Macrocyctic Anemia Intro

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►👨‍🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Let's talk macrocytic anemia which has 2 subtypes: megaloblastic and non-megaloblastic.
In macrocytic anemia, the mean corpuscular volume (MCV) is higher than normal...The normal MCV is about 80-100 fL, but in a macrocytic anemia, it's usually more than 100.
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We have talked before about microcytic anemia: check my playlist on hematology/ oncology goo.gl/KxAu6F
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In brief, macrocytic anemia is an anemia where the RBCs are relatively larger in size raising the MCV. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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[@brandidonneforti1885]

I was told years ago that I have Macrocytosis caused by b12 and Folate acid Deficiency. I am always extremely tired and fatigue, Last year I got blood work done and my MCV Levels were high. What can I do to cure this? What can I do to help me feel less tired?

[@MedicosisPerfectionalis]

Please talk to your doctor to know the cause of the underlying problem.

[@deepakkumargupta9511]

folates are absorbed in jejunal cells

[@deepakkumargupta9511]

i think drugs(pyrimethamine,primaquinine ,5 FU ) are the cause of macrocytic with megaloblasts,but u said it was macrocyte with non megaloblast . i am confussed .please clarify ..

[@md.sharifulislamswapon2685]

C

[@rathodnehal2869]

Dude Is Just Feeling Ill Bro Duodenum- Iron , Jejunum-Folate ,Ileum- B12 this mnemonic is not made by me but i copying but its really helpful 👍😊👍

[@MedicosisPerfectionalis]

That's a good mnemonic

[@astre935]

perfect

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When I think about "Feeling" word I am just focusing to "Fe..." . Please forgive me 😂😊

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I have my 2nd year finals just after a month and i was completely clueless, crying, depressed until i found your channel. Thanks for lighting me up and motivating me to give whatever i got! Love you

[@MedicosisPerfectionalis]

That’s one of the best comments I have received recently...I am sure you will do fine, have a strong desire and write down a plan...and you will succeed...Best of luck!

[@prithvisenajas7156]

@@MedicosisPerfectionalis thanks

[@MedicosisPerfectionalis]

My pleasure!

[@comradejames451]

Agreed, old boy is now my favorite m.d.

[@MedicosisPerfectionalis]

Thanks 🙏

[@hadeelhassenaltalhi5365]

FOLATE: JEJUNUM, B12: ILIUM, IRON: DUODENUM

[@MedicosisPerfectionalis]

Excellent! You got it!

[@ranjamedi4717]

*ileum

[@sameer-zk2jn]

Tired & pale .Pale & tired😂 Love this line so much.Keep it up🙋

[@MedicosisPerfectionalis]

I am so delighted now :) Thanks, please share!

[@user-qr4te5pv7e]

Folate antagonists (eg, methotrexate ) Purine antagonists (eg, 6-mercaptopurine [6-MP]) Pyrimidine antagonists (eg, cytosine arabinoside [ara-C]) Alkylating agents (eg, cyclophosphamide) Tyrosine kinase inhibitors (eg, sunitinib, and imatinib)

[@user-qr4te5pv7e]

Basically it seems that any oncology drug that interferes w/ cell cycle can cause macrocytosis.

[@elaineluther1799]

Folate is absorbed in the jejunum with the help of the enzyme folate hydrolase, located in the brush border.

[@mrabin8098]

i found it helpful thank you

[@khalildaoud671]

thx

[@maemai1011]

Thank u

[@queenbeequeenb9]

Thnx

[@SarahE1005]

My dream job is a dr. I am currently in the process of being diagnosed and of course I've googled all my results. I'm not a medical student but these videos are great. Whoever you are you're great and funny too

[@MedicosisPerfectionalis]

Thank you so much 😊 Good luck to you! I wish you a speedy recovery!

[@giridhar3000]

hematology was a scary subject for me . these lectures will really help me a lot . thank you.

[@MedicosisPerfectionalis]

Thank you 🙏

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[@MedicosisPerfectionalis]

Great insight...I try to stay relax in order to help me enjoy the subject!

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[@MedicosisPerfectionalis]

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Sana T. - I watch them for the same reason. I've been practicing medicine for 30 plus years. I found these videos this year & enjoy listening to them while driving back & forth to work & home, as well as while walking the dog. It's an enjoyable, informative way to pass the time. I would not wish to go back to my med school days but, if I did, I'd take Medicosis Perfectionalis along with me.

[@MedicosisPerfectionalis]

Kevin, you’re amazing! Thank you so much 😊 for your kind words:)

[@Choogaleh]

Thanks for this video! I am self-studying and this helps with learning the material

[@MedicosisPerfectionalis]

Awesome 👏....Good luck to you!

