Parkinson's Disease (Shaking Palsy) - Clinical Presentation and Pathophysiology

[@armandohasudungan]

🧠 TEST YOUR KNOWLEDGE FROM THIS LECTURE! ✅ youmakr.ai/test-playground/questionnaire/673d42de859b9c170836eeac

[@prem5864]

I am a doctor and I can say , this is by far the best pathophysiology explaination I have heard .

[@sonavarghese7146]

Are u sure this is all correct?

[@lapharmacie98]

I can’t believe it, every single topic in physiology and patho I’ve ever needed some help with Armando has a video on it. What a legend

[@lightblue3747]

Yeah!! He has been helping me throughout my med school! 🥰🥰❤️❤️

[@aribabatony4035]

Thanks you DR Rorpopor Herbal on KZbin for curing my herpes totally God bless you DR Rorpopor Herbal on KZbin contact for any candy of sickness.....💯

[@adrenaline9182]

You can help me out? Though

[@aribabatony4035]

@@adrenaline9182 kzbin.info/door/kZwKW6qES4dXDWzb0YQErA

[@Mosinee565]

👏👏

[@barbarabrennand7016]

I studied neuropsychology in my work with learning disabilities. This is the best information I have seen to explain Parkinson's on a neural level. thank you so much for this info.

[@iqraahmad2451]

I can't believe you have explained it so well. I have been dwelling on research papers for so long to connect these points.

[@MaitsaaRihhadatul]

The most clear explanation of Parkinson disease pathophysiology in whole KZbin ❤️

[@MaitsaaRihhadatul]

6:20

[@MaitsaaRihhadatul]

8:20

[@mokhles703]

This only explains the akinesia/bradykinesia, what about the tremors and the hypertonia?

[@drtanveerahmed3373]

This guy deserves a Nobel.

[@andresbadilla3220]

You did this 6 years ago, and here I am, getting it clear. You are a blessing.

[@anushakarukola]

I never thought it could be easy to understand such tough topics in a simple manner with less efforts ❤️❤️

[@dr.s.choudhury8089]

Not all heroes wear capes. Some make amazing video lectures for med students on youtube. Armando: The true legend! 🥰

[@Enceladus007]

Have to play this again.

[@ju_7114]

Thanks you! You’ve taught me Parkinson’s in 14 minutes when my professors couldn’t teach it in a 2 hour lecture

[@aleksandrassaraskinas713]

Thank you mister for making easy to study neurological diseases. It really helps me to prepare for exam!

[@doc.jayantsingh9236]

wow really helpfull in understanding the complex biochemical interaction at tissue and cellular level . thanx

[@travisgrenke]

fantastic video. my roommate has parkinson disease. thanks for posting

[@c.b.2]

This was absolutely brilliantly explained! Thank you so much! I'll be sure to send all my med school classmates here!

[@robertofernandez7195]

Nice. It is nice to mention that the Striatum naturally produces Acetylcholine, which also over induces the inhibitory pathway contributing to that Bradykinesia seen in Parkinson's. Great job!

[@robertofernandez7195]

Since ACh is a pharmacologic target in Tx Parkinson

[@laurenjohnstone9765]

You are magic.You make complex concepts seem so simple

[@Scrubsandscreens]

This is the best I am not kidding . I am shocked how beautifully someone can explain such a complicated topic

[@gloriaakinyode3279]

VERY NICE VIDEO OF Parkinson dz. Never heard anything so CLEAR and detailed of Parkinson

[@cesarmichaelalvaradoibarra4215]

Amazing explanation, neurology it's one of the most complicatedsubjects in medicine and you make it look so simple. Keep on the good work! (y)

[@Dayv7]

Brilliant as ever! Thought it was going to be a nightmare to remember the dysfunctional pathways involved but this makes it a cinch.

[@MaekaElaKimDimayuga-qx9rp]

I subscribed because the information is very detailed. And for a nursing student like me, it helps very much. I will recommend your channel to my classmates...

[@symbyxbiome]

Beautiful illustrations - a great way to teach. Thank-you. Would be good to better understand or explain some of the changes found in the gut microbiome of people living with Parkinson's, not just the brain.

[@christinevakas92]

Wow, I really like in particular how to summarise the whole picture, how you show us the whole picture at the end, so helpful. When I see your video in our class readings, I know I am going to get great grades. Thank you for sharing your knowledge and talent.

[@Greanestbean]

Great video, I only wish it also included treatment

[@Self-actualizer]

Thank you so much for all the efforts for making the concept sooo easy❤❤

[@alexisdaniel3313]

Could you explain why there is no tremors during sleeping? Why tremors start a couple of minutes after awakening ?

