Hemoglobin, Bohr Effect, and Fetal Hemoglobin

[@mimo5463]

It's a video from 2013 but I just found it and want to thank you. This really helped me understand how the reactions work between Hb, O2, CO2 and H+. And also how allosteric regulator works for Hemoglobin.

[@courtney8690]

YOU'RE SERIOUSLY HEAVEN SENT. EVEN THE DESCRIPTION LAYS IT ALL OUT. T minus 2 hours til my exam and this helped so much. Thanks again!

[@MoofUniversity]

Haha! THANK YOU! I'm glad you found the video helpful. I hope you do well on your exam! :]

[@KelvinMagun]

Ah! Thank the world of KZbin for your videos! Clarified like everything I was confused about! Final exam in 1 hr! 🙌🏽

[@minareddy9895]

Your videos are concise, hit on the important points, and extremely clear. i am extremely happy to have found these videos.

[@nawshinahmed3082]

This is amazing! Made the concepts so much simpler than I learned in class. Thank you!

[@MoofUniversity]

N Ahmed Sweet! Happy to have helped! You're welcome!

[@m.t1446]

Man idk what you did with your life but I hope you accomplished great things. You're and awesome tutor. I would pay you the money I give to my shitty class for some lectures like this. Thanks

[@MoofUniversity]

Thank you for the kind words of praise and appreciation!

[@ambergiles2117]

Hi you referred to a video before this one. Which video on Hemoglobin is that? Talking about the cooperativity. Thank you so much!!! This was so helpful!

[@farcry2ism]

Got to say, thanks for these videos, it's helped me a lot for my biomedical course =D

[@MoofUniversity]

I'm glad, dude. You're very welcome! :]

[@sporter2442]

Thank you! Very helpful. Thank you for taking the time to make the videos.

[@MoofUniversity]

Sarah Lawrence Sure thing! I'm glad you found them helpful.

[@rachelo7946]

Thank You for helping me finally understand Hemoglobin. You rock!

[@beutifulamit]

oh man. these videos are so accurate to what im learning in class, and then i see that you are also from UCR! yay go highlanders! :)

[@saeedmansuri6482]

Best 😍. You really made it very easy...

[@kawanganyirenda452]

The Histidine since it's found the myoglobin being positively charged amino acid but why saying it's the T- State of Hemoglobin conformation being stabilized . Kindly make mention of the connection between these two globular proteins Sir .

[@yulingtsui7374]

Thank you for the amazingly clear explanations! :D

[@MoofUniversity]

Yuling Tsui You're very welcome! :]

[@parmiiidaaa]

OMG u totally saved me from my bichem midterm tomorrow

[@MoofUniversity]

parmiiidaaa Lol. Sweet! I hope you did well!

[@sophi1208]

Thanks !! it makes things easier to understand !

[@vinhtrinh233]

Thanks! This helped my understanding greatly.

[@allaalbonijim2748]

So helpful, helping me see the bigger picture. Thanks. :)

[@pneumonoultramicroscopicsi4065]

I feel that I'm lucky when I found you!

[@wsuadpiphilanthropychair3789]

Your videos are so helpful!! Thank you!!!

[@liamdrans]

You are such a legend, thanks!

[@MoofUniversity]

Liam Dransfield Lol. Wow! Thank YOU for calling me a legend! Haha!

[@adidii]

"baby blue"

[@ChrissywantsYOU]

thank you, thank you, thank youuu. Lifesaver !

[@muhammadsalman8311]

Hey great video :), but can you explain 2,3 bpg relating to high altitude.

[@MoofUniversity]

King James Details aside, people who've grown accustomed to living at high altitudes (where O2 concentration/pressure is lower, essentially) have higher 2,3-BPG levels. The higher 2,3-BPG levels causes the oxy-Hb to more readily give up is O2 to the tissues. This way, the tissues are not O2-deprived, despite the lower O2 levels at higher altitudes. This is the basis for altitude training. Distance athletes will often train at higher altitudes over long periods of time so as to get their bodies adjusted to the lower O2 concentrations/pressures. This way, their bodies basically get better at getting O2 delivered to their tissues, helping to increase their performance during races, particularly races at lower altitudes.

[@jinkyounglee4860]

U rock man and im a fan

[@richmoriarty6478]

thanks. great video

[@3wJblind0114]

•2,3BPG lowers the affinity of Hb for oxygen (raises the P50 of Hb from ~12 torr in aqueous solution to ~26 torr in blood - i.e. respiring tissue) Can you explain the info in parentheses? Its on my professors slides, how does this change the P50?

[@MoofUniversity]

3wJblind0114 Yeah. The p50 of Hemoglobin (Hb) is the partial pressure of oxygen necessary to make Hb 50% saturated. 2,3-BPG (being an inhibitor of Hb) raises the p50. That means, with an inhibitor, Hb requires more oxygen (26 torr) to be 50% saturated, whereas without an inhibitor, Hb only requires 12 torr of pressure due to oxygen to reach 50% saturation. I apologize if this response is two weeks too late, though. :/

[@sushmita1436]

awesome explanation :) thank you so much...

[@aiasami3542]

so helpful thank u

[@fatimahhassan2150]

You're the best THANK YOU

[@brendanb209]

Don't use dark colors on dark background, hard to see

[@verdeapplesify]

But I thought histidine is neutral at the physiological pH, how can it be the reason that maternal hb is more susceptible to 2,3 bpg?

[@katy-janeangwin3012]

+verdeapplesify I think it's because 2,3-BPG binds in the tissues, which is at a much lower pH due to CO2 from the muscles. The CO2 from the muscles is turned to carbonic acid. The extra protons flying around bind to histidine, which gives the it a positive charge, allowing the 2,3-BPG to bind. At least that's how I understood it!

[@hak8755]

pls mention in the video that what ever u said all is written it took me week to write down what ever u said and then after a 1week what i saw was ..... pls mention it

[@inspirationelham2239]

Tank you sooo much

[@MoofUniversity]

You're welcome sooo much!

[@AllieSmellzBigTime]

p-crease lol.@6:08

[@MoofUniversity]

Lol. I'm glad I wasn't the only one laughing at myself.

[@tuck295q]

That lung and actively metabolizing tissues are really confusing. >.>

[@anjaligarrett5044]

That was too many ads for this one video

[@MoofUniversity]

Ya boy gotta get paid. Lol. I hope you found the video helpful, though! :]

[@tutu7365]

Bookmark 10:26

[@NightSirius]

lol lets use baby blue since we are talking about babies XD

[@qaisjan123]

i can't see the writing through a microscope

[@thisgirlyljenn]

just do full screen brah.

[@carloscanales9867]

amazing video thank you