Ep:384 HELP!!! MY CARDIOLOGIST SAYS LP(a) IS TRYING TO KILL ME

[@deborahbrown4775]

OMG Doc, FINALLY! This makes perfect sense. This is the ONLY , I mean ONLY ,explanation that I have found of how LPa works in our body. This video is the #1 post of your youtube career, and I’ve watched them all. Thank you once again for your work Doc. 🙏🙏🙏🙏

[@larryadams9083]

I just got my test results back. All my markers are PERFECT. BUT.....my lp a is 124. I follow a carnivore/ketovore diet. This number terrified me....until I heard this video. Thanks for the explanation. You are a godsend.

[@kathryncustadio]

I have an LP (a) of 368... Low carb, high LDL high HDL and low Tri... Zero score on my CAC❤ thank you for explaining all this!

[@sheddkkhan6758]

how much ldl highest you had

[@patvaughn9987]

Thanks for your explanation of this item. I’m a genetically prone person to create high levels of this substance. So my take away is to look for changes in inflammatory markers especially if I’m maintaining a ketovore/carnivore diet. The lipidologist I went to a few years back wanted to place me on a statin…which I have now refused twice in the past 4 years. 71 years old, maintaining a normal body weight now for the past 4 years. (Lost 80 pounds through lifestyle changes)

[@walterski8377]

What is your coronary calcium score? If you haven't done the $150 test go now.

[@pieguy279]

This the first explanation that i've seen for what lp(a) actually does.

[@mariagibb8185]

Keep that inflammation as low as possible. …. Thank you Doc

[@michaelhimes8778]

I’m 49 with high Lp(a). Zero Calcium score. My cardiologist has me on Nattokinase and anti-inflammatory diet. He said no to statins for me.

[@tedgardner5544]

Good doctor

[@robertcywes2966]

Good

[@janapeony8561]

excellent MD

[@dpk1385]

Same here. 49, zero CS. My cardiologist is concentrating on the diet aspect 👌

[@peterdorrfuss2680]

@@dpk1385wow, these specialist$ earned enough money already, or they now overworked since the ‘rollout’ of the yk

[@amypetra5021]

You sir, are the first person to more than adequately explain how apoeblittle-a works and why it’s important, than anyone else I’ve ever listened to! Thank you from the bottom of my heart ❤️!

[@rdc3397]

I truly hope all this information is true, as my Lp(a) is close to 100 😮 It also appears that i don't need to eat so many oranges & kiwi fruits for vitamin C 😀 On a side note, i love the simple language Rob uses to convey his passion and his message 👍

[@burrsniffen9688]

Thank you Dr. As usual, your knowledge, and insights are trenchant! Your couching the discussion at the beginning from an evolutionary perspective is brilliant. Putting into PROPER perspective the reason for LP(a). And at the same time beautifully lampooning the folly that is modern medicines interpretation of, and therefore sabotaging of, normal human health. I consider myself blessed to have been able to learn so much from you. As a patient, and a subscriber on here.

[@robertcywes2966]

Love the way you summarize

[@arwenhardy1995]

@@burrsniffen9688 Count yourself blessed that you're able to have Dr. Cywes as your physician.

[@XaqNautilus]

More people need to see this.

[@DCGreenZone]

@@XaqNautilus Everyone needs to see this.

[@cloudwhite8400]

Very Informative video, there is lots of misinformation about LPa but you are amazingly described. Its help to me for further process. Currently I have LPa 115 and Homocysteine 24.

[@tombarrett7797]

This was a great video Robert. I have very high LP(a) and have been worried about it. I now focus on inflammatory markers like homocysteine and hs-CRP. Both of those have been dramatically reduced as I have gone ketovore for the past couple of years. Thanks for all the work that you do as it means so much to many of us that feel like the healthcare industry is not structured to actually promote and educate on true health.

[@nasirvaidya6213]

I have very high hscrp and also lipoprotein an and ldl. What are you doing to lower hscrp?

[@walterk8602]

Thank you Dr. Rob. You have answered a question that has bugged me since I started keto.