[@oliversykez7292]

Thanks for this in a nutshell explanation! Very helpful in the end stages of studying for USMLE!!

[@sdazxcf]

u r amazing to draw such complicated neuroanatomy into clear figures! salute to u

[@keruanmendonca6220]

Very good explanation

[@bintenur6684]

Very nice and easier presentation. Thanks

[@MPPSVennached-zd7yg]

Nice explanation sir

[@croock3]

This a great video, fantastic for all levels of understanding and with amazing drawings. Really helpful, thanks!

[@mercyngeru3924]

This was very helpful. Thank you so much

[@ЈованаКијановић]

wow thank you this saved my life literally

[@ummejoynabhabiba9484]

Thanks for your amazing videos! Love from Bangladesh 🇧🇩

[@abhisheksinha4605]

very concise n informative,thnx for video

[@pharmacistkhan5969]

Plz through that yellow marker... good lecture

[@danjbundrick]

Fantastic lecture. I learned a lot. One request: please throw that yellow marker away.

[@XxwoodyleexX]

+Daniel Bundrick agree.. it's too pale..

[@danjbundrick]

Indeed.

[@danielbedford6539]

are you Yellow?

[@AsgarAli-wh9vl]

Danimal Bunjee hi danimal i have a problem

[@nectarandice]

Another request: please throw the yellow marker at Daniel Bundrick.

[@mariacabreragonzalez2]

I really like to watch these videos for some context before I study my teachers slides, this was great. Thank you!

[@IR240474]

Thank you for this, great instructions and I love the pictures, I make mind maps but I will add this to them today for my exam tomorrow.. Thumbs up who is also cramming for exams!

[@buzzlair27]

This was really helpful for my next test, thank you so much.

[@alessandrasousa3402]

ozone

[@jaumepp1975]

Brilliant!!!

[@celestie02]

Great work sir!! 11.48 when you said hope it makes sense, yess

[@AyushiRai04]

Great Explanation! But how come smoking comes under protective measures?

[@incognito5064]

You are a brilliant and talanted person

[@srinivasyadavkasraveni7497]

Fantastic explanation sir love you

[@balukujoseph3714]

So amazing I understood the pathophysiology finally from here

[@tushardesai256]

I watched it over and over..... question 1: why dint the excited glutamatergic neuron in subthalamus which stimulates the gabaergic neuron in GP.Interna , didnt stimulate the gabaergic neuron in the externa ? Quest 2: Why didnt glutamatergic neuron in the striatum , not stimulate the gabaergic neurons ( the one towards the GP.Interna)? Anybody please answer.

[@daocherry7014]

it helps a lot for my upcoming board exam. Thank you!!

[@charmedbabe64]

How is smoking a protective factor against Parkinson's? Does the nicotine help somehow?

[@stubbornaneed]

That was part of her name if you didn't notice she chose it, she is proud of it, and that is cool, so let me ask you, was the word "necessary" necessary?

[@stubbornaneed]

ok, hope you got it right.

[@charmedbabe64]

The name is from a Marina and the Diamonds song.

[@DrArjunKataria]

it makes release of dopamine so somehow make it working.. same like ejaculation decreases chances of prostate cancer in men

[@cesusjhrist3913]

Yeah, smoking weed helps as well, it's on youtube btw, look it up, a patient was really stoned but his tremor was absolutely gone. Ofc, it's temporary, but still is a thing.

[@96areejfatima11]

Thanks a lot for all of your videos.

[@acousticankit4408]

If in a normal person. The last GABA neuron gets inhibited than how the signals are transmitting to thalamas

[@lupo_mangiafrutta]

hi, do you have other videos on the basal ganglia or the neuro circuits? thanks i love your videos, you're helping so many med students out there :)

[@A4arooj]

i really needed this, thank you so much.

[@EduLuminescence]

Armando sir, you are just awesome...I am amazed... beautifully explained...love from India...

[@okomosimon9941]

you are very bright. thank you for your share. i have read pathophysiology PD but i was not understanding. Now i understand it

[@l.g.a.8930]

Excellent presentation. Many thanks :)

[@Homoeopathicore]

I am Classical homoeopathic physician Homoeopathy is a science which treats holistically... Basic principle is all individuals are different so every individual is treated and given medicine totally different whether 2 individuals or more suffer from same disease... Not only this any individual who is suffering from one or many diseases at a time only one medicine will b given on the basis of his constitution... During case taking ( His medical history his family history his emotions intellect delusions fears hobbies choices manners sensitivity will power dreams physical general pathogonomic generals and peculiar symptoms and modalities all are taken into consideration to give his contitutional medicine...) Thats why in homoeopathy every disease is curable whether it is genetic auto immune chronic etc...

