Can we stop aging? | Andrei Gudkov | TEDxMorristown

Scientist and expert Dr. Andrei Gudkov tells us what aging really is, how and why it happens, and what our future might be. What is the key to longer, healthier lives, and is it in our reach?
Andrei is a preeminent cancer researcher, Senior Vice President for Basic Science; Chair of the Department of Cell Stress Biology, and a member of the senior leadership team for National Cancer Institute (NCI) Cancer Center Support Grant at Roswell Park Cancer Institute (RPCI). He is responsible for building on the basic and translational research strengths of the Cell Stress Biology program in DNA damage and repair, photodynamic therapy, thermal and hypoxic stress and immune modulation. Andrei was formerly at the Lerner Research Institute, Cleveland Clinic Foundation, where he served as Chair of the Department of Molecular Genetics and professor of biochemistry at Case Western Reserve University. He earned his doctoral degree in Experimental Oncology at the Cancer Research Center, USSR and a Doctorate of Science (D.Sci) in Molecular Biology at the Moscow State University, USSR. He has authored or co-authored 218 scientific articles, holds 54 patents and co-founded six biotech companies, including Everon Biosciences, Inc. that develops antiaging drugs.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx

[@irinagadolina7453]

Thank you dear lector!

[@annadenkova]

I love this presentation! Smart and with a great sense of humour!

[@Rico-Suave_]

Watched all of it, great news and video

[@DeepakKumar-uv3zo]

Amazing

[@user-xx2bj2xt9b]

How I have never heard of it?Mind blow

[@johnkopf6816]

I like the ideas shared. It does seem like the start of of a scary movie where they wake up something in our DNA and it spreads.

[@conversascontroversas7384]

WE NEED THIS, SAVE US, SAVE HUMANITY TO THE TERRIBLE END

[@jeremyanderson6789]

Yeah save humans and animals too making becomes younger.

[@conversascontroversas7384]

@Ana Niorba yes

[@shanthithomas3675]

Interesting

[@charlesdavid7762]

As noted, there are multiple causes of aging. The first is due to thermodynamics and the increase in entropy that occurs in a system that uses energy to process information. There are just a few states for a living cell while there are almost an infinite number of states of death and decay. The second is due to the accumulation of damage that occurs when there is no proper repair. The body is excellent at healing when provided the resources to do so, but most people do not provide the proper resources. The most important resource is pulsed nutrition with periods of feasting and fasting in synchrony with one's neuro-endocrine cycles. This allows the body to clean house via the cellular mechanism of autophagy while activation of the sirtuins in the presence of high levels of NAD+ facilitate DNA repair, including restoring the telomeres. The re-feeding/feasting phase activates the stem cells to rejuvenate damaged cells, like the immune system, brain, and muscles thereby preventing the onset of frailty, autoimmune disorders, inflammation, and dementia. Also, maintaining proper methylation of one's DNA prevents endogenous virii from activating and causing harm. Receiving blood transfusions or vaccinations that are contaminated with retrovirii can also activate those endogenous virii. While treatment with retro-viral agents such as those used for the treatment of HIV (AZT) might help to fight off any activated retrovirii, there is no evidence that it can perform the other tasks needed to prevent frailty and the steady progression to death. Sorry, but that is not the fountain of youth.

[@nz7921]

Who is here during the COVID-19 pandemic?

[@donovan3956]

Me, and COVID-19 reminds us of the importance of fighting against aging (especially against the aging of the immune system) because the elderly are the main victims of the virus.

[@Discoverythepast]

correct!

[@royzlatanestevez9843]

FIVE years ago and we are still aging. They will still be talking about "stopping aging" in 30 years (well, probably different people, because AGING) and nothing will change. AGING is a FACT of life.

[@iche9373]

Never heard of Biotech company Altos Labs sponsored by Elon Musk, Jeff Bezos and other rich guys? Just saying.

[@royzlatanestevez9843]

@@iche9373 Sure, I did. They are still saying the same things, with more money, as people like Sinclair etc have been saying for the past two decades (a bit shorter if you only count social media presence). They'll still mutter about it when they are in the OLD PEOPLES' home, DEMENTED by AGING, babbling to themselves. Bezos is in his 50s now. You really think he will get away? Aging will crush him before he gets very far. He almost literally needs a breakthrough technology TOMORROW or he is done for.

