CAR T-cell Therapy explained (Manufacturing process & how it works)

Hey friends,
CAR T-cells are modified T cells which express tumor specific receptors. CAR T-cell therapy is therefore used as a treatment option against some sorts of cancer. How CARs (= chimeric antigen receptors) are expressed on T-cells will be explained in this video.
Best
Henrik
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References:
pubmed.ncbi.nlm.nih.gov/32301...
www.cancer.gov/about-cancer/t...
www.cancerresearchuk.org/abou...
Time Codes:
0:00 CAR T-cells in the fight against cancer
0:26 What are normal T-cells?
0:51 CAR T-cells
1:37 How CAR T-cells are produced
2:34 Mechanisms of action of CAR T-cells
3:03 Outro
#CAR #T-cell #Therapy #Cancer

[@mikedaniels3009]

I salute in advance THE ONE Person who'll finally explain WHY they are called "T-cells".

[@arshpreetsingh8971]

Because they mature in Thymus gland

[@mikedaniels3009]

@@arshpreetsingh8971 aah, well done, truth be told, from one medical guy to another, no-one in the content creating community seems to care much about talking laypeople's language.

[@AtronsTube]

It's phenomenal explanation brother. Thank you! Keep up the good job.

[@Rocknload33]

Short and very informative video, thank you!

[@julioalexo]

Thanks for the links!

[@swadhasingh6095]

Thank you it is very useful video .I have easily understand this topic

[@solonass.9481]

Well explained !

[@mohamedsamir6751]

excellent summary

[@rufinamenezes7712]

Very informative video. Thank you very much

[@cchiliman]

Really helpful, thank you

[@risharajkhowa5060]

Amazing video

[@deepanwitaray2382]

Very helpful video sir....Thank you.

[@Vietnam_Da]

It is an inspiring opportunity of treatment. against cancer. I am really interested in Human Medicine and successful treatment against cancer and new treatment opportunities. My biggest dream is to become a surgeon and to doctorate about tumors and cancer and new their therapies.

[@yahyayozbatiran]

Could you please tell me how to design CARs? I understand CARs are delivered via lentivirus or CRISPR-Cas9 but how CARs are modified I mean there are so many CARs such as anti-CD19, anti-HER2 etc... If I want to design anti-CD123 CAR-T cells what are steps should I follow?

[@bencyber8595]

CAR-T cell chimeric antigen receptor CT19

[@madalinapopa1006]

Can someone please tell me what protein is present on the surface of tumor B cells?

[@ezekielzuniga8127]

There are multiple proteins present on the surface of any cells. Malignant B-cells often times express CD-19. This is why CAR-T cells are engineered to express this protein.

[@WhirlwindHeatAndFlash]

Aye-moon

[@vikky4209]

0:55

[@maygapiano3318]

Hello, I'm from China, and my mother is initially suspected of multiple myeloma, and she also wants to use this kind of treatment. Which city and hospital do you need to go to for this kind of treatment? thank you！Save my mother, I will thank you all my life! thank you

[@henrikslab]

I am not a medical doctor, I am sorry not being able to help you. Please contact medical staff for those matters. I wish you and your mother all the best!!!

[@avaxfuture8282]

You can search it as immunotherapy on the internet as well. It is a form of immunotherapy.

[@demogyani2419]

Waiting it for HIV.