[@iangorner]

Thank you ….endlessly fascinating.

[@phantomguard71]

18:15 tell that to Peter Attia 😆

[@robertcywes2966]

😊

[@markujcich4245]

Fantastic! Counter point noted. I'm liking the comments from my fellow health champions. A contribution to your coffee fund is coming shortly 🖖

[@robertcywes2966]

Thank you!

[@valeriestevens5250]

Thank you for the "nerding" Doc; I like it too. I have Lp(a) in the 175 range and have had some concern about it, but the keto/carnivore docs on YT say nothing about it. Glad to know it isn't a problem if I keep inflammation down. Again, thank you!

[@judywentling764]

P. 😊😊 😊 😊😊 😊😊 😊😊😊😊 😊 😊

[@fiddlerJohn]

Wow! Great video. Thanks.

[@robertcywes2966]

😊

[@UrsulaPowers]

I have Lp(a), 67 years old, zero CAC for 10 years now but high LDL but good HDL, Triglycerides, etc. keto/carnivore for most of the past 15 years. My doc wants me on statins. I am saving up money to become one of Dr. Cywes patients now.

[@robertcywes2966]

See you soon!!

[@sheddkkhan6758]

How much lp a

[@sammietong7108]

I’m another 49 (female) with zero CAC but high APO B and high small dense LDL My triglycerides is 71, HDL 77 A1c 5.9. My cardiologist prescribed 20mg of Crestor and also injectable statin. I refused.

[@robertcywes2966]

Work on A1c reduction

[@heatherburt2818]

@@robertcywes2966 Thanks so much for this latest video, Doctor C. I have T1 diabetes (dx 1987 @ age 21). Been low-carb/whole-foods for 10 years; switched 3 months ago to ketovore. LDL & ApoB spiked out of range and doc is heavily pushing statins. I refused, but I'm a bit scared nevertheless. Despite serious efforts throughout my diabetic life, T1D management is tough and *completely* avoiding out-of-range blood sugars is impossible. Before I went low-carb, my A1Cs were mostly in the 6's. Last 10 years, they've been mostly in the high 5's. Latest was 5.8%. I guess I just keep trying to normalize as much as possible ...?

[@topquality9949]

Very interesting,thank you very much

[@beepbeepnj2658]

"Nonetheless, the apo(a) size distribution in centenarians did not entirely explain the high Lp(a) levels observed in this population. Factors other than apo(a) size, and which may be either genetic or environmental in nature, appear to contribute to the elevated plasma Lp(a) levels of our centenarian population. We conclude therefore that high plasma Lp(a) levels are compatible with longevity." 1998 article by J Thillet

[@mattfisano]

Wow, a lot packed in this video. Thank god no quiz at the end, I had to replay and google some of it to see diagrams

[@robertbucsh8840]

Dr. Cywes, every time I want to get my nerd on, I watch one of your videos.

[@Wendy8888]

This makes so much sense. Thank you.

[@mollysteele4773]

I got my Lp(a) results back yesterday and they are 453. I am speechless. I am terrified. Any recommendations?

[@sheddkkhan6758]

you can take livalo

[@jahiddle]

@@sheddkkhan6758 No Statin will lower it. In fact it raises lp(a).

[@susanott8101]

Thank you for explaining this !!!!

[@Michael-pn2ye]

Doc I love your information keep up your great work Thanks 😊

[@beepbeepnj2658]

1) "Remarkably, one-quarter of the centenarians had high Lp(a) serum levels even though they never suffered from atherosclerosis-related diseases." 1998 G. Baggio. 2) 2012 article title: Low Lipoprotein(a) Concentration Is Associated with Cancer and All-Cause Deaths: A Population-Based Cohort Study (The JMS Cohort Study) Lipoprotein(a) is in your genetics for a reason to be protective for a long healthy life.

[@DCGreenZone]

I found out I had an irregular heartbeat due to plague built up in my veins, 3 years ago. I've been taken Nattokinase daily for 2 years. My last checkup with a cardiologist 2 weeks ago. Heartbeat was completely normal. Bloodflow normal. Will continue to take this supplement forever. 1 pill a day on an empty stomach, 1st thing in the morning.

