CAR T-cell therapy: Reprogramming the immune system to treat cancer | Rob Weinkove | TEDxTauranga

At the Malaghan Institute for Biomedical Reserach,researchers are developing third generation CAR-T immunotherapy treatments which aim to be more effective with less side effects than previous therapies.
Using patients own modified T-cells, CAR-T therapy has the ability to vanquish cancer cells, vastly improving outcomes of once life threatening diseases.
This year, 2019, Rob hopes to begin clinical trials for CAR-T therapy in New Zealand through the collaboration of scientists from the Malaghan Institute and international researchers. He is optimistic that this next generation treatment will present a new paradigm for treatment of lymphomas and possibly for other cancers in the future.
Dr Robert Weinkove is Clinical Director of the Malaghan Institute, a biomedical research institute in Wellington, New Zealand.
After studying medicine at the University of Cambridge and Kings College London, Rob trained in Haematology in London and Germany before moving to New Zealand in 2008 and gaining a doctorate with the University of Otago.
Rob is a key member of the Cancer Immunotherapy Programme to develop and manufacture ‘chimeric antigen receptor’ (CAR) T-cells for treatment of lymphoma and other blood cancers. He also holds a joint role as a Haematologist at Wellington Blood & Cancer Centre.
www.malaghan.org.nz/our-histo...
LinkedIn: / robert-weinkove-8a1b3842
Dr Robert Weinkove is Clinical Director of the Malaghan Institute, a biomedical research institute in Wellington, New Zealand and holds a joint role as a Haematologist at Wellington Blood & Cancer Centre.
After studying medicine at the University of Cambridge and Kings College London, Rob trained in Haematology in London and Germany before moving to New Zealand in 2008 and gaining a doctorate with the University of Otago.
Rob is a key member of the Cancer Immunotherapy Programme at the Malaghan Institute, where he leads a programme to develop and manufacture ‘chimeric antigen receptor’ (CAR) T-cells for treatment of lymphoma and other blood cancers. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx

[@H-TownSportz]

I am the first ever Hodgkin’s lymphoma CAR-T cell transplant recipient at MD Anderson in Houston, Texas. I am being discharged today and am looking forward and hoping for complete remission and healing! Big shout out to all the doctors who have been following me and guiding me through the process! Strength and encouragement to anyone going through cancer and I wish you the best in your fight!

[@elidamuse1085]

Tux k hoj

[@vanitapatil9897]

How are you now? Plz reply 😭😭😭🙏🙏🙏

[@palmtree9815]

Prayers for your healing! I’m here at MDA now and waiting for insurance to cover my car-T cell therapy! Thank God for these heroes and hospitals. 🌴🙏🎯

[@anuragcvsr7169]

How are you doing mate? Have you been healed and cured from your disease?

[@palmtree9815]

@@anuragcvsr7169 I’m recovering slowly but well here in Houston. Haven’t had scans yet-Jan 13! Very hopeful.

[@rongwang9067]

I am a cloud architect that helped piecing together the under ping IT systems for completing the CAR-T treatment lifecycle. Proud to be on that project

[@kanavgupta9136]

👏🏻👏🏻👏🏻👏🏻

[@kenyanqueen7634]

Am a developer tooo.. happy to see you here too.. actually my dad has squamous carcinoma.. with no fear trying to get him through this therapy.. I realized as developers we are blessed coz we know how to Google everything and find best solutions. Information is power

[@kenyanqueen7634]

Update:after realizing this therapy is alot of money.. my dad wants to go through chemo. And also am giving him colloidals of solver and copper at the same time.. with some nutrients that I got from a scientist here in India. I'll Share it here in abit

[@kenyanqueen7634]

Again am not a doctor to prescribe anything for you.. but those are suggestions. Food can be cure 😋

[@vilmaescobar1875]

Thank

[@lisafolsom4947]

I was treated this way in one of the earlier trials. I'm not only alive I'm better. It works, it works, it works.

[@loniromero6310]

My mom will be getting this soon

[@PJ-cu4cl]

@@loniromero6310 hey how did it work for her?

[@exploringwitheve2787]

My boyfriend will be starting CAR T-cell therapy to treat him for ALL Leukemia. I’m amazed with how much medicine has changed, I’m truly faithful this will work! I’ve heard really good things about this therapy.

[@fightfannerd2078]

it can end cancer

[@MindsetPower]

@Evelyn Villegas how much it costs ?

