David Sinclair: Revealing the Biggest Myths About Diet, Stress, and Death

Check out my New York Times Bestselling book, Clear Thinking. It's packed with proven frameworks and practical strategies that will give you a roadmap to navigating any situation with poise and intelligence - fs.blog/clear/
Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes in-depth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it’s never too late to slow the process of aging, and so much more.
Dr. Sinclair is a professor of genetics and co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and he is best known for his research on aging, with a focus on epigenetics. He’s been called one of the 100 Most Influential People in the World by Time, and in 2019 he released the New York Times bestselling book, Lifespan: Why We Age - and Why We Don't Have To.
--
00:00 - Intro
01:24 - What is aging?
02:52 - What happens in our body during aging?
06:10 - How fasting decreases aging
15:00 - On eating three meals a day
18:39 - The best things to eat to reduce aging
23:05 - Organic v non-organic foods
27:04 - Should we only eat food that's "in season?"
29:46 - On sugar
31:42 - How to test your biological age
33:22 - Using exercise effectively
36:18 - Sleep and aging
40:36 - The benefits of saunas and hot tubs
45:04 - The relationship between stress and aging
47:55 - How positive attitude impacts lifespan
48:34 - NMN, Athletic Greens, and resveratrol
52:57 - Why David quit dairy (and did it matter?)
58:00 - When should you start slowing your aging process?
01:01:05 - On puberty and aging
01:02:53 - Are biological problems becoming engineering problems?
01:08:54 - Using drugs to reverse aging
01:11:24 - On lyme disease
01:17:06 - On hip-replacement and increased death rates
01:21:36 - How to think about aging before it's too late
01:23:30 - What's the ultimate age we can live?
01:28:30 - Second-order effects of living longer
--
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Like the mentor you’ve always dreamed of having, The Knowledge Project shares timely yet timeless lessons for work and life. Past guests include Naval Ravikant, Daniel Kahneman, Jim Collins, Angela Duckworth, Seth Godin, Melanie Mitchell, & Esther Perel.

[@tkppodcast]

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[@RoninSerradaEscrimadore]

David Sinclair lobbied the USFDA to ban NMN out of greed not safety. It's time to sue him with the Sherman Act. Time to take him to court and expose his greed.

[@Maverick7642]

AI stocks are currently dominating 2024. so its definitely a good buy, NVIDIA is one of the good buys because they are better placed to maintain long term growth potential, and provide a platform for other AI companies. I know someone who has made more than 200% from NVIDIA last year.

[@Christian67337]

you are absolutely correct on that kasun. I bought NVIDIA around September 2022 because my financial advisor recommended it to me. She said the company is selling shovels in a gold rush. It accounted for almost 80% of my market return last year.

[@Damon4324]

That's a great analogy and I love the insight. Professionals could make a really big difference in investing, and I think everyone should have one. There are aspects of market trend that is difficult for the untrained eyes to see. I've made over $675k in three years.

[@Hudson367]

Mind if I ask you to recommend this particular coach you using their service?

[@Damon4324]

Aileen Gertrude Tippy is the licensed advisor I use. Just research the name. You’d find necessary details to work with a correspondence to set up an appointment.

[@Hudson367]

She appears to be well-educated and well-read. I ran an online search on her name and came across her website; thank you for sharing.

[@PinaDebbieR.]

Successful people don't become that way overnight. What most people see at a glance-wealth, a great career, purpose is the result of hard work and hustle over time. I pray that anyone who reads this will be successful in life..

[@robertbrown374]

My doctor prescribed medicine because he said I should watch my cholesterol that I should keep it very very low. I never took his medication but I changed my diet change my diet I went back to him 6 months later and he said wow did it ever work so good I've never seen the drug works so well and I told them I didn't take the medicine I changed my diet and he changed the subject. He never asked and wasn't curious what I did.

[@lilyl9992]

Wow 😮

[@snowyowl6892]

THAT’s DOCTORS FOR YOU !! …. Give them as wide berth 👈🏿

[@Steven-ze2zk]

@@snowyowl6892 Why? Why does the doctor change the subject because he's been caught out? Why not because he knows how dietary changes can work too and so what's the point of having a conversation about it? He didn't ask what foods this guy ate because only certain foods produce results and thus the answer is already known.

