Dr. Aubrey de Grey and Dr. Rhonda Patrick Talk Aging

Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process. In this episode Rhonda and Aubrey discuss the types of damage that cause aging, how aging results in a decrease in the capacity to repair damage, what role epigenetics play in aging, how people age at different rates, chronic inflammation as a driver of aging, factors that are in young blood that repair damage, the role of nutrition in aging, and recent technologies such as CRISPR, induced pluripotent stem cells that will advance anti-aging research and more.
You can find Aubrey on twitter at @aubreydegrey, and his foundation at www.sens.org.
▶︎ Get the show notes!
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Chapters
00:00:00 - Introduction
00:01:03 - What is aging
00:04:58 - Epigenetics
00:09:37 - Biological clock
00:15:08 - Drivers of aging
00:18:52 - Inflammation
00:23:09 - Parabiosis
00:28:00 - Nutrition
00:34:20 - CRISPR/Cas9
00:38:27 - Placental stem cells
-------------------------
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[@FoundMyFitness]

This episode now has show notes and a transcript! Get that here... www.foundmyfitness.com/episodes/aubrey-de-grey

[@SilhSe]

Ha ha ! First to thumbs-up 😆

[@PopArt]

Hands-down, the best de Grey interview I've seen (which is just about all of them). Thanks to Rhonda for a fantastic job only possible from an impressive base of knowledge and passion for the subject. This was amazing!

[@athanatic]

He got to get away from the central complete layman description of SENS because the whole field finally is.

[@garvintimmann]

Yes best interview so far. What i would love is the real technical aspects, even if it is just medical publications listed. Does Hypoxia-inducible factor 1-alpha pathway bring a cure to COPD? COPD is damage, and in terms of age reversal part of the problem, as COPD is linked to physically becoming disabled and even dementia.

[@TheGrasspond]

Rhonda is providing an amazing service to the world

[@qf6894]

Very true!

[@tomsport4537]

Yes, that‘s true. Greetings from Germany

[@Apoestasis]

Powerful Dr. Rhonda Patrick!

[@decotawilliams6944]

this is great and useful information.. I listen to Dr. Patrick all the time . I undertook a sauna project while lifting weights and the results were huge!!!

[@tadghsmith1457]

The crux of the discussion came at 28:20 when Rhonda laid out her approach and Aubrey responded by politely giving his opinion on it. It's obvious they were both trying hard to find some common ground but there's no getting around the fact that when it comes to dealing with ageing De Grey regards Rhonda's nutritional strategy as merely tinkering around the edges of the problem. I tend to agree with Aubrey. Physical ageing is an exponential process, that's why while about 1 in 10 people makes it to age 90 only 1 in 10,000 people makes it to 100 only 1 in 10 million to 110. Optimal nutrition is not going to go very far towards beating those kinds of odds. The most It'll do is double or triple, etc, someone's chances of reaching a particular age. So with optimal nutrition your chances of living to 100 go from 1 in 10,000 to maybe 5 in 10,000 or 1 in 2000. It's still little better than a snowballs chance in hell for most people. If we want to the average person living to 100 or more we need to start developing medical treatments that tackle ageing directly and that go way beyond what we currently have available. If you have any money in your weekly budget to spend on increasing your longevity, In my opinion you'll get better results by sending it to Aubrey De Grey's SENS foundation (where they do primary research into tacking the causes of ageing) than spending it on vitamin pills. Because if SENS manages to develop and get to market even one anti-ageing treatment in your lifetime it will almost certainly out-perform a lifetimes worth of vitamin supplements in the effect it will have on your and everyone else's longevity.

[@hYpYz]

+Tadgh Smith although nutrition might have some minimal effect on longevity i think what should be emphasised is the improvement of quality of life that proper nutrition and exercise can deliver in very short time. From my own experience and by looking at people around me it seems that lifestyle changes like nutrition and exercise can have dramatic effect on your outlook on life and general well being.... i know its not double blind long term study but hard not to make that conclusion just by looking around. Saying that i agree about sending money to SENS :D

[@takinyele]

+Tadgh Smith I think the tension comes from the differences in their field. Rhonda is a nutritionist. No one thinks that eating more vegetables is going to making you live forever. Its Aubrey's goal to live forever sooooo he is un impressed with nutrition because it won't achieve his goal.Aubrey wants to develop techniques other than nutrition so he ain't thinking about a nutritionist. Broad generalization is....... macro nutrients improve quantity of life. micro nutrients improve quality of life. So Rhonda's work will make your life happier but not much longer. I just wish my two favorite people got along better. Rhonda's work could easily lead to innovations in Aubrey's work so maybe they need to make love not war.