[@robertcywes2966]

Excellent

[@s12_22g]

what brand are you taking?

[@JJ-jl1ge]

I was taking two a day but it caused awful aura headaches soon after swallowing.

[@Renee-radc]

Would you please share the brand name you are using?

[@DCGreenZone]

@@Renee-radc Sorry for the confusion, I should have put that in quotation marks, it came from another video and I don't remember which one.... And even if I did name a brand, YT would disappear it immediately.

[@gdecollibus]

Wow man. Explained so well. Thank you!!

[@Lizz7711]

I have high Lp (a) along with celiac and hypothyroid, and I’m post menopausal. About to start carnivore to heal my gut and body hopefully, and this is good to know that once I heal as much as I can, the high Lp(a) will be of benefit.

[@LalitKumar-xh3rf]

Dr Cywes has a great abiliy to explain complex medical stuff for a common person. Thank you Dr. I do have a question that pops in my mind. Why does LDL goes up on carnivore or keto diet? Is it a response to some elivated inflamatory activity going on with an understanding that LDL is just to adddress injury and inflamstion in the body? Thanks again for sharing the knowledge and educating us.

[@georgewright1093]

Fantastic video! I never upvote videos but I did this one.

[@rodneyhopkins2241]

Dr Cywes, that was a fantastic micro lecture explaining physiological mechanisms that get misinterpreted as pathological. Going to talk with my cardiologist about this one. Thanks

[@David-hp9tr]

If Lp a is >75 you will get the statin answer until the targeted drug comes out in 5 years.Nothing available yet lowers it significantly. ASA and LCHF,possibly Natokinase best bets at present

[@rodneyhopkins2241]

Thanks

[@jarichards99utube]

THANK You Dr Cywes...! 😊👍

[@navirose9133]

I'm posting my story as I'm sure I'm not alone in being overwhelmed with conflicting information and the understanding that everyone concerned will have their own unique circumstances. I'm a senior with very high lp(a) along with a sister with whom I share a range of similar conditions. (Other siblings are not carriers of the elevated lp(a).) Our parents lived into their 80's and 90's with no CVD, so we don't know which side we got it from. We both have Type 1 Von Willebrand's Disease as well as having had extensive endometriosis pre-menopause. Both of us have 'borderline' high LDL but optimal HDL and triglyceride levels. I cant help but wonder if there might be a link between our lp(a) levels and the VWD as well as lp(a) being available to help to repair the damage to the soft tissues from the endo? Also my understanding is that statins actually raise Lp(a) levels. This is such a complex issue. Of course our doctors are pushing statins. I've chosen not to go that route while my sister is now on Repatha. What I have chosen to do is to give up the anxiety and pursue the most healthy diet and lifestyle possible. Much gratitude to Dr. Cywes for his courage to present his most reasoned and wise approach in face of the reality of the pressures from the traditional medical establishment. (P.S. my dad was a pharmacist who became a top sales director with one of the world's largest pharm companies. The spin for the profits are real.....)

[@robertcywes2966]

Thanks for post

[@MayBee-gb5rg]

What’s the best way to know if we have arterial inflammation??

[@adamsimpson5573]

really interesting. keto diet for years but high LDL 220 but great HDL and Trig. pressure from GP to go on a statin

[@fiddlerJohn]

20:21 "the American Academy of Pediatrics now recommends All children between the ages of 9 and 11 years of age be screened forhyperlipidemia LP (a) levels should be considered in particular children and treated with statins." Crazy

[@terfalicious]

Aren't these the same docs that recommended babies get the covid jab at 6 months old?

[@peterdorrfuss2680]

@@terfaliciousyou spelt doctor$ wrong

[@fiddlerJohn]

@@terfalicious Good point. I hadn't thought of that.

[@AntoineEstEnChine]

Why would they prescribe statins for lp(a) when it doesn’t lower it

[@jahiddle]

@@AntoineEstEnChine $$$$

[@beckywang5624]

I am 79 and no events ever. My LPa is 170 and my LDL was 152 Triglycerides 63 and HDL 104. My Cardiologist wanted me on a stain and I agreed to 5 Crestor daily but I am rethinking it and may stop it since my LPa went to 170!!!