[@destinystriffolino567]

@@williamanstett5305 if you look on her page it seems he's passed unfortunately

[@silverstone9952]

@@destinystriffolino567 how ?

[@vanitapatil9897]

How is he now? Plz reply 🤗🤗🤗🙏🙏🙏

[@robanio100]

I just got interviewed for a role that would lead a team manufacturing genetically modified viral vectors that would be used to enhance the efficiency of T cells. I am excited about this opportunity. Wish me good luck :) !

[@QuestionTheNarrative1984]

Out of curiosity, what viral vectors would be genetically modified ??

[@elenanapolskaia1647]

thank you! I am a medical oncologist. and CAR-T cell therapy is very interesting for me! it is a future of oncology. but there are some not "inflammation " types of tumors. and we have to think , what to do with it.

[@lisafolsom9601]

I received cart- t cell treatment for acute myeloid leukemia six years ago. I remain cancer free. And on top of that, my immune system is amazing. I rarely get sick anymore. Im healthier and I look and feel better than even before I got sick. Truly a scientific miracle.

[@user-ff6nn7wb7n]

Where did u get this treatment? only usa, what is the cost?

[@ludoviccruchot5984]

Starting working on CAR T-cells this week. So excited !

[@markhughes6803]

Hi hope this finds you well 🙏

[@alannahfitzgerald]

A beautifully inspiring and very accessible talk, Rob. Brilliant work.

[@juliacameron6916]

Wow Rob. That was Informative for the lay person and educational.

[@xamanakukulcan7619]

I have Kappa Light Chain Multiple Myeloma. I’m in my third round of chemo (CyBorDex). I’m so excited to learn about the Malaghan Institute In Wellington and I’m hoping to be part of their next CAR T cell trial 🙏🤞

[@leonafriedman4049]

This is an excellent talk. The background information on the lymph-nodes/immune cell types makes this science accessible to anyone.

[@ValerieIddison]

Excellent presentation, CAR T cell therapy is explained in details with a language accessible for all! Thank you Dr. Weinboke

[@1284raul]

Quite possibly the best presentation, articulation and explanations I have ever heard! Awesome. Thank you

[@zhenlingwang8058]

Great speech, thank you Dr. Weinkove!

[@RedwingHockey10]

Truly well spoken, easily understandable explanation of CAR T. Bravo!

[@RameshPatel-bw3bz]

So eloquently said & representation so easy to understand for common people. Thank you doctor for enlightening us to understand the most feared disease cancer & how to tackle it in life with treatment options.🙏

[@jonniemaemiddletonlotte6747]

Thank you for your presentation.

[@stormbytes]

i love the juxtaposition between humility and forward thinking

[@bobbythompson3544]

This is the first time since 2016 that I have listened to an explanation of the process involved, I had a bone marrow transplant in the Belfast City Hospital for Mantle Cell Lymphoma and feel well now in 2021, but the follow on research is very encouraging for those facing trouble! Very well explained and thank you 🙏

[@markhughes6803]

Hi did they mention this treatment to you in Belfast hospital I hope your doing well 🙏

[@ArthaShastra504]

An excellent talk! I work in this field and this is one of the best introductory talks I've seen - a very complex topic made easily digestible

[@marymary20]

My husband will be admitted to the Hospital at the University of Pennsylvania to participate in a CAR-T therapy clinical trial for his AML (leukemia) that has relapsed after bone marrow transplant. Thank you for this excellent explanation.

[@samlantier4268]

Sad, how governments rich or poor spend so much on military and so little on scientific research that leads to drug discoveries that not only saves people, but keep their families together.

[@timedone8502]

While I hate wars I must say that many military technologies become extremely useful in daily life. The money invested in military technologies were with bad intentions, I agree. But the impact of these technologies later on medicine, telecommunication, foods, apparels etc.. is immense.

[@deborahdana3057]

i was surprised to see that my type of cancer made the "big time " and appeared on a ted talk! amazing

[@charliehannaah]

hope you're doing well

[@michaelisaac2944]

Going through CAR T CELL now , day 2 and no side effects

[@namitamishra5368]

@@michaelisaac2944 : How are you doing now?

