Folate deficiency - Megaloblastic Anemia - Macrocytic - Hematology Series

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Medicosis Perfectionalis

Medicosis Perfectionalis

Күн бұрын

Folate deficiency anemia - Folic Acid - Megaloblastic Anemia - Macrocytic - CBC - Complete Blood Count - Hematology Series
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Пікірлер: 246
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
💉 📜 50 hematology cases: www.medicosisperfectionalis.com/ 😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119 📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis/
@Zain_altouka
@Zain_altouka Жыл бұрын
I wish I can 😢 Im from Syria .. I don't have any bank account ..🚶
@elaineluther1799
@elaineluther1799 3 жыл бұрын
Homocysteine in the blood creates a hypercoagulable state. Therefore, all the complications of homocysteinemia have to do with the damage that can be caused by excess clotting: ie thromboembolic nasties such as CVA, DVT, MI, etc. In the blood homocysteine also causes megaloblastic anemia. Now, medicosis perfectionalis, I'm not sure if you wanted the non-blood complications, but I'll go ahead and give those. Excess homocysteine can deposit in the eyes (causing myopia and ectopia lentis) the bones (causing brittleness and deformities) and the brain (causing intellectual impairment). But if your homocysteinemia is temporary due to a folate deficiency, it should not get so bad that your eyes, brain, and bones are affected. That happens in babies with the genetic defect.
@martinkhashihiri4825
@martinkhashihiri4825 Ай бұрын
Folate deficiency leads to homocysteinaemia. Homocysteinaemia causes hypercoagulable states and thrimboembolitic nastis, Right? Then the same folate deficiency causes pancytopenia due to ineffective Haemopoiesis. This means we have thrombocytopenia due to pancytopenia, leading to increased bleeding due to defective clot formation. Now tell me, does folate deficiency cause hypercoagulable or hypocoagulable states?
@user-gp9cc7up9l
@user-gp9cc7up9l 28 күн бұрын
⁠​⁠@@martinkhashihiri4825thrombocytopenia doesn’t stop blood from clotting in hypercoagulable state. In hypercoagulation you just need a little push from platelets to start clotting, you don’t need a lot of them. The same thing happens in lupus with APS: there is thrombocytopenia and still hypercoagulable state.
@lisasloane3807
@lisasloane3807 3 жыл бұрын
Thank you for not slide reading! Thank you for TEACHING!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
You are so welcome
@dylanmcfarland2405
@dylanmcfarland2405 5 жыл бұрын
At 1:29 when you say "pay attention please", how did you know I was playing on my phone?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
My seventh sense can pierce through your soul 🤫
@queenhelena1515
@queenhelena1515 4 жыл бұрын
LMFAO SERIOUSLY
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
😁😁😂😂
@Sarah-fy2vf
@Sarah-fy2vf 4 жыл бұрын
@@MedicosisPerfectionalis Why 7th what about 6 😊😂
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
That’s already taken ☺️
@11ayesharinad27
@11ayesharinad27 3 жыл бұрын
Complications are osteoporosis and fat deposit in blood vessels🙏😊thnk u and I really appreciate ur way of teaching. I am going to have my exams next month ur videos really help me out, always.
@nevinkuser9892
@nevinkuser9892 5 жыл бұрын
I'm very impressed with your videos. Such a nice, clear explanation of a somewhat complex topic. Clarity, I find, is the most difficult thing to find in videos these days. Some people should absolutely not be making videos. But you sir are gold, very clear and precise. Thanks again, I'm not even a biology or medical student but I understand what you're saying very clearly. 💪
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Awesome 👏 Thanks 🙏
@nomnomnom3110
@nomnomnom3110 6 жыл бұрын
Thank you so much! I wish all my professors were this clear and concise 😊😊😊
@MedicosisPerfectionalis
@MedicosisPerfectionalis 6 жыл бұрын
Wow...that’s a boat load of a complement...Thank you :)
@whatadrag27
@whatadrag27 3 жыл бұрын
I'm pharmacy student! You help me alot sir.
