Applied Pharmacology 3, First Pass Metabolism

Pharmacokinetics and Pharmacodynamics
Bioavailability - the proportion of an administered drug that reaches the systemic circulation in unchanged form.
First pass metabolism, enzymes in gut wall, hepatocytes, Smooth ER detoxified toxins.

[@Summertimeangel]

wow just in time for my pharmacology class :) I just started this unit too! Thank you Dr. Campbell.

[@jo6161]

thank u prof that's illustration keeps helping me throughout studying medicine you have very good methods and most importantly you can simplify the information in no time ^-^

[@helenabonwitt925]

Thank you Dr. John! I'm a vet student and find your videos very clear and informative

[@ronnie.1983]

Thank you for the explanation Prof.👍

[@deeptinagar4078]

Thank You! Dr Campbell

[@rachelmacleod6962]

Many thanks, this helped me a lot!

[@ramubadireni5126]

Thank you sir..and one thing to ask you sir. .. Metabolism(anykind) is a biochemical reaction that resulting a reversible/irreversible product ..and those can be happened through out the body.we referring the first pass metabolism as the drug (any biochemical) that transformed in the liver before entering the systemic circulation.If any bio transformation through parental route (or direct in systemic circulation), what it called so.I mean why we used to say like that (first metabolism) instead it is metabolism as all over the body differ in type of enyme systems AS we don't know for new drugs in the coming days.

[@rororonan]

Thanks for the video! Just one question, I often seen first-pass metabolism defined as "the metabolism a drug undergoes before it reaches systemic circulation"; is the breakdown of an orally-administered drug in the stomach/intestines included, or is it only the action of the liver that makes up first-pass metabolism?

[@xDomglmao]

Wikipedia: "[...] It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall." I guess technically you're right. Thanks for asking this, I think I would have overseen it otherwise. EDIT: Just checked quickly the French and German wiki version, German says liver only (beginning of wiki), later adds some other stuff; French is not stating it that clearly and mentions only liver.

[@traceymacgregor4337]

many thanks for your easy to understand explanations

[@xixi2693]

Sir please I have a question When everything exists within nature, whether it is vegetable fruits or allopathic medicine, how the body detects that allopathic medicine is a foreign material ? ? Because allopathic medicine is man made but it from a combination of the matter that exists within the nature so we consider it as natural. Then how the body detects that allopathic is foreign material ?

[@sweta4211]

tq sir made it so easy to understand☺️

[@geojor]

thanks for this ...

[@tamhewitt-baker5602]

also thank for a great lecture. test incoming

[@sopheaptharyna8985]

Hi I am in Cambodia.i just study medicine for first year.i still don't know a bout which book I have to choose.please give me some information.

[@nadiaaref4627]

Thank you so much

[@angelaisacliche]

Hi Dr Campbell, I'd really like to buy one of your books, but it looks like they only ship to the UK and the US. Is there any way I can get one all the way over here in Australia? Thanks :)

[@Campbellteaching]

Sure, Australia is no problem, but you do need to order in dollars, there is a link on; campbellteaching.co.uk There is one book on Physiology and one on Pathophysiology

[@Campbellteaching]

Sure, download e copies from campbellteaching.co.uk

[@junczhang]

thanks!

[@nadiaamniouel2188]

good job

[@ramubadireni5126]

And what the FATE of a drug at site of action as it leaves the site unchanged after the pharmacological action .I mean without any lose or gain how the reaction is governing.

[@ramubadireni5126]

So then we say A Drug is an Enzyme.

[@Campbellteaching]

This fate depends on the drug, some drugs are acted on by tissue based enzymes, such a cholinesterase, others are metabolised in the liver as they circulate systemically.

[@njeong]

ramu badire --/

[@sabar8]

Thank you

[@jamestucker1068]

@ Dr .john sir i want a piece of advice from you sir i want to study medicine at 31?is it feasible given some people say it is voluminous and gruelling nature of course.do course require a total dedication and you have to neglect other family duties ,i run a small business(whole sale distributor) .can i manage simulltaneously both .sir please guide me to have proper insight on rigours of medical school .how important are practical classes (like dissecting bodies ).is theoretical knowledge enough?am i too late to study medicine that it sounds ludicrous .A detailed response will be highly grateful? And if you think i am feeling particularly brave, if anyway would you suggest to test my aptitude.

[@Campbellteaching]

For sure you can study medicine at your age, its just a matter of how you will finance yourself. If you have the time to dedicate to the work, you will be able to do it. Running a business at the same time will of course make it more difficult. If you have experience of science and care work, that would be an advantage. The more specific answers to your questions will depend on where you want to study, it would be worth arranging a visit to your local medical school. There are also possibilities to study related professions such as nursing or pharmacy.

[@Campbellteaching]

I know lots of people who have done medical and nursing courses in later life, of course its not too late.

[@tamhewitt-baker5602]

I wonder if I have an avocado heart too.

[@Campbellteaching]

what does that mean?

[@tamhewitt-baker5602]

@@Campbellteaching the shape of the heart you drew reminded me of an avocado. Im just being silly. a solid week of study will make you slightly delirious. that's my excuse. again many thanks. very helpful.

[@Campbellteaching]

@@tamhewitt-baker5602 O, OK I get it now

[@fir7102]

Fell so hard it's sad

[@lyrebsuniverse9319]

that sound of the pens and markers are painful!!!!!!!!!!!!

[@sopheaptharyna8985]

Hi I am in Cambodia.i just study medicine for first year.i still don't know a bout which book I have to choose.please give me some information.

[@xDomglmao]

For which subject?

[@Campbellteaching]

You need to read a few and see which ones you like. I did some teaching at Life University Cambodia, love the country.