[@snowyowl6892]

@@Steven-ze2zk what ??

[@pete-m86]

You are very fortunate to control your cholesterol with diet alone (for now!), but keep an eye on it. For many of us, medication is the only solution as most of the cholesterol is produced by our liver, not the food we eat. But a bit of friendly advice for the handful of people that might read this. Never go behind the back of your doctor. Your brief moment of triumph is not worth the price of pissing off your doctor, and losing his or her trust in you as a patient. You should have told your doctor you want to try diet first. That's a reasonable action. That way you wouldn't look like a fool had your cholesterol gone up.

[@shekatagani]

You don't need to go as long as 3 days for Major Health benefits, Eating one meal a day and eating whole foods, cutting Carbs and Sugar, limit Alcohol. Do this with a little exercise and you will be a very fit person. I am 67 and I've taken on this way of living and I'm more healthy now than I was 20 years ago.

[@freemocean489]

Yes Sir. I concur 100%

[@orion9k]

I can't do omad, I tried and got severe constipation 👎

[@ana-mariaalrasul9231]

What kind of carbs did you cut?

[@shekatagani]

@@ana-mariaalrasul9231 Bread Potatoes Pasta Rice and Cereals and all packaged snacks, chips Pretzels etc.

[@shekatagani]

@@orion9k One thing you have to be mindful of is Drink lots of water, it also helps to eat more fiber. When eating fill up on Vegetables.

[@susanschaffner4422]

Fasting on a 16-18 hour schedule has changed my life. Weight loss, energy, stamina. I walk, drink water, and have no cravings.

[@5minsleft542]

as much of a scientist he is, he does show a lot of human sides in him. No fancy terminology, his messages are easy to understand yet with precision and concise

[@aclearlight]

Let's not forget GREED. He has gotten NMN BANNED by FDA so that he can become the sole source of it in the USA...NOT COOL.

[@swisstrader]

Huh? The guy sold out with the NMN/FDA fiasco

[@aclearlight]

@@swisstrader ...right on. F that greedy scuz. He gives scientists a bad name.

[@jwheeler9991]

He also agrees to drinking several glasses of water before eating. This dilutes stomach acid.... Not a good start to the digestion process.

[@user-bd4bo4tb8u]

@@jwheeler9991 Does he advocate drinking that immediately before eating? If not, maybe drinking water works to minimize overeating.

[@jillross7876]

David Just started following your talks and enjoy them. Very much . I am 82 years old. I have had a triple bypass,cancer and most recently 8 months of black mold exposure, not knowing at the time why I kept getting sicker as time went on. In spite of it all, I strive to get better and and achieve good health. Thank you for all the information and inspiration to do so. Anxious to learn more.

[@rdallas81]

You are blessed Ms. Ross!

[@DennisSmithGrandCayman]

Fascinating subject. I bought David’s book 6 months ago and enjoyed reading it. There’s an awful lot of KZbin advice, re: fasting, and And longevity. Since my wonderful wife is 50 and I’m 75 I’m looking for at least another 50 years in order to keep her company. Fortunately, I have never been overweight and I really don’t care if I eat or not so I can go for a week or two with just fasting although I realized I have to replace my electrolytes. That got me into trouble once. I try to get to the gym, at least three times a week and would prefer every day, but since I’m starting new businesses scheduling sometimes becomes difficult. In any case, I have no idea when I will be old but it’s certainly not for the next 30 or 40 years.

[@denaaustinmiller1331]

David Sinclair is such a generous speaker. I love how much kindness he brings to interviews. I have to admit, as many of his talks and my application of the methods I still gain a better understanding as I listen to him speak each and every time.

[@dalelerette206]

You confirmed the Wisdom of what I was living. I fast everyday until 4 P.M. I gave up smoking, drinking, and almost all drugs. I still drink caffeinated drinks as I eat no solids until 4 P.M. I was told by 'some sources' that I could not build muscle after 40 years of age. But that photo of me is when I was 47. I consider regular physical exercise a form of preventive occupational therapy. When I am fully shaved and cleaned up I've been mistaken for 38 when I was 52. Keep up the good works, sir. May the Lord bless you.

