Are NAD Supplements (NMN) Causing Kidney Damage?

[@jackkrauser1763]

Thank you! Keep those short videos coming.

[@workingTchr]

The study behind this I believe is, "Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation". A very interesting point of this study is that they were not out to show NMN harmed the kidneys. Their discovery that it seemed to harm elderly mice ONLY came as a surprise to them. That kind of surprise occurs in the best science and, to me, makes it more newsworthy.

[@gregsLyrics]

Matt presents science data - period. He is amazing and saving the health of all those who will listen. Ignoring science is NOT an effective health strategy. Bravo, Matt!

[@atHastin]

Basically, the research is not conclusive as far as I watched this clip. In my opinion, Matt should not even talk about it when it is not conclusive. There are probably million of people talking NMN or NR for the past several years until today. There should be at least a first smoke of data to show if there are people having kidney problem after taking NMN or NR. My guess is Matt cannot explain that phenomena.

[@workingTchr]

I would also want to know, is the damage likely to be reversible upon cessation of NMN supplementation.

[@theancientsancients1769]

I had renal angiomylimpoma benign tumour on my kidney after NAD booster one month NMN and over few months gap NR . No i avoid them .

[@theancientsancients1769]

My previous scan just a year before had none of that on my scan

[@fishnski9211]

I have one too...maybe 3 years now since they found it and I get scanned twice a year to make sure it hasn't grown...it hasn't so far and I've been on NMN for about a year...no correlation...

[@theancientsancients1769]

@@fishnski9211 So NMN hasn't grown yours I guess? I stopped NMN despite it helping with long COVID symptoms ( fatigue muscle aches etc) . What type of scan do you get annually twice if I may ask ? Ultrasound? Thanks

[@workingTchr]

Sinclair said he takes TMG because nicotinamide levels increase in response to NMN supplementation. His aim (as I understand) is not to reduce nicotinaminde levels but to restore methyl groups that nicotinamide commandeers from. Still, I'm wondering if supplementation with TMG would offset the harm caused to the kidneys of elderly mice.

[@danieltait8564]

I’ve been taking 300 mg of nicotinamide riboside for the past four or five years and I have no change in kidney function.

[@theancientsancients1769]

I had kidney angiomylimpoma benign tumour on my kidney after NAD booster one month NMN and over few months gap NR . No i avoid them . My blood work looks good for kidneys but the ultrasound scan picked this up.

[@workingTchr]

The key question is your age. The negative effect on kidney function seems to only effect elderly individuals.

[@theancientsancients1769]

@@workingTchr I'm not 40 even. Sinclair warned about NAD boosters and tumours and said avoid it if risks exist

[@workingTchr]

@@theancientsancients1769 What were the existing risks? Generally he's such a proponent of NMN.

[@theancientsancients1769]

@@workingTchr No risk kidney function are fine . Scans done before just under a year were normal . After NMN NR usage things got picked up. Sinclair many times talked about risks of NMN in interviews. This is a new molecule and people screaming through the roof for it are Only Americans who listen to social media doctors . In Germany it's not even recognised as a food supplement. It reminds me of the hype Resveratrol again it was Americans doing the hype and the British pharmaceuticals that put it to the test after purchasing it from Sinclair scrapped it after it failed in research.

[@Leto2ndAtreides]

We need better tools for continuously monitoring the body, and using interventions in a more adaptive manner... Which likely needs more data and AI to help manage things.

[@invertage]

The natural way to boost NAD is with fasting autophagy. I used to take NMN but I stopped when they pulled it from the US market. I do a good amount of fasting, so I dont think its beneficial for me.

[@jerrywest7068]

To br fair even many common foods and drinks a are to be avoided by Stage 4 and even in Stage 3B kidney function

[@SilverFan21k]

I think you gotta have on more and more prominent guests, to hit that 10k

[@diamond_s]

unpublished research indicates life extension and healthspan extension on rodents. So even if this is the case it seems benefits will likely outweigh downsides.

[@jamesmcintyre3456]

Unpublished information? From where, Yahoo answers?

[@diamond_s]

@@jamesmcintyre3456 iirc Sinclair mentioned it in one of his interviews, that some yet to be published experiments yielded life extension

[@theancientsancients1769]

​@@jamesmcintyre3456I had renal angiomylimpoma benign tumour on my kidney after NAD booster one month NMN and over few months gap NR . No i avoid them .

[@jds02153]

👍👍

[@newyorkskier]

Matt is on a crusade to discredit NAD boosting at any cost. He could become another Brenner

[@jds02153]

You do realize Brenner sells NR which is an NAD booster? You need to become better informed.

[@newyorkskier]

@@jds02153 Everybody knows that. That does not mean that boosting NAD has no benefits. There are no obvious longevity benefits (except in certain disease conditions or background) but several animal studies and clinical studies have shown one benefit or another by taking NAD supplements like NR, NMN or NA or even NAM (especially for skin). So that that Brenner sells NR does not make the facts go away.

[@itsnotu-its-me]

So... No evidence just guessing.