[@IndefiniteMark]

+hYpYz Well put.

[@conniepayne4425]

+takinyele deGrey's PhD is in Biology. He is a Biomedical Gerontologist. Patrick's PhD is Biomedical Science. To classify someone whose fields include molecular genetics and neuro-biology as a "nutritionist" is a bit simplistic. I've seen other talks in which deGrey speaks about the importance of nutrition. I thought Patrick's involved and obviously informed questions gave deGrey a chance to explain the current problems research into anti-aging is encountering. And yes, anti-aging is his specialty. It is always exciting and informative to see scientists who are not invested in an opinion discuss the research. I don't know if I would characterize that kind of discussion as "tension."

[@takinyele]

your right I didnt mean to devalue Rhoda's work. I have a lot respect for her.

[@bobfazio2051]

Great interview, it was a big help having the definitions at the bottom. Thank you for not talking down to us and making us stretch to learn more.

[@joesilkwood4958]

He was a great interview! Meeting of the minds.

[@kral3046]

Rhonda, you are hands-down the best interviewer (at least on KZbin that i've seen) out there. You can literally get anyone technical about their profession unlike on anywhere else, if you watch other interviews of Aubrey de Grey, David Sinclair etc. they all seem to be basically repeating but here it's so different and detailed that 45 mins felt no more than 5 mins, The only down-side to all that was that it ended (Although it seemed like he was actually gonna continue talking about growth hormone), i could literally watch you talk with anyone for hours on end, And please get Dr. Aubrey on the show again for an update after 5 years and keep up the amazing work! I literally cannot believe how underrated you are. I hope everyone reading this gets to reach the Longevity Escape Velocity. ❤ (I'm 17 so i think i have a chance :) )

[@froilananthony7391]

thank you very much dr rhonda patrick for coming in the philippines , your great knowledge in biochemistry and nutrition, filipinos needs it so much. thanks for the collaborations with dr ted achacoso. thank you so much more of it in the philippines maybe in cebu.

[@noobspwner]

perfect combo for a talk!

[@flexnetuser2268]

This is such a great interview because Dr. Rhonda is also very articulate and knowledgeable.

[@hoffmancapote]

I found this discussion really helpful. The whole discussion was in everyday language that made it quite easy for the layperson to understand. Well at least a layperson with prior knowledge about aging

[@qones3574]

Based on some of the comments, I was expecting antagonism ... They're working on the same problem in different ways. One is learning techniques that delay onset, waiting for the cures to be available at the personal level. The other is trying to create technologies faster than they would be, so they're available for more people.

[@conniepayne4425]

+Q Jones Bingo!

[@xyhmo]

Great discussion, thanks.

[@kimberlydeprey]

First KZbin video I’ve had to slow down just to understand this guy

[@nickgulgren5906]

I could listen to this stuff forever! Great job!

[@FoundMyFitness]

+Nick Gulgren Thanks! Glad you enjoyed it... More to come.

[@joshuaTNE]

same

[@rebelglory5898]

+Nick Gulgren *laughs* You guys do realize that this is sciences version of porn, right? More specifically, this is what you call "Sexy Science".

[@exercisepedia.eu1]

haha :))

[@earthlyng_official4599]

id have to agree cause i hear her talk about this shit and i get deviant thoughts lol.. i love this chick

[@gaston.]

appreciate the work she is doing... I think this all has value for decreased age morbidity..go strong and kick the bucket quick. I haven't seen an ageing expert yet that doesn't look their age.

[@exercisepedia.eu1]

Very good information, as always, Thanks

[@Botanifiles]

Something we can all do to expedite the science on this is either donate to SENS directly, or at the very least set them as your nonprofit to donate to through AmazonSmile and Amazon will give them 0.5% of every purchase you make at no cost to you

[@Brandon-eh4tz]

Rhonda Patrick’s work will help us live long enough to live forever as De Grey and Company break barriers.

