Fasting & Gut Health: Regeneration + Stem Cell Production

New research suggests fasting & autophagy support the regeneration integrity of the gut barrier.
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Link to show notes and research: bit.ly/2RCnAI2
----------------------------------------Show Notes-------------------------------------
0:00 Intro
2:05 The best way to enhance autophagy is with diet and exercise.
2:44 mTOR is the autophagy break and AMPK is the gas. AMPK also puts the break on mTOR.
3:25 These enzymes cannot be directly tested.
4:20 If your glucose is high in a fasted morning test, you may not be experiencing autophagy.
4:40 Your body upregulates APT with activity after your night’s fast. This increases AMPK and puts the breaks on mTOR.
5:40 mTOR is activated in the post meal window. This helps you body take the nutrients.
7:00 Exercise stimulates AMPK, as does intermittent fasting and taking berberine hydrochloride.
7:40 Paneth cells are key at releasing antimicrobial peptides which keep pathogens from entering.
9:40 Endotoxin/LPS (lipopolysaccharides) are found on the surface of gram-negative bacteria. Because of these, many of us with leaky gut have low grade sepsis after every meal.
10:44 Paneth cells and intestinal stem cells are intimately connected to the autophagy process.
12:20 Paneth cells control your intestinal stem cells. Stem cells help replenish and repair damaged cells.
14:00 Intestinal permeability can be tested via Dunwoody Labs.
14:22 Tight junction proteins are the mortar for your gut lining.
15:50 Dysfunction in your gut endothelium cross-talks with lung and cardiovascular endothelium.

[@doctablademd]

Nice to see a discussion about fasting that goes beyond just weight loss. The pain and impact of having gut issues is a pretty strong motivation to try out fasting and it makes sense why it could help. Gonna share this with my clients

[@TteokbokkiNari]

Fasting while being almost completely carnivore helps me a lot with my gut issues. 😊

[@lawdogwales5921]

@@TteokbokkiNari Me too.

[@queenofthesouth4205]

Dr. Blade, THANK YOU FOR ALL THAT YOU DO TO KEEP US HEALTHY....just checked out your channel today.

[@randyross5630]

Yeah, Okay Day Walker! You being a Doctor makes it Impossible for me to believe you want what's best for people... You Want Money, Power, and Social Status, that's why you are a Doctor!

[@moenibus]

Exactly. I hate this obsession with weight loss. There are some of us who want to gain weight and muscle.

[@haydencook682]

We've spent about 275k years as a species not really knowing when or what our next meal was...we developed this way. It makes sense why we WANT to eat all the time, but it's also not hard to see why a huge shift in our eating habits has caused massive issues.

[@matejsmrekar1218]

I would only like to add that even when we wanted to eat all the time , we couldn't. If the hunt was unsuccessful then its fasting time. I watched some videos about current tribes going without eating for like 6 days sometimes simply because they didn't catch anything so I think our bodies are well designed to survive well enough without food just as long as you carry some body fat.

[@TerriblePerfection]

Bottom line for me, after self-experimentation and observation: LESS IS MORE. Less food, less often. And you can immediately see why this idea would be hugely unpopular: millions of livelihoods depend on us eating more, more often. Thank you, Mike, for telling it like it is. Let's get excited about NOT eating! 😂

[@springteen3743]

But as long as people gold is to work 8 hours a day 6 days a week then people will be in bad shape cause people have to feed to perform 😁

[@DomFortress]

@@springteen3743 nope, I eat one meal a day 6 days per week, and I work full-time in a warehouse doing manual labor, plus I train in powerlifting first thing in the morning 6 days per week. I can still maintain my 222lb weight on my 5'11" frame with a 14% body fat.

[@TerriblePerfection]

@@springteen3743 Look around you. Humans are killing themselves slowly, with excess and consumption of non-foods. The point isn't to starve oneself but to eat to live, not live to eat.

[@TerriblePerfection]

@@DomFortress Wow! I'm impressed! I have trouble getting enough calories at one meal. I'm short and thin, so I can do OMAD occasionally but find that I'm ravenous the next day. You mentioned 6 days a week. What do you do on the seventh day, if you don't mind me asking?