@guin8630
@guin8630 5 жыл бұрын
You are great! I have an exam today in two hours, and had 5 lectures of anemia that I couldn't understand because our doctor is so bad at teaching.. yesterday I only studied from your videos and I really feel confident to take the test. Thank you so so much 💕💕
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Very nice...that’s amazing....and how was your exam?
@guin8630
@guin8630 5 жыл бұрын
@@MedicosisPerfectionalis It was good! I think I'm getting an A+ on this one hopefully ^^
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Excellent! Good luck! Please consider sharing these videos with others, it really helps me! And I am truly grateful! Thanks a ton!
@guin8630
@guin8630 5 жыл бұрын
@@MedicosisPerfectionalis Sure thing! 🌼
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Appreciate it!
@oktamrd
@oktamrd 2 жыл бұрын
I'm just so late I have just found your channel. Youre a blessing, thank you for everything you put here for free. 😰😱🖤
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
Thank you 🙏
@orangepeel1366
@orangepeel1366 2 жыл бұрын
ME TOO JUST FOUND THIS CHANNEL AND I LIKE IT A LOT
@loayibrahim1855
@loayibrahim1855 4 жыл бұрын
you are perfect .... I'm very amused when I watch your videos
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thank you so much 😊
@dayanavidova1671
@dayanavidova1671 4 жыл бұрын
You are my favorite teacher
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thanks 😊 Please share!
@khamikos1
@khamikos1 6 жыл бұрын
YOU ARE THE BEST. MAY GOD BLESS YOU.KEEP IT UP
@MedicosisPerfectionalis
@MedicosisPerfectionalis 6 жыл бұрын
God bless you too...Thanks a million...Please consider sharing with friends, it really helps me...I wish you all the best, and thanks again :)
@user-qr4te5pv7e
@user-qr4te5pv7e 6 жыл бұрын
Homocysteinemia: thrombosis, eye down and out, intellectual disability, megaloblastic anemia
@kyle610
@kyle610 4 жыл бұрын
i was told mine is low. light headed, blurred vision, depression, fatigue i been getting
@kyle610
@kyle610 4 жыл бұрын
can food allergies cause deficiency
@saraahmadi3939
@saraahmadi3939 3 жыл бұрын
Dear professor GREAT AS ALWAYS ...
@annjean4369
@annjean4369 6 жыл бұрын
Great video! Thank you for sharing.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 6 жыл бұрын
Thank you for watching!
@reachtt
@reachtt 6 жыл бұрын
I think the beauty of your video is you try to help us remember things, which unlike many professors I know who are just trying to show you how smart they are, listing out facts after facts in their lectures.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 6 жыл бұрын
Thank you...I had the same feeling with my professors, unfortunately. That’s why I would like to change that. I want every medical student not to suffer. I will tell the silliest jokes, and make fun of myself so that a student can remember forever...Have fun!
@youwhatmadeidk
@youwhatmadeidk 5 жыл бұрын
Medicosis Perfectionalis that’s brilliant :)
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Thanks, dear!
@qubicracks6386
@qubicracks6386 5 жыл бұрын
i noticed he sounded a word out slowly so you could see the parts of it and understand instead of just memorizing the word
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Yup! Indeed
@MsMadamadamada
@MsMadamadamada 5 жыл бұрын
Please be the hero we don't deserve and do a cardio playlist (with EKGs would be perfect).
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Excellent! I hope so!
@Mariam-nv1fk
@Mariam-nv1fk 3 жыл бұрын
thank you very much !!! wish u all the best ♥️♥️
@mariyajacob4107
@mariyajacob4107 3 жыл бұрын
Amazing work and good explanation .thank u
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
My pleasure 😇
@farahkhan7718
@farahkhan7718 4 жыл бұрын
Thanks again ❤️.... U make me to memorize all the things right away....
