Does Red Light Therapy stimulate Mitochondria? Not always...

[@Physionic]

Audio in this Video: Before the comments arrive, I’ll go ahead and acknowledge the audio is a bit off on this video. I’ve been transitioning audio recording systems and ran into issues, so I had to use AI to fix the bad audio (couldn’t re-record, tight deadline). Either that ^ or I never existed and I’m actually an Artificial Intelligence program created to indoctrinate you with science and bad jokes - whichever you prefer. No Amendments, currently.

[@MegaMrWrong]

Have you heard of Gerald Pollack? www.ncbi.nlm.nih.gov/pmc/articles/PMC3192026/ This paper seem to suggest that light reduces the random brownian motion. I personally think microwaves increase brownian motion and infrared decreases it.

[@MegaMrWrong]

Gerald Pollack proposed that infra redlight is absorbed by water and it forms Exclusion Zone water on our cell and mitochondria membranes. This EZ water has some structural arrangement that excludes solutes in the immediate vacinity. Though I am skeptical of his ideas.

[@Physionic]

I don’t know him, but that hypothesis was also mentioned in some of the scientific reviews.

[@littlevoice_11]

Don't worry about the audio, the words you actually share more than distract from any slight audio issues 😊

[@ErnestLemmingway]

@MegaMrWrong EZ water is very real. The question is can we modulate it? That's the focus of Geralds experiments. So it's perfectly fine to be skeptical.

[@DecentGradient]

Great video! I was looking forward to you delving into red light therapy. I developed some kind of eczema about 6 years ago leaving my fingers dry and cracked all of the time. It was a painful nuisance. Nothing was really working so I tried a low powered red light glove. That made it worse. I was about to write off red light, but thought to try one of the expensive high powered name brand panels as a last ditch effort. Within 2 days my hands were healing, and within 2 weeks they were completely clear. I use it every day now and my hands have stayed clear ever since. It's interesting that it correlates with that study you showed first, where low power actually made it worse. There seems to be a goldilocks zone. It's good to hear some potential explanations as to how it works too. You're right that there's a big lack of information on that front. I knew it worked to heal my hands, but I was curious how exactly. Keep up the excellent videos sir!

[@airheads24]

Which brand of IRL panel did you go with?

[@DecentGradient]

@@airheads24 I got the Platinum Biomax 300 originally, and have since added a Biomax 600 and a Mito Red Adapt for a full body setup. The Platinum are more powerful and seem to work best for me.

[@edl653]

It could have been coincidental improvement resulting from some other changes to body function and or diet. It would be a good experiment to do the therapy on one hand and not on the other giving it a couple of weeks to see what changes.

[@DecentGradient]

@@edl653 I agree, you never really know for certain. There are an awful lot of variables at play. I actually did try one hand first with the glove, but didn't continue that when I switched to the panel. I just wanted them healed. Although it's a far cry from a definitive well done study, I'm still fairly confident it was the red light. I hadn't made any other lifestyle changes at that time and it was a pretty immediate and noticeable change.

[@airheads24]

@@DecentGradient Thanks for that info on the brand and model you use.

[@DoctorEyeHealth]

Love it! Thank you so much for going this in depth! 🎉

[@jacobdahl7747]

Hi again! In the last video, I asked for more nuances on red-light. It's great that you provided research from another field. I want to commend you for not always making myth-buster videos, which I see are becoming more popular among, shall we say, longevity influencers (or scientists like you). This actually leaves a more... shal we say positive result.

[@richardburklin4861]

According to dr. Glen Jeffery the time ofday plays an important role in that the effect of red light or infrared light . exposure needs to occur early in the day. I just thought you might want to look at that.

[@richardpeddie2060]

Glen who has extensively researched Red Light in University College London says you don't need more than 3 minutes maybe once or twice a week and in ideally early morning, at any other time it's a complete waste of time - kzbin.info/www/bejne/iGrOd2Odft53ppI

[@marcelguldemond2523]

Did you see the explanation on the MedScape channel? The doctor there was talking about how NIR stimulates an enzyme/protein that generates melatonin inside the mitochondria, where the melatonin is a strong antioxidant, thereby helping to reduce oxidative stress on the mitochondria.

[@rickduker4969]

Yes, that was Roger Seheult on Medcram. Excellent video!

[@nielsniels5008]

I like this video. I swear by my red light pannel. It really improved my hair growth by a lot. It really is night and day from when I started using it a few months ago. All my other treatments only affected the hair edge but red light also affects regions much faster away from my hairline. It really is something else. I wouldn't be surprised if high red light intensity only has negative effects in dead tissue, where it dries it out or heats it up too much, something that's harder to do with live tissue.