[@DomFortress]

@@TerriblePerfection I don't eat on the 7th day, a 40hr fast.

[@steveking135]

Love the science on this Mike. I was on 5 prescription meds a decade ago and when I addressed gut health I got off all my medications. Basic stuff like eliminating sugar and processed foods, compressing my feeding window, and getting more active was the key to healing my gut.

[@albongo3949]

Indians spoke about this through mentioning prana. Always thankful for you man🙏🏻👏🏻

[@pip3670]

Have been an advocate of intermittant fasting for three years now. Initially lost 60lb and felt great but the pandemic set in for two years and disrupted my sense of well being and I re-gained 30lb due to the stressors of being frontline critical care nurse. Now retired and struggling to regain that feeling and lose the 30 plus another 30 for my much awaited knee replacement. I am on day 3 of a 7 day fast to kick start my journey. First two days were a struggle with weakness but I knew if I got to day 3 I'd start to feel better. It's working! I hope to reduce all the inflammatory markers and reduce swelling and pain ...very serious arthritis in feet, ankles and knees. It helps to know the exact science of what is happening in my gut, which I think has been the major contributor to my physical dis-ease.

[@vibrantly50]

Adding in rebounding on my Bellicon lately. Really starting to enjoy exercise for the first time in my life. At 66 years young I feel hopeful that with Carnivore, IF and rebounding I can regain my health.

[@loganchamp]

Thank you so much Mike. I’ve suffered from depression for practically my entire adult life. I have also suffered from so pretty bad acne. I have always instinctively known that the worse my GI tract feels, the worse the depression and acne will get. And it just happens that I have that terrible tendency to eat pretty much around the clock. I have watched a lot of your videos recently and you have inspired me to give fasting and a regular excerise program a try. I’ll report back in a couple weeks on how things are progressing.

[@ensar2805]

Please report back, i have a similair story.

[@lilascharmante2712]

Did your lifestyle changes help?

[@brendamartin3444]

I am currently healing my diverticulitis with 6 day dry fasts, then a one day feeding with bone broth… This is week four and my gut health is already so much improved!! The power of Autophagy is amazing!!

[@fortyfiveseventy2994]

6 day dry fast.. so no water or food?? 6 days.. mmkay

[@andyrandy0815]

that sounds tough, dry fast for 5 days, maybe there are easier fast schemes

[@a2a918]

A 14 day fast completely reset my gut health. Plus I broke it properly and now I only crave earthy tasting foods now. Literally hooked on avocados now

[@Absolutebeach]

Always appreciate the advice and information. Been very helpful this year. Thank you

[@bjsmjx98]

This is great awesome explanation! Keep on telling good news!

[@TheBeautyanna]

Fasting is amazing 🤩 I have been doing for 12 years and I feel great and I look great! Learning always!! Thank you 🙏🏻

[@jerrylisby3440]

12 years is too long. Eat something already.

[@TheBeautyanna]

@@jerrylisby3440 😂😅yes right? I will eat right now!! 🤣

[@valtsanev4665]

Extremely insightful and valuable. Thank you for taking us to school 😀

[@Juznik1389]

THANK YOU MAN! I'm battling against IBS right now and this is SPOT ON

[@besseracademy]

Thank you for the detailed talk on the importance of fasting!

[@ChrisAbbott]

Love your vids... always so informative.

[@gstlynx]

Reliably informative and motivating. Thanks Mike, as always good explanation.

[@LiseBarrett]

Thanks so much for this video! This was illuminating and I really appreciate your hard work in breaking it down for us!

[@Joy80JJ]

Great information Mike. Thanks for such great videos to help us stay healthy.

[@ChrisLock-kt6ic]

Excellent video! Thank you!

[@terrydummitt]

fantastic video... perfect presentation... your such a great resource for keeping up to date with the latest and greatest on health info... Thanks so much for this! been watching for a few years and your presentations keep getting better.

[@TMiller808]

Excellent! Thank you! Sharing

[@digitalbrand2930]

Thank you for this great video!