[@iche9373]

@@royzlatanestevez9843 They made progress, just saying.

[@iche9373]

The problem is that you are BIOCONSERVATIVE. A lot of Japanese people or Weebs are conservative.

[@royzlatanestevez9843]

@@iche9373 Yes, I think so too. In the long future, people will be able to use this technology.

[@noemorin2169]

TY

[@quinnjones1655]

Amazing what can happen when enterprising students have access to research grants ... \

[@ralphrose1]

This TEDTalk reached so many pathways of mind stemulation.. Genius Talks Ted👍😃

[@wabisabi6802]

14:47 Exactly

[@MrMpalmer33]

Examples please...

[@caroledevlin5185]

I am time traveling. I started in 1960. From my experience, our vision is going to improve January 1. We will all see 2020!

[@FarfettilLejl]

This comment did not age well

[@bengil4862]

farfett_il-lejl 😂😂😂

[@elementofpower4140]

Thanks for Jinxing it.

[@jdtv50]

“There were no people born of the 19th century here today” The immortal dude in the room: *adding that quote to list of coincidences since he’s present*

[@ConfirmedCynic]

Four years ago now. I don't see any publications on this. What progress has been made?

[@funnyfyr]

I recommend following the SENS foundation or David Sinclair for news on this topic.

[@gaurd3]

Scotty!

[@faismasterx]

I quickly read the title as, "Can we stop arguing?"

[@squamish4244]

Harder question to answer :)

[@gabrielincognito8855]

Only if you accept that gender is on a spectrum.

[@happinessyogateacher]

lol

[@jeremyanderson6789]

Stop, yes, delay Yes! Younger awesomeness.

[@faizan9697]

😍

[@Coinpicker]

Aging cell damage sounds like effects of free-radicals.

[@shanthithomas3675]

Wow

[@ennervool7771]

Make a self-improving A.I and task it with finding inmortality

[@n3gi_]

I'm sure that the scientists would have already done it if that was possible.

[@gabriellitewski7988]

Where do decide when I've had enough!?

[@lordvoldemort6008]

Only I can live forever..!

[@j.milleraabamsc9400]

lmfao!

[@faizan9697]

Wait and examine

[@aaliyahlee1265]

There is actually no problem with aging. It comes naturally and it is beyond our control. However, we are the ones responsible on how to slow the aging process. Can you notice that many people in their 50s actually look like 30s. 70s look like 50s! Well… Growing old is no piece of cake, that is for certain. NMN and resveratrol are seen to affect health positively and do reverse aging. Since no healthcare company wants people to live a healthy life (how will they run their business if that happens.) I started taking the NMN by Vitruvin with 500mg and seeing very good results. Especially, NMN is boosting my energy levels very effectively. I also think the results might vary from person to person.

[@darrendwyer9973]

82,000 dna extractions or executions means 3420 or so dna extractions per hour, which means about 57 extractions per minute.... or approximately one protein sequence interpreted each second... by extractions, I mean, dna is encoded and is submitted to the ribosome which creates proteins based on the instructions in the dna. maybe people could think about this more.

[@wilhelmkiev1223]

At first I read this "can we stop arguing" lol

[@galtbarber2328]

If he is right (and I doubt it is so simple) then using genome editing tools to remove endogenous viruses in our junk dna would greatly expand the lifespan of many creatures.

[@DieterBuys]

Yeah but this accounts for such a huge proportion of our DNA and so much of it is profoundly entangled with actual working systems of the body. It's not like you can just delete 8% or more of a complex mammal's DNA and expect good results, although perhaps in the end game we will be able to break these viruses permanently through rearranging their DNA to something harmless in humans.

[@Victor-Alexander-J]

how about accumulation of mutations in DNA repairing genes (due to radiation etc.)? some estimates put this mutation rate at 1 / 25 years, ( or 4 per 100 years, which is estimated to be lethal)

[@faismasterx]

Dieter is right. Invading the genome and abruptly lacerating huge parts of the code may very likely (with a high degree of probability) have unforeseen consequences in normal functions in a way that might have the opposite intended effect. The converse is also likely to be the case wrt gene editing in fully grown organisms. Gene sequences aren't lego blocks. Though, sometimes I wish they worked that way.