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
You’re always welcome 🙏
@AnaBellaOfficial
@AnaBellaOfficial 4 жыл бұрын
Hyperhomocisteinemia: Thrombosis, pregnancy complications (abortion, pre-term, neural tube defects), osteopenia
@drswetaruparel
@drswetaruparel 5 жыл бұрын
Really very very very helpful !!! 👍
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Superb...Glad you liked it!
@user-jz2nx6xt3t
@user-jz2nx6xt3t 3 жыл бұрын
Ur voice for some reason make the info stuck in my head 🤣🤣🤣 thanks anyway
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
My pleasure 😇
@syedasadullah9839
@syedasadullah9839 5 жыл бұрын
awesome work sir ....conceptual method.....thanks sir
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
You are very welcome!
@madhukardeshpande563
@madhukardeshpande563 5 жыл бұрын
Thanks,nice explanation
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Thanks for your nice comment...I appreciate it
@sophiebai5540
@sophiebai5540 6 жыл бұрын
you are truly amazing ;thank you
@MedicosisPerfectionalis
@MedicosisPerfectionalis 6 жыл бұрын
+Sophie Bai Thank you for your great words! You made my day! Keep Studying hard!
@annjean4369
@annjean4369 6 жыл бұрын
Sophie Bai , agreed!
@khamikos1
@khamikos1 6 жыл бұрын
EXCELLENT. GREAT .THANKS SIR
@MedicosisPerfectionalis
@MedicosisPerfectionalis 6 жыл бұрын
You’re always welcome. Best of luck 👍
@ilsakhan9631
@ilsakhan9631 4 жыл бұрын
3:20 the enzyme isn't homocysteine synthase, rather it's "homocysteine methyltransferase" or "methionine synthase"
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Yes...All the mistakes in my videos are corrected on my website.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
My website is: www.medicosisperfectionalis.com/
@gourangomandal6743
@gourangomandal6743 Жыл бұрын
Excellent teaching love from India 🇮🇳
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
Thank you 🙏
@meo2607
@meo2607 Жыл бұрын
I loveeee urrr video an u😔💞thanks for your work it's really help us alot
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
My pleasure 😇
@tuqa777
@tuqa777 5 жыл бұрын
Amazing video 🌸❤️🌸
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Thanks ❤️
@zenmentenoo2811
@zenmentenoo2811 3 жыл бұрын
You are the best 🤗🤗🤗
@priscillal.2409
@priscillal.2409 5 жыл бұрын
Thank you so much
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
My pleasure!
@banzobeans
@banzobeans 11 ай бұрын
How sensitive are serum folate and erythrocyte folate tests to supplementation and food? E.g. I take 500mg oral methylfolate for 5 days. Then I don‘t take folate supplements for 5 days. Then I do a blood draw. Are any of the results relevant? How about if I‘m supplementing methylB12 oral: will this influence folate test results? (asking for a friend)
@priyankatiwari3434
@priyankatiwari3434 5 жыл бұрын
Nicely explained
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Thanks:)
@hanisahab8336
@hanisahab8336 5 жыл бұрын
Hai... I really admire the way you make us understand with your beautiful explaination and the graphic illustrations that will stick in our mind... I am request for microbiology video... please... thank you in advance... love you...
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Thank you so much...Which microbiology video would you like to see?
@hanisahab8336
@hanisahab8336 5 жыл бұрын
@@MedicosisPerfectionalis gram negative and positive cocci...
@lisagonzalez2902
@lisagonzalez2902 4 жыл бұрын
Hi again! I was wondering how come this video and B12 are not part of the Biochemisty playlist? It took me a few mins to realize these B12 and Folate videos were made in 2017, not in 2020, like the playlist. I was waiting for Vitamin C, K, etc etc, I'm sure you have them around too.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Hey 👋 Lisa, How are you? New videos are coming soon to my Biochemistry playlist...I will finish all the vitamins including updates to B12 and folate. Thank you so much 😊
@lisagonzalez2902
@lisagonzalez2902 4 жыл бұрын
@@MedicosisPerfectionalis You always reply so quick. Looking forward to the updates. We all appreciate it.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thank you so much 😊
@drsyedasania5605
@drsyedasania5605 5 жыл бұрын
thank you soooooooooooo much
@amaniamorri8063
@amaniamorri8063 5 жыл бұрын
Veryyyyyy good excellent excellent excellent ...........