[@dort5436]

I used fasting for 3 days weekly to heal long term problem with Diarrhea. It took 8 months to completely fix it. Yeah. Side benefits was 10 lbs lost down to size 10 and BMI of 23! It has been one year and things are still great

[@whitewolf6730]

Great stuff. Going to give it a second listen to absorb it.

[@queenofthesouth4205]

Thank you!! We need to fast for mental and physical health. I am currently doing ADF and feeling great. I have mental clarity and weight loss is a plus.

[@xp1296]

Thx Mike, awesome content as always 💥

[@ts31966]

Your channel has more information than almost all.

[@SharkFishSF]

almost all.... modern medical pill pishers

[@SharkFishSF]

*pushers

[@a2a918]

Except for healthy alternatives .

[@SharkFishSF]

@@a2a918 wdym?

[@drewbarefoot4428]

Thank you! Great breakdown of mtor and ampk

[@LordStanley94]

Today is Day 10 of my water with electrolytes fast. (10 May 2022) Best to all.

[@raobdywse]

thank you for your explanation on the physiology. i use your videos often with clients. 👍

[@spinthma]

Great talk!!!

[@justrione]

Thank you. Great information always

[@samliotta9732]

Very good talk. Something about what you said has helped me to understand a little bit more about the need for fasting. Thanks!

[@detoxinglifepodcast]

Dude! This is the realist posts you've done...for real, you got so much more passionate since the YOU KNOW WHAT! TRUTH IS TRUTH! We are trying to awaken humans to many truths... Now you see... Great job.

[@BioStuff415]

tight junction function is also related to vitamin D status. Slow down a tad... there is no rush. Th intensity is fatiguing. Use it for emphasis.

[@gogogardener]

I need to make changes and then this video pops up. It's more than I can absorb in one viewing. Its helping me understand my body's strengths and weaknesses.. and changes that I need to make . Thank you.

[@illpj]

Great info.

[@goddess.110]

Thank you for this 🙏

[@glenmorse9533]

That is great information!

[@erikasanchez7972]

Sad that the last 40 years has seen such a rapid decline in the education a medical professional gets. They have been reduced to chart readers that will actually tell you “I don’t know anything about diet, vitamins or minerals. You would need to see a holistic doctor.” Come to find out this is also by design. Now it is better not to get medical, care in the USA. My new question now is what type of person would pay 8 years of schooling to be dumbed down by the education system and big pharmaceutical, not a person that wants to help others🙁 only a person that wants to pay their BMW. Thank you to all of the people on utube that put out content that makes sense and is natural

[@Hunterveit]

Always appreciate your content! I've been experimenting with fasting for years. Life changing stuff!

[@fair98fair]

Nice. Whats your current eating window?

[@lawdogwales5921]

Yep.

[@DefinitelyDean]

Amazing information 🙏

[@galinatushka1356]

WOW I’m first🤩Mike influenced me to buy sauna and ice barrel. It’s awesome!

[@bunnykinsx3]

Lol I misread “posted 4 min ago” as “4 months ago” and I was like WOW, only one comment on this video in 4 months?!”

[@galinatushka1356]

@@bunnykinsx3 😂👍

[@actyrrel]

Rhonda Patrick got me into sauna. Mike got me into ice.

[@galinatushka1356]

@@actyrrel, I am from Siberia originally, love the sauna all my life, but was reading about it before that it was no benefits from it, I’m glad there is more evidence now about it🤩

[@Highintensityhealth]

Lets go!

[@davidb3070]

Great video im learning great habits and life style changes so many thanks

[@cynthiaburman1776]

Thanks for the great info

[@ryanlynch3579]

I'm trying to go 30 days water fasting right now. I believe it has saved my life. Have seen 18 doctors in the last year(ill skip the part where all of my problems started after one dose of pfizer, too long a story). Im 42 and was active, not overweight and ate fairly well.. Although the doctors have found numerous serious issues none can find the cause. I went from non functioning and incapacitated with back pain, liver and intestinal inflammation due to elevated enzymes, bacterial or viral infection, body was making antibodies to 5 different viruses none of which I was showing any symptoms, elevated heart rate,, high blood pressure, elevated troponin, and the list goes on. Im now 18 days into this fast(against the recommendation of my primary doctor) and every single marker I have has improved so significantly it borders on miraculous. I wish I understood what is going on but with no education in biology I will prob never know. But whatever is happening is nothing short of a miracle and im shocked (well not really) the medical industry isn't aware of this process and the benefits associated with it. Although maybe they do and that's why people don't know.

