AUTONOMIC DRUGS; PART 1; Parasympathetic Agonists & Blockers by Professor Fink

This is Part 1 of 4 Video Lectures on AUTONOMIC DRUGS by Professor Fink. In this Video Lecture, Professor Fink describes [1] the Parasympathomimetic (muscarinic Cholinergic Agonist) Drugs and [2] the Parasympatholytic (muscarinic Cholinergic Antagonist) Drugs. Prototype Drugs are cited and their mechanism of action, clinical uses & adverse effects are explained. Reference is made to cevimeline (Evoxac), Sjogren's Syndrome, pilocarpine, Glaucoma, atropine, belladonna alkaloids, enuresis, IBS, & ipratropium (Atrovent).
Any drug that works by blocking the "muscarinic" ACh Receptor sites will block the parasympathetic actions on the visceral organs. This allows the sympathetic autonomic motorneurons to exert the dominant effect ON THE VISCERAL ORGANS.
IN ADDITION, any drug that works by blocking the "muscarinic" ACh Receptor sites will ALSO BLOCK THE ACTION OF ACh IN THE CNS (BRAIN). In the CNS, ACh is primarily EXCITATORY. This causes an overall decrease in electrical activity in the Brain, causing drowsiness & lethargy.
YES; on the surface it looks a paradox: "Stress state" on the VISCERAL ORGANS (peripheral action), but drowsiness in the Brain (central action)!
BUT it is all based on blocking the muscarinic ACh Receptor sites: (1) on the visceral organs and (2), in the Brain.
Thus, drugs that block muscarinic ACh Receptor sites, like atropine, or many drugs with "atropine-like" actions (including Antihistamines) cause CENTRAL sedation (drowsiness) and are even used to slow-down electrical activity in the Vestibular (Balance) Reflex Center and Vomiting Reflex Center and are prescribed to reduce "motion sickness" (such as meclizine & cyclizine.)
Check-out professor fink's web-site or additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com
Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: wlac.redshelf.com/
“Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: onlinestore.wlac.edu/fink.asp

[@polysuazo3209]

You were my savior during A&P 1 and 2, Now you're doing it again for me, Pharmacology class for Nursing School! Thank You Professor Fink

[@malithjur2382]

Prof. Fink I want to thank you for your efforts to help the world have excellent Doctors tomorrow, am from S.Sudan and your lectures have helped me out during my intermediate exams however I look forwards to see you in the future if visit United States.

[@malithjur2382]

You deserved my respect sir and may God give you good health to continue to teach the future Doctors of the World.

[@professorfink]

Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore on-line. The LINK is posted at the bottom of the Video DESCRIPTION above.

[@professorfink]

Any drug that works by blocking the "muscarinic" ACh Receptor sites will block the parasympathetic actions on the visceral organs. This allows the sympathetic autonomic motorneurons to exert the dominant effect ON THE VISCERAL ORGANS. IN ADDITION, any drug that works by blocking the "muscarinic" ACh Receptor sites will ALSO BLOCK THE ACTION OF ACh IN THE CNS (BRAIN). In the CNS, ACh is primarily EXCITATORY. This causes an overall decrease in electrical activity in the Brain, causing drowsiness & lethargy. YES; on the surface it looks a paradox: "Stress state" on the VISCERAL ORGANS (peripheral action), but drowsiness in the Brain (central action)! BUT it is all based on blocking the muscarinic ACh Receptor sites: (1) on the visceral organs and (2), in the Brain. Thus, drugs that block muscarinic ACh Receptor sites, like atropine, or many drugs with "atropine-like" actions (including Antihistamines) cause CENTRAL sedation (drowsiness) and are even used to slow-down electrical activity in the Vestibular (Balance) Reflex Center and Vomiting Reflex Center and are prescribed to reduce "motion sickness" (such as meclizine & cyclizine.)