[@changjeffrey829]

Galt Barber there’re actually a lot of research papers supporting his claim. Obvious you can’t get eternal life from just doing this, but expand it 20 percent is actually possible. There’re other issue such as lack of NAD+ and stem cell we also need to deal with but we are definitely on the right track.

[@rhyothemisprinceps1617]

@@changjeffrey829 I've searched for papers that support the claim the endogenous retrovirus activation is responsible for the induction of cellular senescence but have not found any. If you have citations, please list them.

[@vitaminboss]

Doesn't telomere shortening lead to DNA damage which leads to cell senescence?

[@adrianapalumbo6889]

That's what I was taught.

[@arthuralmeida3319]

Senescence can be induced in differents ways

[@averagesauceenjoyer7209]

Maybe we should think of a different methode to reduce H2O2 production in our system.

[@happinessyogateacher]

Funny ending! Watch all of it!

[@vulcanprincess1584]

in other words how can we call ourselves so civilized when we're still losing battles to microscopic "non-intelligent" organisms

[@curtseed11]

Most humans want to dominate other others human they see beneath them since that has proven to be simple compared to past civilizations. The unknown is not worth their time even if that means death will come knocking. If we were really serious about stopping ageing or slowing it down so that our brains match our bodies we will make it an institution to stimulate all minds to contribute to the cure. Until then everybody will just be in denial like everybody else until they die and rinse & repeat. We are the laughing stick of the universe.

[@myearsgotyouthsystem8802]

@@curtseed11 unfortunately it wasn't a priority.

[@theflippestside]

If the science thing doesn’t work out this dude should go into comedy.

[@saraiwongkaew2113]

I am trying to learn about all chakra for absorbing energy of life from nature.I meant trees, water, wind, sun,wind. Particularly trees have energy of life. Meditation will promote young cells to all of lives.😁🌱💑 That why human should keep and increase pure nature .

[@lupaman100]

Dr Andrei Gudkov is both smart and funny at same time....I cracked up when he said the word "Alcohol"..lmao

[@ghffrsfygdhfjkjiysdz]

There in an alternative theory, which suggests that it is the length of telomers that determines how healthy the dna and cells are. It clearly correlates to health of human body. Interestingly enough, part of that theory is that the telomers can loop back to the middle sections of dna and repair the sites that turn genes on and off. As telomers get too short to keep turned off genes in check, the "virus" genes turn on and mutate cells perhaps?

[@suncat9]

It's not an alternative theory. It's ANOTHER cause of aging, of which there are many. These include the accumulation of senecent cells and DNA damage from chemicals and radiation.

[@henryaguila2772]

I found a way to slow aging, through G meditation.

[@kkostadinof]

Virii don't care about meditation. They will kill you just the same.

[@olesyasen3988]

can I get a couple of these drugs, please :)

[@darrendwyer9973]

what happens if you imagine dna is like a ticker-tape, being fed incrementally into the ribosome to create 10,000 or more protein types each day.... maybe this ticker-tape of dna is fixed length, say, 100 years or so, and then the ticker-tape simply runs out of code? what would happen if you extended the length of dna?

[@chrissilliker8633]

There is a cap on our dna called the telomere cap

[@LilRedRasta]

Stop? No. Delay? Yes.

[@LaVictoireEstLaVie]

Stop? Not yet. Delay? Yes.

[@MrChiangching]

Stop? No. Clean up and repair? Yes. Just as good.

[@jeremyanderson6789]

Stop aging forever yes , stop growing up forever in real life yes. Remove time and death.

[@averagesauceenjoyer7209]

Relinking nerves again ? Yes.

[@kaininjathundermmandopoke5167]

@TrzpGzd yes it is.

[@sarah.taylor]

Who’s here after Age of Adaline ?

[@xtertristl]

I'd be happy with 20% longer life assuming 100y life span that's 20 years

[@curtseed11]

More like 20% longer youth.

[@GeorgeEast-hj5zt]

If you can still make it to the toilet on your own, it's good! If you keep aging but just survive 20 years longer, that's a definately NO, THANKS!!!

[@TheProRebel00]

If we managed to pull this off and completely stop aging, then what about world population?

[@abdelmanzalawi8957]

The universe has 2 trillion galaxies as far as we know. There is Unlimited number of planets out there.

