Bruce Ames: Vitamin and Mineral Inadequacy Accelerates Aging-associated Disease

Most of the world's population, even in developed countries, has inadequate intake of one or more of the ~30 essential vitamins and minerals, mostly used as cofactors by the proteins/ enzymes of metabolism. A varied and balanced diet should provide enough vitamins and minerals; an unbalanced diet with too much refined food provides calories, but not enough vitamins and minerals. Triage theory posits that, as a result of recurrent shortages of vitamins and minerals during evolution, natural selection developed a strategic rationing response to moderate shortages so that the scarce vitamins and minerals are preferentially retained by vitamin and mineral dependent proteins that are essential for short-term survival and reproduction. In contrast, proteins needed for long-term health, which defend against the diseases associated with aging, are starved for the vitamins and minerals and thus are disabled. Moreover, since the damage from moderate deficiency is insidious, its importance for long-term health is not clinically apparent. Strong support for triage theory comes from the analyses of published data on proteins dependent on vitamin K and on selenium. Both of these vitamins and minerals have built into metabolism a triage-like trade- off between short-term survival and long-term health; each uses a different mechanism to accomplish this end. Mechanistic, genetic, and epidemiological evidence suggests that this metabolic trade-off accelerates aging-associated diseases, such as cancer, cardiovascular disease, immune dysfunction, and cognitive decline.
Dr. Bruce Ames is a Professor of Biochemistry and Molecular Biology, emeritus, University of California, Berkeley, and a Senior Scientist at Children's Hospital Oakland Research Institute. He is a member of the National Academy of Sciences and he was on their Commission on Life Sciences. Dr. Ames served on the board of directors of the National Cancer Institute, the National Cancer Advisory Board, from 1976 to 1982. His numerous awards include: the General Motors Cancer Research Foundation Prize (1983), the Tyler Environmental Prize (1985), the Gold Medal Award of the American Institute of Chemists (1991), the Glenn Foundation Award of the Gerontological Society of America (1992), the Honda Prize of the Honda Foundation, Japan (1996), the Japan Prize, (1997), the Kehoe Award, American College of Occup. and Environ. Med. (1997), the Medal of the City of Paris (1998), the U.S. National Medal of Science (1998), the Linus Pauling Institute Prize for Health Research (2001), the American Society for Microbiology Lifetime Achievement Award (2001), the Thomas Hunt Morgan Medal from the Genetics Society of America (2004), and the American Society for Nutrition/CRN M.S. Rose Award (2008). His 550+ publications have resulted in Dr. Ames being among the few hundred most-cited scientists (in all fields).

[@NikoHL]

Prof Bruce Ames is still carrying out research at 93 Y/0. This man knows about longevity!

[@micaonyx5301]

Thanks for the info I was wondering if he was still around and if he was still working, good to hear.

[@user-gp4ge9yb5s]

are you sure he is not freemason? He is working in Children hostpital institute, hmm, better question everything.

[@drironmom6673]

No wonder Dr Rhonda Patrick is so amazing. She studied under Dr. Ames. Imagine having such an inspiring mentor!.

[@lyonsailing7520]

Totally. I'm so happy they were able to work together.

[@swim610]

If I saw this earlier in my life, I would have gone into science. What a person this is!

[@tauatrader]

wha a breath of fresh ideas from a man of wisdom and excellent perspective on health and well being.

[@javigr3951]

This is the kind of people like Stephen Hawking and Carl Sagan that not only make science progress, but also make it understandable to the public. Thank you Mr. Ames

[@SI-ln6tc]

Even though this video is 7 years old its just as important back then as it is now. More people need to see this. BTW I didn't know Rhonda Patrick was one of his researchers.

[@LaneCodeRedCarnivore]

I remember Rhonda said "it's so complicated " when she was discussing diet and nutrients in one of her videos

[@debwest7816]

Fabulous speaker..love all the good information and the humor is an added bonus.

[@thefragranceoftruth9320]

Thank you Dr. and all your colleagues. God bless you for helping the human race ❤️🙏

[@aliriozavarce2358]

This is awesome. Very inspiring. People are waking up to the importance of nutrients.

[@randieharrison2582]

This man is brilliant and thank God for the information. He knows what he is talking about. I know for a fact that Vitamin D does make huge difference.