[@szymonbaranowski8184]

do you do methylene blue as well?

[@ErnestLemmingway]

If you want to learn from the best listen to Jack Kruse. Roger Seheult is also good and Alexis Cowan is becoming a badass. The guy studying mitochondria the longest is doug wallace and a very important book for understanding our electrical potential is "the body electric " by Robert obecker. Also Gerald Pollock is doing some very important work related to the metabolic structured water within our cells.

[@BODYCOACHable]

Best comment of all!! Never miss another sunrise.

[@Justin88800]

Jack Kruse? Hard cringe.

[@BODYCOACHable]

@@Justin88800 reading “The Body Electric” now. What do you think Hard Cringe?

[@jameslmccauleyjr7334]

My understanding is that effects of NIFR light is not just about energy production. It also increases melatonin production in the mitochondria which reduces ROS thus improving the mitochondria function. What do you say about that?

[@thewoodworker1703]

Anyone looking to further their knowledge , you have to check out Glen Jeffery, Professor of Neuroscience at UCL (University Collage, London), is studying the effect on infra-red radiation on the body. Some of his talks are on KZbin. 👍🏻

[@TCBytom]

One remark. Shutting down ATP production actually may be beneficial in some states through activation AMPK pathway. For instance Belarussians over a decade ago developed method for killing cancer cells with LLT of specific wavelenght (I don't remember exact value), In general you need specific power (typically miliwats per square cm) and specific total energy of irradiation (in joules) to get required results. Typical wavelenght used in practice is 660 nm or 630 nm or 880 nm. In order to avoid harmfull sideeffects power is reducted to max 100mW/cm2 but energy to stimulate is between 1.5 - 10 Jouls per session, for killing pathologica cell - >10J but below

[@rosaflorpuig3971]

Dr. Verhoeven, please do a video on Trigonelline. And, thank you for everything you do.

[@mco51193]

I would love to see this as well.

[@lorenzocollado325]

Same. I’ve been hearing much about its potential to increase NAD- even better than NMN or NR!

[@rossentownsend4936]

Inconsistencies in effect have been explained by the time . Tests that were performed in the morning had a much greater effect than test in the afternoon .

[@quitwastinmytime]

I'll watch this later but I remember it was only a couple of weeks ago calling you out for not mentioning all the studies about red light. I assume you will make me look foolish but I appreciate that you took a look at it.

[@netybar7136]

Amazing work thank you for this channel ❤ But I didn’t understand the but line IS IT WORTH IT???

[@smarzig]

You can buy a simple device for $50

[@toriwolf5978]

@@smarzigreally??

[@00bikeboy]

Very informative for those of us looking to go beyond the superficial. I wish you would have mentioned more on the specifics of the red light intervention with the mice. Was it a full-spectrum light bulb? LEDs? Which wavelength(s) were they exposed to?

[@petercandance2330]

The thing is mice/rats are nocturnal creatures, so in the course of evolution, light in general should have a different effect on mice cells.

[@daviddean4061]

Yup, the studies referenced in the video are complete bullsh1t unless they can be reproduced in humans under full spectrum light.

[@SessleIsosceles]

I have never felt a more repeatable, robust, consistent and efficacious effect for my well being that I have from consistent red light therapy since I started using one a year ago, and at first it felt almost negative like a detox but soon turned into one of the most enjoyable lifestyle staples I've incorporated thus far. The dose makes the poison or the medicine, red light has been no different for me.

[@MiroBG359]

what device do you use?

[@SessleIsosceles]

@@MiroBG359 platinum LED, I became an affiliate if you want a discount code , I also have experience with Infraredi as I'm Canadian so are they, and have a affiliate link as well. Both have great irradiance numbers and jewels delivered.

[@user-Red5hield-exp0ser]

Hello. How long and frequent do you use your light for?

[@carma23]

I’ve used a 1500W professional RLT bed for 4 months. Both Red light and NIR. In the beginning it gave me a bit of a strange feeling, like I was perhaps a bit stimulated but I did not experience much of an increase in energy levels. Other benefits are minimal or non existent for me, not really sure like decrease of wrinkles. All in all I didn’t feel it was worth the money and is rather hyped up. I’m returning this device while I can

[@Nelis1324]

Could you please do a video on micro needling/derma rollers? I’m hearing a lot of positive things about it, but have not yet seen you or Dr Brad talk about this. I’m curious to see where you stand.

