Regulation of Cholesterol in Humans

[@carlor.s.4742]

Fantastic, informative presentation Dr. Ali. I had a stent put in in 2006. I was put on 20 mg Atorvastatin. Later my DR. put it up to 40 mg. I discussed with him how the statin blocks the CoQ10 pathway & he agreed. So I supplemented with CoQ10 while on the statin. I took the statin for 15 years, but after researching went off in March 2021. I then went on intermittent fasting for 6 months & still continuing. I took up weight training, building muscle & shedding fat & weight. Also started doing some HIIT. I was trying to get my A1C down & am still trying to get it lower. My LDL went up & m,y new physician sounded an alarm. I told him I expected it. He sent me to a cardiologist who told me I was the healthiest 77 year old he has ever seen. He was impressed with my regimen, yet he still suggested I take a statin. I demured. Your presentations have convinced me I made the right decision. I can hardly wait for the presentation on what happens to the cholesterol pools on fasting!

[@timt1069]

Yes, Dr Ali is wonderful! I have a similar story as I had a stent put in 7 years ago and the doctors (not Dr Ali) worked me up to 80mg of Lipitor. I did this for a couple years, meanwhile doing some study on cholesterol, statins, etc. I started getting brain fog and had joint pain, which I feel was from the statin. I decided to go on a LCHF diet with intermittent fasting, lift weights a couple times per week and do cardio via HIIT on the Elliptical 2 - 3 times per week. My results have been great! Trigycerides went down from 91 to 56. HDL went from 63 to 91, CrP at .32. My LDL went from less than 100 to 313. I lost 25 pounds over 15 weeks and am now down to my goal weight. I plan to continue this lifestyle and really appreciate the info provided by Dr Ali and others in the LCHF world as a great alternative to the standard American diet.

[@robertcampbell9364]

I am a chem/biochem major with some undergraduate courses in epidemiology, med tox and physiology. My most fascinating course was in membrane biochemistry. I had a cardiac ischemic event after a collision on the hockey rink that I think knocked some plaque loose. Two stents LAD and circumflex fixed that...back on the rink 3 weeks later. After that the acceptable levels of my LDL was redefined to reduce my risk of further plaque formation .I also did some graduate biostats while doing clinical research associate role in a regional respiratory referral center here in Canada. Frankly, I took myself off of statins as I was very uncomfortable with how much they interfered with cholesterol metabolism. Thank you for the ammunition in the fight against my GP!!! I had no idea the the relative risk reduction in absolute terms is about 1%. It was presented to me as about 33%!!! - yes I watched some of your other videos...all of them seem to be detailed enough to allow one to dig further. My complements on your presentation...nice balance of mechanisms with reference to RCTs.I also was a site coordinator in a clinical trial for RNAse in COPD and was struck by how much bad science the drug copanies get away with. Incidentally I also had an acute case of reactive arthritis and was on VIOXX for a couple of years as well as methotrexate. Took myself off of VIOXX before it was pulled. Not sure why except it was pretty new in 2010 so I went with Ibuprophen. The RCT was discontinued due to more deaths in treatment than placebo on interim analysis. International multicenter trial where i was struck by the extent of morbidity in the US sites versus Canada. Inclusion criteria included admission to hospital. The bias in the US toward admission for people who had relatively mild symptoms was striking. I assume that the admission decision process was influenced heavily by whether or not they had insurance to milk and the risk of litigation if they turned worse. Our patients were much much sicker before they were admitted. I do drag on...lots of medical doctors in the family but only some scientists!!! No offense. You seem to have the mark of a true scientist. Read Karl Popper. My father was an MD Phd Physiology, chair of medicine as well as a great educator and he went to the grave muttering about the principle of falsifiabilty in research hypotheses. "Do your best to get valid results and then distrust them." I can remember hearing on more than one occasion. That level of criticality is what science is all about. Big pharma needs to be closely watched. They will warp the data won't they! Frankly I think the insurance companies in the US could do a better job of keeping an eye on them. What is the economic impact of these marginal improvements in isolated outcomes when the potential for iatrogenic effects in such an important metabolic cascade is so high? I think you are on to something so keep pressing. Good science with mechanistic explanations is about pin steps and the drug companies try for the long jump.😮 I really like your videos. Thank you for posting! Please keep them coming!!!