[@judithhatch6175]

actually I'm doing well with the one meal a day , just on my 4th day, but going well. Drink my coffee in morning, followed by water, hot non caffeine tea and water in afternoon. Getting off my butt every hour walk around trying to get 4000 steps a day and more on days off. Whole non processed plants, fruit, egg and fish, beans. 65yo will see how it goes. but can tell fluid retention down, less joint pain already. This is for long haul. As I age in years want quality of life while I'm here. Dr. Sinclair has tapped something in me to be motivated., thank you!

[@leticiatann1281]

Well, I am small 4’11” and I am now 85 yrs old , still healthy , live with my 23 cats and a dog . I eat a lot of grapes.

[@sueanncrawford6217]

When I contracted Lyme disease I also had paralysis in my face as well as a bullseye rash, and I was treated like I was crazy. The initial testing came out negative so they told me there’s no way I had Lyme disease. When I finally got diagnosed after taking it into my own hands It had been 12 years. As a result I still have remaining paralysis in my face after being on antibiotics for five years in order to get it under control. It’s medieval the way they handle Lyme disease.

[@rdallas81]

Sorry.. I am from Hudson valley NY. TICK HELL! So many sick people who aren't aware they have LYME. What a shame. I watched and participated in a mess of people all sick throughout their lives (me including). They have LYME disease. I was never actually diagnosed with LYME but I have been treated for Rheumatoid arthritis since age 12, migraines and even seizures. All started at a young age around the same time when we all used to play in the woods.

[@GenkiSugiru]

A close relative of mine went through the same mis- / delayed diagnosis as you did, but in the 1970's when Lyme Disease was first appearing in CT -- and this person lived within a few miles of Lyme, CT! The hospitals then had no clue what it was.

[@suzannehodgkins7197]

I may be not be remembering this right, but I think I saw some association between facial paralysys or Bell's Palsy and B1, or Benfotiamine. Probably on Dr. Berg's channel.

[@davidhasselhoff5010]

@@rdallas81 From the Hudson River Valley as well. Its bittersweet living here as the Woods and Mountains are utterly magnificent yet most locals don't hike anymore due to the abundant level of ticks. As you know, half of Manhattan has moved up here since 2020 and I try to warn them as much as possible. Here in the Catskills, locals drink lemon Himalayan pink sea salt to flush out the spirochetes.

[@rdallas81]

@@davidhasselhoff5010 I used to live in Ellenville, Kingston,.Middle town,.Newburgh areas.

[@lindamarsh3335]

Dr. Sinclair's Mom and Grandma would be very proud of him. Helpful and kind man.

[@robertkuiper1423]

Thank you David for the open heart and inspiration!

[@Adrian_Adam]

I'm grateful your interview with Dr. Sinclair pushed onto my feed. Your questions and the flow of conversation couldn't have been better. Very informative, especially for myself who is in this battle between progressing my strength-training and muscle-building (which requires generally less than a gram of protein per lb) with the desire to increase my lifespan and overall health as I age. Thanks and I'm excited to view more of your content!

[@emeraldgreene9600]

I love the information I cannot get enough of Dr. Sinclair

[@1nterpretThis]

Great interview. It's interesting to talk about this subject, specifically aging and what the average human lifespan is, and what it could become if we only took better care of ourselves. The majority of the population, it seems, doesn't understand the impact of quality sleep, good diet, regular exercise (even 15-20 minutes a day), and sun protection on general health (and looks). I have a couple of friends who wouldn't even try to reduce their coffee intake, even though they've been experiencing major sleep disturbances for years now.

[@arbiter3297]

Great interview, Shane. You asked excellent questions and David always does a good job of giving clear and understandable replies. Blessings to you both.