[@larrygarms7230]

Another +1 for algorithm. Amazing video! You should have WAY more subs!!

[@christopherebhabha]

Yesterday I used red plus near infra red on the cold sore on my lips, today it’s dried up and it is healing, it is relieving pain on my knees after exercise, lost weight…..7lbs in two weeks, stomach is leaning out, relieves tension at the bottom of my feet. I respond very well to this stuff, I am still learning how to be more effective with it hence I listened to your video. Experience will always top scientific data: there might be other factors why we all respond differently, blood type, genetics, phenotype! As long as it is safe, individuals should monitor and learn from their personal experiences, do not be deterred by scientific data ever. Science is the extrapolation of commonsense into quantifiable data and structures, but commonsense and human intuition is superior to science, ultimately advances in science have to dip into commonsense and intuition to first arrive at an advance that makes no sense, until experiences verify that it makes sense. Dear humans, don’t be afraid, don’t be deterred in your natural curiosities for their in lies our primal power gifted by nature and the original creative intent otherwise known as the spirit or intelligence of God. Intellect is still second place to primal intelligence by which we know things, and understand things intuitively. Intellect is supposed to be an assistant to common primal sense, not its master.

[@toriwolf5978]

Glad I found this video I have a freind says you have to pay 2000 bucks for one so expensive, how do you know if a cheaper one works or do you really have to spend that amount of money for one ?

[@krisba9124]

I love your videos. You are the best to explain things in depth for common man. Please keep them coming. Can you look at C15. They say it is a new essential fatty acid. Is that true?

[@theanswerisprayer]

I tune in to your channel even when it’s over my head….

[@Physionic]

Thank you - hopefully not over your head too often. :)

[@pavalacheana-maria154]

Me too! I take little breaks to be able to keep up with the detail: not a science gal here but I have huge interest. I also love the humour 😃 I use chatgpt to help me understand studies but this podcast is PERFECT! Thank you!

[@awjay9670]

Thank you, I've been really interested in this since the medcram red light therapy for long C*VID paper

[@bubblybull2463]

So glad you picked uo the subject after asking us what we’d be interested in ! Interesting to know that red light has an effect on complex 4 ❤ Do we know how the light gets to our cells ? Is it converted into another wave, with other wavelength ? Does it triggers hormones which then trigger functions in our cells ? Or does it just go right through our body like X-rays and neutrinos?

[@Physionic]

Covered some of it in video, but there’s certainly more mechanisms. I think some of the questions are better for a physicist. :)

[@MegaMrWrong]

Water absorbs microwaves, radiowaves and far infrared spectrum. Not sure about mid and near infrared. I read somewhere that I forgot to note down that infrared increases melatonin around the mitochondria and it exerts it's antioxidant properties via glutathione there aswell. That most of the melatonin is made during the day via infrared, and the rest is made by pineal gland at night.

[@Dr_Boult]

Light cannot in general change wavelengths except when things are moving at relativelhi high speeds to each other. The photons can hit things, and that can bounce off (diffuse), eject an electron, or change the energy state of an electron in things, but either it hits things or passes in. It can also diffuse, i.e. change direction if it hits something and Shorter wavelengths are more likely to hit things, so. UV light does not penetrate far. Red light and NIR can go to 50 mm into the body through soft tissue, i.e. it can be almost 2 inches as it diffuses in tissue.

[@bubblybull2463]

@@Dr_Boult interesting… Would that be enough to generate an effect in mitochondrial energy generation in the overall body? Wouldn‘t it only generate it locally? If that‘s the case, then whole body panels would be far more useful for our energy level than spots, would it not? Or does ATP travels throughout the body to where it is needed most?

[@superfinevids]

Doesn't red light therapy use red light and infrared light? Red lake can barely penetrate your skin whereas infrared can penetrate much deeper into your tissue. I'm not really sure which one of these studies just used red light versus near infrared light or infrared light.

[@rehabhqofficial]

This is super helpful. Thank you!

[@millenniummastering]

One of the most consistent and powerful health and sleep improvements in my life is using a 250 watt full spectrum lamp daily. Been doing it for years and just the improvements in sleep alone vs not doing it are enough. Let alone seeng the healing effects on skin repair from infection damage etc etc. Full spectrum is the way. And so much cheaper.

[@DIABETESHEALTHS]

What is the device you are using.