[@fredmatthews5256]

That's something I have all ways new. I been taking vitamins and minerals and other things for over 40 years and I still take them today. And I am 67 and still fill pretty good. Some arthritis from lifting heavy weights over the years.

[@yz915]

Hey Fred, how its going?

[@Tishashah9]

TRT is also an option

[@coolroy4300]

Have you tried Lutein with Zeaxanthin supplements and Guava leaf tea ? 👍👍👍👍👍

[@beereel5734]

Bruce Ames is an excellent instructor; informative and entertaining; he holds your attention.

[@johnschlesinger2009]

Fascinating, and beautifully delivered and illustrated.

[@daveoatway6126]

Brilliant! He should be a role model for students everywhere.

[@LaRoucheisright]

A role model for teachers everywhere.

[@daveoatway6126]

@@LaRoucheisright Point well taken!

[@mellasone]

Wow the information here is totally amazing, I need to sit down and take notes, this man is absolutely brilliant. I am one of those with an MTHFR mutation and the currrent treatments aren't up to scratch, I have here lots of information to work out a better treatment for myself. thank you so much for posting.

[@franklinayala4879]

How you coming along?

[@kennethmoore3783]

Bruce Nathan Ames (born December 16, 1928) is an American biochemist. He is a professor of Biochemistry and Molecular Biology Emeritus at the University of California, Berkeley, and a senior scientist at Children's Hospital Oakland Research Institute (CHORI). See Linus Pauling. Still need evidence.

[@lindamahrer1760]

Phenominal knowledge and great humor. Thank you

[@BRM101]

What a lovely guy, bless you sir

[@tulkupema]

Bruce Ames is great and is funny too.

[@yomanspray]

Deficiencies and toxins are the problem

[@bitebonumbere1426]

Please can you please add subtitles to all of your KZbin videos

[@Thom61152]

Very informative and convincing discussion. Dr Ames seems to be proof he knows what he is talking about.

[@lenkavolnhals7197]

Thank you for sharing your knowledge.

[@yewwoodknotfarm2463]

Great information, but what a great guy!

[@Ruangsaknok]

หำกพปำปะภปๅฃปพำผฃผำะำปำปำปปๅไปพำำฟพำหผกผ

[@ScrivR]

What a wonderful presentation. And I agree, an engaging and stirling gentleman! The triage hypothesis is fascinating. I wonder however... of course a nutrient bar is much-much better than no nutrients, and I understand the purpose in supporting the health and nutrition of the poor who cannot afford nutrient dense food. But to what extent would someone miss out on the 'interaction effect' I.e. the notion that nutrients are more potent/more beneficial when whole foods are ingested because perhaps yet undiscovered (or indeed, known) nutrients play a symbiotic role?

[@LaneCodeRedCarnivore]

I'm sure people would be eating plenty of food !!

[@junemalcolm-evans7409]

Have you ever heard about "Bowtie Analysis?" If Bruce's bowtie speaks to his character then it might be safe to say that he is unique, genuine, and individualistic yet is still mindful to please others.

[@Sheahova]

This guy not only baffles me he also makes me laugh he's soo tender XD

[@gregbalteff1529]

THANK YOU FOR POSTING !!

[@capresti3537]

This is very important information and it is the right information.

[@daniellos333]

Sadly, the entire western medical sphere considers people like him to be hacks.

[@daveporter4667]

Vitamins, minerals cannot be patented hence no profit, no market control. Vitamin D is a lot cheaper than a chemo-therapy. The crocked baloney system we lives works for profit built on lies. And there are so many naive out-here that are addicted to sugar. BS & fear sell well, truth not much. The proof is here, only 64k views for a 2014 clip, but a meme with stupid faces will have this volume of views in a month.

[@Thefunksoulbro]

@@daveporter4667 Check Alan William celery juice. Meditation is the future my brother. Check out Dr Joe Dispezer..

[@wizardatmath]

Fυκεm. I trust his science.

[@lyonsailing7520]

Most maybe, not all ;)

[@djp1234]

Imagine the things we could accomplish if we funded science instead of wars. We'd be immortal by now.

[@arthurdick9553]

It’s not a lack of science that is the problem. It a human race that “pick and choose “ their favourite likes , ie sugar and no exercise. They avoid science like the plague.