[@amy11228]

I’ve read that they find high LP little a levels in centenarians. I wonder if it is somewhat related to longevity even if we don’t understand the mechanism yet.

[@robertcywes2966]

It is. Protection from injury

[@googlefriend8410]

Great stuff, great explanation of why my doctor, although well meaning, is still trying to shove statins on me. I quit taking them several years ago. Not sure GLP-1 drugs are any better. I have heard that the drugs raise glp1 levels 4 to 5 times the natural level, which results in slowing down the digestive processes of the stomach and intestines, leaving food in the system much longer than supposed to resulting in festering food, nausea, gas, etc. Also an indication that longer term use could cause permanent damage to the system. As per Ben Bikman and others. You and Ben are two of my favorite people in the low carb communities. He provides some of the best in scientific metabolic studies, and you provide the more day to day patient experiences. Where the rubber meets the road so to speak.

[@gdecollibus]

Does your LPa number change? If so, what changes it and how often should one get that blood test done. Thanks

[@penelopewilcock3847]

Thank you so much. I'd be so grateful if you were to make a video explaining how to proceed if a person *has* arteries narrowed by arterial plaque, has had stents fitted, and now wants to transfer healthily to cleaner arteries. Do they need to continue with blood thinners etc? Here our doctors offer no helpful advice on this. What's the best way to proceed, assuming no useful medical help is accessible?

[@robertcywes2966]

Several of my previous videos discuss this

[@penelopewilcock3847]

@@robertcywes2966 Thank you - I've watched loads but will search more carefully.

[@amberh476]

🙏 Thank you

[@michaelbuck294]

After 2 heart attacks, I have asked my cardiac nurse about my LP(a) results, she had no idea what I was talking about and had to google it and no I have not been tested. Thats the UK NHS for you!

[@fooltx]

How does Dr cywes feel about psk9 inhibitors, this is what my cardiologist wants me to do

[@lonewolf7803]

Dr, Cywes, what is your LP(a) number?

[@paolabulgari6298]

Study the work of Dr. Linus Pauling and Dr. Mathius Rath on LP(a).

[@debbiesue4287]

Interesting. I certainly hope you are correct. I don't smoke.I've been low carb for several years and my LPa is very high ( over 2000) even though my total cholesterol is under 190. I don't quite understand that math but that's what it comes out on the blood test. I'm not gonna take drugs for it if anyone ever suggests it..I'm just gonna keep Maintaining the Healthier lifestyle. I Don't have high blood pressure don't have diabetes. I get sick for about two days with a head cold about every five years... That's it. Even when I got covid at work all I got was a headache for about five hours. I feel good, I sleep good, I don't have. Inflamed joints or arthritic pain. SO If it's a kill switch, so be it.I'm doing pretty good and maybe one day when it's my time it'll just be click and done.... That's far better than taking a bunch of pills for the rest of my life With side effects that make me feel like shit.

[@jobrown8146]

I'd rather quality over quantity.

[@robertcywes2966]

The science and logic are correct. Even cardiologists are starting to grasp this

[@debbiesue4287]

@@robertcywes2966 Thank you!!!

[@walterski8377]

Do get a coronary calcium score done $150 as soon as possible

[@sheddkkhan6758]

@@debbiesue4287how much ldl you have

[@WhiskeyCurious]

Dr Cywes please share the data sources for this talk.

[@robertcywes2966]

My head😊. Whole variety of physiologic sources

[@arwenhardy1995]

@@robertcywes2966 Unique brilliant and beautiful mind.

[@lonewolf7803]

@@robertcywes2966 All hat, no cattle.

[@dubsbarry9963]

This reminds me of cholesterol. They find it in clogged arteries, so they vilify it. Yet it's actually trying to fix the problem. Like vilifying fireman because they're always around fires.

[@pkilam]

LPa is for sure atherogenic, but eating a low inflammatory diet keeps LPa almost irrelevant despite raised cholesterol levels.