[@hornet224]

Dr, Ali gives us a comprehensive scientific explanation of cholesterol that is understandable for laymen, Great job nobody else on youtube can explain, Thank you!

[@LowCarbLowDrama]

ABSOLUTELY!!!

[@Nadeem3335]

This world need a brave doctors like you sir who speak the truth 99% of the doctors not saving life’s they killing people they think about money and business but forgot about humanity GOD BLESS YOU

[@johnfontana7256]

Cholesterol is said to be made by the body , irregardless of dietary intake, to help the body manage inflammation,so blaming the ambulance for bringing you to the hospital makes zero sense!

[@225rip]

So cool that you have your bikes in the office. Thank you for a fantastic talk.

[@jrgenhermanrudfjeld8464]

Interesting presentation! Some feedback: * The sound quality was a bit off (for me at least). Could you invest in a better micrphone? * The slides were a bit small to follow. I would have preferred the slides in fulls creen and you in a smaller window. * Maybe you can time the music slightly differently, so it doesn’t compete with you speaking? * Do you have a patreon page where people can support you? If so, maybe you can put the link in the description? Regardless, thank you for great work from one ApoE4 low carb/carnivore community member who got his health back, his parents off the SAD diet, and my father off all medications (Statins, Blood Pressure, etc.)

[@greglaroche1753]

Thank you for your interesting and informative videos. In the past you have made your slides full screen, while you were explaining them. With them in small boxes on the screen, they are mostly impossible to read on a smaller screen than a full size monitor.

[@rikwen96]

Great talk! I am looking forward to part two of this discussion. As to the slides being too small, can you change the pictures around where you are the inset and the insets are the picture? I have seen that in other presentations and it is easier to see and follow along. Thanks.

[@blackbandit1290]

Excellent presentation! Now if I could only get my cardiologist and doctor to listen to my protestations about taking statins.

[@grantbuckley5528]

Absolutely brilliant presentation. Thankyou for all of your wonderful work. Hope you book is coming out soon?

[@debiheaton6812]

Thank you for putting these seminars for us!

[@jerrysims6691]

Superb vid, Nadir. BTW you look younger and younger every time I see you online - vive low carb!

[@MS-lg1bv]

Dr. Nadir, @eatmostlyfatali You may not know this but you’re a hero to many of us. I am 53 year old woman. I was recently told by my doctor my cholesterol came back at 368 and of course my LDL was at 285 my triglycerides are at 130, which I know is very high. At the same time I was having a bit of chest pain. They want me on statins. I said no, what would you do? I appreciate any help. God bless you Dr. Nadir.🙏🏼

[@jezzab01]

Fascinating stuff. I'm loving this learning curve I'm on. Thank you!

[@davidprossen849]

Nice presentation on cholesterol. We all need to learn cholesterol in our body is a good thing and not a bad thing as many in the medical community preach to peddle more drug sales. How we have failed our people in this health care area in the USA.

[@robertwood9984]

So much good info. So many good questions at the end. TY!

[@gonenh2]

I was doing ketogenic diet, but was struggling to reduce my triglyceride, only after watching one of Dr. Ali webinar, I found what was holding me back, and when I done his recommendation my triglyceride went down and my blood works become fantastic. very high HDL low triglyceride, ratio of 0.85 triglyceride/HDL

[@roselovell4096]

Herpes virus has a complete cure if only you are able to meet with the right Dr Odulapar on KZbin, this good herbal doctor cured my herpes virus with his herbal meds within 2 weeks, I’m free from herpes now , Dr Odulapar also has cute for HIV,Cancer HPV , fibroid,diabetes and any kind of infections or stds.

