☺️

[@raspberry765]

Thank you for the video! Which one makes PGI - COX1 or COX2?

[@MedicosisPerfectionalis]

PGI2 is by COX-2...Mnemonic: 2 by 2

[@lakshmij2989]

Hello sir, can you please do a general pharmacology videos

[@MedicosisPerfectionalis]

I have an entire series of videos (course) about general pharmacology here: www.medicosisperfectionalis.com/products/p/general-pharmacology-course/

[@mennaashraf4410]

Amazing but i have one question so cox-1 is responsible for stomach protection by which prostaglandins is it PGE2 but its also responsible for pain

[@TheRealMorgs41]

So does this pathway, work differently in different cells. So the membrane phospholipids of platelets dont produce leukotrines do they. So its not really at multiple choice pathway but a single choice depending on what cell you are?

[@jamiek6471]

precious explanation1

[@MedicosisPerfectionalis]

Thanks 🙏

[@GurvinderSingh-vg1pq]

Hi, very informative video thanks for it. I have a question for you, my diet was high ( now realized) in Salicylates & histamine for few months. After all I am now suffering from Chronic Sinusitis & hypersensitivity to salicylates in food. As COX is blocked. My question is how you unblock COX. Even a tiny amount in food gives me bloating. Can salicylates free diet for long term will help? Or reducing omega 6 & boosting? omega 3 will help. Thanks