[@franceschukwukere209]

7 Epigenetic Regulators 1) skipping meals 2) being hot and cold 3) eating less protein 4) eating right types of food (meditarranean diet) I didn't get the remaining 3 regulators. Pls help me here Thanks so much, Professor Sinclair.

[@sophie4636]

Fantastic interview. I've watched many interviews with David Sinclair and this was the best by a long mile. You've definitely got a new subscriber here!

[@Killdarian]

I don't want to be harsh, but do some deeper digging on David Sinclair and you will find out he is a bit of a fraud. He had been descredited 2 times by scientific comunity. But for the sake of financial gain, he is still propagating a lot of disproven myths he imagined/reviewed.

[@petermalmgren1207]

Me as well

[@natashaedwards373]

I also subscribed. I'm trying very hard to reverse 40 year of misinformation for my own health and learning to be a better influence for my children.

[@fiercebon14]

This was such a good podcast! Thank you for keeping it simple and letting the messenger spread the message without an exaggerated amount of ads constantly interrupting! Thank you!

[@mjgrant1515]

great interview. thank you for the time stamps, they are super valuable when wanting to zero in on topics. i wish all interviewers did this.

[@JagVama]

David is a humble and compassionate scientist...though his achievements are great. His personal traumatic experience with losing his mother shows his human side. I read his book lifespan...brilliant! I am on omad, metformin 2G, niacin, quercetin, veg diet no diary no alcohol 40 min walks....I feel great at 61!. I have never felt better even at 30! More power to you Dr David Sinclair! Medicine plus technology is going to revolutionize how we live longer and healthier....

[@zbigniewbrzezinski8869]

Is 2 gr Metformin not too much?

[@Sunnyfield323]

Fantastic ..! Please tell me whst the 2G refers to. Metformin 2G

[@JagVama]

@@Sunnyfield323 Brand name 👍Carbophage xtended release tablet - Metformin 2 Grams - so far no adverse effects. Please check out Nir Barzelai videos on Metformin for lifespan -best

[@ramask31]

Congrats. David's video has been quite inspirational for me to make positive changes.

[@davidwood9991]

I can't give up the diary - I love the diary!

[@debstayblessed9549]

Dr. Sinclair G.O.A.T. Taking on the medical community by changing the paradigm 👏👏 Got his book and he keeps it simple and practical, very doable.😉

[@sarahdeck520]

As a society in whole we have to change our thoughts, beliefs, and communication. Learn to start loving who we are, care for our bodies, slow down breath and listen to what our body need to keep us living healthier longer lives. We are our own best doctor in life if we pay attention to our bodies, rather than living in this stressful world we created in the mind. (I have been going through a major body transformation and I have to say when I spent 40yrs living in my head rather than the whole body, my body was sick!!!!) Our bodies are frequency and when our frequency lowers in the body it creates the horrible diseases that impact the mind.

[@swisstrader]

Yes, but give us your thoughts on the FDA now banning NMN and what’s your involvement in all this?

[@user-ih2xs4mk6t]

Professor David has been educating us in order to live happily and healthier with a purpose to serve mankind. Excellent episode. Thanks a lot.Dr.Jayanth Pathirana Attorney

[@Myrslokstok]

I sean a dussin of Davids interviews videos but his comfortable her this is a good one.

[@MmrBader]

This and many other talks by Dr Sinclair are so interesting and inspiring. If you're seeing this dr sinclair can you tell me if you are basically consuming all your required calories intake in one go each day? If you are regularly fasting and only eat once, how do you eat possibly 1500 to 2000 or more calories on one meal or are you consuming a low calorie diet? Do you ever let yourself go when on holiday and eat local snacks ? Also curious to know if everyone eventually ends up with some insulin resistance over time?

[@Ron-rk6iz]

There is a "Law" of nature that we will leave the body, no matter what. Leaving the body has a purpose, but Sinclair is so identified with his little body that he is afraid of dying.

[@kimwolfe345]

Thank you for sharing your life! Notes taken…

[@joyce5341]

Amazing interview! I've been following David Sinclair and this interview is the best of the many I have watched. Excellent, probing questions and thoughtful answers.

[@laaneychoonz1330]

David Sinclair should write a Cookbook! Foods to live longer!