[@millenniummastering]

@@DIABETESHEALTHS Just a Philips 250 W heating lamb in a proper ceramic light socket as regular plastic ones will melt. Cost me under $50 and hits all the isolated NM wavelengths from 1 foot away with more wats per cm than any of those $1000 and up panels do at 8cm from the skin. I also use a 50 wat reptile lamp on my desk indoors during the day to offset the LCD lighting from the computer and indoor lights and that has made a massive improvement to my sleep cycles. Everyone I tell who tries that reports back that its made massive improvements to ong tem concentration, mood, sleep etc as well. Costs $30 as you can just use any cheap open desk lamp.

[@esthermitchell7131]

Thank you for this wonderful tip could you say what web site you purchased im n New York..Blessings ​@millenniummastering

[@millenniummastering]

@@esthermitchell7131 In Australia so not useful to you. Just google the bulb etc

[@chernovolk5095]

Which photobiomodulation device is best to buy? Does anyone know any brands or a trustworthy company?

[@BODYCOACHable]

It’s free the ☀️

[@felipeherrerasalinas9488]

How about EZ water that make the interior of the membrane negative and IR therapy make it? Interesting investigations about that.

[@BODYCOACHable]

And NNEMF DEHYDRATE MITOCHONDRIA

[@_negentropy_]

Thanks Dr. V! This is a multi-watch episode! I’m not sure I understand how red light/NIR find its way to deep tissue cells. Is that a physics question? And are there cell types where we wouldn’t want mitochondria to respond this way? Like cancer cells? And further to this could IR/NIR peripherally affect mtDNA mutations?

[@ddfdefea7367]

I have used it in the last 6 months and had unbelievable results with pain reduction - also noticed my skin got better however, my blood work for blood cancer that has been under control for years all of a sudden went haywire. I think there is a theory that it can stimulate unhealthy cells but also cancer cells. Timing seems ironic to me.

[@azdhan]

Super Interesting. Many thanks for sharing, much appreciated

[@r4tgl]

So should we be using our red light/ NIR devices or no...if so for how long to receive a benefit rather than a detrimental effect. Would be super helpful to know

[@jwinthepro]

There’s not solid methodology on this but most stuff I’m seeing says you shouldn’t do red light for any longer than half an hour a day.

[@AmphibianDev]

6:25 But why did the CON+NIR did worse?

[@Sleepdriver1984]

I keep on with my PQQ, Ubiquinol, Carnitine and Pycnogenol combo, also since red light deprived from the UV is indeed anti-aging but it also further thickens the collagen layer in tissue and I'm instead trying to increase the elastin amount, especially in the tunica albuginea (to prevent penile shrinkage)

[@Viertelfranzose]

I would add Methylen Blue

[@Sleepdriver1984]

@@Viertelfranzose I'm considering it, waiting for my next supplement-bound budget to decide what to order together with that 🙏🏻

[@wread1982]

Add creatine and broccoli sprouts to your ATP mix

[@Viertelfranzose]

@@wread1982 creatin is everyday in my mix. Just for the sprouts...i don't trust the Capsel Stuff so I use a different Type (Mix) of fresh red onions....garlic and cutting all in little pieces..then mix in a bowl together with a mustard horseradish creme and put it some hours in a cooler. If I get fresh Broccoli I cut it in little pieces and mix it in this bowl together with all the onion and garlic stuff😄...of course I am single since over 10 years

[@Sleepdriver1984]

@@wread1982 I use creatine but as for broccoli, I'd prefer not to take potent anticarcinogenic extracts that might interfere with the HIF-1 pathway

[@tracymullane8818]

Back 10 years ago or more they it was discovered that diffused red light therapy was very effective for skin improvement. It was also recommended and taught by Thor to limit use to short treatment periods- 5 to 10 minutes tops. Seeing your analysis would indicate that diffused near infrared as opposed to straight beams could work better for mitochondrial improvement and short, bursts of treatment could stimulate protons at a better depth for the exchange is necessary to set off the cascades we're looking for.

[@jbarron4596]

Informative and well presented.

[@Physionic]

Thank you:)

[@Zergosss]

Is RLT more useful for humans than, let's say... walking outside while wearing sunscreen if needed?

[@JonTodt775]

Sunscreen is used to block UV light from Sun

[@iche9373]

The sunlight only delivers that specific red light by sunset and sunrise.

[@KarenParkerArtist]

So, natural sunlight or an incandescent light. Even in outdoor shade, you'd get a broad spectrum of IR.

[@Anna-uv4gr]

I think (I don't know much about it but I do think based on stuff I've read) that sunlight doesn't have the same effect. This is because it also has other wavelengths of light, such as blue light, which supress mitochondria, and thus it cancels itself out. This makes sense in an evolutionary context as well.