[@garethbaus5471]

I certainly hope so.

[@retniretep9477]

LOL.

[@sightlesswisdom2559]

I feel bad for Dr Patrick here and in several other interviews I have seen her do. As a lay person I really appreciate what she tries to do for people like me, but when she speaks to these hardcore researchers and PhDs I feel like they look down on her and don't relate to what she is saying and constantly correct her and sometimes it seems they are holding back their frustration in communicating their ideas. I hope she does not allow that to discourage her and continues to try to bring us valuable insight into current research and science regarding health. Over all I think her videos are great and very useful.

[@AdonisGaming93]

I didn't get that feeling at all.

[@59250em]

It's the second time I watch this exceptional video and I think I will translate it for the French audience of my blog :-)

[@fleiteh]

you can really see a difference in perspective between the two of them

[@byronchurch]

Woop! That was a great dialog. Thanks !

[@yeoramsantos5170]

It is like getting the combination of a safe, but with some preliminary data and a way to go (replacing cells).

[@jdthakid2]

awesome!!

[@Dr.Cunt-.]

A great man.

[@zxtenn]

Hello Doctor Patrick, very interesting conversation. I see you have a different or more expanded definition of inflammation, when I think of inflammation I think of an ache or pain due to inflammation.Regarding your statement about obesity yes its an epidemic and not only being obese [fat] unhealthy but being obese is a spin-off contributing to other serious diseases like heart disease, diabetes, etc. so yes being fat makes everyday life more difficult by making doing simple things like walking, working much harder than if the same person was at a healthy weight, a simple thing like say taking the Bruce protocol test is too much for many obese people regardless of their age. I am 60 now, had open heart surgery in 2002, a 4X bypass and still do very well on the Bruce test and I take the echo test which is more difficult. People need to realize that when they eat non healthy and high fat food for years and years and have been constantly overweight for years more often than not bad things will happen prematurely, such negatives weigh heavily when it comes to recovery after an operation like mine. Smoking goes without saying that is a bad thing to do.EPO does increase red blood cell count which is why athletes use it however too much is dangerous as you know, I heard that a few athletes have died due to its unmonitored use, Lance Armstrong was working with a Doctor in Europe regarding taking EPO etc. during his cycling and winning years that can be seen on an HBO movie called Armstrong lies., blood packing has been around for years and I was reading that people who use certain steroids need to give blood to keep red blood cells at a reasonable level if they are unmonitored by getting blood work. I totally agree with you that diet is important for staying healthy.Interesting that growth hormone is good for younger people but not that healthy for older people, the people who need them most, I have read that taking growth at advanced age can lead to cancer.

[@TheMechanic204]

YES

[@hYpYz]

Great conversation. End of the interview looks like there was power outage :D

[@resovoirdog100]

POWERFUL RHONDA PATRICK!! THANKS JRE!!!

[@shelkett]

Thank You Rhonda Patrick for all your contributions to the science of health. I finally realized why no one listens to me about vitamin d or sunlight or sauna, it's because compared to her artistically informative expression and verbiage, I sound like an ape. How would I contact her for research I'm doing related to the field?

[@Farve4ever589]

Is it possible to have him on again in the future?

[@2DReanimation]

If you've listened to a few of Rhonda's videos, you will understand just how composed she is here with Aubrey. She has extensive knowledge of gene activation and how it relates to ageing. If she had the time, I think she could have convinced Aubrey of how amazing *naturally* modified gene expression is. And I'm fairly certain the best methods for reversing and slowing aging will be almost exclusively natural for a few decades more, or until AGI arises (Artifical General Intelligence).

[@edstud1]

Dr. Patrick's work may not dramatically extend human lifespan, but it may improve the quality of life in later years of life!

[@dr.samierasadoonalhassani2669]

TO WRITE WHAT IS HE SAYING ON THE SCREEN WOULD BE VERY HELPFUL FOR NONE ENGLISH SPEAKERS LISTENING.THANK YOU AND MAY GOD BLESS YOU BOTH.

