Von Willebrand Disease (VWD) | The Most COMPREHENSIVE Explanation!

Von-Willebrand factor (vWF) comes from the meagakaryocytes (bone marrow) as well as the Weibel-Palade bodies (endothelial cells). Von Willebrand factor (vWF) helps the platelets adhere to the sub endothelial collagen via GP1b receptor on the platelet.
Von Willebrand disease (vWD) is the most common inherited bleeding disorder worldwide.
Primary hemostasis involves forming a platelet plug (thrombocytes) whereas secondary hemostasis involves making a fibrin thrombus (coagulation factors).
Ionized calcium helps blood coagulate.
We test for primary hemostasis via platelet count, bleeding time, and platelet aggregometry.
We test secondary Hemostasis via prothrombin time (PT), activated partial thromboplastin time (aPTT), and the old coagulation time (or clotting time, or thrombin time).
Von Willebrand Dusease (vWD) affects primary as well as secondary Hemostasis.
Hemolytic Uremic Syndrome (HUS), atypical Hemolytic Uremic Syndrome (aHUS), and Thrombotic Thrombocytopenic Syndrome (TTP).
Atypical hemolytic uremic syndrome (aHUS) is similar to thrombotic thrombocytopenic Purpura (TTP).
Typical Hemolytic Uremic Syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.
Thrombotic thrombocytopenic purpura (TTP) is a pentad of microangiopathic hemolytic anemia, thrombocytopenia, acute renal failure, fever, and neurological abnormalities.
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Bernard-Soulier Syndrome (BSS) is an autosomal recessive (AR) disorder characterized by a defective GP1b platelet receptor leading to a problematic platelet adhesion process (primary hemostasis).
Glanzmann Thrombasthenia (GT) is an autosomal recessive defect in the GPIIb/IIIa (GP2b/3a) receptor on the platelet which leads to defective platelet aggregation.
Ristocetin Cofactor Assay (RIPA) is usually abnormal in cases of Bernard-Soulier Syndrome (BSS).
Bleeding time is prolonged, platelets are big in size, but few in number (Macrothrombocytopenia).
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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
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As students, many teachers and educators will pass through our lives without remembrance. Yet, a special few will leave a lasting impression. Thank you for being one of the special educators who will live on forever in the minds and hearts of the students whose lives you have touched ❤

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I appreciate you!

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[@SilvanaMoran_Radish]

I am not a medical student, but I do have type 3 vWD. I was able to understand some of this video and even learned some new things. Thanks so much :)

[@MedicosisPerfectionalis]

I am honored!

[@darkspirit8896]

I have vWD type 3 too!

[@aneeketmodak5740]

Peter schmeichel, manchester united, fan. My favourite yt channel just got a whole lot better ! Amazing videos, great content. Your humor is absolutely top-notch !

[@MedicosisPerfectionalis]

Thank you so much 😊

[@rukiee.b.ovwigho5709]

The best video on Von Willebrand disease. The best channel on hematology. From Nigeria 🇳🇬❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@rasha6597]

I'm finally understanding hematology! You are brilliant ,thank you so much❤️

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I am so happy for you!

[@TheBeatyoutube]

This is really interesting and couldn't resist my laughter after listening your change in dialects....love you mahnn❤️

[@MedicosisPerfectionalis]

Thank you so much 😊 I appreciate it

[@Kajalsharma22404]

Thank you so much for making us understand in the most simplest way💓

[@MedicosisPerfectionalis]

My pleasure 😇

[@Extarte]

My friend told me that she has VWD and I really want to somehow support her and thanks for your videos I can know more. Thank you

[@MedicosisPerfectionalis]

You’re welcome! I wish her the best of luck!

[@GiasAhmed-tq8cx]

@12.00 the Soup analogy was EPIC! Love your videos and learning a lot! THANK YOU !

[@MedicosisPerfectionalis]

You are so welcome!

[@mixie3830]

"Oooh I made the soup" "Shut up you didn't "😂 I love it

[@MedicosisPerfectionalis]

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[@Rina.136]

Watching and learning from beautiful Greece!!

[@MedicosisPerfectionalis]

Thank you so much! Would you please help me by sharing?

[@Rina.136]

@@MedicosisPerfectionalis yes!