[@michaelisaac2944]

@@namitamishra5368 It was on May 3rd that I received my genetically modified T cells. After 28 days I had a PET SCAN and it showed Zero activity. My doctor at the Colorado Blood Cancer Institute called it one of his best responses. Today is "Day 47" and I fell feel better than what I was told and what I expected. I did have to have a couple of shots to bring my white cell blood count up. As for on going side effects I have had some minor short term memory loss. Example I will go in the kitchen and forget what I went in there for, till I look down and see the coffee cup in hand. Other than that I will have to go to my local oncologist weekly for blood tests and monthly checkups at CBCI.

[@namitamishra5368]

@@michaelisaac2944 : Oh... So you're doing fine.. That's great... Are you also into some kind of a special diet?

[@sarahcopeland8187]

Excellent video!

[@juliokemajou6580]

Brilliant talk

[@markdennis8932]

A wonderful discovery.

[@tesfulab]

The so fantastic innovation!

[@pearl7457]

My husband did the C-T cells a week ago and is responding very good .we has a great team at Moffitt cancer center in Tampa Fl.

[@PEMF.Hydrogen.LLLT.Experts]

Interesting for sure!

[@beautyofnature4280]

Superb... 👍

[@colorado-vn5hz]

Amazing stuff

[@walterruano9831]

Partner starts this treatment next week. Heart is pounding…

[@vanitapatil9897]

How is she now? Plz reply 🤗🤗🤗🙏🙏🙏

[@nissing57]

Yes how is she doing? my husband starts this November 9 th am scared but at least there's a chance

[@sundarramanp3057]

Awesome talk! The joke made me emotional

[@ojfulbright9276]

Awesome talk.... but, ooo, I see 2 or 3 things in the cleanroom that I would have to change for GMP!

[@fromthefuture7172]

Automation would be the most efficient and cost effective way to carry this out.

[@rob2848]

Everything sounded so good in theory.

[@hypernova3011]

That is going to be breakthrough in cancer cure.

[@remuspierre8038]

Bravo

[@nataliaspencer2831]

IV Ozone, Mistletoe Therapy, & Rife Machine would be helpful to get rid of the cancer.

[@ahmedahm1]

17:58 The Good Dr says: I hope we see less of you and your friends & family see more of you ! Lovely & kind

[@catherinegeil1011]

I've been saying for decades that my psorasis is a cure. Having an overreactive immune system is a BLESSING if we are able to just tap into HOW to reprogram the T cells that MAKE psorasis. Reprogramming!! MCV Massey Cancer Center is now FDA approved to use the Cart T therapy!! I'm telling you, if psorasis sufferers like me could one day be donors for things like this, it wouldn't be diagnosed as a disorder anymore. It would be a cure.

[@manojkrishna4935]

Haha sadly that doesn't work that way baby And I'm a psoriasis patient too As it is like immune system doing some unusual activity and not an increased activity

[@jacquelinenieto508]

Good luck to all the ppl who r looking to get this. It didn't work on my daughter sadly to say. Lost her battle 7-20-2020

[@fatima11218]

Hi, I am sorry to hear about your loss. Did she undergo cart T cell ?

[@jacquelinenieto508]

@@fatima11218 yes she did.

[@cubbylion2162]

Need some inputs pls. Will this work in Adenocarcinoma patients? Most likely liver?

[@tragic6162]

This give me high hopes We may have the cure maybe

[@amulyadash384]

In future this technique can also be applied to treat many Autoimmune diseases successfully......

[@remuspierre8038]

Good important

[@janephillips8583]

Can the t-cell therapy help with glioblastoma.

[@markhughes6803]

Please can anyone tell me will this help oesophageal adenocarcinoma as I need to know ASAP please 🙏

[@Cos3D]

Please the intro song

[@raviaryatube]

My mother is suffering from lung cancer...does the immunotherapy works for it,if yes for which types..ang success stories especially from india or Netherlands

[@reginafisher9919]

What about histasonics

[@rmd8790]

Have any clinical trials been conducted with CAR-T cells targeting solid tumours such as Osteosarcoma? My son was diagnosed with Osteosarcoma in June 2018, and since then he has had limb salvage surgery & multiple rounds of aggressive pre- and post-surgery chemotherapy. Sadly he has had a few relapses since his treatment finished earlier this year, and his recent PET scan in November 2019 has detected multiple tumours throughout his body, including in his lungs. He is now back on chemotherapy, and we are now resigned to the fact that the chemotherapy is just a short term solution. We have read up on CAR-T cell immunotherapy, which seems to be quite effective, and would be very grateful if you could advise whether this may be an option in treating our son's diagnosis. If not, are you aware of any other treatments available? Thanking you very much in advance.

