AWARD WINNING Animation Explaining Excitation Contraction Coupling & Muscle Contraction

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Video Summary:
From the nerve, the signal is transmitted to muscle fiber at the neuromuscular junction. The action potential spreads along the entire surface of the membrane. It penetrates deeper into the cell through T tubules. T tubules have L-type Ca channels that open in response to this action potential. Their opening physically opens Ca release channels. Through both these channels, Ca enters the sarcoplasm. Then it binds with troponin. It moves the tropomyosin away from the binding site for myosin. So now the myosin head binds and pulls the actin towards the center of the sarcomere. The cross-bridge cycle keeps repeating as long as Ca concentration stays high and the binding site on actin is exposed. Eventually Ca is released from troponin and the cycle stops. Na-Ca exchanger and Ca pump on T table and SERCA on sarcoplasmic reticulum moves Ca out of the cytoplasm. This decreases cytosolic Ca concentration which in fact is the reason for the release of Ca from troponin in the first place.
⚠ Watching the below video is must before watching this video:
Physiological Anatomy of Skeletal Muscles: • Structure of a Skeleta...
📽 More videos on Musculoskeletal System:
• Neuromuscular Junction & Transmission: • Neuromuscular Junction...
• Physiological Anatomy of Skeletal Muscles: • Structure of a Skeleta...
• Pathophysiology of Myasthenia Gravis: • Pathophysiology of Mya...
• Treatment of Myasthenia Gravis: • Treatment of Myastheni...
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Chapters
00:00 Intro
00:26 Relevant Anatomy
02:50 Excitation Contraction Coupling
05:09 Myosin Cross Bridge Cycle
06:36 Muscle Contraction
07:34 Termination of Action
08:47 Summary
Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

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Very interesting video, it would be interesting to know how the presence or absence of alpha actin 3 affects this process and what happens to reduce the integrity of the Z band in ACTN3 r577x homozygotes. Which parts of the structures are being weakened and by which process?

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