[@desh7120]

Please tell me what you did to achieve your iwn reversal. Also, please me to the specific Dr Ali video which informed you as to how to correct your issue. My husband has the same problem.

[@gonenh2]

​@@desh7120 I don't know if your husband exercises or not? but I was doing a lot of running long distances that were not helping my triglyceride, and what I learn is that for me it's more important to do two kinds of training, one can be cyclin on the Bicycle but like in a spinning class, not only ride in a low effort, you must try to work on high-density training, like go up the hill or make a sprints intervals, the other important training(maybe more important) is to do resistance training to encourage muscle building, both will help to reduce insulin resistance and will improve triglyceride. (I don't remember in which clip Dr. Ali talked about it, but after I heard it from him I change my training routine and my blood work improved)

[@craig2493]

@@gonenh2 Thank you, sir.

[@madhurhatiskar3348]

Brilliant as always. God bless you sir 🙏🏽 :)

[@muratrustu1]

thanks for the presentation. is it possible to make the slides bigger? impossible to read on the phone screen.

[@LowCarbLowDrama]

Totally agree! 👍🏻 Really Would appreciate larger slides, zooming the Image on phone distorts the quality. Watching it on large TV screen also doesn't help with the slide clarity, the images get distorted. Posting a link of the slides would be another way to do it, if editing the video is too laborious. Such precious information. Thank you!

[@castelliclinic]

Excellent lecture would be even better if slides were more prominent i.e minimize your image and make the slides prominent. this mwould make it easier for viewer to follow along Great videos Keep it up

[@farzanafmt2883]

Thanks sir for excellent information about our health care really thankful 💞

[@Harrycowlton]

Fantastic! You are back!

[@sabby123456789]

I am a cholesterol hyperabsorber as well as an ApoE4 carrier. When I ate a lot of eggs, my cholesterol and LDL were in the 500s and 300s. Even after I stopped eating eggs, I also had to stop eating animal fats in order to get my cholesterol under 200 and LDL under 100. Dr. Steven Gundry says ApoE4s who eat saturated fat will raise their small, dense, and oxidized LDL particles, so we have to replace them with olive oil and fish. Dr. Tom Dayspring says that hyperabsorbers need to reduce egg intake because of it. What does Dr. Ali think about this? It is very hard eating a low-carb diet low in saturated fat and eggs.

[@dawnelder9046]

You should look up the Korean Cholesterol Mortality Study published in 2019. Not the first study to show this, but the largest with over 12 million subjects. I think it will help you.

[@rajatsrivastava1884]

Where and why would an LDL particle get oxidized? I just hear that it is 'bad'. From inflammation? The body does so many protective functions against what we do. Eating animals from CAFO surely will cause all kinds of problems as will industrial PUFAs.

[@monetaryjack1705]

I'm now on 7th day of fasting but I did my cholesterol on the 1st morning (14hrs fasted) My TC is 400, but my TGL is 52, HDL is 76 and thus LDL is 314mg/dl....this morning my Blood Glucose was 54mg/dl and Ketones 6.8 mmol/l.... feeling fine though (snake juice!) and I'm not that concerned about the LDL and TC as the TGL/HDL ratio is 0.68 which is excellent... now just got to decide how long to go for, probably 10-15kg overweight so plenty of fuel!!

[@desh7120]

Very impressive!

[@cynthiameachum5552]

Thank you for your presentation. I am a carnivore for over a year and have ldl over 400. My A1C was borderline at 5.6 and my triglycerides went up to 125, which is high for me. How can this happen? Do I have a problem I should investigate? I have lost 40 pounds and am quite thin. Also my blood seems to be thicker than normal with normal clotting factors.

[@BenyaminMentchale]

Thank You.

[@vadimesharak726]

Eager for the next session

[@zorinaganpaul1598]

Thanks Dr Ali for exploring this topic👍. I'm trying to learn all I can about cholesterol as my total number is high and I want to know if this is a bad thing

[@cloud-db48]

should have made slides bigger and your office smaller, the info is in the slides which could not be easily be seen ... otherwise thank you for the great information!