[@KarenParkerArtist]

So , logically, what you are suggesting is that there is no benefit to the body from sunlight exposure. So why didn't we just evolve to live in underground caves? That seems just about as likely. I'mma make a KZbin channel suggestion,. From a real lifel medical educator : MedCram - Medical Lectures Explained CLEARLY. He has an entire series of videos (more than a dozen) on the effects of infrared light, from actual sunlight, on the body. He , like Physionics, not only shows you the studies, but breaks them down into easily understandable language. Watch a few. Get back to me on that.

[@rickduker4969]

And early and late light have the most NIR

[@Always-xl9db]

I was hoping you’ll talk about viscosity explanation - after all, this is what makes the most sense from physics point of view. Regarding “how”.

[@23952AAB]

Just revisiting this after Michael Lustgarten and Roger Seheult brought new light into this topic! :D

[@patrickbeck4062]

Knowing how it works at the smallest level is great and all, and may be needed to get the most out of it, but I'm still for now more interested in the effects it has on on humans (effects of pets is great too), because that's how it's going to be used at the end of the day. Even if we figure out exactly what it's doing at the smallest level, we still have to go back and figure out how to get the best results at the human level. For example, even if physicists are still trying to figure out how gravity works on the quantum level we're still up here at human scales feeling it all the time and being able to calculate its effects well enough to be able to do things like calculate when and where comets will be seen again, launch satellites into space and keep them orbiting the earth. We can still do a lot just knowing the effects, even without knowing the exact cause at the smallest level.

[@blackpoolbootz2790]

Wonder how methaline blue interacts and does it bypass one of them complexes?

[@DougHaight-g2g]

I have a question. I'm a 73 yo male with type 1 diabetes. I have been using a full body panel of red lights for about a year. While standing in front of the lights my fitbit will show my beats per minute going up to around 115 bpm. After leaving the light my rate will fall to normal. Why is this?

[@MichaelGGarry]

Probably the wavelengths used by the fitbit (and any other smart watch) to measure your pulse.

[@byronsmith1982]

El secreto es exponerse a la primera luz del día y a la última. Lo que ocurre es que si te expones a la luz predominantemente roja de la mañana esto permitirá a tus celulas en la piel prepararse para la exposición a la luz uv mas fuerte del mediodía. Si tu te expones a la luz durante todo el año verás que tu piel soporta mucho mejor la radiación solar haciendose mas gruesa. Tambien muchas personas reportan estos beneficios haciendo la dieta cetogénica y aquí podríamos hablar de la estructuración del agua en la mitocondria y la activación de otros mecanismos muy interesantes. Saludos❤

[@post.newness]

Thank you for the excellent video! At 46, I've experienced impressive results using an affordable red light therapy panel from Future Form Official. My skin's texture and wrinkles have noticeably improved, and people often think I'm much younger. Red light therapy is supported by science, so it's definitely worth a try. Thanks again!

[@2BWiley2]

Probably posting this waaaaay too late to get a response, but I had hoped to see more on the physics. I feel that by saying, essentially, “red light enhances the ability of proteins I, II and III to do their job” (i.e., pump protons back across/out the inner membrane) is just passing the buck on the ol’ “red light is beneficial” spiel. I.e., that’s only a very slightly more sophisticated explanation but it still doesn’t answer the question, “But how?”. One of the things I’ve always wondered about, for example, is how the higher photon frequencies (shorter wavelengths) associated with red light are supposedly able to penetrate much beyond the thickness of human skin. If we’re just absorbing those photon frequencies at skin depth how do these “enhanced ATP production” benefits get passed to mitochondria located within cells deeper into the human body? This question becomes particularly relevant when considering not only the skin, but more importantly red-light photon penetration through the human skull and into mitochondria residing within our neurons (which seems important if cognition improvements are the therapeutic target)…. I assume mice skulls are thinner than human skulls so mice models probably wouldn’t be a good comparison for cognitive benefits if photon penetration is an issue (which I strongly suspect it would be). It just doesn’t seem possible red light photons could pass through the human skull at amplitudes much lower than might otherwise “cook” our mitochondria (or the proteins I, II and III those photons interact with). Might also be fun to visit the relationship between red-light wavelengths, photon energy, and atomic structure of the proteins I, II and III to understand why/how such wavelengths cause the change in potential that supports the proton flow back out of the inner membrane. If you come across this Nick, maybe talk to your Dad and such questions could be the topic of a later video revisiting the mechanisms? Or maybe these questions (if anyone sees them at this late posting date) just aren’t interesting to broader audiences…

[@willyengland]

Important questions, I agree. I have seen an article which shows minimally invasive techniques to bring in a laser into the brain and irradiate certain areas with red light to activate them (Alzheimer etc.).