[@nosilverbullet4pd998]

thanks for sharing

[@jonathanespach7876]

Still no cure? Why is this such a difficult problem to solve

[@essamalielmisherghi9693]

Thank you so much , this was really great Video lecture. Dr.Essam Elmisherghi from Libya.

[@net28573]

If I had resources like this video back in 2009 I would have self diagnosed my SSRI-induced-parkinsonism a long time ago. The most helpful point in this video for me is the differentiation of D1 and D2 in this motor circuit. You just saved me hours of research, good sir!

[@ahmadqubo]

came in time ! thanks armando :D

[@mohamedorayith4626]

at 8:38, you say that the d1 receptor is excitatory but stimulates the GABAnergic (although the GABA is inhibitory)? I'm confused...

[@mdisqa2696]

Same confusion broh😐😪😥

[@hustler3of4culture3]

You can stimulate inhibition

[@Veruvir]

Loving the detailed flow diagram.

[@dr.varsha8810]

Awesome lecture! Easy to remember.thank you

[@AaRtI0404i]

Thank you for the video. Can you please do a video on Traumatic brain injury?? Pleaseee....

[@Taniaturnbull]

Smoking is a protective factor???? How? Its stimulates dopamine release?

[@Dennis.bergkamp]

Thank you.You help me a lot for my research.

[@user-sl3rv8hs2k]

Thank you doctor 🌹🌹🌹

[@maryaali9375]

kindly upload tehse topic becoz aftar a month my exam will held

[@user-fh7lo6si8f]

Four months TRACKING improvement FIRST STEP: a UPDRS test, a push test with video, a walking and turning test with video, a talking test with video and possibly a writing test, standing from seated on hard back chair video with your arms crossed. These videos are kept on file to be used for comparison with future videos. This is a fairly accurate means of documenting improvements over time as it is actually fairly easy for some people to not realize how much they have improved over time.

[@philipmilner9638]

I have many of the symtoms you mention (some of my relitives thing I have Parkinson's disease), but I have many other illnesses including cerebral palsy, epilepsy and others). Should I try and see my doctor?

[@leemouzee]

Thank you so much! you explain so well and clearly, much better teacher than our professor.

[@NabeelAhmed-od4mo]

No mention of Excess AcetylCholine??

[@worldofwaali2750]

Fantastic video!! I have a question though. I can see that the glutatamatergic receptor in the subthalamic nucleus also synapses back with the GABA-ergic receptor in globulus externa. Wouldn't increased glutamatergic input to globulus externa then lead to inactivation of the subthalamic nucleus?

[@hoangminhhoang9900]

Thank you so so much. My teacher makes me confusing in this disease when her talks about its pathophysiology. How can I get the HD picture of this lession?

[@mohamedorayith4626]

Wait, smoking is a protective factor?

[@hemantpaikrao4671]

Congrats for 1M subs...

[@inzerinzer5425]

Thank you for your video. Its great. You explain why person with Parkinson disease has hypokinesia and rigidity but dont give explanation for tremor ( your video is started with presenting tremor). And secondly, what do think about - why or how substanstia nigra is activating?

[@sharafkhan9333]

Why is the D1 pathway excitatory when it inhibits gabamineurgic neurons similar to the D2 pathway?

[@nitinmukesh9807]

Everything is fine but why when i download this video, there is no audio??

[@dineshphysio7462]

awesome lecture sir... keep going on...

[@fakhrizaidan6718]

Sir, what makes rigidity in Parkinson's disease?

[@ZaidKhan-eo6hn]

very helpful sir

[@prateekkumargautam6952]

Can i get notes of what u teach plsss....

[@hhykk]

In antipsychotic drugs,, its mechanism is blocking the D2R.... does that has sth to do with D2R( inhibitory effect) in here

[@bhargavibk3383]

A very good video sir! Thank you so much!

[@eddel.6003]

Can you do one on Alzheimer's diseases and what occurs in the brain when the develop AD.

[@monalidave8297]

Can you please upload pharmacology of drugs that acting on Central nervous system.. pls

[@rajanbalakrishnan821]

hey dude pls avoid light colors.. it is less visible..

[@rahim7133]

thank you sir

[@MrFASSOLY1990]

Little bit complicated 😅 Thank you for your great efforts 👍🏻

[@navyasribhargavikondisetty9729]

Will u please explain,which signals make dopaminergic neurons release dopamine.

[@momolulu8910]

please explain further the indirect pathway; Glutamate + GPi = then....????

[@TheChantelleBell]

perfect timing. csn you do one on alzheimers and cjd

[@lifeisbeautiful3083]

Great video!

[@fihimefihi]

concise and rich, thank you for the video