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Thanks a lot 😊
@Moath1277
@Moath1277 4 жыл бұрын
Thanks again
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
My pleasure 😇
@comradejames451
@comradejames451 5 жыл бұрын
Thanks
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
You bet
@laughingisouridentity9766
@laughingisouridentity9766 3 жыл бұрын
Complications of homocysteinemia are DVT & Atherosclerosis
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Yes!
@mystudy7712
@mystudy7712 6 жыл бұрын
thx alot good luck
@MedicosisPerfectionalis
@MedicosisPerfectionalis 6 жыл бұрын
+My Study You are welcome! Good luck to you as well!
@shikhavats7898
@shikhavats7898 3 жыл бұрын
When u teach I love to study constantly @🙃🙂
@nikih.3
@nikih.3 5 жыл бұрын
If one doesn't handle Methyls (or glutamate) at all, where are things going wrong. MCH/MCV always slightly above 100 for 25yrs.
@noorhamed4690
@noorhamed4690 5 жыл бұрын
Your video give me huge information.....so I wish you success
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Thanks, bro
@noorhamed4690
@noorhamed4690 5 жыл бұрын
How can differ between CLL and nonhodgkin lymphoma????
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
CLL is a leukemia, and non-Hodgkin’s is a lymphoma...But, when CLL is accompanied by small lymphocytic lymphoma (CLL/SLL), the SLL is a non-Hodgkin’s lymphoma.
@noorhamed4690
@noorhamed4690 5 жыл бұрын
@@MedicosisPerfectionalis thanks....but how differ between it by clinical feature or investigate??
@noorhamed4690
@noorhamed4690 5 жыл бұрын
Because I read difficult distinguished between it
@mariem9296
@mariem9296 3 жыл бұрын
U are a genuis man thank u so much❤❤❤
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
My pleasure 😇
@mohammedamir2918
@mohammedamir2918 3 жыл бұрын
Brilliant
@divyaa3379
@divyaa3379 4 жыл бұрын
Sir my husband as vitamins B12 and D3 difficiency ... I was carrying at 13 weeks came to know baby was with anencephaly... reason may be those deficiency or no... so that I can plan for other baby .... pls sir pls reply... 🙏
@aaronjiang2989
@aaronjiang2989 Жыл бұрын
How does the monoglutamate in the GI convert to THF in the blood?
@fluffyberry2222
@fluffyberry2222 Жыл бұрын
HOMOCYSTEINE: Vit B12: homocysteine and methylmalonic acid are both raised B9: homocysteine levels are elevated but methylmalonic acid levels are normal Both used in conversion of homocysteine to methionine as part of DNA synthesis METHYLMALONIC ACID: VitB12 (NOT B9) is required in odd-chain fatty acid synthesis where it acts as a co-factor in the conversion of methylmalonyl coenzyme A to succinyl coenzyme A VitB12 Def gives neurological symptoms Propionyl-CoA and methylmalonyl-CoA are dangerous in high amounts because these odd chain fatty acids will accumulate and incorporate into the myelin of the neurons in the central and peripheral nervous systems, making myelination unstable. The conversion of methylmalonyl-CoA to succinyl-CoA is catalyzed by methylmalonyl-CoA mutase which requires vitamin B12 as a cofactor. Lack of vitamin B12 thus leads to the build-up of methylmalonyl-CoA and propionyl-CoA (a precursor of methylmalonyl CoA) in the neuronal lipids. This is the reason why B12 deficiency is associated with neurologic complications.