[@lawdogwales5921]

Keep your tight junctions tight brother!

[@kelseydimattei6662]

Good read ... So much info it could take hours upon hours explaining in great detail on this topic and what is involved in intermittent fasting. I’m on the edge of my seat throughout the whole video wanting more! I’m on this roller coaster of fasting b too much cheating in between really negates what I’m trying and needing to achieve to obtain my fullest optimal health at the ripe ole age of fitty five!

[@juneweeks3539]

Thanks. Good information on benefits to digestion of fasting.

[@Santos-ek8md]

Great video Mike 😊👍 I tried that 6 meal a day crap & couldn't stick to it. Fasting & Feasting seems the way for me. I just feel better overall. Instead of stuffed. If I miss a meal time due to work or other. I just skip it & pick up from my next eating time 😁💪🎉

[@thegram9207]

Thank you, Mike . You the man. And so much more calm and collected . Easier for us non English speaking to understand .

[@flyingdutchmasta]

This has inspired me to do a 48hr fast thanks mike.

[@andyx8440]

Very interesting, thank you.

[@hellacooook]

doing god’s work brah, thank you very much! I recently finished a 48 hour dry fast where the only water contact i had was either showering or hand washing and let me tell you, in all my years of water and dry fasting, over 10 years, this particular hard dry fast provided more autophagy than the time i did a 7 day soft dry fast. definitely worth trying! the nose breathing for sure improved my life to the fullest happiness. one more note about dry fasting, be sure to have salt to avoid hyponatremia

[@jameshouse2588]

bruh ya lucky ya didnt have a stroke

[@hellacooook]

@@jameshouse2588 why would i have a stroke?

[@epicchannel4724]

VHFILM just did a great video on life extension in mice achieved just by eating during active stage of day and fasting the rest. Another great video and very in tune with current information on the virus.

[@garyteters7273]

Thanks HIH

[@laurawhy8813]

Great information I really loved it! Can you give links or help me find the Information about the milkshakes please?

[@mikefortney7879]

I like the way you talked about over consuming energy. In other words not just over eating, putting too much energy producing food into your gut. I have lost over 100lbs thru simply controlling my fasting/ eating window.

[@dort5436]

Thank you for covering this issue! I'm a senior concerned about losing leg strength. I do a walk/run one to two times daily. Also do squats on Vibrating plate and 30 lbs weight. How about covering exercising for seniors using home items. I don't want to go to a gym.

[@marynguyen6417]

Thanks Mike! I recently heard from Stephanie ( you once had her on your channel) and she's against fasting...From what she said, and comments from her subscribers, I feel confused about benefits vs downsides of fasting!

[@Katsem]

Great information, as usual. I think Dr. Mindy Pelz would be a great guest for you to invite on. Fasting for healing is her expertise. Haven’t seen a guest for a while.

[@hockeymomavalon2499]

I second this idea!!

[@daliab8493]

Yes, she would be a good guest to invite

[@dannymarinos]

Great video Mike This helps to explain part of my question. There seems to be some new studies and debate around TRF (Intermittent fasting) vs calorie restriction protocols for weight loss and general health. I wanted to know if you can create a video on the pros and cons, nuances of each with regards to weight loss, overall metabolic health, level of autophagy and other parameters, etc Also, what would you think is best.

[@ThadcJarvis]

Motivation for me to make healthier lifestyle choices! Fuck yes Mike, can’t tell you enough how appreciative I am of you!

[@ultralyrics1]

I can't believe info like this is free haha, what a world we live in (thank you Mike hehe)!