[@josematos5219]

Anecdote story: My Grandfather took *cold* baths (anti-inflammatory) till he was 97/98 years (he got a cold :) and lived till 100y and 11month old.

[@szpakna]

Great interview! Any plans of inviting him back again? :D

[@gales9969]

Such a fascinating subject.

[@circleinfinite]

The Grim Reaper gave a thumbs down.

[@rui-9-cs315]

wow, super exciting

[@bevillenz]

I appreciate the effort of Aubrey to match his tee shirt with socks.

[@59250em]

I agree!

[@giuseppeg3672]

Dudes not even 60 and he has a wizard beard, proof of wisdom

[@larryphillipsjr.1607]

Giuseppe G 😂

[@Kube_Dog]

Proof of poserdom.

[@flowerpt]

proof of not working with machinery.

[@MMABeijing]

and no teeths, that s wisdom taken to the next level

[@christopherellis2663]

Mine is fifty-two in June 2020

[@vincentdc211]

I know he must have some great points, but I can't understand what he's saying a lot of the time!

[@stepananokhin693]

1:16 - if aging is the consequence of accumulation of various molecular and cellular changes, which results from imperfection of our metabolism, then how a single mutation in a single gene (namely mutation associated with Werner Syndrom) could cause lots of hallmarks of aging simulatneously? And how the same mutation can lead to the progeria in yeast? How to explain that facts from Aubrey's stand point?

[@garethbaus5471]

The mutation that causes Werner syndrome effectively disables a significant repair mechanism, which obviously would allow damage to accumulate faster. It is actually really good evidence in support of the validity of de Gray's model of aging which is more accurately described as conceptualizing aging as the accumulation of damage.

[@emilphoryew9436]

Both of these people have great hair!

[@WarmWeatherGuy]

He talks about ranking the population by nutritional status and comparing the middle 10% to the top 10% and saying there is not a lot of difference. The implication is that if you're in the middle 10% then don't expect a lot of improvement in health/longevity by better nutrition. I think he said something like this is what the data show. The problem is that the data don't include anyone with optimal nutrition. We don't know what optimal nutrition is because of the poor funding for such research. For example, virtually all of humanity has been severely deficient in vitamin D for the last couple of hundred years due to getting out of the sun. Most all of us are deficient in vitamin K2 due to CAFOs and the advice to eat a low fat diet. If you're aware of The Iodine Project it appears that we would all benefit from very large amounts of iodine due to the new halides in the environment that have only popped up recently (particularly bromine). I think he is missing an opportunity for much gain by ignoring improved nutrition.

[@davidsink5076]

WarmWeatherGuy you are correct

[@squamish4244]

Controlled studies of human longevity are difficult simply because you would literally have to start in the 1910s to get the complete population picture lol. There weren't a lot of centenarian studies started in the Edwardian Era when babies were still dying of common infectious diseases etc. One of the closest things to a 'controlled' study we have is the LDS Church, which follows a vegetarian diet, non-smoking, active, and a strong social life. Their life expectancy is 88 years, 8 years over the American average. Pretty remarkable when you consider that is an average.

[@Chris-MusicTheoryAndFretboard]

If you look at the data, nobody really followed a low-fat diet. Fat intake increased and calories increased. As a percentage of calories, fat decreased, but only because total calories increased by so much.

[@qones3574]

True, but it still might only be a marginal Improvement compared to what can happen once the science is really unlocked

[@benyaminewanganyahu]

If you're still reading these... I think the point is that, if the optimal produced significantly better results +10 years on life expectancy compared to the median, we would see something similar between median and top 10%. I.e. there's a clear pattern: as you increase environmental intervention to produce more longevity, the effect gets smaller therefore, the longevity of the top 10% (controlling for genetics) is probably the best you can do. Having said that, like they discussed, it's really very clear that our modern lifestyles increasingly make it difficult to meet this minimum healthy life at the median. If you eat burger and chips all week, perhaps some broccoli sprouts will make a lot of difference!

