Basal Ganglia physiology | Neurophysiology | CNS Physiology

In this physiology lecture on central nervous system physiology Understand the physiology of basal ganglia in detail along with the physiological basis of basal ganglia disorders.
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The video describes the connections and functions of basal ganglia in detail. In connections, it explains the direct and indirect pathways in detail. First it describes the basal ganglia circuit. It then explains the role of direct and indirect pathways of basal ganglia in initiating and suppressing movements as direct pathway facilitates movement and indirect pathway inhibits movement. It also explains the origin of hyperkinetic and hypokinetic disorders due to lesions of basal ganglia.
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[@pachunoorisatyam945]

Solved a complex circuit in just 10 min Thanks for your sharing Ma'am😊

[@PhysiologyOpen]

Most welcome 😊

[@porngambayor9658]

totally agreed. she is an angel and so intelligent.

[@PhysiologyOpen]

Basal ganglia acts as a switch for initiating or not initiating motor impulses for movement.. Hyperactive switch causes hypokinetic disorders while less active causes hyperkinetic disorders.. if you know how.. comment below.. if not watch the video and find out..

[@single2002]

Most underrated channel 💯💯

[@PhysiologyOpen]

❤️🙏

[@dr.kaliprasadmishra]

thanks alot mam your leacture r so helpful for my university exam 🙏

[@PhysiologyOpen]

Happy that you liked it. Don’t forget to share with others too

[@aadityasinha6961]

Thank you for clearing my doubt ma'am , love you maam !!! You have been kind to me ! 😊

[@PhysiologyOpen]

My pleasure 😊

[@milindkalra470]

Maam If dopamine inhibits indirect patway So there should be less inhibition of movement inhibitted by indirect earlier ? So how it facilitates movement ??

[@PhysiologyOpen]

The answer lies in your statement itself. indirect is inhibitng movement, if dopamine inhibits this inhibition, it is equivalent to facilitation

[@milindkalra470]

@@PhysiologyOpen THANK you ma'am😇😇

[@krishsavani3082]

Mam, mind blowing 🤯 lecture...very nice lecture...

[@PhysiologyOpen]

Thanks a lot

[@walkureunruh2580]

When GPe also inhibits GPi, why doesn´t it lead to a disinhibition of the thalamus ? I thought the direct pathway also inhibits the GPi so that the Thalamus is ultimately activated, isn ´t it the same mechanism?

[@Ranvirkaur6555]

I am also confused

[@winifred9862]

I think it’s because at that time the striatal neurons aren’t activated. So GPe inhibits GPi on way or the other.

[@shaziafarooq7804]

Mam dopamine being inhibitory nt should inhibit striatum in direct pathway as well... Why it's not so

[@PhysiologyOpen]

Whether a neurotransmitter is inhibitory or not deoends on the receptors it acts on...Here in one pathway it acts as excitatory while in another pathway as inhibitory

[@shaziafarooq7804]

Thank u mam

[@brahmamg1885]

Mam 1.If basal ganglia should inhibit antagonist and stimulate agonist it should know the present position of the body like cerebellum is knowing through spinocerebellar pathways but even though it is not having connections like that how is it able to inhibit some and stimulate some? 2.What is the difference in functioning of cerebellum and basal ganglia with regard to planning and programming a motor action.Can one suffice the other in its absence means if cerebellum is damaged can basal ganglia compensate not all but atleast the planning and programming function of cerebellum? 3.Will cerebellum and basal ganglia work synnergistically ?

[@shomianand8905]

Mam is there separate video lectures related to hyperkinetic or hypokinetic motor activity - Applied physiology of Basal Ganglion pathology

[@PhysiologyOpen]

Not yet

[@that_mbbs_nerd]

Big fan madam.. kaash clg mei aise pdha dete.. aate hai ppt run krte hai Kuch smjh nhi aata

[@PhysiologyOpen]

Thank you Rahul

[@022amjadparambil8]

Mam can u pls explain cerebellum,spinal cord, reflexes

[@55_benshanthr20]

Thanku... Vry useful lecture

[@PhysiologyOpen]

Thanks and welcome 😊

[@ramyarengaraj9411]

What neurotransmitter teleased by pars reticulata?

[@PhysiologyOpen]

By pars compacta: dopamine. Substantia nigra pars reticularis is output nuclei of basal ganglia: releases GABA

[@ramyarengaraj9411]

@@PhysiologyOpen thanks mam

[@PhysiologyOpen]

@ramyarengaraj9411 my pleasure

[@rvvv5899]

Mam u said indirect pathaway actually inhibits thalamas but incase if Globus pallidus externus inhibits subthalamic nucleus whose function is to excite Globus pallidus internus then it will be no longer excite Globus pallidus internus, but if globus internus gets activated so it can easily inhibits thalamas but here is not happening. Why ???? Please clear this concept mam

[@PhysiologyOpen]

Indirect pathway inhibits thalamus in 2 ways by Gpi and via SUbthalamic nucleus

[@rizahafas6563]

Can you tell me what references of this video?

[@PhysiologyOpen]

Kandel and purves

[@ramyarengaraj9411]

Why are u mentioning only pars reticulata while saying substantia nigra? Mam

[@PhysiologyOpen]

Is it... Pars compacta releases dopamine

[@1176minion]

10000 thumbs ups👍!!

[@PhysiologyOpen]

Thanks 🤗

[@shaziafarooq7804]

Thanks you so much... Mam

[@PhysiologyOpen]

Most welcome 😊

[@fahmincv5545]

Thanks a bunch ☺️

[@PhysiologyOpen]

Pleasure is all mine