[@jon0604]

Although what you’re saying is correct, considering something atherogenic would mean that it alone would produce the damage. LP(a) is the firefighter along with ApoB etc.. if any of the lipoproteins were atherogenic then there would be plaque evenly distributed across the entire lumen of the arteries; not to mention the veins. Seed oils are another contributor that he didn’t mention which would be involved in inflammation.

[@JMK-vo8pv]

@@jon0604 I agree with you, Jon. I don't think Lp(a) particles are "atherogenic" at all. Lp(a), just like LDL, is a firefighter, only showing up at the scene of atherosclerosis AFTER the initial damage has occured to the coronary endothelium. This is also the opinion of cardiologist, Dr. Nadir Ali, who says he sees some elderly patients with LIFELONG high Lp(a) levels and they have ZERO atherosclerosis/plaque when they undergo a coronary angiogram.

[@jft8994]

Nadir was wrong in looking at the elderly group in France. Read comments under his video.

[@JMK-vo8pv]

@@jft8994 Thanks, jft, for your reply. I went back and looked at both Dr. Nadir Ali's KZbin video on Lp(a) and the original article on French centenarians that Dr. Ali was referring to. In the conclusion, the authors of that 1998 paper, J Thillet, et al, state "We conclude therefore that high Lp(a) levels are compatible with longevity." I think that maybe Dr. Ali got mixed up on how he reported/presented the graph that compared Lp(a) to levels to longevity.

[@Mat_Scott]

The problem with taking fish oil is there is so much bad product out there, and they are doing more harm than good. Can you recommend a good fish oil Doc and what exactly do we need to be looking for in an effective fish oil product?

[@Renee-radc]

ConsumerLabs tests fish oil supplements.

[@lonewolf7803]

Eat fish high in omega3 instead of fish oil supplements. Real food is always better than a drug (that includes supplements).

[@ilonabaier6042]

My Lp(a) is less than 20. Should I fat-stuff to increase it?

[@petegrant4111]

Excellent information- makes sense- deal with the root cause through proper nutrition !

[@lonewolf7803]

Most garden variety cardiologists recommend low fat and "healthy" low carb, citing the long-term risk of heart disease in high fat no carb diets. They love Mediteranean and DASH diets.

[@jeffledel7331]

Do you recommend natto.

[@scottweinstein4255]

Props for the Voltron reference, even if you called it transformers. 😅

[@simonevancoller6168]

Very interesting. And 100% on the other side of all other information. The feeling of being told my Lp a is very high would have been just a number. But my brother died of a heart attack at the age of 29 and was very healthy. So trying to figure out the way forward as my GP has no idea and just gave me a script. I have 3 little kids so need to make good decisions and with all the information I feel lost. Help aseblief Dr Rob

[@GJJC13]

What an excellent video! My lp (a) is 4! Too low? I'm 67 years old, always weigh 135 lb. LDL skyrocketed to 280 {from 110) when I started lower carb, which was already low, and in intermittent fasting. HDL improved to 78, Trigl 48, LDL Small particle size 253 (high), LDL Pattern A, Insulin 4,. Apo b 147, A1C 5.7, LDL 2743 (high), LO Plac2 actuv. 151 (high). Glucose fasting 110 (high)... Sorry for the excessive information but I seem to be a mixed bag of good and bad markers.... How bad do you think I'm doing and what would be a good advice? I'm a subscriber and really look forward to your videos which are excellent 👍👍

[@Peter-vn5jq]

Lol, you're about to make me worried about my Lp(a) levels- the test came back as "below assays sensitivity". I have so little Lp(a), that the machine couldn't find any. And now I'm wondering if that' a problem. Then again, I'm sure I have some, just not a lot, and for some reason my body decided its gonna be that way.

[@suewilkinsonmorrobayca6590]

Thank you❤

[@janew6704]

Can LP(a) be lowered by diet and exercise?