[@cheese-san8846]

Thank you so much for this video. I have type 1 vWD and wanted to learn more about my disorder but I just didn't know where to find it. You've made me feel seen and I thank you for that.

[@MedicosisPerfectionalis]

I appreciate you and I wish you all the best!

[@RA-om8ck]

Uterine atony is the most common cause of post-partum bleeding.

[@MedicosisPerfectionalis]

Excellent!

[@eleazarjohncruz2595]

watching this before my small group discussion in med school. tasked to do a report on vWD. will inform you on our progress after the reporting. thanks!

[@MedicosisPerfectionalis]

Awesome 👏 Good luck 🍀

[@muhammadaliffarhan1825]

So cool, funny, and understandable man! Love it!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@jeroddobson4680]

I only found your videos last week and I love them. Have to say though that you labeled Northern Ireland as Scotland.

[@MedicosisPerfectionalis]

Oops 😬 I am sorry!

[@oclaureoclaure7036]

WHAT'S THE MOST COMMON CAUSE OF POST-PARTUM BLEEDING? - Uterine Atony

[@MedicosisPerfectionalis]

Excellent!

[@mixie3830]

🌸Love the drawing .. really helpful.. Thank you so much medicosis for all your efforts🌸 .. 💫brilliant 💫

[@MedicosisPerfectionalis]

Thank you 🙏

[@rhyes8538]

I want to tap on every topic of my notes and listen its summary in your voice hahahahaha awesome video btw!!!

[@al3ksandr0va]

Forever in my heart! Thank you! ❤️

[@MedicosisPerfectionalis]

My pleasure 😇

[@manarsmaan2624]

Hello Doctor I am preparing for my ASCP board exam and i like to learn from your lectures . Thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇 Good luck 🍀

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I love you and your videos so much!

[@MedicosisPerfectionalis]

Thank you 🙏

[@hananhs8462]

You explanation it’s supercalifraglisticexpialidocious .🙏🏼thank you

[@medicaluser5833]

Autosomal dominant inherited diseases that I remember (besides VWD) - Marfan syndrome - Huntington´s disease - Polycystic kidney disease - Short QT-syndrome

[@dr.derbyallen7063]

Amazing explanation

[@MedicosisPerfectionalis]

Thank you so much 😊

[@awadhswaleh3361]

Hellow medicosis I am currently doing my MMED /Resident in internal medicine.thank u for making learning interesting for me. Fadya

[@pavanbevoor8636]

Thank u so much. Love from India.

[@MedicosisPerfectionalis]

Love ❤️

[@lphoca8861]

Amazing video! Cannot stoping laughing 😂 I've recommended to my colleagues🤣

[@Hudamk99]

You’re unbelievable 😍❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@shaheenmalick5999]

Hi sir, I believe you may have confused Ristocetin cofactor assay and Ristocetin-induced platelet aggregation, No? RCo will be abnormal in vWD, but it will be normal in Bernard soulier's. However, RIPA will be abnormal in both Bernard Soulier and vWD. Please let me know if you think I am mistaken.

[@MedicosisPerfectionalis]

Hey Shaheen, I understand your point. I made an entire video about that: Ristocetin Tests | Hematology kzbin.info/www/bejne/f6Gxfmueab9rrLc/

[@hananhs8462]

Two questions 🙋‍♀️, i have read tht patient with o blood group have low level of VWF comparing to other groups , would tht lead bleeding complications? …2 - does tht cause WFD ?

[@livestreamparty27]

I inherited Von Willebrand Disease factor viii. I went to hemophilia summer camps as a kid. UC Davis in California used to do timed bleeding on me as a kid. I still have the scars.

[@MedicosisPerfectionalis]

Wow 😳

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

😇😇

[@Abccddeeff]

Thanks!

[@andygreeen]

My mother has VWD I think I have a mild form of it I am now 42 years old does it get worse as you get older?

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Does antiphospholipid form antibody against pf3?

[@nicolealexandra8185]

Amazing!

[@MedicosisPerfectionalis]

Thank you!