[@VeganSemihCyprus33]

What was that look at 0.02? :D

[@bobsmith2705]

Humm... Crisper is awesome! The issue is effectively targeting cells. The difficultly is the massive size of (cas 9, guide RNA, and template) fitting that into a virus is difficult. If you used an AAV, you would have to break it into components and hope both viruses infected the same cell. If you used a lentivirus, there would likely be tones of mutations. Crispers is the best when you can select bacteria with antibiotic resistance. A large organism is beyond challenging to infect an appropriate amount of cells with crisper. Modifying a small number of cells won't make the changes you want in terms of changing proteins, gene expression, and RNA you want in the whole organism.

[@larssonk22]

your website is down :(

[@rkuehhas]

This is the first interview with Rhonda where it just ends abruptly without thanking the guest. Really demonstrates how she feels about him on a personal level

[@MortimerYoung]

I don't think it demonstrates much

[@serenityjewel]

Y'all really be looking for drama don't you? Here let me help: "His knee was crossed and pointing at her so you can tell he was trying to keep her as far away from him as possible." Or "Look how straight she's sitting? You can tell she didn't really want to interview him." Or "He's laid back in the chair so you can tell he wasn't taking this interview seriously." 🤦🏽‍♀️ I sound ridiculous and so do you.

[@garethbaus5471]

Could just be an error in the video editing, I wouldn't read much into it one way or another.

[@qones3574]

The advantage of the charity science is that there is some Synergy between the different research branches. In my mind, I want to make sure that the Therapies are available before I need them. If I cannot canvas someone for sens, they might be willing to give for Alzheimer's, Etc

[@loremipsum7471]

Wow! I haven't looked up Aubrey for a couple years. Look how de Grey has gone de gray!

[@AngelOne11]

Was thinking the same thing

[@nozhki-busha]

Yes because like us all he is aging, the technologies are not ready to deal with that

[@AngelOne11]

I think it will take more time to figure things out but I am glad that they are treating age as a disease. I am pro that thought and as a medical professional I say use all the tools to fight it.

[@tmg81]

That's only because he doesn't care for Rhonda's nutritional advice...

[@doglasxuxu6004]

obrigado pela entrevista.

[@droidekka2]

cant read his shirt's website cuz of his beard lmaoooo

[@gregde3176]

the hell. it's an actual website about beards... okay then.

[@scottwalker678]

Niels his shirt says if you can read this shirt my beard is not long enough

[@naimulhaq9626]

Is melatonin helpful for sleep, or is it harmful? Can anyone please help?

[@MikeG-js1jt]

They should have clipped the mic onto his beard

[@TheGrasspond]

Rhonda you are a gift

[@mariekirby1683]

Two words summarise this interview - Keith Richards.

[@Mike9201984]

What is happening at 29:55???

[@Stratocaster893]

This is fascinating but I've got to ask the question: How long till we have a treatment?

[@boricuachiko]

+Stratocaster893 There's no definite answer, but some say that the first 1,000 year-old has already been born.

[@xyhmo]

Aubrey estimates he has a 50% chance of making it, and he's like 52 or something. Add 10% for someone ten years younger and so on. But it hinges on funding, donations matter at this early point (later the industry will provide the funding). Consider setting up a donation subscription, even a small one of a few bucks/month is helping.

[@qones3574]

+Stratocaster893, that seems like a question of how many people actually work (or pay) for the progress.

[@MrCmon113]

@@xyhmo To the Sens foundation?

[@18francesco18]

what I wonder is since eating, digesting, etc is pro-aging would eating things like soylent slow down aging considerably?

[@garethbaus5471]

I don't think we have enough information to determine if that is the case. Despite that I still like Soylent, and huel.

[@whiteninja9481]

How does one of the Smith Brothers brush his teeth after taking a cough drop?

[@theultimatereductionist7592]

Dr de Grey is the beard behind the SENS research foundation.

[@dannyalford1807]

This is like Anakin Skywalker(Rhonda) vs Count Dooku(Aubrey) in Star Wars Episode II. She lost her arm in this duel but she is still very young and got a lot to learn. Over time she will become Darth Vader.

[@weewilly2007]

These 2 people seem to be getting on like a house on fire! Surely they are cognizant enough to realize how accurately this saying fits with the bio/psycho/social phenomenon they are exhibiting? What are the implications of this to the rest of us, given that we are dealing with personalities and practitioners, who's preoccupations and personality profiles have immense implications to the rest of society?