[@kunmunnayak3575]

I simply loved how u correlated all the stuff during that bit of folate absorption...❤ the video is great

[@MedicosisPerfectionalis]

I am so happy to hear that 😁

[@kunmunnayak3575]

@@MedicosisPerfectionalis all your anemia videos are awesome...thank you so much ❤❤😊

[@Qwerty3456]

Thank you so much In med school hematology was a difficult subject for me. Now its easy for me because of ur videos. Once again thank you

[@MedicosisPerfectionalis]

My pleasure 😇...You made my day!

[@mosesalexander225]

Love the way you explain terms by explaining their original greek/latin meanings. I do that too!

[@MedicosisPerfectionalis]

Glad you liked that! Thanks

[@sophiebai5540]

i have a hematology exam next week ,and your videos helped a lot ,thank u

[@MedicosisPerfectionalis]

+Sophie Bai That’s why we are here! Good luck!

[@Dentalmasterychannel]

Your videos are justttt amazing watching them for my exam

[@MedicosisPerfectionalis]

Thank you so much! I wish you all the best!

[@email1123]

I love how you always draw the patient/people with huge foreheads lol keep up all the good work that you do. Thank u!

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@leavinoneday]

Your channel is fun and helpfull!!! Love this hematology playlist Doc.

[@MedicosisPerfectionalis]

I appreciate you so much!

[@ferashijazi1299]

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[@MedicosisPerfectionalis]

You’re even more awesome 😎...Please share my videos with others.

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[@user-by8zu5ob9h]

I like you're way of explain !!!

[@emanali9010]

You are beyond good ... Thanks a ton ... Loads of good wishes and luck your way.. 😍😍😍

[@MedicosisPerfectionalis]

Thank you so much 😊

[@noumanmajeed6266]

Azathioprurine, cyclophaphamide, flurouracil, cytarabine, mercaptopurine

[@MedicosisPerfectionalis]

Great!

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[@MedicosisPerfectionalis]

Hey! I am so grateful to you...Don’t worry about the website, just share my videos and that’s more than enough 😊...Plus there is nothing more satisfying to me than to help others struggle less with medical books 📚...Your comment means the world to me...Best of luck!

[@rofaidamamutuk9368]

​@@MedicosisPerfectionalis You are welcome! I can't help dropping these comments. Because after reading the mother books - physio, histo, biochem - patho - combined, I was dumbfounded to realize that have I watched your videos ahead, it would have been 10x easier for me to read those boring books. You give us a lighter version of Harper (biochem), tbh. Your work does not only help us medical students, but will also, inshaa Allah, could save thousands of patients ahead. God bless!

[@rofaidamamutuk9368]

@@MedicosisPerfectionalis Sure thing, I will share your videos! Kudos!

[@MedicosisPerfectionalis]

Thanks a ton 😊😊

[@sixstrm6542]

Lol I’m watching on 1.75

[@ibtesamawad746]

You made my day! 💙

[@MedicosisPerfectionalis]

Thank you so much 😊

[@user-qr4te5pv7e]

So from a bichem standpoint, a B12 deficiency can present with homocystinemia as thrombosis, marfanoid appearance and downward lens subluxation.

[@IceDr4gonfly]

FIC is absorbed in the proximal intestine (Folate, Iron, calcium). B12 is absorbed in the distal intestine (ileum)

[@MedicosisPerfectionalis]

Folate is in the Jejunum

[@MommaBearsCorner]

then clearly i need to work on my intestine enzymes! low in them all. knew i found find answers on here. but waiting for doc also to see lab work. lol gotta learn whats going on today

[@user-nt5iv8gl4i]

Thank you, you make things so easy for us.

[@MedicosisPerfectionalis]

My pleasure 😇

[@darkblue1423]

Wallah THE BESTTTT!!!😍

[@millicentmmuwomba1850]

Well explained,thank you for making life easier for us med students

[@MedicosisPerfectionalis]

My pleasure 😇

[@malissacampbell634]

Answer: Distal portion of the ileum. thank you again! great videos

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@Weirdandwacky1028]

an excellent explaination....loved it....

[@MedicosisPerfectionalis]

This makes me super excited...Thanks for watching!

[@robertoconnell8153]

Im studying for the last final exam of my nursing program!! In nursing school they have done a really good job of teaching the macro view of medicine. However, I learned to connect concepts and understand how different pathologies are related from your videos. I felt like I had to thank you for all your help the last few years. What you do is SO important to people, thank you!