[@dapawap]

Maybe he can’t cook?

[@rohlay00]

He doesn't eat! He fasts!

[@carolinelewis952]

I love this: Every day make a decision to live longer. Eat healthy and exercise.

[@milenadeltorto7158]

Thank you so much. Great talk!

[@ammabraun4514]

Thank you

[@DBMMMMM]

I'm happy Sinclair admits his sleep habits are not optimal, its the same as me. Many nights i don't even sleep, i know it's bad, but this is reality. I worry too much and need to change it. But i never wear jackets, even not when its below minus 10°C and i am much younger looking than my brother and cousins who are bald grey already for years

[@DH432hrtz]

David is such a knowledgeable and incredible aurato of the biggest event we have been told - that one day we will die! That one thing is as toxic as it gets. To walk through our lives knowing we have a finality is more then we can cope with. I follow David's advise for nearly 4 yrs now. I take NMN resveratrol and other high dose vitamins and it change my entire life. I love this man because he walks the walk and he is incredibly inspiring for me! The best way not to die is education. I'm fond of this quote ( if you want things in your life to change CHANGE things in your life ) Happy Living everyone

[@neonomad1939]

Fruits and veggies are healthy when they are bright coloured/stressed, but also the poisonous ones give the same signal as a warning to stay away. Thanks for the enlightening interview.

[@tomscott3]

This was an exceptional interview. I knew less than 5 minutes in that these were two highly intelligent people. I figured the interviewer to be an engineer type. And like the doctor, I'm in far better health in my 40s than I was in my 20s and am still setting personal records when I train/exercise.

[@omittapir5986]

He is one scientist with such humbleness. He speaks so softly and comfortably that it seems like I'm talking to someone I know. Have been following him for last one year plus and very thankful to him for what he is doing for longevity and bringing it to the general mass. Don't ever lose your next door guy image Dr Sinclair.

[@creightonfreeman8059]

Regarding sleep, the Yogi Sadghuru says rest is essential, but distinguishes between rest and sleep. Most people do not know how to rest without sleeping though. I have noticed that when doing certain kinds of breath work, I need less sleep.

[@valery4872]

I tried it for 9 months, and can confirm that fasting on 18-6 or 20-4 mode does reduce hunger, not reduce much weight (those my little belly fat has gone).

[@igordoizha8641]

really great guy, shares so great information. interviewer is also cool. thank you both!

[@lloydbruemmer2465]

I enjoyed every minute of this episode!❤️

[@tkppodcast]

Timestamps: 00:00 - Intro 01:24 - What is aging? 02:52 - What happens in our body during aging? 06:10 - How fasting decreases aging 15:00 - On eating three meals a day 18:39 - The best things to eat to reduce aging 23:05 - Organic v non-organic foods 27:04 - Should we only eat food that's "in season?" 29:46 - On sugar 31:42 - How to test your biological age 33:22 - Using exercise effectively 36:18 - Sleep and aging 40:36 - The benefits of saunas and hot tubs 45:04 - The relationship between stress and aging 47:55 - How positive attitude impacts lifespan 48:34 - NMN, Athletic Greens, and resveratrol 52:57 - Why David quit dairy (and did it matter?) 58:00 - When should you start slowing your aging process? 01:01:05 - On puberty and aging 01:02:53 - Are biological problems becoming engineering problems? 01:08:54 - Using drugs to reverse aging 01:11:24 - On lyme disease 01:17:06 - On hip-replacement and increased death rates 01:21:36 - How to think about aging before it's too late 01:23:30 - What's the ultimate age we can live? 01:28:30 - Second-order effects of living longer

[@nidiyagaspar6303]