[@doncorleone6182]

So we have been moving towards certain death since before birth itself. I feel better now.

[@electricsheep7633]

It is indeed four years and not five. In Japan and other Asian cultures when a human being is born they are already considered to be 1 year old. So when comparing data involving ages from western and eastern countries that factor has to be considered which is how he is getting the number four. So Dr. Aubrey is correct. He was tactful enough to not correct you during the interview.

[@garethbaus5471]

Interesting.

[@flexnetuser2268]

I love his work and his brilliance. However it’s completely untrue that nobody’s had any success in slowing down some of this damage. One of the things that requires the most energy is the digestion and elimination of food. So why not lift the digestive load from the body by eating everything that is already in the most broken down and nutritious form?. If you were to live on the juice of fruits and vegetables or a that, along with sprouts, raw nut milk, raw fruits and veggies, fish oil, the highest grade supplements as researched by someone like life extension foundation, “superfoods”, the best amount of exercise for your body, and a decent lifestyle ,you can dramatically alter the processes of aging. For example, instead of eating meat or other forms of protein, one can use freeform amino acids, which require no digestion.. And, we are only at the beginning of exploring the possibilities of improving the gut biome, and there is much research on the benefits of well tested probiotic strains.

[@AerialEyesProduction]

Ok, I'm off to find ways to force my body to lower its inflammatory responses, in conjunction with finding more discipline in my dietary and exercise regimen to help reduce inflammatory stimuli. Add that to sauna and ice baths after every hard workout to enable beneficial production of heat and cold shock proteins and hopefully I get a couple of years more to sit around watching youtube....

[@xyhmo]

Or you can support SENS and help bring about treatments that will let you live indefinitely and in perfect health without much effort.

[@qones3574]

+xyhmo, it's not either/or

[@teamtaylor6674]

@Louis hopgood ... best response to this remarkable interview .. I'm with you on this one.

[@malcolmlklein]

Thanks for this wide ranging interview- much better than the usual de Grey interviewers without a science background who question the viability of his approach or even the desirability of reversing aging. Wish you had touched more on the whole calorie restriction/mimetics (rapamycin, metformin, mTOR, etc) focus of most of the other anti-aging companies/labs out there. He has a rather discouraging view of that whole area gaining at most a couple of years. The unfortunate influence of the weather on the rate of aging: why human caloric restriction or its emulation may only extend life expectancy by 2-3 years www.sens.org/files/pdf/weatherPP.pdf

[@krilza]

How old is Dr. Rhonda Patrick?

[@Yosef9438]

37

[@WOLFMAN2975]

Lesson learned. Note to self, Put him in a Stationary! chair. : )Tyler

[@robertsegovia4663]

I am aware that this observation is not necessarily relevant to the discussion, but Dr. Aubrey de Grey sounds like the voice of the late Cary Grant.

[@SeraphXeno]

And what causes inflammation more than does anger?

[@SeraphXeno]

That is one focused dude.

[@danno8322]

it's only 4 YEARS, it's only 4 YEARS !!!! this fact makes me sad....

[@HendrikGriffioen]

Great geek talk on aging, thanks for sharing! Pity you didn’t touch on the topic of glycation though. According to Ron Rosedale, Tim Noakes, Thomas Seyfried (to name a few) glycation is one of the major causes of aging. Most, if not all, age-related diseases are caused or accelerated by a decline of the immune system, largely due to a gradual shrinking of the thymus as we grow older. Dr. De Grey mentioned the thymus, but I wished he had expanded on that a bit more. Most thymus research has been done in Germany. The main takeaway for me is that you can’t fight infection properly without inflammation. At the moment I have a cold - almost four weeks now - which does not seem to get better. I take curcumin (665 mg a day) as part of my life extension regimen. Maybe it’s a good idea to temporarily stop taking curcumin, being an anti-inflammatory agent. Curious about your view on this. Greetings from the Netherlands!

[@emilphoryew9436]

What the hell was that at 29:54-29:55?

[@snapman218]

Did anybody else notice him moving his eyebrows really quickly at the start of the video??