[@MedicosisPerfectionalis]

Wow 🤩 Thank you so much, Robert! I really appreciate you! Best of luck!

[@swatibhatt552]

it's Very helpful video watching from India thank you so much

[@saralissali1090]

Thank u doctor proud of you

[@laptopfamily-tj9uc]

thank you for existing

[@MedicosisPerfectionalis]

I appreciate you!

[@imanbakk3138]

I love your voice OMG thanks alot

[@MedicosisPerfectionalis]

My pleasure!

[@sadie7617]

You're so awesome thank you so much

[@newbox2178]

Thank you so much, very helpful

[@MedicosisPerfectionalis]

You’re welcome 😇

[@anjalianjan4643]

Love ur explanation✌

[@MedicosisPerfectionalis]

Cool...I am honored!

[@fatimasuleman1980]

Thank you so much. You are really awesome 😊😊

[@MedicosisPerfectionalis]

Thanks a lot!

[@homoeoscience139]

Thank you very much

[@safilotra]

folate is absorbed by the mucosal cells of the jejunum and folate reductase inside these mucosal cells act on the folate to convert it into the mono form so it can be absorbed.

[@naluh_n]

I love it here🥺❤

[@MedicosisPerfectionalis]

Thank you 🙏

[@loumartinq]

i have been watching you videos recently thx

[@MedicosisPerfectionalis]

My pleasure 😇

[@user-qr4te5pv7e]

So non-megaloblastic anemia has all of the features of macrocytosis EXCEPT hypersegmented neutrophils? So this means you'll just see a big neutrophil with less than 5 lobes and big rbcs yet sx pt will px the same way (anemia, murmur, fatigue)?

[@carolinepate2119]

love the intro xD

[@MedicosisPerfectionalis]

Glad to hear that! Thanks a ton!

[@user-qr4te5pv7e]

folates exist as polyglutamates and need to be enzymatically converted into folate monoglutamates by folate reductase in the jejunal mucosa in order to be absorbed.

[@AU-yx5gn]

the intro was much needed 😭

[@MedicosisPerfectionalis]

:)

[@h.medicine9119]

thank you soooooooooooooooooooo much

[@MommaBearsCorner]

have vitamin issues and labs came back. thanks for sharing. you and others here cleared up some things for me. and someone answers his question at end! lol >> Is absorbed primarily from the upper third of the small intestine. and i am not a student. haha

[@MedicosisPerfectionalis]

You’re very welcome! Best of luck to you!

[@mounia1mimi281]

Thank you

[@madhukardeshpande563]

Thanks for explanation

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@wilsonkaseha2034]

Perfect!

[@MedicosisPerfectionalis]

Thank you so much, Sir!

[@gsilawat]

Very very nice thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@shikhavats7898]

In jejunum part of the bowel folate become absorbed and enzyme responsible for it is folate reductase. Sir is it right ans ?

[@jaysoncaliba3054]

What do you mean by macrocytosis with normoblastic view?

[@ocots]

Is the answer metformin? Cause it can inhibit B12 absorbtion?

[@emanuele2398]

Thank you medicosis

[@MedicosisPerfectionalis]

My pleasure 😇

[@umarkhader7313]

u r the best

[@MedicosisPerfectionalis]

Thanks, brother!

[@diptosusmay6179]

Hemolysis of magaloblasts occurs in where? Within bone marrow or within spleen? Davidson says it's within marrow, Btw you're the best of the bests'❤️

[@drvictorious1387]

Your videos are making my mind to apply for mrcpath 😅

[@MedicosisPerfectionalis]

I wish you all the best!

[@laila1483]

So the methyl group holds the B12 from synthesizing DNA and this is what causes mutations in DNA?

[@zainabhassan7905]

Nice explanation ❤

[@MedicosisPerfectionalis]

Thank you so much 😊

[@noname-ry3ln]

THE BEST OF BEST

[@MedicosisPerfectionalis]

Thanks a ton!

[@duaa7240]

so with vit. B12 deficiency we can have a "Hyperchromic" anemia right? since protein synthesis is not affected then Hb will continue to be synthesised and concentrate?

[@MedicosisPerfectionalis]

According to Harrison’s, when RBCs have more Hb, they become larger, not darker...Therefore, technically, there is no such thing as “hyperchromic”

[@raminbarzani8977]

Ohh it really makes sense now

[@ayuniakainya4620]

Can B12 deficiency cause impaired folate absorption or folate deficiency? TIA

[@vaibhavsaini6522]

I was actually desperate to listen to those first few words u said at the start of the video 😂, thanks 😁

[@MedicosisPerfectionalis]

My pleasure 😇

[@veroverdino]

"that makes sense"

[@MedicosisPerfectionalis]

Indeed! Thanks for watching!