[@victorfigueroa2934]

Thank you Dr. Fink Greetings from Mexico

[@kimhab5536]

Luv u Dr.fink, From Cambodia

[@giobasta6918]

professorfink You are my idol

[@VickiBee]

You sound like the guy I used to know who made new drugs. He was the Science part of pharmaceuticals and worked in a lab. He used to work for Procter and Gamble.

[@gaylordmenlord]

we need more teachers like you that have your clarity, your understanding and your ability to communicate. You make learning difficult concepts easy. Thank you Professor Fink.

[@mirandax0417]

Thank you for sharing. How lucky are they to have you as a lecturer ❤

[@lydiabielicki8880]

You, sir, are a fantastic instructor. You have perfected the art of teaching. You make the material crystal clear and present information in a way that is exciting to learn about. I watch your videos for clarification on topics I need more help with in my program. You are a gift to everyone watching, thank you!

[@professorfink]

Dear Lydia, Thank YOU so very much for your kind words. I sincerely appreciate it! Best Wishes for your Success!

[@ibrahimjumu2968]

You will ever remain the best

[@windygraff6763]

Your lecture is always really clear!! I recommended your KZbin video to my sister so she'll have a good understanding of Pharmacology. Thank you so much, Prof. Fink. You're the best!!

[@Chaunguyen1502]

Thank you professor Fink. I watch your lecture over and over before the final. You are great professor ever.

[@sanatjankarriev9249]

It would be unfair not to tell you thanks dear professor. long live and happiness in your life. greeting from Uzbekistan

[@danielaarbelaez3848]

BEST PROFESSOR EVER! everything makes sense thanks to you

[@deec3158]

Thank you! You've helped me understand these drugs a whole lot better!!

[@scuhsa]

Thanks a lot. You are a saviour. Take a bow man.

[@woloabel]

The Professor is highly effective in illustrating medical/physiological phenomena of the human body....cheerz

[@TrollDad3]

I'm from Chile and i was having some problems with Pharmacology, Proffesor, you are an excellent teacher, this is just what i need for my test, it would be great if my teacher was like you

[@ganeshbastola9006]

Sir you are one of the best teacher I have ever seen, thanks for all your lectures.

[@mustafa-aljuboori]

thank you so much professor i wouldn't understand pharma without you

[@mrgilbert9749]

I really love your lectures prof Fink thank u so much for such an effort u show.ALL THE BEST from Rwanda!

[@johnnyamal4101]

Thanks alot Prof. for being such a wonderful and kind person., I prefer your videos to the rest

[@patilgunwantpatil4792]

this is the best lecture I have seen on autonomic nervous system.now I can remember it without much confusio

[@gigikwok5874]

Thank you very much ! Your lecture helps me clarify most of the concepts

[@kenicefrew6504]

Thank you so much professor for your great videos.. Without, your videos it wouldnt be possible for an A in anatomy and physiology 1 and 2 .... Here to get an A in pharmacology... God bless you.

[@soosoo4929]

Wow this is the lecture that i tried to find!!!!

[@mosiergirl1]

very clearly presented and informative! Thank you, Professor Fink!!!! I will review this over and over!

[@lauralopez8396]

I´m studying to take the NBDE part 2. and your videos are helping me a lot. you are amazing. I send you greetings from México

[@nellyhoffman6194]

Professor fink you are amazing,, God bless you !

[@professorfink]

+Lighto Yagami Thank you very much. May God Bless You!

[@anthonykim9422]

Great lecture!! Thank you!!

[@nairdarumani5450]

prof fink you are one of a kind thanks a lot nairda from albania

[@lagucoverai]

Very clear. Thx prof 😍

[@samahbezry5534]

very nice lecture i remembered so many things i have studied from 23 years thanks dr fink

[@aoifewest]

Why I never got such a good lecturer. thanks for sharing.