[@tgaudlol]

at 2mn52, the study is wrong. If its a control group, each complex value should be the same both on the "After 5minute", and "After 60minute"' graph. Since that for a control group, both a just a "normal situation with no difference", but we see huge changes. So that mean the mesurment technique is useless

[@AmirKhan-lp1tl]

I wish he had gone deeper between a medical grade Red Light Laser therapy versus an LED panel. I work at a medical clinic with a Class 4 laser and do treatment of muscles and joints and seems to be very effective. But my LED red light panel had never done anything for me.

[@itsshepherd5618]

The depth of a class IV laser is part of what sets it apart for efficacy with deeper tissues. Class IV is only sold to those with medical degrees/training. 808nm is Class B only 2-3 inches depth if memory serves. There are many variables. Whether it’s pulsed or not. Depth of Fat layer. I have a class B laser at home for my dogs muscle pain. Class 2 also that’s just skin depth for surface wound treatments. I take them to a certified rehab vet when they regress and need the class IV treatments. It most definitely helps them. My male suffered a spinal injury and consequent muscle weakness and nerve pain. I’m a layperson. Statements based on personal learning and experience. Edit I’m in USA. I’ve not heard of laser therapy from a doctor here for human patients, only vets and animals. But maybe some clinics offer it

[@AmirKhan-lp1tl]

@itsshepherd5618 yes we are using on human patients and it works really well. Especially for arthritis and muscle pain. I work for a doctor and got training for it at the clinic. It's really effective.

[@coolatma]

How about melatonin being produced in mitochondria due to NIR light and mopping up ROS? Any current studies confirming that? Thanks

[@chrishowe8614]

Since the heat from the sun is infra red light, I would be highly interested in how therapeutic the red light from the sun is. AND! How much does the actually effective red light therapy correlate to the red light from the sun. It makes sense that the sun's red light would be good for us since we have spent 10M years evolving on this planet under that sun!

[@Videolistener]

“It makes sense that the sun would give us skin cancer since we have spent 10M years”…you get the idea

[@FTKiTzFakie]

@@Videolistenerthe sun doesnt give you skincancer. Do your research. Skincancer often develops in regions that doesnt receive as much sun light as areas that are closer to the equator.

[@jaro6985]

@@Videolistener Most people that die of skin cancer are past their reproductive prime age, so doesn't really matter much in terms of evolution.

[@barbaravincke2823]

​@@Videolistener and indeed in Africa, where we all originate from, people are dark so they have a higher protection against UV, while in Europe they needed less protection, so the lighter skin tones were better to survive as the allow to produce more vitamin D... All happening according to the laws of selection and evolution ;) of course the recent destruction of the ozone layer didn't really help...

[@SydneyCooper1]

Yeah there's the idea that infrared light stimulates subcellular melatonin which could act as a strong antioxidant.

[@joe2341]

I LOVE all the details

[@seranonable]

Okay, so, circling way back to the other video... does this activity with mitochondria have any implications for skin in the realm of anti-aging, etc.?

[@patrickbeck4062]

Yeah, still more interested in the effects it has on humans overall. Especially things like joint pain/recovery/inflammation/general aging ect. But there's also a bunch of more specific uses being tested, like doctors using it on the brain for certain issues.

[@homesignup]

Hey thanks for the info! Fascinating.

[@madsencc]

Could you investigate the possible synergy between red light photodynamic therapy and methylene blue. Many are claiming that they are synergistic because methylene blue can enhance mitochondrial respiration and ATP production,

[@JinaLampropoulos]

Thank you for the good work you do. Could you do videos on Radio Frequency for improved skin and Coolsculpt for fat loss. Thanks

[@VeganLinked]

That was awesome, definitely doing a rewatch

[@MrDjhealth]

When you refer to "red light", I assume the labs use red LED lights as the source. Incandescent red light heat lamps operate at a much higher wattage. Do you think this makes a difference?

[@makerus]

Thank you! But where is your sofa?

[@thatonedood7]

So why does it have to be isolated red light? Doesn’t a flashlight also contain red light? Would that have the same effect on the mitochondrial complexes?

[@pjaworek6793]

I'll be honest, I use a $12 heat lamp like there used to be in most bathrooms. I figured there'd be some of these wavelengths on the cheap. If anything it's great while drying.