[@zazaz44]

excellent.

[@faylouise8169]

In the skin 7dehydrocholesterol is a pre cholesterol substrate. It can either synthesize cholecalciferol vitamin D3 via mechanical changes induced by UVB +heat, or it will be turned into cholesterol via enzymatic process. 7 dehydrocholesterol is a precursor for both cholecalciferol and cholesterol in skin cells.

[@SergioGarcia-db6fu]

Dear Dr. Ali, thank you very much for your so important presentations. They let us understand clearly all the biological complex processes behind them. Please keep on working and enlightening us is all the so relevant issues as cholesterol, insulin resistance, fasting, and so on. Also, it would be great if you be able to link all your data and researches with another issue that I think will be the next cornerstone next years... how all these thing (managing them correctly) could impact over the "aging". Best regards.

[@bobcocampo]

Please maximize the illustration

[@Sewmore]

Very good info. Thanks!

[@cintiaspataro3205]

Thank you Doctor! What about for those that have gallbladder removed?

[@jezzab01]

Good question. I was wondering the same thing ...

[@eucapsiolatina]

Could anybody recommend me a cardiologist in, Maryland who supports LCHF diet and has a better look at cholesterol like Dr Ali, please? !

[@DanhNguyen-qm7kw]

Hi Dr. Ali. I was prescribed PCSK9 inhibitor Repatha but I did not take it without my cardiologist's knowledge. Instead, I have been following your advice regarding LCHF + IF for 8 months. I couldn't feel better, and my bloodwork is wonderful except for very high LDL. My cardiologist was upset with me. I am afraid that he would stop taking me as his patient. So, could you recommend me a cardiologist in Toronto, Canada, who supports LCHF diet and has a better look at cholesterol like you, please? I live in Toronto, but I can't find one. Any cardiologist that I came to focused on lowering cholesterol only. I am so disappointed. Please help me, doctor. Thank you.

[@eucapsiolatina]

Here is a Canadien doctor with the same philosophy. kzbin.info/door/oyL4iGArWn5Hu0V_sAhK2w

[@rajatsrivastava1884]

This is really the tragedy of our times re heart health. Doctors are chasing a LDL # since they are paid to prescribe Statins. No focus on patient health or beneficial long term outcomes. And LDLs are provided by evolution for s purpose.

[@cybersal7]

Since LDL transports CoQ10 and K2, I wish your doctor would do some more research but they’ll never probably learn until you and I both are dead. People live longer with higher. LDL is proven by the people in old folks home that have plenty of it an and are still alive.. I posted an answer to a comment above on websites to find keto friendly doctors. There might be something for Canada in it.

[@DanhNguyen-qm7kw]

@@cybersal7 Thanks a lot.

[@desertviews]

If a person spends a lot of time with their skin exposed to the sun, will that decrease their cholesterol since it should be used up making vitamin D?

[@silviopina_111]

Doctor, this is STELLAR! My ONLY suggestion would be... I would have put myself in the small picture and put the illustrations in the bigger one ❤️

[@monnoo8221]

i was amazed about the little amount of cholesterol made by the liver in humans. Actually, now I do not understand any more how it all fits together. Or is it just because we have a much bigger brain, which contains and produces (?) 12 times more cholesterol than the reset of the body. Where is this 1g chol. created and how does it get assembled and distributed? Is it the intestine? I thought, everything gets packaged in the Liver which produces and recycles the lipoproteins...

[@shirleywilkinson9335]

Thank you Dr Ali for your wonderful learning videos. MY Husband and Adult Children Have Cholesterol 99- 125 . Is that normal and a inherited trait ? one doctor told my middle child she needed to eat more fat ??? all 4 of them are over weight. but Healthy??? It is so confusing what is correct. can you address this some time?

[@mrhalattar]

Great video… keep it up 👍🏼

[@mrnobodyjo]

Came here for questions at 37:06 which remain as questions.