[@reussirvotreresidanatphrmc1546]

your are amazing thanks a lot

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@ahmdooz]

we need next video of their subtype and Hemophilia..... we will waiting

[@MedicosisPerfectionalis]

Coming soon

[@n.b3973]

booooooooooii im addicted to your videos, im currently enjoying this at 3 AM instead of studying my boring ppts ;-; good bless your soul #life_saver

[@MedicosisPerfectionalis]

Thank you so much 😊

[@n.b3973]

@@MedicosisPerfectionalis im sorry to bother you, but i have a question: how can we differentiate between hemophilia and vWD clinically ? are there any specific symptoms that will lead us to the right diagnosis ?

[@MedicosisPerfectionalis]

Hemophilia patients are overwhelmingly males. Bleeding is usually more severe. Most patients with hemophilia know that they have hemophilia (because the symptoms are so severe that they seek medical care). However, most patients with VWD probably have no idea (an example is a young lady with slightly heavy menstrual periods).

[@n.b3973]

@@MedicosisPerfectionalis oooooh makes perfect! sense thank yoou so much ^^ i almost watched half of your hematology/oncology playlist just now !! i LOVE how short but detailed your videos are

[@MedicosisPerfectionalis]

My plan is to make videos about all medical topics.

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[@MedicosisPerfectionalis]

Thank you so much 😊 Would you please help me by sharing?

[@ahmdooz]

great one 💕

[@MedicosisPerfectionalis]

Thank you so much 😊

[@ravitejasamudrala4]

Hi my family history all members have Von Willebrand disease factor 8. We can take Covid-19 vaccine or not.lot of confusion please help me

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As a part of the polyglot community I am so hyped when he introduced the european countries one by one!

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thank you for this you just gave me a boast to study...why is studying with you so fun

[@MedicosisPerfectionalis]

Thank you 🙏

[@bentonalex9150]

I want to know, difference between haemophilia and BWD ?

[@MedicosisPerfectionalis]

What’s BWD?

[@audreyconnolly1104]

Thank you. I have von willibrands disease type 2 N. Interesting to watch your video. I'm Irish and Your map of Ireland is a bit weird and I think you called Scotland what is Northern Ireland. Thanks for the video, good fun!

[@MedicosisPerfectionalis]

I made a mistake! Sorry!

[@kellynisbett5876]

I was told 26 years ago I here von willbrands disease with two factors missing 8 and H cant remember the other .How did you find out you have 2N type ? My health is not great and I continue to bruises. Many dont look like a normal bruise. My GP only says it states mild von willbrands disease but cant say the type J have. I think I will have to see a private blood doctor. Any information would be appreciated.

[@Mona.Arekanti]

oh even I have VW type 2

[@shahtajaslam5608]

Fun videos makes learning eas♥️✨

[@MedicosisPerfectionalis]

Thank you 🙏

[@Mercyforthewicked]

im obsessed with you sir

[@laurataylor847]

謝謝🙏

[@MedicosisPerfectionalis]

🙏

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Really thank you ...God save you

[@MedicosisPerfectionalis]

Thank you so much 😊

[@sarahahmad4147]

thanks

[@MedicosisPerfectionalis]

My pleasure 😇

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Autosomal dominant - Familial adenomatosis polyposis, Marfan's, MEN syndromes, PCKD, Familial hypercholesterolemia ...

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Wondering what was ur very first video..😊

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Please live longer 🤣 I enjoyed watching your videos 🤣

[@MedicosisPerfectionalis]

Thank you so much 😊

[@CiaraLiptrot]

You should not start a geography channel, that's not Scotland 👀 love the haematology videos though, amazing for exam prep!

[@MedicosisPerfectionalis]

☺️

[@user-nd8rp1rk5u]

The best forever

[@OnlyJalenPhd]

I was recently told I have the factor. I didn’t go back.

[@zigmeebhutia2780]

I have vwd.. can i take covid vaccine

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What medicosis mean ...please reply me

[@MedicosisPerfectionalis]

-Osis = condition. It’s the condition of perfect medicine.

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I am from India and want membership then how can i make payment if I don't have card from VISA, master card Or american express... Plz help

[@MedicosisPerfectionalis]

Send me an email please!

[@omaalmnafy]

Egyptian is the best ❤ thank you for amazing video 🥰

[@MedicosisPerfectionalis]

Thank you!

[@ayeshaygul5494]

Can hemophilia A and vwD be together

[@MedicosisPerfectionalis]

It’s possible!