Thank you 🙏🏻

[@d-granter5126]

picture billy connolly as Zeus in demi- god mode fuming out the balcony of the emporium thiers not enough super minds fierce enough to deafen the jungle im tellin you now thiers tens of billions to push a new major project i need a sanctuary lab haven in ireland to sinc with another more tropical version its just a building overseeing projects with a view no ones ready for this but its gonna be incredible i need robert downy junior im talking space vendors oceanic robotics fundimental basic stuff no one has a clue how to orchestrate with trillions and the gods just praying for this conversation to fruition from jets that can extinguish forest fires overnight to asteroids heading for earth that can be obliterated with the satan 2 hell nukes threatening to end ww3 just send everyone to dan pena and from him to the president of ireland we need e.s.a and spacex on an offshore luanchpad i have a space studio ready to go into convention centres but i need a round table 2 week meeting im just your average genius with too many certs in too many fields with access to nothing as usual we have all the contacts with little to no comprehension of the next major step for society to evolve efficiently and swiflty other than relying on the internet to gradually hopefully get us thier which im optimistic it will but i cant sit through another day of this might happen or that might happen we have to grab the wheel or ship goes around in destructive circles

[@d-granter5126]

im holding all the keys to the evolution of society but not without yourself, hyberman, clive de carle, a list of others to step in the complex we need a good space studio aswel and its not that complicated adam savage has team just ready and waiting but theyll be busy enough with thier own version as it will be compteting against ours but well all be chilling in a space hotel one way or another were racing against having to fend off the mad max era when we should be running rings around utopia

[@joanfisher1573]

p

[@adyscorpius2614]

I might be wrong, but I think Horace Fletcher first started recommending three meals a day.

[@obduliocerceno4984]

Doctor David i am 62 and looking for to live up to 100 and will follow through your advices. And do hope to live up to the moment in time where I will see (or hear it about) that you will bring flowers to the graves of your today’s naysayers!

[@viswashh]

Thank you so much David for all these insights. Thanks Shane. Definitely gonna start with the small changes David shared here especially the fasting thing. Good luck to everyone who has taken a resolution for more healthier life in general.

[@carolinelewis952]

Water has helped me so much just to keep going until my one meal🙂 Thank you for giving us so much information and time!

[@falcon127]

THANKS, GUYS GREAT VLOG!

[@woodworkingaspirations1720]

Beautiful discussion

[@ginakhaziran2820]

Thank you for your time and advise 🙏, which kind of NMN, is good?

[@mohibquadri4053]

Great One ⭐

[@ilyab.5127]

currently i stopped intermittent fasting because there is a drawback, you have difficulties to keep lean muscles. As i try to be an advanced athlete, I feel better with proteins and enough nutrients. The last thing you want is to fall and break a hip when you are old (it is like a death sentence) so i need to maintain strong muscles and reduce muscle wasting due to aging. i still adhere to midetterenian diet of course.

[@aaliyahlee1265]

Life expectancy is the average length of life of a group of individuals. The way to increase this is to get more individuals to live longer than the current average than die sooner. One way to do this is to persuade the members of the group to eat a healthy diet in moderation and to get regular exercise. I have been watching Dr. Sinclair's interview and bought his book “Why We Age and Why We Don’t Have To” very eye-opening and educative. In there, there's no point increasing lifespan without health span. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. I hate aging and the illnesses it brings over time. NMN Vitruvin Health is the most cost-effective brand for me.

[@drizzt8965]

Wow! Thank you!

[@adilduredoran2477]

What a great interview and the host has been extremely patient and asked great questions 👍. Subscribed

[@brandonhenley3597]

That ending blew my mind. "Every year you live you gain another year of life."

[@valeriehopebennett]

THANKS GREAT

[@vassilikistathopoulou3672]

Amazing scientist!

[@gb8518]

This interview was the best a watchbon the last time. It's blow my mind !! So much precius information. Absolutly excellent .

[@natalieaxl804]

Longevity is a Lifestyle 🙏🎊💕 thank you @David Sinclair 🙏

[@javadhashtroudian5740]

At 75 I have been practicing intermittent fasting for about 20 years. I exercise most days. Recently I started taking nmn and berberine as well as other supliments . I weigh less than I did 50 years sgo

[@carolinelewis952]

I am 54 and just started those supplements as well. So glad I found this scientist!

[@user-cz6cd6eg9b]

服用了这些补剂，您感觉管用吗？

[@grantburris]

David, I made my original comment when the talk was half over. Now that I have heard the entire episode, I want to stress again, how valuable this talk was. This was miles ahead of all the others. Thank you.