@kushcloud420
@kushcloud420 2 жыл бұрын
Can it cause numbness and pins and needles in hands and feet cos I get that alot
@nutterbutter66
@nutterbutter66 4 жыл бұрын
How does a folate deficiency and a mutation in the MTHFR Gene, C677T strand, impact a persons development? I.e. more high risk for stroke, seizures, seizure disorder? Thank you!
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
I don’t know 🤷‍♂️ The only thing I know is that folate is necessary for the development of the neural tube (brain and spinal cord)
@asmachouhazderdous8170
@asmachouhazderdous8170 5 жыл бұрын
Thank you very much!!!! that's very helpful I really wish you all the best ..
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Same to you!
@welcomebackn8266
@welcomebackn8266 Жыл бұрын
King of medicine ❤
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
Thank you 🙏
@Jb-ky1ri
@Jb-ky1ri 2 жыл бұрын
Hey nice presentation, but how can one fix the b12 or folate deficiency properly, like can grains or other foods stop or slow down the fixing of these deficiencies? thanks
@Noor-jw2tn
@Noor-jw2tn 2 жыл бұрын
He said greens.
@Jb-ky1ri
@Jb-ky1ri 2 жыл бұрын
@@Noor-jw2tn what kinds of greens?
@alidavis6650
@alidavis6650 4 жыл бұрын
I don't understand why/how goat milk can decrease the intake of folate? By the way, these videos are very helpful even though I am a DVM student not an MD student. Because of that, I would really like to be able to tell future client owners what goat milk can do...
@ranicefreire2611
@ranicefreire2611 4 жыл бұрын
Did you find why goats milk block folate..?
@annawright4545
@annawright4545 2 жыл бұрын
@@ranicefreire2611 Yes: see my note to Ali.
@shikhavats7898
@shikhavats7898 3 жыл бұрын
Complication of homocysteinemia is osteoporosis, Parkinson disease, dementia, stroke
@emilywood6830
@emilywood6830 3 жыл бұрын
I'm not studying, I just think I have this based off my routine blood test results
@jamesheseltine8283
@jamesheseltine8283 3 жыл бұрын
Same
@rajeenarasvin9306
@rajeenarasvin9306 7 ай бұрын
i have buring sensation lower back.some time hand.vittamin12normal so florate test also normal or not
@jahzeellariosa6412
@jahzeellariosa6412 Жыл бұрын
Hi, why neurological symptoms can only be present with b12 deficiency and not in folate deficiency?
@tineeazyabuvall151
@tineeazyabuvall151 Жыл бұрын
I don’t think it always have to be b12 with neurological it also can be zinc or choline.:) 😅
@Pedro-hk9ng
@Pedro-hk9ng 4 жыл бұрын
Good speed.
@strawseunie8152
@strawseunie8152 3 жыл бұрын
Hi! Thank you for this. Just wanna ask, does this also work in alcoholism? I mean folic acid deficiency in alcoholism. Thank you.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Yes
@strawseunie8152
@strawseunie8152 3 жыл бұрын
@@MedicosisPerfectionalis sorry I'm kinda lost. Hmm, so if you have folate deficiency it can affect rbc which will lead to macrocytosis? And alcoholism is another factor too? thank you so much.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Alcoholism can lead to folate deficiency which causes macrocytic megaloblastic anemia (high MCV).
@strawseunie8152
@strawseunie8152 3 жыл бұрын
@@MedicosisPerfectionalis omg thank you! ❤️ Really a big help. ☺ ❤️ Please create more content. Your videos really help a lot! ❤️
@allenjeraldbisin346
@allenjeraldbisin346 3 жыл бұрын
@@MedicosisPerfectionalis I think alcoholism/chronic alcoholism is more associated with non-megaloblastic anemia, not megaloblastic anemia?
@CJ-ox4oc
@CJ-ox4oc 3 жыл бұрын
Does low folate prevent b12 being metabolised? Can folate cause worsen neuropathy if supplementation is given
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Folate doesn't worsen neuropathy. If a patient has both vitamin B12 deficiency AND folate deficiency, then supplementing folate alone will mask the symptoms of anemia, and if the doctor forgets to supplement B12, then the neurological symptoms may worsen because they are not being addressed.