[@entengummitiger1576]

What does he say at 10:52?

[@mikevectorkilo4410]

Entengummitiger what he's stealing from me ???

[@benyaminewanganyahu]

"it's like 70% or something like that". Funny that so many people can't understand him haha

[@jamessteele7102]

I agree with some of the other commentators that he is hard to understand. This is the first time I've heard him speak so I'm not sure if it's him or the audio equipment that's causing the problem.

[@SladkaPritomnost]

It's remarkable how his beard attenuate his voice.

[@MMABeijing]

it s the missing teeths

[@MrMaxxstiles]

The Grey specs

[@relativityboy]

What's with the 0-300 count?

[@flowerpt]

it's like nobody is supposed to talk about that ...

[@benv.5170]

Sirtuins, MTOR and AMPK

[@dcjohnson2208]

I keep Alexa, Google and Seri next to me. The best is Google! The meaning of any words they use do not escape me!

[@Kube_Dog]

I still miss Duck Dynasty too. I feel ya, Doc.

[@curtseed11]

Immiss honey boo boo too. Doc Patrick is beautimous

[@ronaldmcarther8141]

When I first heard of Aubrey, I thought he was a quack. Now considering he's been making scientific progress, I've started taking him seriously.

[@emailjwr]

Ronald Mcarther genuine question, any evidence of his making progress?

[@SeanDavies-Roy]

emailjwr check out his foundations website: sens.org They have published a number of academic papers; the problem is, not many people will pay attention until there's a breakthrough in human trials.

[@sylviapolak3001]

Deswamping Aubrey

[@larryphillipsjr.1607]

Ronald Mcarther there both quacks.

[@stevebuss4330]

Rhonda... Great interview... Aubrey uses the phrase 'genetically programmed" just after 7:15...

[@aovint63]

Ageing is walking in a mine field. Anti-ageing is avoiding stepping on mines.

[@joeamrine7450]

LOL these male scientists LOVE to disagree with Dr. Rhonda Patrick... Patrick: Exercise promotes longevity Aubrey: Well actually falling from exercise can lead to atropy and premature aging Patrick: Yeah a better example is cigarette smoking should be avoided Aubrey: Well actually it’s a great technique to reduce stress which has been associated premature aging Patrick: Yeah you were right about that Aubrey: Well actually I was wrong about that

[@enkibumbu]

I can't hear him through that beard.

[@christopherellis2663]

I bet that you have hairy earholes.

[@PaulCooijmans]

I too can not hear him. I can not "catch" what he is saying through the beard.

[@davidanthony6408]

@@christopherellis2663 Brilliant

[@ashleydjanie7633]

@@christopherellis2663 😆

[@victordasilva5255]

cannot understand anything he says. jeez..glad it has sub titles. good stuff...when did he leave zz top?

[@dr.samierasadoonalhassani2669]

PLEASE PUT THE WRITING IN WHITE OR YELLOW ON BLUE BACKGROUND.NOW IT IS VERY FAINT FOR HEALTHY EYES NOT USUNG EYEGLASSES EVEN IN IN LATE SEVENTY OF AGE.PLEASE THINK OF THESE FUTURE SUPER CENTENARIANS( AJOKE).THANK YOU ..

[@filipe5678]

whats the point of his beard anyway? never got it,lol. Great vídeo.

[@WarmWeatherGuy]

+Phil Drt He discussed that in a Ted talk years ago: Aubrey de Grey: A roadmap to end aging

[@povijestpovijest9569]

+Phil Drt His wife likes beards and asked to to grow it, that's all.

[@TheSmiaf]

Pity of the audio quality.. He is hard to understand.

[@FoundMyFitness]

Those were early days! We're trying to do better with the audio now. A transcript can be found here... www.foundmyfitness.com/episodes/aubrey-de-grey (This episode is also close captioned very accurately if you'd like to use that.)

[@budte]

I had no problem with the audio quality. Just Aubrey talks fast and through a beard. I just slowed him down to 0.75 on the settings and that also gave me time to try and absorb what he was saying.

[@timmoteus]

Hey, look. It's Goa Gil out of Last Hippie Standing!

[@ericburke9708]

#beardgoals