[@christopherellis2663]

The good doctor is somewhat younger than me 🖤 yet I look younger than he . LXX 💱 XXL 💙 Senescent cells do not need some laboratory 🔬 concoction to be removed, because the natural bodily processes, if left to it, can process them. 💚 🧙‍♂️

[@donovan3956]

Except that this system is imperfect and sometimes it forgets certain senescent cells.

[@ismaeelmahmood7259]

Bro your profile pic looks atleast two decades older than him. And besides, humans have been leaving things to 'bodily processes' since we first walked the planet, its never stopped our aging yet, we have no choice but to intervene if we want any change. I'm not trying to offend tho, gl man.

[@splash-ce4ry]

20 % longer life is much tho ? isnt it ? or did i understand it wrong

[@prabhdeepsingh1]

Is this video not like the backstory of a zombie virus that will kill humanity

[@Noum77]

When I like the idea of living longer as much as the next guy, I don't think the Earth can support more people

[@abdelmanzalawi8957]

Hi there. Comparing to our sense of space, the universe is unlimited, the energy out there is also unlimited. The raw materials of living can manufacture to a point that it seems unlimited. We can manage to cultivate a trillion person civilization if we want to. Think about how much we've already achieved. With the right guidance, we can do an infinite wonders. Thnx, a sociology teacher 🍵

[@Noum77]

@@abdelmanzalawi8957 I'm more onto a biological point of view of the universe, and we human can only survive by depending on biological diversity. And turns out, 99.9% of stuff that fills the observable universe are just dead rocks/gas/water... and life can't survive there. It's very optimistic to think that we can be as infinite as the universe but until our technology was able to terraform planets to make them habitable or turn any dead matter into something edible, I'm afraid we are stuck here on Earth for the time being, unless of course we all turn into robots lol

[@compucentrum]

All of the free lectures on slowing aging are meant to discourage you from prolonging your life. Eat foods that accelerate aging, wait and grow old. We have known since 1956 how to prolong life two to three times. But we will not tell anyone, certainly not for free.

[@weirbm]

This comment makes no sense.

[@curtseed11]

Why wouldnt those "in the know" just show some samples of longer lifespan humans and charge everybody once it is proven in front of their eyes?

[@absoluteunit3885]

@@compucentrum Cool story bro but you sound like a scam artist

[@compucentrum]

@@absoluteunit3885 - You sound like a victim who has succumbed to mass hysteria.

[@compucentrum]

@@absoluteunit3885 - Let me ask you a question: How do you know people who take synthetic anti-aging chemicals? Are they young? No. For example, the Queen of England is 95 years old and her husband 99 years old. They are old. Those twice-life-prolonging drugs cause those who take them for 20 years to be 10 years younger than they are. That's simple math. E.g. he starts at 50 and at 70 looks 60. Just 10 years younger. Foods that accelerate aging are not as effective. Whoever eats them 50 years old looks 10 years older. There are a lot of such people.

[@jacobalmeda1182]

YES CAN LIVE LONG BUT FOR DISTRIBUTING HOW ARE NOT NOW, NEEDS TO TEACH FIRST THE PEOPLE BECAUSE IF ALL HAVE A LONG LIFE TREATMENT PLANET WILL BE OVER POPULATION AND PLANET WILL DESTROY LIKE WHAT WILL HAPPEN NOW

[@SI-ln6tc]

Live in space

[@squamish4244]

My back hurts. My knees hurt. Where are these drugs?

[@katiie7]

valar same, & I’m 27 haha. Fasting has been actually helping through i must say

[@hemie67]

NAD+

[@averagesauceenjoyer7209]

Last time I checked I didn't find a way to reshape and build knee bones or pelvis bone with bone cells themselves. But I don't know really.

[@user-hf2gh3vp5p]

100 years ago we didn't had cars now we are weekly flying to space and created AI thats smarter than any human. I dont believe i know we can stop aging and maybe even in less than 50 years from now.

[@cluelesscastelino150]

Get ready to be disappointed

[@fitzroyarmour7391]

the fossils and geology prove All created as in Genesis

[@mirzakadric8257]

So basically that ancient DNA virus trigger mammal evolution???

[@zettcompact8586]

Do not tell about that to Putin!