[@Kalster1]

I threw my red heat lamp away. It is not the correct wavelength, plus it draws much more power. Invest in a red and near infrared LED lamp. Mine cost €28.

[@rickduker4969]

I also use a reddish heat lamp because it has about 38% of its spectrum in NIR 700-1400nm. The best source is to get outside sunlight, especially around greenery which reflects the NIR to you

[@stefanweilhartner4415]

yeah, nice. but the only real interesting question is, if the mitochondria itself changes into something healthier for getting a lasting effect. or, if we get more ATP during a 20min IR session, there might be a benefit for the cell. or not? is it just gobbledygook at this point.

[@Miramisu]

Very interesting and helpful! Thank you.

[@jonese007]

How was oxygen concentration controlled? As the final electron acceptor a low O2 concentration would limit electron flow and ATP synthase spin regardless of light exposure.

[@MineCartable]

It's interesting to see the cellular mechanics for this one. Though, I'm still left wondering where this comes into play with aging. Like, since Nitric Oxide is a reactive oxygen species, could antioxidant supplements be helping this problem of Nitric oxide clinging to the mitochondria? If it is, how much of the benefit that we see is because of that effect? How does this come into play with mitochondrial dysfunction? Could producing less energy as a result of less efficient mitochondria be a contributing factor for aging? So many questions, but I suppose that at least I had one of my questions answered on how exactly Red-light therapy works.

[@deama15]

A question I had was... is just shining redlight onto yourself externally suffecient? Maybe would be fine for skin, but what e.g. brain?

[@studentaccount4354]

TYVM ❤❤

[@davidford8539]

So should I do infra red or nir light therapy? How much of a benefit is there….

[@ellydavis2066]

What about other colours. I've been looking at Green Light therapy (supposedly good for pain and hyperpigmentation) but is it enough to get a light that simply shines green or does it need to state a specific frequency? I've seen a mask on Amazon that you can set to lots of different colours and it's only £31 but surely that isn't the same as a therapy-grade light. This whole thing appeals because no pharma, no side effects and I just listen to audiobooks whilst doing it (I have a good red light machine) but also getting something off Amazon, I just think it can't possibly be anything other than a light that just shines a particular colour, surely? Thanks, love your videos. I have a handful of carefully selected medical/science people I trust and you're one of them.

[@FrostDrive]

So basically it knocks the pebble out of the windmill. Letting it operate again?

[@cryptogeezer8219]

Very cool...thank you

[@debmanrique6466]

Red light mats, belts, etc have less power than the panels, but are closer to the skin, which I always concluded would compensate. No? Only the high-powered panels have a positive effect? Or are the lower level red light products of cheaper and inferior construction? What is low level?

[@quatropontoum]

Correct me if I'm wrong, but in the case of the experiment with the rats, couldn't the red light perceived by the rats' eyes make them more stressed or calm and thus influence the results?

[@Physionic]

Yes!

[@wonderdr1]

I've always heard light activates cytochrome C in the mitochondria. Is that one of the complexes you mentioned here?

[@kinpatu]

I'd like to see you review RF treatment for loose skin after weight loss.

[@LesleyPeach]

Please tell me we can photosynthesise! That would cut my food bills down a bit…

[@Dreamopticsredlightglasses]

Thanks

[@luismaruendaterres7399]

I like you brother, you're awkwardly funny.

[@jackbuaer3828]

Yes, and he leans into that.

[@SteakandChains]

Great video, can you have your dad do an interpretation of the relationship between calories and the laws of thermodynamics. I personally don’t agree with the calories model since humans can only use specific molecules as fuel, but it would be nice to hear his interpretation of it

[@DavidePalmer]

I have a complex I deficiency, and red light has a significant impact on my energy levels. I know it's not a placebo, because I have experienced 8t consistently over a long period of time.

[@ErnestLemmingway]

Instead of worrying about isolated infrared lights, why not go out in the sun? Our biology is adapted to receive every single frequency of sunlight. The visible part of the spectrum is only a fraction of it. We have non visual photo receptors throughout our body. So we should expect that even infrared by itself can have negative effects because its not found in nature. Maybe not as detrimental as blue light but it will still cause a problem with our circadian biology.

[@iche9373]

Because the sun has dangerous UV light and it only delivers the infrared light by sunrise and sunset. Have fun catching that specific time window, man.

[@happymouse442]

well, haven't you noticed all youtube "skin gurus" are vampires?? They tell you to wear sunscreens day and night, indoor or outdoors... and reapply every couple of hours!!! They think their skin will wrinkle to death otherwise :)

[@BODYCOACHable]

Actually this comment is even better! Uncle Jack could run circles around this guy.