[@areejabbas3165]

great

[@MedicosisPerfectionalis]

Thank you so much 😊

[@jamesischool]

The poor Scots @2:27 being confused with the Northern Irish 😂

[@MedicosisPerfectionalis]

Sorry!

[@jay-rama]

What’s GU bleed?

[@MedicosisPerfectionalis]

Genitourinary

[@jay-rama]

@@MedicosisPerfectionalis thanks boss

[@MedicosisPerfectionalis]

My pleasure!

[@caramel_honey]

You're wrong about Scotland's location

[@haifaalhaj9523]

هههههههههههههه حوار السوب رهييييييب أقسم بالله أنا قلت اللطافة وخفة الدم دي مابتجيش من أجنبي

[@kavya6342]

Familial hypercholesterolemia Marfan Huntington ds

[@MedicosisPerfectionalis]

Excellent What else?

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تحيا جمهورية مصر العربية الشقيقة >> من السعودية

[@MedicosisPerfectionalis]

Thank you so much 😊

[@She_is_Chris]

Anyone in the Von Wilebrand community vaccinated? Pls share

[@nikolaborisavljevic5266]

And Balkan is a legend...

[@ellehan3003]

Scotland is not happy you got their location wrong 😀

[@ZenoDovahkiin]

I'm surprised at the lack of Angry Scots and Irishmen in the comments.

[@medicaaam2197]

Huntington DMD Wilson Migraine Spherocytosis

[@tinasaini2529]

i love your commentary lmfao

[@sweatshirtguy367]

uterine atony is the most common cause of postpartum haemorrhage

[@MedicosisPerfectionalis]

Excellent!

[@sweatshirtguy367]

@@MedicosisPerfectionalis thank you so much for your videos, they are very helpful

[@TheSocialGathering623]

Erik von willebrand made medicine more intense, medicine in 1920 was way easier, if a patient came bleeding you’d just put cow dung and call it a day😪

[@MedicosisPerfectionalis]

🥸

[@mhasenhumtsoe1363]

A fan of Man Utd until The Egyptian king arrived at Anfield

[@MedicosisPerfectionalis]

Haha 😂

[@user-nu7vc8lw5g]

you are fabulous man, where do you come from?, you sound like an immigrant not a native american!

[@drdramatik]

2:24 Are you Egyptian doctor?

[@khizerbaig9796]

This is what i have to live my whole life with ☹️

[@MedicosisPerfectionalis]

I am so sorry to hear that!

[@khizerbaig9796]

@@MedicosisPerfectionalis don't worry it got much better by growing up i am 20 and i am far more better than before

[@patricknorris5989]

Great vid but scotland isn't northern ireland

[@MedicosisPerfectionalis]

Sorry 😢

[@dailydoseofmedicinee]

👌

[@MedicosisPerfectionalis]

Thank you!

[@aubreydayon9776]

❤

[@MedicosisPerfectionalis]

Thank you 😊

[@WeijieYao1994]

I love you

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@alexshi9095]

Hello. I have V W D I had to go to emergency room a few times. :/ And I'm only 10 and I have to take this a needle everyday 😭 Btw I have no clue why I searched for this video so ya.

[@glitchingout7219]

ha same, but i dont have exactly the disease, I have a different but same type. of disease but I feel ur pain and im also young

[@alexshi9095]

@@glitchingout7219 Ty for understanding!

[@mubassirkhan3997]

♥️♥️♥️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@mahsamazdak2755]

Where maps make perfect sense😂😂😂 dead🤣

[@MedicosisPerfectionalis]

:)

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@@MedicosisPerfectionalis by the way you're amazing!❤ I was wondering if you could make a video about yourself and your med journey😃

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Atonicity

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dude you're hilarious

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You rrr ❤️❤️❤️❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you :)

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,✌✌✌✌🤣🤣🤣🤣amazing

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حاساك هتطلع مصرى يارب تطلع مصرى

[@MedicosisPerfectionalis]

Yes! مصري وبابا مصري :)

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انت مش متخيل انا مبسوطة بيك قد ايه بجد ربنا يفرحك زى ما فرحتنى دلوقتى 🥰🥰 So proud of you 👏 and thanks for helping us 💕

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Manchester United 🥳🥳🥳

[@MedicosisPerfectionalis]

:)

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Slow down