@venkybly
@venkybly 4 жыл бұрын
Tq
@fadelbendaba3284
@fadelbendaba3284 Жыл бұрын
انت اكثر من رائع
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
Thank you 😊
@tineeazyabuvall151
@tineeazyabuvall151 Жыл бұрын
The co factors to choline is vitamin b1,2,3,5. ❤
@hassinayazid99
@hassinayazid99 3 жыл бұрын
I think methionine synthase rather than homoysteine synthase!?. Am I wrong?
@helenegrdem8208
@helenegrdem8208 4 жыл бұрын
Hi! Can you help me with something? I have to little folate (5), my mcv is 95, b-evf 0.44 but my hemoglobin is 14. So this means i dont have anemia right? 😊
@helenegrdem8208
@helenegrdem8208 4 жыл бұрын
And my b12 is at 300.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
What are the normal values (reference range) for your lab? Also, how about the RBC count, hematocrit?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
What are the normal values (reference range) for your lab? Also, how about the RBC count, hematocrit?
@namatullahsharifi5131
@namatullahsharifi5131 2 жыл бұрын
At 3:15, that's not homocysteine synthetase. It's methionine synthetase. I highly appreciate your time and effort and contribution. Keep it up
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
Yes! You’re right. It’s methionine synthase (or homocysteine methyltransferase).
@kirankumbha9239
@kirankumbha9239 7 ай бұрын
Sir my son age 3.10 years and having normal B12 and Folic acid levels and increased homocysteine 17.8( Normal
@mazza1933
@mazza1933 3 жыл бұрын
My haemoglobin levels normal. My hematocrit levels low (I think) looking at my own blood test results. Red blood cell count little high 4.82 instead of 4.80. Ferritin level low and folate level low. Confused!!!!!!!!!!
@fatmaalfarsi5131
@fatmaalfarsi5131 2 жыл бұрын
thank u
@MedicosisPerfectionalis
@MedicosisPerfectionalis 2 жыл бұрын
My pleasure 😇
@pedrosilva-im2kk
@pedrosilva-im2kk 2 жыл бұрын
I have folate deficiency but every time i take metafolte i get severe anxiety... How can i get pass thus problem ?please help..
@asmaaasmaa1924
@asmaaasmaa1924 4 жыл бұрын
The answer is b12 deficiency and b9 deficiency
@rakshnaram7777
@rakshnaram7777 5 жыл бұрын
Thank you for such a good explanation! But, a small doubt. Can jaundice be caused because of folate deficiency as there can be ineffective erythropoiesis and destruction of erythroid progenitors?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
The process you are describing is not sufficient to cause jaundice...Remember, for jaundice to appear, the serum bilirubin level has to be 2 or more.
@rakshnaram7777
@rakshnaram7777 5 жыл бұрын
@@MedicosisPerfectionalis But isn't that the same process by which mild jaundice is caused in Vitamin B12 deficiency?
@ezatkhalil4879
@ezatkhalil4879 4 жыл бұрын
Awesome
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Thanks a lot
@ezatkhalil4879
@ezatkhalil4879 4 жыл бұрын
Regarding cANCA and pANCA I am confused about diseases related to them. Kindly would you update us? Thank you.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Made a video about them in my Rheumatology playlist
@Viv8ldi
@Viv8ldi 5 жыл бұрын
I am vegan. I take 1000 mükrogramms of B12 and 800 mükrogramm of 5-mthf quatrofolic folate, is that too much?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Talk to your doctor, I don’t know
@user-hs5cy3sz2v
@user-hs5cy3sz2v 5 жыл бұрын
Thank you! What a great video 🌺 1 question, increase homocysteine leads to thrombosis, and thrompocytopenia leads to bleeding, so what is the final result? 😳
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Final result of what?