[@chamuuemura5314]

“This guy”? Oy vey.

[@bill9989]

I have 2 units, and I've used them several times a week for a year. I've never detected any energy improvement. I still do it for other reasons, e.g., stimulation of stem cells (if it actually happens).

[@Videolistener]

I’ve seen some papers covering the biphasic response curve of LLLT, but couldn’t find a mechanism that explains this. You mention it, but would be interested in a mechanism behind this since people might just blast themselves with red light to the point of detriment 😂.

[@jefflittle8913]

Have you ever noticed that your microwave oven passes a lot of heat to foods with water and very little heat to dry things? The reason is the water molecule has an electron jump energy that corresponds to the energy of the light wavelength. The Photoelectric effect is actually the paper that Einstein got his Nobel prize for.

[@david-jr5fn]

Mitochondria evolved from Phototrophic Bacteria so that is why they have the ability to convert light energy to chemical energy

[@safedba]

That sounds like a "just-so" story.

[@david-jr5fn]

@@safedba well maybe you should try doing a search first 😉

[@Max-bh1pl]

I thought that mitochondria evolved from aerobic bacteria and produce chemical energy through cellular respiration, not by converting light energy.

[@safedba]

@@david-jr5fn I've read all the relevant literature and it's shoddy just-so story tales. Zero scientific evidence. Just conjecture.

[@adiaphoros6842]

​​​​@@david-jr5fn I researched, and found that chloroplasts came from photosynthetic (i.e. having the ability to convert light energy to chemical energy) prokaryotes, while Mitochondria came from aerobic prokaryotes. So you're confidently incorrect.

[@lucycooper55]

So true about us as a population accepting “red light do good” and with other product ad statements . Way to nip it in the bud, Nick

[@orange_jam209]

Are we going to ignore how porous the outer membrane is? The H+ in the intermembrane space leaks out into the cytoplasm, so usually there's only a pH of ~1 difference between the intermembrane space and the mitochondrial matrix.

[@BarnesThe3rd]

It definitely was (and is), a good one.

[@zakmatew]

It doesn’t always work because it is heavily dependent on the frequency used, duration, and local tissue characteristics. The method is effective but the above points have to be taken into account.

[@ChickyPumpkin]

4:12 near infrared, not near red

[@ZJK727]

You should look up what Morley Robbins says about the complex 4

[@hindoocow]

Also effective for COVID / LONG COVID

[@susymay7831]

Summary? What is the bottom line?

[@saliksayyar9793]

Measurements of mitochondrial complex and oxygen consumption using SeaHorse instrumentation can be all over the place.

[@jeangodbout]

Was looking to see if you had a Facebook account so I could send you a personal msg, but didn't see any, therefore I will ask and hope you see my message here. You have on one of the charts ATP verse qty of watts and the effects on the mitochondria, but I didn't see any time references. I personally base myself on an average of 60 to 80 joules to my cells everyday, for the last multiple years I have been using RLT and Infrared. I based myself on the formula mW/cm2 divided by 1000 x time exposed which gives you the amount of joules/cm 2. Now if I use your chart at .1 watt or 100 mW, and I want to get the same results as your .7 watts,.... all I have to do is add more time to reach that goal, do you agree with this conclusion? Looking forward to your feedback.

[@littlevoice_11]

Hmmmm. So osteoarthritis... yes/no? Emphysema.... yes/no? Did you see the large review of studies and reviews of clinical practice on Medcram channel in relation to infection and specifically covid19?

[@edl653]

All the hoopla over Red Light Therapy is just the result of a good marketing campaigns to sell a product. Whatever effects it has good, bad or none it is about selling and making money. For the consumer is it really worth the time and cost? Are the therapy's the result of actual photon interactions in the mitochondria or is it more of a thermal reaction to extra penetrating heat? Were the experiments conducted with a non-redlight device that could contribute an equal amount heat? As IR and nIR only penetrates up to 5mm plus or minus, most of the light would be absorbed by the epidermis and dermis, what is the benefit to this increase activity? Let say a person does 20 minutes of therapy and the skin produces more ATPs. Did it need those ATPs during that time and are ROS concentrations and cell damage increasing accordingly? Does the production of ATPs drop after therapy to the point where the total ATP production actually remains unchanged for over 24-hour period? So many questions.

[@babybalrog]

No mention whatsoever that at 6:30 the control + NIR rats do WORSE than control?!