[@gabriellitewski7988]

I hate myself!!!!!

[@christyndoh3953]

Sin=Aging and death. But death will be destroyed forever and those who believe in God will live forever. So, sorry guys, this mortal form of ours can only take/handle so much before "the center can no longer hold". Death should not be feared, it is not the end, its just a state of waiting.

[@curtseed11]

So what's the point of being born and dying shortly thereafter along with the potential of being afflicted with disabilities, diseases, mental distress, hard labor throughout, sleeping for 1/3 of it and being being paralyzed either mentally or physically for the last few years? Why keep rinsing & repeating millenia after millenia? Sadistic God much?

[@christyndoh3953]

@@curtseed11 I can't say i understand your perspective totally. And i don't know if the picture you painted in your reply is reflective of your situation or maybe that of a loved one. Either way, it must be hard. And often times, nothing makes sense anymore. But the bible teaches that the only solutions to man's problems and confusion can only be found in God's word. The only way to know about His plan is studying the bible. I pray that God will help you or your loved one through this process.

[@curtseed11]

@@christyndoh3953 I would recommend you work on relieving some of the headache most of humans go through instead of praying and recommending others read that bible. There are enough of us doing that already and have been doing it for millenia. Time to try different approaches. I'm speaking on behalf of the human species. We all are brought to a wasteland with being asked. We suffer throughout our lives pretty much with new challenges and pain every year. If we humans found ways to make things easier on ourselves like the pain associated with ageing we might still look forward to spreading that gospel and entering that kingdom with a lot more anticipation and less feet dragging. What's the point in learning all these lessons if we dont get to take those experiences and memories with us to a place never been proven before? One big crapshoot and can't end quick enough for most of us. Now we have to feel guilty or pressured into doing something based of off two choices given to us? When do we decide what choices we make for ourselves and choice which one we select? There will be human tech that will stop/reverse ageing and followers of faith will jump on it as well and never retract their opposition. And everybody knows it. Thanks for trying to pray for me but try to help scientists figure out how to keep us stronger longer. Any ideas?

[@christyndoh3953]

@@curtseed11 people may be living longer, but we actually happier? Prov. 3:1&2 tells us how we can live happier, healthier, longer lives. I hope science breaks the code soon. But for anyone who have enough faith to believe (though the world call it FOOLISHNESS), death will be defeated and they will live again- free from disease and fear of death( 1cor15:26). Pls open your heart to this good news and accept God's free gift of eternal life.

[@curtseed11]

@@christyndoh3953 Supposedly it is better to give than to receive so says wisdom. So why would we take a free gift of eternal life? We never asked to be here in the first place so why would we given a choice of life and death when we weren't given a choice of life or death before we were forced here? Seems pretty sick and sadistic. As for people living longer being happier, I'm not sure but it is what it is & since it has become that way then men are going to be more curious to see what else can be accomplished like quantum computing, AI, nanotech and the cosmos. I think we should figure out death first as a way to deal with being brought here in the first place. We didnt ask to be here. So while we are here shouldnt we have say in how long we want to stay without suicide being the only way out?

[@darrendwyer9973]

3,000,000,000 or so dna 'bits'... divided by 100 years == 30,000,000 genetic sequences are decoded each year.... oh, it's 82,000 dna extractions per day...

[@kicknadeadcat]

Could you imagine the size of the population of the earth if everyone could live past 100. This planet can barely sustain us as it is. Solve one problem start another.

[@javierderivero9299]

Nothing new ...Malthus wrote about the same, over 200 years ago....he said that we couldn't live in the planet if we were over a billion people......then we are still here, breeding and kicking living longer lives than ever, and yes we are almost seven billion people, seven times Malthus limit

[@julianlockwood3040]

The rate of deaths would resume at the normal level once the average extended lifespan had been reached, and the age of fertility would remain unchanged. The population increase would therefore be quite manageable, unless the increase in lifespan was very substantial.

[@joejimbo9907]

Over population is solved. Have less children,

[@Flying1Machine]

colonize other planets duuh

[@Phatnaru0002]

A) We just have fewer children naturally (look at Japan) B) Even if people didn't naturally have fewer children, we could always impose laws if it became an emergency. Not the Best solution, but still a solution. C) As we spread out into space, which, with that increased lifespan would happen much sooner than you would think, we wouldn't be able to reproduce fast enough.