[@odisiusX5]

On the chart it says that Adr agonists have a stimulant effect on the CNS (increased alertness), and the Ach decreases alertness. So : 1. how come Ach is excitatory on the brain if it decreases alrtness ? (Isn’t that same as depression of the CNS ?), i.e, the opposite of the sympathetic adrenergic stimulant effect 2. Anticholinergics have a depressing effect on the CNS, hence the sedative use in twilight sleep…which means cholinergics have the opposite effect, i.e, excitatory (stimulant) 🤯🤔 That’s the only confusion I have over these whole autonomic drugs magnificent lectures given by maybe the best professor I have ever seen teaching pharmacilogy !

[@odisiusX5]

Where’s the error ?

[@professorfink]

ACh does have an "excitatory" action on the (muscarinic) ACh receptors in the Brain. And, of course, Epi also has an "excitatory" action on the Adrenergic receptors in the Brain. In the Stress State there are sympathetic actions on the visceral organs & increased release of Epi to stimulate the Brain. HOWEVER, in the "Rest & Digest" State there are parasympathetic actions on the visceral organs and DECREASED release of ACh in the Brain, causing relaxation & drowsiness. Thank You for your kind comments about my Video Lectures. Best Wishes in all your endeavors! -- professor fink

[@ArgentDawn55]

Your videos are great!

[@TooCooLFoRYou123]

Amazing lectures. I hope I get a prof half as good as you one day!

[@HafizahHoshni]

Thanks a lot Prof. ! :)

[@dr_iq9438]

you are the best thanks alot Mohammed from Iraq

[@VsVSandhuvsv]

thnk u sir may god bless u always.....

[@shoteit]

Awesome awesome lecture :) At my college we were already suposed to know all this before we even had the lecture :/

[@alhmdm1879]

Thank you dr

[@edss7778]

Great mind

[@anas4413]

i respect u prof :)

[@nenanena3266]

realy thanks

[@ibrahimjumu4973]

I can pass my pharmacology. Drugs affecting Neurons

[@najiaougzin2911]

Nice, Thank you professor Fink for passing your knowledge to us. This is actually the best deeds that someone wants to earn in this life. Thank you again.

[@noureldinmohamed7051]

thank you great I just change my career

[@moy2010]

Thank you, professor Fink :). About this class, I have a question: Why does stress causes the release of urine? I thought that this was in the domain of the parasympathetic system (Rest, Digest and Excrete)...

[@sophie8977]

Could somebody please tell me, if this is a good rapid review lecture for someone who is preparing for USMLE step 1?

[@andraacram]

Another way to remember symptoms is "Granny." She's Hot, Dry, Mad, Red, Blind, and Full for anticholinergic toxicity.

[@muhammadyasir6068]

Today we studied that edrophonium is used for diagnosis of Myesthenia Gravis and neostigmine for its treatment....... I asked a question but I wasn't satisfied with my teacher's answer Other treatment we were told was... 1=Immunoglobulins 2= immunosuppressive drugs..... Immunosuppresants are logical coz its an autoimmune disease..... but why they use immunoglobulins?

[@beccaisonnn]

I don't see pharmacology lecture outlines anywhere on the bookstore website. Are they still available for purchase?

[@usmansarwar4528]

hi professorfink .. can you please upload the chart which is C-21 in thic lecture....or gimme the link plzz

[@ASADFDGHG]

: the low dose of atropine will block presynaptic m1 receptor - bradycardia and the higher dose of atropine will bock m2 receptore - tachycardia

[@ASADFDGHG]

@Ali Mahmoud

[@egglplant96]

I want a copy of that chart on page C 21

[@avchuseang3931]

Ashuuuuuuuu

[@alig6279]

Hi professor fink Can you email me page c21 of this lecture the chart plz

[@ZokieZol]

I WANT THE FULL NOTES PLEASE

[@lilyctse]

i want the notes

[@ASADFDGHG]

Hello

[@ASADFDGHG]

Is that right or wrong....?!

[@arykhoon]

this guy forgot to take his lithium.