[@samsayn5170]

there is not much successful trial of CAR T cells in solid tumors,unfortunately. Also,consult your doctor and get a second opinion. they know the best. Not an usual youtube person know the treatment options.

[@fightfannerd2078]

@@samsayn5170 what about in 2020

[@tiptopdekho479]

Please help me... Please please please

[@Kazyman]

MCV Massey Cancer Center uses CAR-T treatment and is now approved by The FDA. May Jesus Bless you all. Also, if T Cell treatments fall flat because of the dominance of existing tumors, I invite you to watch The Rife Machine (the best place to buy one at the best price and most effective generators are at Spooky2.com) kill cancer cells right here on KZbin. Search Rife Machine here on KZbin and listen to the testimonies. My family uses one and it is amazing how it indeed helps us with many temporary afflictions REMOTELY (non hands on) with back pain, my reoccurring sinusitis, my daughter's painful initial menstrual pain and more. Of course, the A.M.A. hated Dr. Royal Rife (who invented same microscope used today to look at cells) and bankrupted him through lengthy court trials even though plenty of witnesses report being brought back from stage 4 cancers. From the sounds of what you say your son is going through, at this point I suggest you purchase either the Spooky Central or Spooky Plasma machine. If you go to spooky2 (dot com), there is staff that can answer any questions you have. May Adonai through His Son Jesus cradle your beloved son no matter what His will for him and may he ease the immense pain you and your family are bearing at this point in your lives.

[@rmd8790]

@@Kazyman Thank you so much, will definitely look into these options that you have kindly provided. And thank you for your thoughts & prayers for our son!! God bless.

[@bobhensem3425]

What i hope,this treatment are esily and cheaply acessible to anyone

[@nolifeols]

Awesome innovation that helps tens of thousands with haematological malignancies. Just need to figure out how we can apply CAR T cell therapy to solid tumour growths that are not floating through the peripheral blood.

[@mjhv287]

Exactly!

[@markhughes6803]

Is there any hope of that yet ?

[@yassiec5294]

Hi Everyone, I'm currently doing a school project on the use of CAR t-cell therapy in the UK vs the USA and it would so helpful if I could have some opinions or experiences from anyone in the comments! Any contribution would be helpful to build a strong argument either for or against the process. It could include financial factors or emotional stories that I would be able to quote. Thank you so much :)

[@balinoruo]

There's really no argument against if it works.

[@kaloudasotirakoglou7592]

I’m in Athens Greece is anyone involved with T Cell help sos

[@feiyiss]

are those crocs?

[@NikhilMandrekar]

Would love to hear stories from patients who have gone through CAR-T cell therapy below if you would like to share!

[@balinoruo]

Are you Indian Nikhil? :) It looks like car t-cell is going to open up there soon. Or might have already. But the first hospital is being consulted by Dr. Bruce Levine there. He's a pioneer in car t-cell therapy. It's nice that India has chosen to use this, it's amazing. I should be dead, not typing this to you. :) Yet here I sit.

[@silverstone9952]

@@balinoruo yes Nikhil is an Indian

[@vanitapatil9897]

@@balinoruo how are you? Plz reply 🤗🤗🤗🙏🙏🙏

[@SS-bl7dk]

More solid tumors could be treated with immunotherapy in the future. So I'm also going to store my healthy immune cells.

[@markhughes6803]

Hi do you know if this helps with oesophageal adenocarcinoma I’m at my wits end thanks you can anyone help pls 🙏

[@LiuJason-pc4le]

I thought that CAR T cells were gene reprogrammed for specific patient by the antigen that are produced by the cancer in the body of the patient, then, how is it possible to use the same CAR T cells in others

[@leemack8163]

I have seen immunotherapy fail miserably, I hope that in becoming efficient against any kind of pathology, as soon as possible.

[@kathyknepp9883]

My daughter just had cancer removed from her tongue. She's waiting for a pet scan and see a specialist. I would love to have any advice to help her. (She's never used tobacco in any way)

[@Randomstuffs261]

fasting is said to be pretty effective in helping fight cancer

[@kathyknepp9883]

@@Randomstuffs261 thank you. She & I were talking about this yesterday.

[@Randomstuffs261]

@@kathyknepp9883 You're welcome, I wish you both the best of luck in fighting this awful disease.

[@deliveringIdeas]

@@kathyknepp9883 Hello Kathy, I'm wondering how the little one is doing. Any improvements?