[@mrpig6742]

What is high lp a level

[@thomasbrennan1703]

How about apo b. Since I have been on carnivore my apo b has gone up to 134 and cholesterol went up to 453 (345 ldl / 71 hdl ) he want me on 2 cholesterol meds. Before I started my diet my Cac score was 55 Is apo b that critical

[@N7TWL]

Once vascular inflammation is reduced to non-harmful level and is being sustained at that level, does the plaque at the inflammation sites dissolve, dissipate, or otherwise go away?

[@lonewolf7803]

No. but it can become calcified and stable.

[@DCGreenZone]

5. Conclusions In conclusion, our work demonstrates that SRP can attenuate the elevated inflammatory biomarkers (MCP-1, IL-2, IL-4, IL-6, and TNF-α), the production of MDA, ROS intensity, CATx, and GSH impact in the setting of LPS-induced vascular inflammation. SRP inhibits inflammation and oxidative stress through the endothelium MCP-1. We concluded that SRP has the ability to modulate vascular inflammation. Further studies will be required to explore the detailed mechanisms of the cardio-protective effects produced by SRP. These results suggest that serratiopeptidase may be a therapeutic agent for vascular inflammation in cardiovascular diseases.

[@robertcywes2966]

Love needing out. Thanks

[@sharonillenye8036]

so I have sky high LPa and also found out high fibrinogen and homocysteine.

[@greendeane1]

My LPa is naturally 3 nmol/L I had a covid shot and got a brain stem clot. My doctor put me on pradaxa. I eat a lot of salmon. I've always had high triglycerides.

[@lamarodom]

Never seen anyone say anything positive and Lp(a). I don’t know what to believe now.

[@rzagza11]

I have lp(a) of 200. These are my other markers. A1C 5.3. Triglycerides 76. LDL-82. HDL-50. CRP-0.9. With a CRP score that low do I really need to be concerned with my lp(a) score? I’m 5’11, 169 lbs. I’m 46 yrs old. Parents still alive & pretty healthy at 75. Should I get my CAC score?

[@lonewolf7803]

No harm in getting at CAC test to learn if you have heart disease.

[@manny4491]

My LP(a) went up 65 % on just 10 mg of Crestor in 3 months. The data says Crestor always raises levels. I need clarity on this. I have advanced heart disease.

[@nya1]

Excellent explanation, thank you! Do cardiologists get commissions for putting ppl on Satins?

[@thoreevos]

43 year old, 8 month carnivore, just had blood work and found lp(a) 121.3 mg/dl :D

[@frankenz66]

99% North West European and Scandinavian ancestry and never had a LP(a) higher than 10 ng/dl. Last fall it was

[@davidherr6793]

What about somebody with stents, is stopping baby asprin a good idea?

[@lonewolf7803]

Probably not. What's your calcium score?

[@kfernandez220]

My APOb=131, APOa is

[@lonewolf7803]

If you're gonna cave, 5 mg Crestor has better side effects profile than the others.

[@kfernandez220]

@ Good to know. Thx!

[@kfernandez220]

@ Had another test a few weeks ago. My Tri dropped to 86 but my HDL dropped to 65. LDL increased to 175…..I don’t like this result so I’m back to square one and undecided still about the statin. I’m giving it another go with grape seed extract, ACV, and Bergamot.

[@VolkyHaus]

it took 10k years to understand that grains are bad for humans.

[@AmandaViolinGirl]

While I was in the ICU ward in the hospital and eventually was woken up I will admit I hardly knew who I was in the beginning so I took the statin for only a few days. Nobody can get me to take a statin now.

[@MareBlz]

I am so convinced that doctors need to leave people’s lipid levels the heck alone

[@georgeyoung2123]

I assume you meant Lp (a) instead of Apo A2 at the 22:42 point in the video.

[@jeffmcelroy5437]

So basically the current standard of care breaks the Hippocratic oath, and could probably be termed malpractice. Seems like at some point the profession of "practicing medicine" has gone horribly cattywampus.

[@petertownsend252]

No mention of the L(a) null allele that results in a non-detecable level of L(a). Approximately 3% of the general population carries the L(a) null allele on chomosome 6. Perhaps in a follow-up video? My L(a) level is non-detect and a genetic test confirms I also carry the L(a) null allele. Where does that leave people such as myself (3% of the general population) in all this?