@user-hs5cy3sz2v
@user-hs5cy3sz2v 5 жыл бұрын
@@MedicosisPerfectionalis I mean do they have both bleeding and thrombus events?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Who are “they”?
@user-hs5cy3sz2v
@user-hs5cy3sz2v 5 жыл бұрын
@@MedicosisPerfectionalis people with this anemia, sorry for unclear sentence.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
No problem...I just wanted to clarify...So, you have a patient with anemia, thrombocytopenia and increase homocysteine level...and your question is; “will they bleed or clot?”...Is that your question?
@mozntrade3087
@mozntrade3087 3 жыл бұрын
Looove🤩🥰
@MedicosisPerfectionalis
@MedicosisPerfectionalis 3 жыл бұрын
Thank you 😊
@MsMadamadamada
@MsMadamadamada 5 жыл бұрын
what's the difference between folic acid and folate?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
No difference...Any acid can be referred to by adding the suffix “-ate”: pyruvic acid is the same as pyruvate, lactic acid is the same as lactate...and so forth.
@MsMadamadamada
@MsMadamadamada 5 жыл бұрын
hm... but apart from that are you sure? been nagged on ob/gyn rotations that we must recommend FOLATE not folic acid and it's not the same and that folic acid has been associated with birth defects...?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
www.ncbi.nlm.nih.gov/m/pubmed/24494987/ maybe...I am not sure!
@qubicracks6386
@qubicracks6386 5 жыл бұрын
they say folic acid is synthetic, binds to the receptors blockong folate and is not as effective
@virgobutterfly9981
@virgobutterfly9981 4 жыл бұрын
@@qubicracks6386 If people have the mthfr gene mutation, which is around 60% of population, you're methylation process doesnt work properly then you should take Methylfolate (already methylated form) not Folic acid as its synthetic and will build up in your system causing some significant problems. You can be tested for the gene mutation. Pregnant women especially should know prior so they know what they should be taking. Same with methylcobalamin (B12) not cynacobalamine 🙂
@killuminatikilla3235
@killuminatikilla3235 2 жыл бұрын
I think I am dying doctor I have low folate. And I am experiencing vitamin b12 deficiency. Numbness. Drop foot. Tititus. Muscle tingling. Neck and back ache and sweating when asleep. Jesus man I think I have an auto immune disease 😊 I need some help man
@vankyer758
@vankyer758 2 ай бұрын
Do a blood test. And take folic acid tablets.
@unstoppable5121
@unstoppable5121 Жыл бұрын
Can you please say that why neurological effects not improve by giving folate in vit B12 deficiency , can you please explain the reason 🙏🏻 I've searched a lot ,but i couldn't find it Please reply my comment as soon as possible 🙏🏻🙏🏻
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
Because you need vitamin B12 (not necessarily folate) to myelinate the nerves.
@unstoppable5121
@unstoppable5121 Жыл бұрын
@@MedicosisPerfectionalis Can you please also answer this that how high level of folic acid metabolites can worse function of vit B12 in vit B12 deficiency 🙏🏻🙏🏻
@unstoppable5121
@unstoppable5121 Жыл бұрын
@@MedicosisPerfectionalis And which metabolites they are By which mechanism Please please answer my questions Want to say thanks for your beautiful explanations We appreciate you sir 🙏🏻🙏🏻
@ruthsalinas9479
@ruthsalinas9479 4 жыл бұрын
Can you explain a case (mine) in which there’s decreased Hb (10.7) and Hct (35.3), MCV is normal (84.9), WBCs normal (5.82), Platelets high (354), Serum Folate 9.9 (normal), Vitamin B12 normal (613), Ferritin 7. Symptoms are very heavy/painful periods, fatigue, foggy brain, sleep disturbances, anxiety, headaches, muscle pain, numbness/tingling/burning sensation in extremities.
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
What was the reference range for ferritin in that lab?