[@kathyknepp9883]

@@deliveringIdeas they think it's gone for now. I Pray it stays away. My Mom was diagnosed with cancer right after I wrote this. Thank you so very much for asking about her.

[@UsDiYoNa]

Fuckin’ love it 👏🏽👏🏽👏🏽🙌🏽🙌🏽🙌🏽

[@DarkerSideOfDawn]

No doubt this guy cringed multiple times during covid eh? My kid had a NMNA BMT when she was 12. She’s now 31 with 3 beautiful children

[@ivanskinner2943]

I wonder does this therapy may help people with Multiple Sclerosis??

[@ludoviccruchot5984]

Currently, approved CAR T-cells are limited to blood cancers. Working on enlarging the list.

[@CrappyBJJBlueBelt]

For MS, I would think CRISPR technology would be better suited. That is what you can look into.

[@emmacheesman]

Yes it is currently being trialed in this setting

[@wonderwoman9951]

I am a holistic consultant and when a cancer patient asks me what to do to help her, I usually say strengthen your immune system , but natural medicine takes a natural approach by taking herbal medicine like Ashwaganda and Astragulus and eating healthy foods or living a healthy environment, would that be a better solution to some cancer patients in immuno-therapy

[@markhughes6803]

Brilliant advice do you know if this would treat oesophageal adenocarcinoma cancer I would really appreciate it knowing as I’m at a hard rock and a sand bank 🙏

[@tammyslaughter9587]

Absolutely not! It is not only irresponsible, but dangerous and unethical. For instance if someone has cancer of the immune system such as lymphoma you can’t just give them a list of things to eat then send them home and tell them to build up their immune system when the cancer is in the immune system. Eating healthier and having a healthier lifestyle is always good but it’s not going to cure cancer, food is just a small part of it. I have been on immunotherapy for B-cell non-Hodgkin’s lymphoma, and the immunotherapy is a targeted anti-CD20 antibody therapy which targets the cancerous B-cells by attacking the CD proteins on the cancerous B-cells. Blood cancers are very complex diseases that you know nothing about so you really don’t have any business telling people with cancer you can replace a very complex and successful treatment such as Rituxamab immunotherapy with food and supplements. I will tell you I ate a very healthy plant-based diet, did intermittent fasting, exercised extensively for years and was still diagnosed with stage 4 colorectal cancer which metastasized to my liver and lymph nodes. I am here 7 years later with no evidence of colorectal cancer, but I didn’t survive it by eating healthier, I did it by having extensive chemo, radiation, and several surgeries. If you’re having to go on KZbin to ask people whether you should recommend that people who come to you with cancer just take ashwaganda and eat healthier instead of immunotherapy you have no business holistically working with cancer patients. You can’t imagine how many people come on our cancer support groups who nearly die because they try to cure their cancer holistically instead of chemo, immunotherapy, and or radiation. As a holistic consultant if you’re asking the question you asked cancer is way over your head. You can’t help someone with cancer by knowing so little about it.

[@edkasch]

did he say "kills tens of thousands per year" or "Cures tens of thousand of people per year" @ 2:42

[@shannonperez9260]

He said “cures” but the auto-transcriber said “kills” lol.

[@vanitapatil9897]

@@shannonperez9260 now I am confuse By the way how are you? Plz reply 🤗🤗🤗🙏🙏🙏

[@sebkyeisk]

Apparently it doesn't guarantee success. Can cause side effects.

[@scoop5263]

Like all treatments do, just look at how Chemotherapy completely ruins your whole body

[@MicheleCiprianiit]

I have seen immunotherapy fail miserably, I hope that in becoming efficient against any kind of pathology, as soon as possible.

[@fromthefuture7172]

Hopefully it doesn't lead to super pathogens that are just adaptable as these t-cells. Kind of worried this will end up in the livestock industry since it's a more "organic" therapy.

[@kristyc4712]

@@fromthefuture7172 how would that lead to super pathogens in any way?

[@fromthefuture7172]

@@kristyc4712 we'd be naive to think we could outsmart evolution. Any new mechanism we use at scale will likely be absorbed by viruses and adopted for their own use. Not an expert but even I can see that.

[@kristyc4712]

@@fromthefuture7172 you're clearly not an expert because viruses do not work like that... don't make uneducated claims like this. how would immunotherapy end up 'absorbed' by viruses haha.

[@fromthefuture7172]

@@kristyc4712 look up viral genetics. Have a great day.