[@danieljrgensen133]

That probably means you're a rare specimen of the human race. And I wish I had your genes! 😉 The only quoted research citations, about possible side effects from very low lp(a), is there's a trend towards these individuals are at a higher risk to develop type 2 diabetes, if they get obese from eating an unhealthy diet. So, If you are able to eat at least close to what is considered healthy on a daily basis(low on ultra processed carbs and saturated fats), you are one of the lucky few ones that have been given the genetic "gift" of living a very long life, free from heart related diseases! If you want to help mankind, sign up as a volunteer for a medical study, that looks deeper into why you and other people like you, are different than the majority of the human population, which has at least a measurable value in the 0-75 nmol/L range! 😉👍

[@robertcywes2966]

Slightly poorer healing suggest vit C supplement

[@toddinrancho]

Been carnivore/ketovore 3 years and got a DVT in my popliteal vein. Now I know why. Anybody else dealing with this?

[@GregariousAntithesis]

LPa cannot be treated and myself knowing i have high LPa is pointless.

[@Nunawading]

Lordly Levitation

[@monnoo8221]

In general, a good pesentation. Nadir Ali ppresented the same issue some years ago. Interestingly, there is nice research showing that high doses of vit C has a dose relationship to LP(a), meaning ha tvit C in high doses has a highly protective role for the vessels. ...which is not surprising at all. However, the same research also showed that the level of LP(a) is directly related to the number of soft plaques and initial clots. So, i would doubt that high LP(a) is associated with longevity. in old age there are a myriad of reasons for vascular injury, not just carbs and smoking (PM2.5)... even parasitic bugs, or bugs from our internal flesh-borne microbiome getting parasitic, and chronic yeast infections, high CD38 associated with imbalances in the immune system, glycocalyx damages, collagen stiffness, low NO etc. so...high LP(a) always indicates that sth is going wrong, and a root cause for vascular issues is lirking in the dark. (small remark ... Lp(a), appears to play a role in wound healing by preventing the dissolving of a clot, rather than directly activating clotting. Some of statements are thus not quite correct.)

[@amy11228]

Credentials, please?

[@monnoo8221]

@@amy11228 you mean references?

[@robertcywes2966]

It is associated w longevity. Google Swedish longevity study from Oct 2023

[@jon0604]

Statins do not lower LP(a) - there are studies attempting to do it - that’s what they will be pushing soon

[@robertcywes2966]

Exactly

[@GOLFADDICT65]

I would like to know is it worth being on OZEMPIC or is it hurting me been on it for 3 years i started the carnivore diet July 1st 2024 and have already lost 16 pounds its July 13th so i assume i had alot of inflammation so i have stopped taking the Ozempic last week i am type 2 diabetic A1C of 7.5 was 5.8 last year i wanna reverse it I am 59 and suffer from severe PTSD / on thyroid pills / also on 3 types of diabetic pills ( Metformin , Forixga , dimicron ) / prostate pills / mental heath pills x 2 Abilify / Metoprolol I AM PILLED OUT i am done also wanna lose 70-80 pounds by March 2025 my 60th birthday very interested in your thoughts or anyone else thx for reading my post cheers from Vulcan Canada

[@robertcywes2966]

Set up visit to discuss

[@loris7964]

Never had it measured as far as I know who cares I do not

[@planner722]

Back in 11/2015 I had a DVT that led to a massive PE. The Dr’s still do not know how I survived. Before this I had for years had massive inflammation with multiple autoimmune disorders. The put me on blood thinners which then led to me several years latter almost bleeding out in my gut (I flatlined several times in hospital and need several units of blood). I am now on Keto (nearly carnivore), loosing weight and feeling better than I have ever. I suspect many of my autoimmune disorders are gone however I am not certain how to come off some of the things I have been put on ( Humira and always wearing knee high compression socks). I guess once I get to my ideal weight I will talk to the GI Dr about another colonoscopy and find out how I could come off Humira and talk to the Cardiologist about getting a comparative ultrasound of my veins in my legs. Question, will insurance pay for the ‘extra’ procedures- time will tell.