[@dorinbivolaru3330]

Brilliant. Very greatful. Thanks

[@myrnaalexander2090]

I so enjoy your podcasts! Follow in my life and encourage my clients to do. I am psychotherapist and nutritionist.

[@BLACKELK1952]

I had both hips replaced. I currently am working out at Planet fitness 3 years later and healthy as ever at age 70

[@rdallas81]

You are blessed.

[@andrewwelsh131a]

Every day is a miracle in action

[@rdallas81]

Truth

[@JatinderSingh-oz1hx]

What are the tests available to see your health and age? You may live really long, time is changing. Thanks.

[@yeemingbchan3690]

Thank you so much, grateful to both of you! i 'd like to translate or rephrase the main ponts here and will write your channel as my source, do u mind pls, Shane. i think this is so interesting and impressive , many peple can benefit from watching your interview! so please!

[@sallykempis5341]

I love the way you talk..you two..slwly that every word you say can be understood...i love you two..keep it up

[@jontutlewski4728]

Great,Thank You very much !

[@melissahamm8122]

Dr. Sinclair love all yr podcasts. I'm 63 I've recently had both hips replaced due to bone irrotion,is my prognosis the same as if I had broken them?

[@br8355]

I love this guy...he literally is a gene...ious

[@ohfft]

That's the greatest secret to living life correctly. We can take life for granted or actually start recognising this life is granted to us!

[@eduheloucomposer]

Great, congrats thank you so much, it is so simple and it is right in front of our eyes that less is more! It is funny how when we discover that the obvius is genius!!! My dad went almost to 100 here in Brasil following old school life style and tips he was a Karate and runner as well, and always use to tell us eat a little bit of everything with moderation and enough to feel it up both hands together not more than your stomach can handle. And not over or too much sex, sports, work and food just make in way that you enjoy enough to have a wish to do it again! Be happy always enjoy everyday life, the mother nature, music, dance, peace and love!

[@Agapanthah]

Great job...subscribed

[@BoltieBolt]

Great work.

[@snowyowl6892]

I heard a long time ago that the broken hip story is actually back to front. Apparently your hip gives way and *then* you fall. Reason is that the western sugar/carb diet creates an acid environment resulting in a desperate search by the body for minerals to restore the acid/alkaline balance. (to avoid acidosis) Since we are all generally deficient in minerals, the body must take them from our bones resulting in osteoporosis … ie weak bones which give way or break easily.

[@SebastianNiemann]

great interview 🙏🖖❤️

[@oman9492]

This has really changed my opinion on the carnivore diet. Like steroids and drugs they make you feel good but it could have long term negatives.

[@Hollowmoon007]

Really great point!

[@clementvining2487]

But there is no evidence that long term has a negative effect. In fact there seems to be evidence it is beneficial long term as long as you get all the necessary nutrients.

[@rdallas81]

No such thing as shortcuts. Best healthy thing you can do is no sugar, and FASTING

[@rosaalvarado4095]

I wish I had a chip with my medical information on or in my body in case of an emergency. Thank you for your devotion n dedication gentlemen.

[@042Ghostmaker]

Excellent roundoff of some wonderful techniques

[@canalsentir]

Hi from Mexico! This is a great video on the subject of aging, many questions and topics are addressed. thanks. We do creative content on many subjects.

[@KJSvitko]

It is just crazy that Doctors do not get nutrition training in Medical schools. Every doctor visit should include some nutrition discussion. The majority of the population is over weight or obese leading to high blood pressure, heart disease and cancer. Schools and hospital cafeterias should be leading the way to good health by setting the example of what is a healthy meal and teaching people what to eat and why.. Every person in the hospital for heart disease should have a nutrition class before being checked out from the hospital with follow up education and training in nutrition. Medicare and Medicaid should require patient nutrition education as part of their standard of care. Nutrition information should be run on the hospital TV channel.