[@michelangelobuonarroti916]

Unfortunately, there is a growing anti-science movement in the U.S. Climate denial is maybe the most obvious example, but pressure to cut funding for basic scientific research is a problem.

[@hernancoronel]

Or up in smoke already…

[@ProfFeinman]

It would be so crowded. That’s why we have wars.

[@benjaminwillitts7381]

@@hernancoronel Stop

[@lyonsailing7520]

Great presentation, and funny. No wonder he has attracted so many talented people to work with him. This gentleman appears to be an increasingly rare gem.. High quality, durable and likable is a great combo.. Too bad that "science," as it is frequently practiced and represented, is not very high quality much of the time. Unfortunately, is it is subject to all of the frailties of human nature like any other human endeavor. Also unfortunately, it's self correcting mechanisms are sorely ailing at this time. "Follow the science" is a religious uttering. Mainstream science is dogma much of the time and many purporting to do science are just following the dominant and trendy dogma and coddling results and conclusions into existence. Real science frequently has an element of antagonism and iconoclasm built in. Some of its best practitioners are pushy, impatient, and unpleasant. Especially in today's world, that gets one fired and ostracized. Glad his ideas can now find a bigger audience. Who will listen?

[@indianvictim332]

Wow seems like back then type 3 diabetes was not a term

[@littleo353]

Vitamin D sufficiency is MUCH lower than 30% of the people - because the recommended daily amount is, in my experience, too low.

[@bluewaters3100]

In 2009 I saw a book about vitamin D deficiency symptoms at a bookstore. I had been feeling awful and just knew this was my issue and so went to a Doctor and asked to get tested. My blood pressure was high, thyroid messed up, had alot of muscle and joint pain. My Vit D3 was at 6ng. which is really low. I had even begun to get chondromalcia of my knee. I changed my diet to totally organic, quit grains, sugar, and ate grassfed animal products. I am almost 70 now and always talking about Vit.D to anyone I meet. My neighbor would not believe me and went to a specialist because of pain and feeling tired. His doctor tested him and said it was all because of his low Vitamin D.

[@jenrich111]

Brilliant lecture. Thank you.

[@evanrutherfordlazyahole9079]

I feel a million times better when I take initiative to try and intake all these vitamins and minerals.

[@Bibagodiva55]

This man is amazing, fantastic to listen to - I will save this Video forever 👏👏😍😲🥰🤗🤗

[@rutkowsky]

Thank you for sharing!

[@tauatrader]

brilliant work

[@thevoid8238]

Long Live Sir! may Triple gem Bless you !

[@kenlandon7803]

This guys a card. Real gentleman.

[@Vospi]

That was just great!

[@Holmes.2.0]

Vegans need to watch this video

[@Nahulanham]

show us your workout routines that produce the results your describing.

[@bernadettebecher5668]

Such a great lecture- thank you.

[@katelemon2750]

What a legend. !

[@NikoHL]

Natto is incredibly cheap. Normally found in the fridge of yr local Japanese store. Takes some getting used to !! But it will help keep you alive, so, clearly well worth the effort!!

[@RobinHood-ki5gg]

In cancer pyruvate is not properly converted into acetyl co a which means krebs cycle can't run to make ATP, and also lactate builds up. Pyruvate dehydrogenase which is supposed to convert pyruvate into acetyl co enzyme a relies on - thiamine b1, FAD b2, NAD b3, and then co enzyme a needs b5 to be made. Cancer might just be multiple b vitamin deficiencies resulting in the warburg effect.

[@fatandslim5855]

Greetings. The machine mentioned at 53 minutes,being installed in Chinese hospitals, who is the contact for these or the name of the company please!

[@HalemHouran]

C’est le mentor de Rhonda :)

[@benv.5170]

Now in time, you could argue nearly 90% of the population is deficient in NAD+, which NMN and NR help fix.

[@luckssj]

This is good - great points - let's look at the Capillaries and the Endothelial cells with their Glycocalyx on top.