[@reem4890]

I love you medicosis

[@MedicosisPerfectionalis]

Thank you ☺️

[@user-oh7fz6nr3h]

Thanks aloooooottttttt ,

[@MedicosisPerfectionalis]

You're welcome!

[@FAM648]

I love youuuuuu very much medcosis 💚💚💚💚💚💚💚

[@MedicosisPerfectionalis]

Thank you!

[@mariaalexandraflorea6520]

metformin is also imparing b12 absorbtion

[@farahkhan7718]

Thank u so much that's another amazing video of ur's❤️..... I have got a question in my exam but I don't know it's answer.... Can u plz help me with this " differentiate between megaloblastic & pernicious anemia on the basis of microscopic pictures & red cell indices"?

[@MedicosisPerfectionalis]

Megaloblastic includes pernicious. That’s a weird question 🤷‍♂️

[@farahkhan7718]

@@MedicosisPerfectionalis yes I know it is.... I think only my professor knows it's answer😂.... Btw thank u so much for making such a great channel😊... U help me in my self studying during this time... & Thank u so much for always responding to my comments 😘

[@ankitashinchan6289]

Thnkuu very much

[@MedicosisPerfectionalis]

My pleasure 😇

[@suryakantdongre3969]

Thanks sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@sujanbhattarai3698]

Normal mcv but high mchc ? What does this mean

[@user-mw5mz6md1d]

Can you please explain sympathatic and parasymphathtic and their effect on body ??

[@MedicosisPerfectionalis]

+Raneem Salem Sure! I will put it on my list. Thanks for your comment!

[@ahmedsalim8157]

Very nice and simple,thanks

[@MedicosisPerfectionalis]

My pleasure!

[@jabizebadi6982]

chemo (hydroxyurea), anti diabetics like sulfamids can cause macrocytic anemia

[@InTheStrangersEyes8]

Tq 🙏😊

[@MedicosisPerfectionalis]

My pleasure

[@gabrielmorris4247]

Woaaauughw. That makes cense

[@aubioxo]

so what type of drugs causes that ?

[@IVFRegulation]

"Bactrim Forte" cause non megaloblastic anemia, Isn't it?

[@ahmadhammad3769]

Thanx sir😍 I have a question hope u answer Is macrocytic hypochromic anemia the characteristic of true vegetarian ?

[@MommaBearsCorner]

?

[@mutsawashe3607]

Anticovulsant drugs/antifolate drugs eg phenytoin cause non-megaloblastic anemia??

[@soumyadippal5568]

Even as a non medical student , I am able to understand almost 80 percent.... Though, I wanted to become a doctor... I have abc knowledge in biology

[@rockycycle2682]

5 Flourouracil

[@travelongshivangi3579]

How can I help to spread this channel??

[@MedicosisPerfectionalis]

Just share if you'd like! Thank you so much!

[@ocagri]

Can we see hypercellularity in bone marrow in megaloblastic anemia Excellent video!

[@MedicosisPerfectionalis]

Yes, it can happen!

[@veronicsohnamendy1195]

Yes of couse hypercellularity and hypersegmented neutrophil

[@mariya5605]

Duodenum &jejunum absorbs folate

[@MedicosisPerfectionalis]

Excellent. Especially jejunum

[@albyrosecortez1780]

He sounds like this is the easiest thing in the world to understand and this is the millionth time he has had to explain it, I love it lmaooooo kept me laughing and listening

[@MedicosisPerfectionalis]

😁😁😁😁😄

[@shuhaibsaidumohamed6854]

jejunum and caogulase

[@MedicosisPerfectionalis]

Yup 👍👍

[@savingpeace8452]

Why did I get this from fifth disease does anyone know?

[@sofiaahmed3872]

2020/9/2

[@sanariax]

Trimethoprim, phenytoin, methotrexate

[@majchrzak210643]

Zidovudine (NRTI)

[@mariamalmurad4955]

if there is DNA synthesis problem howcome RNA is normal ?

[@lubnaarshi5027]

Not synthesis exactly , the proper term would be maturation which has no relation to rna synthesis . In macrocytic anemia dna maturation lags behind cytoplasmic maturation, unlike in iron deficiency anemia where cytoplasmic maturation lags behind nuclear maturation . Hope this helps !!

[@nisarali9682]

Lubna will u plz elobrate it more???

[@drhamdaankhan3691]

methotrexate,5-flurouracil.

[@ahmedabdalazeez6716]

Duodenum and upper jejunum