[@HBChandler]

Hi doc! Been following you for about a year now. I’m 43 years old. 6’1” and 185lbs. I been a carnivore for 9months and just did my new bloods. My LDL was 645. My doctors are flipping out! They know my diet and we were thinking it would be 350 on the highest end. This was beyond what we thought. Thoughts? Thank you in advance.

[@michellemintz2635]

kzbin.info/www/bejne/rZrGdpyLi9ifitU

[@ElsieDreamWorld]

Not a doctor, but a physiologist, so I think a bit. Do you also have low Vit D? That’s my case, so I think, following doctor Ali explanation, that I should plan on getting much more sun that what I really get, instead of using the statins, which wrecked havoc with my very controlled diabetes.

[@HBChandler]

@@ElsieDreamWorld thanks for responding. I spend the majority of my life in the sun. I’m surf everyday and work at home on my patio in Huntington Beach. So I think it’s safe to say I am not low in VIT D.

[@csstudio3648]

Are you familiar with Dave Feldman? He's doing citizen research about cholesterol and putting together a database. Hyper responders, people with very high LDL when on carnivore or keto is something he has alot of interest in.

[@HBChandler]

@@csstudio3648 thanks Christine! I’ll look him up. I would be super interested in that.

[@trishdexter4834]

Can you address the small dense LDL particles vs the large fluffy LDL and how and why there are 2 kinds?

[@thomassaddul]

The higher small densed LDL is more "associated" with CVD. The theory is that the "small" have stayed too long in the blood stream because they have been oxidized or glycated cannot be absorbed by the liver. Also the fatty liver has diminished capacity to absorb.

[@naveenmsw4959]

i love you dr.nadir .i want to speak to you in my life time

[@samueln714]

Does low carb/keto/carnivore effect bilirubin? Are bile and bilirubin different? Could your bilirubin increase on low carb since your cholesterol rises?

[@mattd5419]

So if someone has Sitosterolemia what diet should they do? can do a keto diet?

[@bobcocampo]

Please have a new video with large illustration

[@bobcocampo]

Too small Illustration. Please edit to show a larger illustration

[@bobcocampo]

What is the effect of SGLT2 to HDL, LDL and Triglycerides? LP(a) PLAC Test?

[@davidprossen849]

Dr. Ali a question: Do you agree that a high polyphenol count in a high grade of extra virgin olive oil is good the the body even though its fat is plant based?

[@galpal2]

So is taking red yeast rice with coqu10 just as bad of a statin?? I’m a lean mass hyper responder LDL at 376 and HDL 131 and TRI @ 54 with a CAC score of 0. 56 yr old female 89 lbs.@ 4’10 keto lifestyle w/ time restricted eating. On 0 medications and not in menopause. Should I even bother to take above meds?

[@Rene-uz3eb]

34:58 given that short chain fatty acids generated by bacteria from plant fibers are essential energy for colon cells, it seems likely that our dependence on some plant foods in the diet also extends to using plant sterols appropriately, in cell walls etc, at a ratio to cholesterol for each cell type that is probably managed by the body, not how much you ate (except that the body cannot produce plant sterols). So I’m more in the camp of guessing the plant sterols are needed, rather than being a problem, and the body can always build cholesterol. Wiki says sitosterolemia (a rare genetic disorder) is similar to hypercholesteremia, ie the issue wouldn’t be too much plant cholesterol vs cholesterol, but just too much absorbtion and inability to get rid of it, like in hypercholesteremia.

[@Spyrit2011]

Wiki is written by everyone, "correlation" and "link to" , are not causation. Epidemiology is not science, it is a hypothesis, with no body of evidence. Epidemiology is based on surveys, no scientific methodology what so ever. Think of it as Kevin Bacon science.

[@btudrus]

the Liverpool, LOL 😀

[@vasanaschenk1943]

Dr., do you any doctor in Switzerland that I can consult?

[@MrChezyoung]

More bikes, yeah. Great work Dr Ali.

[@wanderingfool]

Cholesterol peaks morning hours and what idiots do first thing in the morning is lipid test lol.

[@53531640]

Thank you, good point!