[@derrickforeal]

this is your metabolism. laughs all around. Bruce snaps his head to check the screen, thats what should be up there and its no joke, huh why are they laughing, begins to speak. Thats the serious Dr. Bruce Ames I remeber working with for his Juevenon products line. I still to this day take his products, 7 years later

[@Bpjames]

The laugh in the beginning is because that metabolism chart is so intricate and detailed that there's no way that you could learn 1/1,000th of that information in a 1 hour talk. I have to admit that I laughed too, which I didn't think anything of until I read your comment. But that laugh did set the tone for the talk, I think. Besides being a wealth of information and enthusiasm, Mr. Ames has a great sense of humor which makes listening and digesting the knowledge that much easier.

[@swim610]

I would love a fingerprint to tell me what I'm low in

[@debstayblessed9549]

Have you viewed directlabs.com which utilize Quest Diagnostics so you can get the most accurate diagnosis ie vein draw?

[@dollyproductions1]

Awesome man

[@juieandersonJHLA]

Well, I hope this is less expensive than the "Essential 90" from Longevity. So far it looks good. I wonder where and when this was recorded. Anyone know?

[@IHMC]

Looking at the beginning of the video says it was record by ihmc and on youtube the published date is in March 2014. lmgtfy.com/?q=ihmc

[@juieandersonJHLA]

Thank you, yes, I see that but sometimes posters post things that are two years old, really! Not you. Great, I subscribed.

[@trainingxtrish]

so it is less expensive?

[@yarygork2334]

Dont believe a thing he says! hes really 41. I like his Scottish sense of humor like my dad, Bruce had.

[@thesoundpurist]

49:33 I hope people realize it's involved in trust behavior and women produce more Oxytocin at older age (around 60's) Confirmed by Nathalie Ebner

[@kirayoshikage3133]

hello guys. I live in Thailand could u tell me that how do i buy the chori bar? Thanks a lot.

[@clivewells7090]

Never heard of it. I do know that most essentials are in eggs so that's a supplement readily available.

[@jackfaber7710]

sorry, you can't. this granddad eaten them all

[@YapLapWombat]

Just for fun: below, to put things in context, is a list of the first 54 elements from *H* to Xe ... the ones we need: in bold; round brackets: probable / possible; square brackets: probably not. That makes for a minimum of 20 required elements (i.e. the count of elements in bold). >> + *H* - [He] >> + (Li?) - [Be] + (B?), *C, N, O* - [F - Ne] >> + *Na, Mg* - [Al] + (Si), *P, S, Cl* - [Ar] >> + *K, Ca* - [Sc - Ti] + (V?), *Cr, Mn, Fe, Co* - [Ni] + "Cu, Zn" - [Ga - Ge] + (As?), *Se,* (Br?) - [Kr] >> + (Rb?), (Sr?) - [Y - Zr - Nb] + *Mo* - [Tc - Ru - Rh - Pd - Ag - Cd - In - Sn - Sb - Te] + *I* - [Xe]

[@andiamoci22]

he didnt explain enough about Zinc ?? Wow Rhonda Patrik was in his lab.... he must be good.

[@Sandrae7560]

@andiamoci22 There's about two or three videos where she interview Dr. Ames. It's choc full of info on vitamins, minerals and sulforaphane which is a favourite subject of hers.

[@lindahathaway3519]

It's mutual, I am sure.

[@fondrees]

Rhonda refers to him As her mentor.

[@nickfarrell429]

My only comment is that he keeps mentioning greens when almost all the vitamins and minerals he mentioned are more bioavailable in beef and beef liver. Especially with vitamin K, the plant version pales I’m comparison to K2 which is a fat soluble version only in raw dairy and liver.

[@lyonsailing7520]

Nobody's perfect. I'll forgive him.

[@lf7065]

Vitamin K and Vitamin K2 are not the same thing.

[@lf7065]

Also, the highest source of K2 is Kimchi, which is fermented cabbage. A vegetable.

[@nickfarrell429]

@@lf7065 yes this it’s true. Make sure to eat it with fat though otherwise it doesn’t absorb easily. That’s why they call them fat soluble vitamins. Even though the content is high in sauerkraut you absorb more K2 when eating butter, eggs, and liver because they come with fats

[@nickfarrell429]

@@lf7065 I know

[@bencyber8595]

he make it so interesting 😁😁😁

[@jstock2317]

what a legendddd

[@CraigCastanet]

Minute 52; duped by Theranos.

