Folic Acid Metabolism | Folate Cycle

Folate, also known as vitamin B9 and folacin,is one of the B vitamins.
Folate (vitamin B9) refers to the many forms of folic acid and its related compounds, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid, folacin, and pteroylglutamic acid. Historic names included L. ⁠casei factor, vitamin Bc and vitamin M.[2]
The terms folate and folic acid have somewhat different meanings in different contexts, although sometimes used interchangeably. Within the field of organic chemistry, folate refers to the conjugate base of folic acid. Within the field of biochemistry, folates refer to a class of biologically active compounds related to and including folic acid.
All of the biological functions of folic acid are performed by THF and its methylated derivatives. Hence folic acid must first be reduced to THF. This four electron reduction proceeds in two chemical steps both catalyzed by the same enzyme, dihydrofolate reductase.Folic acid is first reduced to dihydrofolate and then to tetrahydrofolate. Each step consumes one molecule of NADPH (biosynthetically derived from vitamin B3) and produces one molecule of NADP.Mechanistically, hydride is transferred from NADPH to the C6 position of the pteridine ring.
A one-carbon (1C) methyl group is added to tetrahydrofolate through the action of serine hydroxymethyltransferase (SHMT) to yield 5,10-methylenetetrahydrofolate (5,10-CH2-THF). This reaction also consumes serine and pyridoxal phosphate (PLP; vitamin B6) and produces glycine and pyridoxal.[77] A second enzyme, methylenetetrahydrofolate dehydrogenase (MTHFD2)[80] oxidizes 5,10-methylenetetrahydrofolate to an iminium cation which in turn is hydrolyzed to produce 5-formyl-THF and 10-formyl-THF.[77] This series of reactions using the β-carbon atom of serine as the carbon source provide the largest part of the one-carbon units available to the cell.

[@sahanasm3503]

Very nice explained sir❤❤

[@michaeleisenberg7867]

Excellent video 🎬 Shabir! 👏👏👏 Thank you very much. I hope your wrist 🩹 heals quickly. 💚💙💛

[@hussainbiology]

Thanks Dr Mike for appreciation.....My wrist is okay now

[@PegB-pq9tb]

Thanks for this. Can you also review Vitamin B12 and include where it fits in?

[@Noor-mu1bl]

Very well explained! I used this video today as reference to explain the concept in my exam Thank you so much🙏🏻

[@hussainbiology]

Glad to know that...Keep sharing

[@amirhosseinzarei2597]

Clarified explanation! That was comprehensive thank you!

[@hussainbiology]

You're very welcome!

[@CopperKettle]

Щиро дякую

[@CopperKettle]

Please do a short overview of cerebral folate deficiency and the recently-discovered "central B12 deficiency" in which B12 fails to reach the CNS. That would be interesting for people to learn.

[@ThreeEvils13]

Great video, so easy to understand. Thank you!

[@hussainbiology]

Glad it was helpful!

[@mol_biologist30]

Great video sir 👍🏼

[@hussainbiology]

Glad you liked it!

[@youtubeok9228]

Get well soon sir, sir pls add videos in part c for csir . Do videos on problems n graphical sums in part c . Pls do part c videos 🙏

[@hussainbiology]

thanks ...

[@ARUNITABARDHAN]

Calcidef tab containing folic acid (0.1mg)can cause black stool in adult human being?

[@zubairahmaddar2453]

❤❤❤❤ great sir ❤❤❤

[@hussainbiology]

boi cha warie..

[@rajendranbhuvan5287]

Very helpful

[@hussainbiology]

thanks for appreciation..Glad it helps

[@rimmertf]

Get well soon!

[@hussainbiology]

thanks

[@n.oushee_]

👍🏼

[@coachjcpartida3592]

Use Methyl folate Never folie acid

[@rdance3]

Good video but I wish doctors would stop using the term "Folic Acid" in place of Folate. It suggests that they are one in the same and since many people suffer from unmetabolized Folic Acid, they need to know that there most certainly are better, more natural forms.