[@lonewolf7803]

Call your insurance company to find out.

[@robinhood4640]

A common observation seems to be more and more indicative of the root cause of the problems regarding medical knowledge, and the difficulty to "un-know" the outdated knowledge. Many doctors who have questioned their knowledge, and found faults in their reasoning, have only done so, because they became a patient as well as a doctor. You cannot assume the patient didn't take their medication, if you are the patient who took the medication. You cannot accept the patient is exaggerating, if you are the patient who is objectively evaluating the situation. You cannot blame the anxiety of the patient, because of their health issues, on imaginary psychological problems independent of their health issue, because you are the patient. You cannot fob the patient off, with vague explanations to hide your inability to understand what's actually going on, because you are the patient, and you are a doctor so you know it's nonsense arguments without any value. You cannot do any of the things you do with the patient, when their body doesn't do what you have been taught it should do, be it their symptoms, their reactions to medication, treatment or changes to diet/eating habits. When you no longer have the possibility to doubt the patient, because you are the patient, you have no option, other than to question your knowledge. And question your knowledge you will, because your life depends on it. The reason the majority of doctors refuse to question their knowledge, needs to be addressed, because expecting them to believe they are wrong, doesn't work. It didn't work for all, or at least the vast majority, of doctors before they became a patient.

[@Kchamp92]

I am wondering if anyone could offer advice or reassurance. 32 year old female from UK. Non smoker, non drinker, need to improve diet but generally pretty healthy. Elevated cholesterol, 4.7mmol LDL. Triglycerides in normal range and 1.4 HDL! Trying lifestyle changes with food. I am quite active My LP (a) is 101mg/L Apo B is within normal range Liver and kidney functioning fine Should I be concerned? Some family history of heart issues. I’m worried sick… Two kids with special needs and I want to be around for them. I am a very busy and often stressed out mum.

[@Kchamp92]

My GP doesn’t really know what to suggest with Lp (a)

[@lonewolf7803]

Get a CAC scan to learn if you have calcified plaque.

[@capnkirk5528]

While not taking ANYTHING away from the good doctor, your body DOES have a "kill switch". Evolution is the origin of SPECIES, and the SPECIES is best served if there is individual variability and turnover. Individual death showed up as a mechanistic evolutionary advantage and that is the reason why individual species (of mammals, for example) have widely varying lifespans. Google it, you'd be surprised. On the other hand, I don't think that lipids or plaque are the mechanism. (Amyloids maybe?) Also, since this is a genetically programmed imperative (there IS a biological clock, and it HAS an endpoint) it is possible that with the right approach the clock can be extended or reset. We are currently a long way from that point however, but at the current rate of development of knowledge in cell biology and metabolism it might very well be within your kids' lifetime. If we don't collapse society with climate change, that is.

[@jobrown8146]

Evolution is a theory not a fact.

[@gener.1253]

Gravity is a theory. Is it a fact?

[@andrewsherman2398]

Gravity isn't a theory it's a scientific law because it's existence has been proven that's why the scientific community refers to the theory of evolution when they talk about evolution and they refer to the law of gravity when they talk about gravity​@@gener.1253

[@BillyBoy66]

@@gener.1253 Some theories turn out to be fact, some don't. Just accept the fact that some people believe the theory of evolution is wrong concerning macro evolution. Many holes in it. Just move along now...

[@zamfirtoth6441]

Things do evolve....modern humans did NOT.

[@gener.1253]

@@zamfirtoth6441 I would agree with you, but then we would both be wrong

[@fiddlerJohn]

19:25 "Linus Pauling a very famous guy in physiology postulated that LP little a is a primate adaptation to the enzyme deficiency that occurs in certain lines of of mammals that creates ascorbic acid from glucose and human beings have to consume vitamin C we have to consume vitamin C because we can't make it." en.wikipedia.org/wiki/Linus_Pauling

[@robertcywes2966]

Yes

[@dustinirwin1]

The longest lived populations eat lots of carbs, grains, veggies.