@ruthsalinas9479
@ruthsalinas9479 4 жыл бұрын
Medicosis Perfectionalis 16-154 ng/ml
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Ok...Thank you! What does your doctor think? Also, The numbness/tingling/burning sensation could be unrelated to your anemia...You can talk to a neurologist.
@ruthsalinas9479
@ruthsalinas9479 4 жыл бұрын
Medicosis Perfectionalis Doctor just thinks I’m anemic due to heavy periods. I’ve already seen neurology and everything is fine in that area. I consume plenty of folate in my food. I do have an MTHFR mutation so maybe I’m not converting things appropriately. But it seems most doctors don’t give MTHFR mutations the time of day. Does my vitamin B12 look ok to you? Are there any other tests I could request to have done? Should I supplement with folate? Which kind of I have MTHFR mutation? How about vitamin B12? Would love to hear your diagnosis.
@ruthsalinas9479
@ruthsalinas9479 4 жыл бұрын
Medicosis Perfectionalis Hello?? You never got back to me.
@greenbanana1001
@greenbanana1001 2 жыл бұрын
My fdoctor said my folate is severely low
@sandrawanemi8801
@sandrawanemi8801 5 жыл бұрын
What was the answer to the question?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
What do you think? I want you to try to answer it first, then I will help you with it...Deal?
@durumutlamonica3856
@durumutlamonica3856 5 жыл бұрын
One mistake- Homocysteine is converted to methionine with the help of enzyme-methionine synthase. U have said Homocysteine synthase
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
You're right, it's called methionine synthase or homocysteine methyl transferase.
@deepakkumargupta9511
@deepakkumargupta9511 4 жыл бұрын
2:11 its methionine synthase enzyme not homocyteine synthase right ??
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
Yes, you’re correct! I have corrected it on my website: www.medicosisperfectionalis.com/
@aysegultosun4772
@aysegultosun4772 8 ай бұрын
My folate is low, but B12 is normal. I dont understand why. Is that possible
@aysegultosun4772
@aysegultosun4772 8 ай бұрын
I'm 22 but feel sleepy and tired most of the day 😢
@neroetal
@neroetal 5 жыл бұрын
Homocysteinemia will lead to a hypercoaguable state
@MedicosisPerfectionalis
@MedicosisPerfectionalis 5 жыл бұрын
Yes!
@VRCM_Skywarn_XUSA
@VRCM_Skywarn_XUSA 3 жыл бұрын
No grass on your plate, no hair on your head. (Folate&B12) Bacteria & Green Leafy Grasses If your a diabetic cannibal, strung out on prescription meds. Drinking alcohol. More wonderful products brought to you by the medical community.
@ipmann25
@ipmann25 2 жыл бұрын
Explain please .. I have hair loss.. so I need b12 and folate to regrow thinning spots??
@biauxchety8129
@biauxchety8129 4 жыл бұрын
Correction: Thank you Methionine Synthase instead of Homocysteine Synthase @3:17
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
You're absolutely right
@bobc.5698
@bobc.5698 4 жыл бұрын
A friend just told me he creates too many red blood cells and he is supplementing with Folic acid? This makes sense?
@MedicosisPerfectionalis
@MedicosisPerfectionalis 4 жыл бұрын
How did he know?
@bobc.5698
@bobc.5698 4 жыл бұрын
. Bloodwork
@kabanzangana3857
@kabanzangana3857 Жыл бұрын
❤❤❤❤❤❤❤
@mmm4638
@mmm4638 3 ай бұрын
It's called lyme babesia. You welcome
@Zain_altouka
@Zain_altouka Жыл бұрын
You are my favourite teacher 🥰🤍
@MedicosisPerfectionalis
@MedicosisPerfectionalis Жыл бұрын
Thank you 😊
@hosamabbas5014
@hosamabbas5014 3 жыл бұрын
Thrombophilias
@theoretickle2084
@theoretickle2084 4 жыл бұрын
I could barely hear a word of this, the sound quality was so bad.
@monsimix6839
@monsimix6839 3 жыл бұрын
Push the Button for higher Volume lol
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