B cell Selection

[@yutong-os8mz]

a clear and comprehensive explanation. thank you so much!

[@royjoseph1498]

I adore you!!!

[@lachlanmcgregor1744]

this was very very helpful

[@immadisarojini2775]

Nice

[@berenicedrabo1573]

Where is the video following this one?

[@karankalani4211]

Great video! An immature B cell has already undergone vj recombination to produce a light chain. Let’s say v1j1. Aren’t the other segments (v2 onwards and j2 onwards) deleted during this recombination? If so, how does the immature B cell go back to a different light chain combination if it is selected for “receptor editing” ?

[@WhyNot-si4pj]

Great question ! In case of " receptor editing " ; the immature B cells take advantage of the " allelic exclusion " property of VJ recombination in the coding allele ! Where the excluded allele of the INITIAL VJ recombination is the one that undergoes a NEW recombination of the V & J segments ! Lord knows best !

[@cindycuriel7164]

Very helpful thank you!! :)

[@seanireland8963]

Is the receptor editing step negative selection or positive selection given it has to have no affinity to pass through to become mature?

[@oliviapereira364]

Hi! Why is clonal deletion called "clonal"? Those cells are clones of the same origin cell? Thanks, your video was very helpful and didactic!

[@alfianrizky117]

so where is the positive and negative selection of B-Cell :(

[@haideralfadhli9444]

Please,i want lecturer about the avidity and affinity

[@premaadhikari128]

Brother Read kuby book