Michael Fossel | Aging: Understanding it, Reversing it

[@GrahamBessellieu]

Michael’s passion is palpable. Excellent lecture!

[@aqswdefr8838]

Michael speaks so crisply and intelligently, a joy to listen to

[@immortalityIMT]

Koko was an amazing creature, how exactly did you reverse aging?

[@Dan-uf2vh]

What is a realistic time frame in number of years until the pace of intervention overcomes aging? I would assume the beginning will produce non-uniform results and actual integral age reversal will come some time after that, perhaps 10 years later. Now that Bezos gave a massive boost to the interest for the domain, is it going to be 20 years until overall aging stagnation? Is it 30? I think that since we will eventually be able to manipulate biology at the molecular level, we will eventually have a thorough intervention no matter how you approach it and that epigenetic cleanup is only the first, most available, step. Eventually we will have a thorough intervention whatever the approach will be.

[@williamwalker6071]

So why haven't we done the obvious experiments in primates with telomerase gene vectors, telomerase activating chemicals, etc.? Dr. Andrews was talking about this in 2008, but AFAIK all this time has passed and there has been no progress. (I worked at Shay-Wright lab 2001-2005 BTW, I remember Shay saying the same thing about measuring leukocytes' telomere length, while i was doing it ;)

[@azuurasmr7937]

What are the easiest biomarkers you can measure at home?

[@travellove8974]

life force is a company that will do 25 biomarkers from home

[@priyagehm3487]

How can one make an appointment for care with Michael Fossel, MD?

[@orphica5739]

I suppose time is always limited, but why in the world didn't anyone ask him why he thinks telomeres exist in the first place and whether elongating them would allow cells which have accrued all of the mutations in the right places to clonally expand into cancer cells and metastasize? Would it really be as simple as elongating telomeres? This seems potentially reductionst, but I would think he would have a good answer for that. Yet it was never asked in all of 25 minutes of Q&A.

[@tylermoore4429]

Dr. Fossel is 71? Jeez, he looks to be in his forties, with his unlined face and neck and smooth hands. We need to find out his longevity regimen pronto!

[@swenic]

He does look young(er) and healthy. Any one know how he's approaching his longevity?

[@tylermoore4429]

I am guessing the recommendations he offers in his book The Telomerase Revolution, a sensible diet, moderate exercise and TA-65.

[@rebornkingofthule7067]

What is a material transfer agreement 🤝

[@woloabel]

(On Wednesday of April 26, 2023). On the Matter of Aging by MD Michael Fossel on Foresight Institute KZbin Channel: 1) Yeah, there is so much Correlation and Misinformation therein and Thereby. I reckon that the same is on the Socioeconomic Status as a Factor of Infection and Neoplasia Incidence and Even the Prevalence Therein. The Diapers and Cardiovascular Diseases, or the Measuring of Telomere Length, and then its the Rate of Shortening,,,,,Damned. I rather Not. 2) I do believe however that Senescence is manifesting simply by a mere chance in the organ system that is most in Attrition or let's say Neurodegeneration of Alzheimer's Disease, Parkinson's or what not is simply where the fastest and greatest Entropy is occurring while the Genetic Side and/or Environmental Debate is useful in the fundamentals, it is not herein anything of Essence. The Neurons are Simply not Regenerating whereas in the least Senescent Human these Cells are possibly even becoming Better upon Regeneration; but therein, there is still an Organ System that is not within such Circumstance or Joie De Vivre Status as the others. It is almost Pathology Within Pathology to try to figure out the Mechanism of Aging and The Cause of the Death at Autopsy simultaneously. 3) Anyway, Molecular, Genetics, Epigenetics, the idea Stands as it has for Millenia. If you like what you see or have, why should it go so easy or last so Little (Rhetorical Question of All Mortals). I cannot add much on to this Topic as I fear this was Proteomics and a rather Expensive Paraphernalia-Dependent chat. 4) What I will say is that it is Professors and Priests that there is the greatest Length of Life, and if you are a Pirate the chances are the lowest Life Expectancy, Assured. Please do not go an Invade these People's Privacy, especially if they have not Consented, in trying to Verify this or Aggrandize therein this rather conventional Investigation Matter. 5) Viral Vectors, well these are exciting as the Chinese tell me they have Cured, Reversed Genetic Aetiologies like Sickle Cell Anemia. I know one Standford Prof attempting to do some damage to Severe Combined Immunodeficiency (SCID) and onwards. This is my kind of Science and if there is something to do. it is to Protect those who have not even had a Chance let alone all have that which comes with fortune and the good fortune of LIFE. For this, I have a Hemocytoblastosis in MInd Scenario if you understand. MD Fossel, es sehr gut zu Gesundheit haben aber besser Gesundheit geben und haben ist. Heil!

[@livelongenoughtoliveforeve1114]

I suppose his research is incongruous with sens approaches?

[@caroledevlin4436]

Wat? Wat are you saying. I donut understand! Wat is sans approach? Wat is incongruous.

[@royzlatanestevez9843]

I rarely listen to a talk that intentionally does not stop at the "handwaving" stage and goes more in depth. This has been extremely interesing. Still think this problem is far too big for us to tackle. Too many parts and pieces. There is no saving the flesh body, and better to leave it. Why do 25 year olds need diapers? And I am so familiar with people like Abdulkader. They are totally unaware of what is happening in a conversation. lol I always wondered what is going on in the heads of these people. "Please explain the abbreviation you use." and he just goes "yes yes" and just continues as if nothing happened.

[@caroledevlin4436]

His analogy with diapers is that a father goes and buys diapers for his kid. 25 year olds are healthy segment of the population. So, his example is to demonstrate misinterpretation of data. I.e. buying diapers make you healthy because 25 year olds buy diapers and they stay healthy. You fool, why does this need to be explained?

[@jennym4127]

Wow! This guy talks a million miles an hour but I picked up some of it.

[@williamwalker6071]

(Andrews was talking about using mouse lemurs, BTW)

[@LAZARUSL0NG]

Is anyone else channeling Rick at the spa?

[@rebornkingofthule7067]

Don't get made get even Fixed low floats are an inflation hedge $PLX 🤑🤑 Probably a thousand share out on margin borrowed money for every 100 you buy with your hard earned cash

[@golgipogo]

She is delightful. Does she have a tank of Nitrous under her desk? Kidding.

[@rebornkingofthule7067]

Don't get made get even Fixed low floats are an inflation hedge $PLX 🤑🤑 Probably a thousand share out on margin borrowed money for every 100 you buy with your hard earned cash