[@maryt7959]

🔥🔥👏👏👏 … finally someone who really cares about the TRUTH of eating , fasting and why …….. I admire YOU and your courage to speak FACTS and educate others !!!! 🙏🏻🙏🏻🙏🏻

[@freemocean489]

David is 5 months older than me. Will be interesting to see how we both age over the next 8 years. I’m full carnivore + coffee. I focus on about 20 min day of strength and mobility work. Randle cycle is my priority. I recommend Bart Kay for actual science on human nutrition. Time will tell.

[@edgbarra]

Dr Sinclair is on the top of the field in longevity. I think his findings after so many years of research would be consider "actual science" 🤷🏻

[@freemocean489]

@@edgbarra you would think wouldn’t you, but he already looks like shit and does not understand basic nutrition such as the Randle cycle or the quality of meat protein over plant proteins. Or the manifold carcinogens and anti nutrients made by plants. I think he only exists because plant based movement financed him. Very sad, but time will tell

[@mowthpeece1]

Thanks for the laugh.

[@abdelilahbenahmed4350]

Yes , time will tell. But, you can already have some little idea about the future by watching these 3 youtube videos: "How long do health influencers live ?" (3 episodes ) Plant Chompers Channel

[@hotchicsf]

Oh good lord. No wonder I'm sleeping less nowadays. I am taking NMN/Resveratrol at night right after dinner, which I didn't realize was kick starting the energy cycle in my body. My bad. I was trying to keep the OMAD clean by not eating in the morning, the yogurt that I put the NMN & resveratrol powder into, but I guess I'll have to start taking it in the morning.

[@robertbrown374]

It's actually easy to get the 3 days you have to build-up to it once you build-up to it you'll find not eating it's just somehow you realize you have so much more time because there's no cooking and dishes and stuff no time wasted at the table eating and in the 3rd day of the while I've had so much time it feels like a whole week went by. Mind you I live alone. I used to get really sick with nausea after missing one meal now I can go 3 days with no problem no side effects or anything. Just practice it you'll see how easy and you'll get there.

[@julesleche6693]

Glad I’ve found this❤

[@juliastantic3033]

I would like to know what he eats for example recipe for one or two meals, would be much appreciated. Thank you.

[@woodworkingaspirations1720]

I sometimes take lemon grass and Rosemary in warm water. Both from my kitchen garden.

[@GS-rw9og]

thankyou

[@NotArtic]

Every day is a 🎁

[@RichardSavery52]

i appreciated your honesty first of all you set you could never do 3 days of fasting but its the tine recommended by experts so as a matter of fact i done 15 days of fasting another time time 14 days of dry fasting another 3 weeks but not in a row countless 3 days i wish & encourage for you or anyone to go the first 3 days in fact are the hardest ...

[@aprilmichael3594]

One of ny faves Mr Sinclair. You're one of very few docs I listen to whenever you upload new episodes. Cheese & wine ohhh my food. Noooo 🙆‍♀️🙆‍♀️😥

[@paulaballetdancer4432]

David is a PhD scientist but not an MD

[@josepho5055]

@@paulaballetdancer4432 *The fact is he knows more and has performed or supervised more experiments published in peer review journals than the majority of "MD's".*

[@paulaballetdancer4432]

@@josepho5055 that is beyond my reply above. I only stated fact not conjecture. Thank you.

[@garyjohnson3751]

Where can you get these 3 supplements as in which firms would you recommend?

[@whittlejoe]

David, please tell us about linoleic acid and how to lower our exposure.

[@partypao]

Fasting - When the body has no materials for building more cells it keeps itself busy by doing house chores: cleaning, reorganizing, keeping tidy the cells that are already there, and maybe throwing out garbage cells that can't be repaired.

[@rdallas81]

I FAST. Can you tell?

[@angelheart408]

Fabulous interview. As an Aussie I am so proud of David. I have just ordered his book. Thanks for the insights.

[@beritmagdalenajohannekuly2980]

It is really important to reduce stress, I take hemp oil and ashwaganda, and other healthy things,because I have ADHD and bipolar disorder, so it is really important for me to reduce stress, because I easily get really stressed more than other people, and meditation is good 👍😊