[@Highintensityhealth]

Thanks! Yet some people still complain lol

[@theblackneon5396]

I've become so good at purchasing food since I began fasting

[@theodoresignal]

This information is simply invaluable. Well said Sir in laimens terms. Just to think if everyone had this info. Wow 👌

[@paulscott88]

Just started a serious plan a little over two months ago, down about 25 lbs already. One meal for two days in a row, and a day of fasting. Still in the miracle period where I'm still able to gain some muscle while still losing weight, even though I'm just doing simple exercises like pushups/squats/similar (was really unfit). And it's really nice that all my pants now need a belt, and that I've even shrunk out of being able to use an old belt. Still a few months away from being merely overweight looking at height/weight BMI charts. No idea when I should expect weight loss to start to slow down though.

[@paulscott88]

@Whatsapp①⑧⓪⑤⑥②②⑨⑤⑦⑧ A channel impersonation attack is pretty silly.

[@drip369]

That is interesting about what you said earlier in the video about allergies and gut health because I was interested in vitamin A (because of your video speaking about how it also can influence allergies as several years ago I developed seasonal allergies and I really don't like it because my job still has me outside most of the day) so I went and found some vitamin A to supplement with my nutrition protocol that I already feel I get plenty as it is, although I still wanted to supplement increase that to help with the allergies, and when I had noticed that the gel capsule was a soy product, I immediately quit taking them because I was already noticing a small shift in my mood and I try to avoid estrogen as much as possible, and wanted off of the allergy pills as they were storing aluminum in my armpit as if I was using an antiperspirant, yet I did notice that when I went from having one cheat meal a week to one cheat meal a month, I haven't had the need to take my allergy medicine or any concern over being deficient in vitamin A just because of that, and since you brought that up, I kind of want to go down to maybe 6 cheat meals a year and see if that further decreases any symptoms of allergies even further

[@lawdogwales5921]

Get down to three cheat meals per year and you won't have any allergies at all.

[@moniryousefian8782]

Is pizza a cheat meal ? Could you please describe cheat meal ? How we can increase vitamin A in a natural way? Appreciate your help 🙏

[@ShingInAction]

Great explanation about ATG (Autophagy) = "self eating" by fasting. Dr. Eric Berg DC, has thousands of videos about intermittent fasting and Autophagy on his youtube channel also. Same with Dr. Sten Ekberg.

[@jenniferwolf545]

Thank You ..... you are amazing ; great teacher ....... so much knowledge . What about bone density and OMAD ? 🙏 🌸

[@DomFortress]

Bone density is closely associated with lean muscle mass, as in they're called skeletal muscles in another name for a reason. So learn how to properly lift heavy for strength, brace your core for stability, and go beast mode.

[@jenniferwolf545]

@@DomFortress Thank You X

[@Ronshydrohub]

Thank you...🙏

[@Ronshydrohub]

You have a fake w app troll...IV seen him with the same message in other posts...

[@pranjal86able]

Really hard to trust without knowing how confident the scientific community is about all this information. Especially since you are selling a course and have financial incentives that might create some conflicts of interest.

[@tommyfreudenthal8084]

Good video

[@danielleduerr418]

I would love if you could do a video on treating sibo! I have leaky gut from it. About to do my 2nd treatment and naturopath wants me on 2 types of antibiotics. Herbals havent worked. 😞

[@solvitasperambulatorum8624]

Wow, super helpful visualization (“vomit and poop”)!!!

[@karenbrummond8507]

I feel so much better fasting.

[@valentinmuller301]

I have been long time wondering about the effects of coffee consumption during a fast. Whether it disrupts these mechanisms or not. Would be really nice to hear your take on it

[@vivaciousom5347]

Black coffee does not disrupt.

[@souldesire5932]

would cause acid secretion and interrupt cleansing in the body..caffeine causes a pretty big reaction in the body..you want to let the body rest, take a break from processing..only maybe coconut water electrolytes, etc..Coffee is not very good for the gut..