[@Coskunmusic]

And then..... 2020 comes into the show with Covid 19, 20, 21, 37, 54

[@kaininjathundermmandopoke5167]

I WANT THIS COID19 NIGHTMARE TO END NOW NOW NOW.

[@Coskunmusic]

@@kaininjathundermmandopoke5167 Yup! Me too haha. I just wish we never had it to begin with!

[@kariahlukemacchan2230]

Noah lived to 800 beat that! Sarah, Abraham’s wife was 100 when she became pregnant. Both didn’t need to fast. Beat that!

[@curtseed11]

Why aren't there any millenials aged human beings now? Shouldnt there be some type of Bible update every millenia just in case people need to be reassured?

[@kkostadinof]

Cool story bro!

[@ismaeelmahmood7259]

If humans managed to achieve biological immortality then we'd probably survive 9000 years before dying of causes such as car crashes. I watched a youtube video that said that and since that's not exactly a 'reliable' source I'd urge you to take with a many grains of salt. Still, a fascinating concept to dreamboat that one day may become reality in some form.

[@michaelshannon9169]

Only time and boomers can stop us.

[@chrissilliker8633]

24000 votes from one address in wisconsin wtf

[@Jgrinnylife]

Only RE5 Wesker has the solution (The right to become a god is mine)

[@manishsharma-fz6sb]

baba tum kitne saal ke ho

[@back2davinci525]

Can we stop aging? Goes on to age himself.

[@jeremyanderson6789]

Time is the true enemy.

[@jeremyanderson6789]

Stop aging forever in real life

[@teenforever16.idontwanttob53]

!

[@harryviking6347]

Even the Universe is aging.....

[@jayydudley5897]

By the year 3000 anything should be possible

[@jeremyanderson6789]

No more years, no more decades hurry it up and sorry

[@kaininjathundermmandopoke5167]

reverse the aging process in humans turn back the clock fountain of youth in real life THIS YEAR, teen forever in real life.

[@jeremyanderson6789]

This YEAR 2021😤

[@TomRivieremusic]

I think ` ALLA `the Muslim said; That there are 32 virgins waiting for a man when he dies. I don't believe him. I prefer to have them now, just in case he is a liar. Talk about virusesand next cliff.This the happiest day of my life.Right up there with my divorce.

[@fubar226]

So this is how we create zombies.

[@postnubilaphoebus96]

Couldn't watch that. He's not very good at giving talks. Let's at least hope he's better with his research.

[@whatever2981]

He is just fine, you should try harder or don't bother criticizing or learn Russian and hear him talk in his first language.

[@nickvk1aa450]

I feel same listening to Trump

[@GeorgeStar]

A health expert that's 50lbs overweight? Not very confidence inspiring.

[@heartbeatstorm983]

No you can't stop the aging process.. Unless you have found the cure for idiotism..

[@donovan3956]

Do you have proof that aging can't be stopped ?

[@donovan3956]

@Ahmad Toqeer Healing aging and overcoming death are two totally different things. Eternal youth absolutely does not protect against external causes of death (cold / predator / disease ...) Some species do not age and are still forever young, but they are still fatal because they can be killed by an outside element. Aging is not useful for evolution because not only does it not contribute to the survival and reproduction of the individual, but it decreases the survival and reproduction of the individual who is affected. And since evolution only works at the individual level, aging cannot be intentionally programmed (as said in the video, these retroviruses have pathologically appeared in our genomes and nature has failed to eliminate them.)

[@jeremyanderson6789]

Yes we defeat the aging process it is possible 😠.

[@jeremyanderson6789]

@@donovan3956 it can be stop too.

[@teenforever16.idontwanttob53]

Aging process can be stoped in humans in real life this is Sci fi 😤

[@om.mohammadibdah2995]

Death is the ultimate fact in life. God all mighty has programmed us to die. Justice requires that. There should be a day of judgment so that those who were oppressed in this life will get revenge from their oppressors.

[@kkostadinof]

How's that justice?

[@faizan9697]

Yes i appreciate u

[@crazyharmless666]

no....no we can't.

[@jeremyanderson6789]

Yes we can

[@teenforever16.idontwanttob53]

Yes….. we Can!!!