[@bobcocampo]

Can't see the presentation too small

[@zenapplejones]

Is cholesterol bad for the Brain ???

[@dawnelder9046]

No Breast milk is full of cholesterol because baby needs it to grow the brain. As an adult you need it to keep your brain healthy. If not you get diabetes of the brain, otherwise know as dementia.

[@carolj.3175]

It's the opposite which is why statins are so bad, creates dementia

[@cybersal7]

Your brain needs cholesterol so much that it makes its own, so no unless you want dementia your brain loves cholesterol of the animal kind.

[@wmp3346]

Peter attia takes a statin as he sees it as beneficial

[@monnoo8221]

that's a good thing, as we do not need to see him very much longer

[@robertwood9984]

​@@monnoo8221be nice.

[@zodiacmadhu]

​@@monnoo8221that's mean..

[@monnoo8221]

@@zodiacmadhu I admit having had ... no no no... Instead I d like to confirm that his influence on average bio-medical laymen is very bad... I can deal with the nonsense he spreads... Many others not.

[@haleemasadia9622]

Sir eating fats heart attack will come in india cardiologist are telling it's true ...thank you..

[@HealthChampion]

Don't eat high carb + high fat. Reduce carb drastically, then fat is not a problem.

[@LowCarbLowDrama]

@@HealthChampion My Indian friends tell me of Dalda and Vanaspati type fats, which are basically hydrogenated fats. Stay away from them at any cost. I hope I haven't consumed them on my multiple trips to India. High quality, grass fed, real GHEE shouldn't be a problem. Plus, real coconut oil/fat is good stuff. They're all healthy I understand, if taken when the sugar and glucose (carbs) are absent. Following a lowcarb doctor's personal advice would be the way to go. Good Health!

[@madhurhatiskar3348]

Haleema ji, like someone else also pointed out earlier. Fats are not the problem.. "Carbs and sugar are". A Low carb lifestyle along with periods of fasting is the only way out. For a person who has lost half my body weight and reversed my type 2 diabetes, I can vouch for it with some authority. Hope this makes sense. God bless. Tc .

[@stan8926]

In the long term most likely. I did 10 years of paleo 50% fat 25% good carbs (fruit, vegetables) and 25% protein. Eventually got high blood pressure and chest pain, plaques in my vessels. WFPBSOS can possibly reverse or stop progression. I managed to stop BP pills after 15 months.

[@LowCarbLowDrama]

@@stan8926 We all have our personal threshold, but the commonality is that the liver is the only organ that metabolises fructose and this dreadful sugar from fruits causes fatty liver (NAFLD). It's a precursor for Diabetes and many other metabolic ill-health, including hypertension. Hence, the high percentage of fruit in the diet might have been the culprit in your CVD. When we eat high-calorie foods and foods high in fructose, the poor liver gets 'stressed' and turns fructose into fat. The liver is also overworked from producing cholesterol when there's insufficient cholesterol input from our diet. When this happens, the insulin comes along and say, "oh, there are too many of you 'loitering', so let me pack you into the fat cells". Tada, so when we repeat this cycle uncountably, day after day, week after, month after, year after, decade after, we become fatter from outside, and most worryingly, fat from the inside. To my understanding, the ratio of 50% FAT and 25% CARBS might have been high as far as the amount of sugar in the body mixing with fat is concerned. The reason I say this is from the process called Glycation. It happens when the protein/fat mixes with the wrong crowd of sugar in the bloodstream. It goes bad. It causes CVD. Most fats are harmless except the hydrogenated ones. High consumption of Omega 6 rich polyunsaturated seed oils, which are cleverly but inaccurately marketed as vegetable oils, are also harmful. In other words, the good fats go bad in the presence of high sugar/carbs. I suppose it's life, "stay away from the wrong crowd, and you'll be ok for the most part". Control the controllable, as they say. Congratulations on coming off medications. Who needs drugs when you can food it! Dr Lustig's book METABOLICAL has fascinating information on all things food, nutrition and beyond.