Positive and Negative Selection for the USMLE Step 1

[@freedaboyoung3722]

Hands down best video ever. After 4 years of med school, never understood this but you guys have made this concept so so clear

[@ben_askalim]

I love this video. Very clear, very concise, very demure. Thank you so much, I now understand the concept!

[@weirdways7966]

Keep up the great content man you're going to heaven for this believe me

[@shalemram4471]

quick and very helpful lecture for understanding negative selection concept, thank you so much sir.

[@princessz5087]

Great work covering the hot/hard topic. Thank you very much. Looking forward to more video of immunology.

[@sarahmina1442]

I really wish I was taught these concept with ease in medical school. Now, going back on my own to review it

[@s.u.k.k.u8765]

Mindblowing video. Thank you.

[@sinigdhabiswas8144]

Most helpful video ever. Thanks!

[@mccoymedlog]

I'm a bit confused. So in positive selection we need the T-Cells to bind to MHC, but in negative we don't want them to? I understand that in negative selection we want to eliminate cells that would cause an autoinmune response because they bind too tightly, but don't we need them to recognize our own MHC? Shouldn't the diagram say "binds to MHC --> no apoptosis", "binds AND responds to MHC --> apoptosis"?

[@Anurag9344-q1i]

Moderate binding - no apoptosis. Tight binding - apoptosis.

[@oumchansopheak5450]

I can't really thank you enough

[@Abr_4040]

This video just cleared all my doubts. Thankyou❤❤❤❤

[@rachelhaley1909]

succinct and great refresher, thanks!

[@headoverclouds]

T cell binds to self antigen in medulla. Medulla APC: So you've chosen death.

[@Unstoppable1001]

T cell doesn't bind to self antigen in thymic cortex Mr Apoptosis: I have a special gift for you baby

[@امجاد-و5س]

Amazing and very simple thaaanks

[@CORPSE77]

best video ever. thank you

[@fatherofmyson7854]

Thanks a lot

[@shahedelnadjar3144]

Best video i’ve found on this topic :)

[@mishkatnoor7501]

Best explanation thank you

[@MariemIbrahim-l3z]

Thanks ❤❤❤❤❤

[@breNdizSxD]

So nice, thanks!

[@tiimm0002]

Great video, really helpful! Thanks for sharing :)

[@freedaboyoung3722]

Bravo to you guys

[@mokshsurya1681]

Good explanation. Keep making videos. 👍

[@yakubuzainab6497]

Thank yiu Sooo much. New active subscriber

[@DrNawalSoud]

guys you are so expensive ! I wish you could put this in consideration

[@karthiksadanand3350]

love you so much

[@TilleTheo]

This was very helpful!! Thanks a lot!

[@talaiscomingafteru]

What type of cells undergo negative selection? DP cells or SP cells ?

[@Be1smaht]

I love these videos

[@dina3630]

Thanks ✨

[@gulanzafar7636]

Was Really helpful, Thank you ✨

[@TachyTutorials]

Great video!!!

[@joannadaniel9396]

Thank youu

[@ShaunCharkowick]

incredible

[@meadhikari]

thank you

[@jeetthakkar8505]

Thankssss

[@akashn4420]

❤

[@Ali_en]

thank uuuuuuuu

[@medicalscience1528]

Hello, can you please clear. In positive selection , where do those MHC molecules come from? Are they part of T cells? Do they present on membrane of T Cells?

[@omarnaasan3536]

Present on the type of stromal cells found in thymus cortex called the thymic cortical epithelial cells

[@anthonyfigueroaa7024]

Requirements. 1) recognize MHC 2) recognize foreign antigens. 3) recognize self antigens (do not bind) 4) cannot bind too strong or light (strong enough) If it fails T cells goes to the negative selection and apoptosis. If it passes, it goes to positive selection and it stays.

[@chocolatykirthi]

Wow

[@OmerMusa-b7b]

Thank you