[@mikimiki6202]

He's so cute!

[@darrenfenton9280]

Dr j Budwig 1950s.

[@CraigCastanet]

I guess it wasn't Theranos.

[@lyonsailing7520]

My thought initially well

[@teresajohnson1352]

👏👏👏👏👏👏💐♥️

[@barry7608]

Thanks but I get nervous when experts list Folate as Folic Acid, 2 entirely different chemicals. Folic acid is the ADDITIVE humans ADD to flour by LAW. For younger people it’s not a problem as Folic acid is broken down to FOLATE which we should get naturally in our food. HOWEVER as we age we are no longer able to breakdown the Folic acid and it becomes TOXIC! So our governments have passed law that ALL wheat flour is to be fortified with Folic acid. Result a beneficial addition for pregnant women and a slow toxic additive for the elderly. Folic acid is NOT FOLATE

[@glennpowell1838]

Re. Omega 3s, where do the fish get them from? They get them from Marine Phytoplankton, a type of ocean algae, a plant. That's where I get mine from too as well as Chia Seeds which is even higher than Flax and more assimilable. It is misinformation that we need to eat more fish. I have not eaten any meat fish eggs or chicken in 46 years and I am 66 yrs old. Why eat dead corpses when everything you ned is found in plants and milk products???

[@davmus1112]

There's 91 essential nutrients plus phytonutrients plus fiber plus leatrile.....this guy is way short on his number

[@fondrees]

Dr. Wallace I presume?...The more essential nutrients, the more profits for Wallace's products.

[@davmus1112]

@@fondrees you're kidding right? Ya he sells products, but the 91 essential nutrients are 60 minerals 16 vitamins 12 amino acids 3 fatty acids. Essential means we have to eat them, it's not a marketing ploy

[@fondrees]

@@davmus1112 just counterpunching your unwarranted hostility towards Dr, Ames presentation. nutrition is a very complicated field and noone has the market cornered on whats true and whats not true. still plenty to learn. i am sure Dr. Wallace would agree.

[@normanspurgeon5324]

I'm surprised that this fellow, who seems so knowledgeable, is referring to folic acid, which is a synthetic substitute for folate, the natural vitamin. Folic acid is supposed to create problems in the liver.

[@joeythehat9]

He says folic acid when he's talking about the dose-response studies and food fortification where they use folic acid. Then he goes into detail about the different forms of folate and says to eat your greens 17:57 Also, the only study I found about folic acid and the liver was a mouse model study but it would be nice to see more on this. The only thing I know is smokers seemed to have higher incidence of cancer when taking synthetic b12 and folic acid supplements.

[@heide-raquelfuss5580]

I sometimes think, you can not study and know everything. But he is cute and he seems genuine in the medical field.

[@kabropatai5476]

Vitamin K2 prevent classification not vitamin k.

[@lilianagay9075]

Calcification

[@bertimus7031]

Extremely dated and disingenuous news. I started listening to Dr Eli Wallach 40 years ago and he should be given credit here. He was nominated for the Nobel prize and he should get it. Take your Beyond Tangy Tangerine.

[@maverickmckinney1796]

Wow, watching how the puddles of sweat just dried up within 48 hours was so satisfying, I used what I read about the other day. Although it actually took about 72 hours for the my sweating to normalize, I went ahead and go'ogled the latest by Cynthia Yulesin and I don’t have to change clothes 2 times a day.

[@malcolmpeppiatt7743]

47.00 autism

[@viralv180]

U

[@LaneCodeRedCarnivore]

That list of what young people eat is what is heavily advertised . Monkey see monkey do !!

[@gitanjalinandan]

This guy looks really old!

[@fondrees]

He was 85 when this was recorded

[@micaonyx5301]

I'd love to see what you look and sound like when you're his age which is 85🤔

[@lf7065]

He'll be 94 on December 16, 2022. 🙂

[@nickkrug8157]

How dare you not mention or talk about the gluten issue !!!!!!!!!!

[@lf7065]

The gluten issue is a GLYPHOSATE issue. Peoples have cosumed gluten for many thousand years as part of their diet. Gluten was not an issue. It is only for modern man due to pesticide exposure and soil mineral depletion and the consumption of foods with chemical additives.