[@Jimbob-zn6bl]

Black is not gonna hurt fast. I drink 4 cups a day fasting & ketones still great

[@souldesire5932]

@@Jimbob-zn6bl forget about ketones though..there are other things far more important..being in ketosis isn't something the human body is supposed to be in so often. It's beneficial for some short term, but it's about other mechanisms..

[@MunsKi]

Dairy coffee sucks

[@motomatta1]

Hi Mike, I would more information on gut health, I am a long time suffer of ibs,sibo,sifo, or candida.

[@shelley_northwest]

Science is great. This was GREAT. 👍

[@noway3372]

I'm up too alternate day fasting never felt better in my life . 36 hr fast. Every other day. Ie Finish dinner Monday 6pm,don't eat again until wensday morning.

[@thomashughes4859]

17:24 - Dr. Salisbury figured this out 160 years ago. Look it up!

[@jutublizard]

Hi Dr HIH

[@bujin5455]

13:20. What do you think of coffee with MCT oil in it? I've noticed, in my own use, that the MCT oil has hugely beneficial anti-inflammatory properties as well as improved mental focus. However, I'm not sure how it relates to autophagy.

[@Highintensityhealth]

Personally this is what I do every AM! But to each their own.

[@jillmartin5734]

Nice to know that as I was wondering about MCT oil every day.

[@miker7808]

I saw a video couple years ago of 2 doctors (husband and wife) where they tested a different drinks to spike insulin or not. Black coffee with mct oil did not change insulin levels at all, as much as I can remember.

[@finagill]

@@miker7808 Probably was Dr. Ken Berry and his wife Nisha.

[@miker7808]

@@finagill No it was Becky something. She has another channel now cause I think he passed away.

[@indral8598]

Pretty succinct lecture, but what do you consider the minimum for autophagy to halt motor generally speaking

[@anyasarebel139]

..Im from Latvia. My feeding fasting window is diet Z7. Astrological diet when there is one abundant time, one survival (fasting) time and two homeostasis times in about 10 day cycle by moon in zodiac signs. I live on this diet more than decade, I am healthy and happy.

[@ejscorp]

I started drinking heavy cream as a way to top off my fat intake. But based on what you said about liquid fat, would it be best if I stopped?

[@Raecrisos]

Can you do one for improved ED and Cirhosis related to fasting

[@Highintensityhealth]

Ok on

[@Raecrisos]

@@Highintensityhealth Appreciate it , Mike!

[@nancymcclymont2858]

Can you say more about what’s in the supplement bundle? It seems like there must be something other than the one you linked separately, or multiples, it’s just hard to know which option to choose without knowing this.

[@kimberleescannell550]

Link to master class?

[@kristinagrausa983]

Where could I find some more information about the negative effects of consuming liquid fat? Does this apply to olive oil, hemp oil and coconut oil also?

[@MrYo12891]

Do you have any videos regarding Neu5Gc in red meat and dairy? Thanks.

[@leeyost9917]

There’s a Dr online saying that omad and fasting for a lifestyle (more than a short period) ruins womens thyroids or metabolisms. I kind of feel it gave me back my life though….

[@treebhouse]

I wouldn't watch the other channel anymore! Fasting is awesome, I'm 67 and been doing it for years and never been healthier!

[@guitargeeknwa]

That Dr doesn't know what they're talking about

[@leeyost9917]

And what if that’s not enough to bring healing to leaky gut? Then what action can we take?

[@aiken510]

Been on OMAD for 1.5 years. I feel great EVERYDAY

[@GTF85]

What time of day do you eat out of interest?

[@janeteddddd]

How yo get all vitamins and nutrients on omad?. I worry about that.

[@gunsnposes.363]

Being in a calorie deficit already activates autophagy, it doesn't matter if you practice intermittent fasting or not

[@leofumano1444]

How long to hit autophagy? I regularly do the 16-8, but feel OMAD is more ideal? What do you think of 20-4?

[@leeyost9917]

Can BCAAs or any amino acids help? I feel so incredible when I take amino acids

[@FirstLast-pp6xz]

What do you consider liquid fat? Melted tallow? Or fat that stays liquid even at room temperature?