How Hyaluronic Acid Reverses Skin Wrinkles

[@DrBradStanfield]

💪 Join Patreon for early access to my videos, the '5-Years Younger' online course, & Discord chat: www.patreon.com/bradstanfieldmd 💊 My full supplement stack: drstanfield.com/my-supplements 📜 donotage.org/product/pure-hyaluronic-acid | Use code BRAD for 10% off

[@FJano12]

Make a vid on grey hair pls !

[@mr.elastomeric1787]

Why does he shake? Is he sitting on a block of ice?

[@tberry79]

Hello Dr. Stanfield. I have just recently found & subscribed to your channel. I really appreciate the way you present research to inform your decisions. All too often, people simply take an “expert’s” opinion on something as gospel. Thank you for trying to be objective

[@freepagan]

Thank you! Do you know how long the skin benefits last after taking the supplements? Do the wrinkles come right back if you stop taking them?

[@vabyg8714]

Can i take hydronic acid, Ca-Akg and Nr at the same time?

[@MB-nk5lr]

The doctor is definitely getting better in the thumbnail game :)

[@Pixel-junkies]

indeed his latest thumbnails have been creative and funny :)

[@andreibaracuda]

I actually feel it's getting click-baity for a serious channel ran by a doctor.

[@tatianaa.3694]

​@@andreibaracuda many doctors here in youtube do that, I don't like it at all 😒

[@pegazeair9916]

Can’t be paid by google and staying non click Betty

[@stevebelzer4758]

Brad - you should look at “one skin “ a disruptive topical skin product developed by 4 women PhD skin researchers The narrowed a library of 2,000 peptides to 2 with lab results of in vitro epithelium forming NEW skin stem cells - AND scavenging zombie cells after 40 days 2x per day Plus highly effective for hydration I’m 69 as we age up with fat loss bone loss muscle loss skin laxity The most effective protocol I have found is VIVACE RF micro-needle with PRP/SELPHYL which is a calcium carbonate that formed a lattice upon which newly formed collagen “hangs “ the RF forces the production of new collagen in the dermis and mesoderm This procedure can be combined with a COOLPEEL laser resulting in skin tightening and elimination of most fine lines , marionette lines and furrows The combined procedure is about $3,500 and recovery down time is only about 3 days

[@carolnewlands8630]

I have been taking them for 10 years..when it was said "they do nothing"..BS I am 71..my skin is at least 20 years younger. That is one ingredient in my must haves!

[@lolerie]

And you're also using KZbin😅😅

[@LunaPaloma77]

Thanks for mentioning it, I'll look into it even though I'm already taking collagen.

[@christineclark2479]

Do you get the brand he speaks of or another one? Thank you for your reply!

[@AmitK]

how much you take, is there any bulk powder form you tried ?

[@sandrag5528]

What brand do you use? :)

[@bestcomment3589]

Dr please do videos on Wormwood and Methylene Blue.

[@krix0043]

methylene blue is wonderful, but better needs to be taken activated by ascorbic acid. wormwood, especially artemisia absinthium that contains thujone is dangerous. after repeated high dose intake I got several epileptic seizures from it, so be careful.

[@BeautyByAnneMarie]

In 2014 I was taking 4 to 6 hyaluronic acid supplement pills a day and I do believe it helped to plump my skin nicely, however I also have Spondylolisthesis in my spine with one vertebrae and after taking the HA for about 3 months I developed a synovial cyst in the joint of the vertebrae that is slipped forward. I am suspect that all the HA supplements I took for my skin had a big hand in the synovial cyst developing. The cyst pushed on my spinal nerves causing severe sciatic pain. I had 5 spinal steroid injections for pain management and they tried to drain the cyst as much as possible to cut down on the pressure on my spinal nerves. I do think HA supplements work but be careful not to over do them like I did (in case it did cause the development of the synovial cyst which I believe is highly likely)

[@Alex-oy6ci]

Thank you for sharing. I hope you're feeling better:) My work friend has something similar with one of his vertebrae and have experimented with a few different strategies. His doctor said daily exercise. Because of his squashed disk, I recommended the nutrients approach to have what the disk needed to try correct itself. He doesn't take any supplements, but I'll mention to him about being cautious with dosages especially with this one, so your information gets passed on well and help others.

[@BeautyByAnneMarie]

@@Alex-oy6ci Thank you

[@abdulbasithkhan5595]

Total How much dose you were taking altogether per day

[@BeautyByAnneMarie]

@@abdulbasithkhan5595 I believe I was taking 500 mg a day

[@descai10]

Why do you assume it caused the cyst? Is there any mechanistic evidence to back up this conclusion?

[@dustyfeller]

Thanks for the molecular wt commentary hypothesizing gastric breakdown of larger to smaller. That was the sticking point on all previous HA videos.

[@hoffmancapote]

Of course all of the studies were industry funded. The only one which was not industry funded was an evaluation of the industry funded research. This does not prove that the studies are wrong just that caution should be taken

[@violetviolet888]

This comment applies to 99 percent of all scientists out of the 100% who exist. Only 1% of scientists are truly independent. Therefore the rest are producing biased studies no matter what anyone thinks. Consumers do not know how to read studies and it only takes one mis-interpretation spoken in simple language to perpetuate inaccurate information that changes consumer behavior.

[@hoffmancapote]

Not so many studies are funded by large companies or organisations

[@jamessorensen1769]

I use a diluted hyaluronic acid serum everyday immediately after showering - I love it, my face shows a lot less wrinkles than before I started. However the real dramatic effect has been on by shins, calves and heels. Every winter they turn dry, cracked and ugly. I've been applying hyaluronic acid serum 2-3 time a week and it's made a huge difference. No cracking and the skin is soft and supple.

[@Soshi701]

Which brand for feet do you like? I'm searching. Thank you!

[@Soshi701]

Thanks so much. I just remember I heard that you can even make your own with HA powder. You add distilled water, I believe. There are some videos on YT here.

[@bgueberdenteich5206]

where do you buy your H-serum ? I buy mine from ISOMERS and it is expensive.

[@violetfem1808]

@@bgueberdenteich5206 I'm on Isomers too !! I finally ended all my other skincare lines & went 100% Isomers. I started her line in 2006 but strayed years ago due to finances. She just sold her large 8oz but I couldn't afford that & the other skincare I needed, I'm going to try supplement form & see how it goes. =)

[@violetfem1808]

@@bgueberdenteich5206 Ya you aren't kidding it's pricey! The shipping off that network is terrible. $6 per product plus then they ship them all in 1 box to me! I wish she'd move over to HSN or something

[@SyedaSamanGulzar]

Pure knowledge without any fluff. Thanks doc!

[@guy.incognito]

Thanks for adressing the high/low molecular weight question more clearly. From previous videos I was under the impression, that you are biased in favor of the "do not age" product.

[@joecam21]

Hi, Dr. Brad could you do a review on 'MSM', Thank you.

[@stevebelzer4758]

MSNBC

[@LTPottenger]

It's also good for the gut, so does not necessarily need to go into the bloodstream to be helpful. The gut and skin cells seems to be able to absorb it themselves.

[@SergiyMichael]

lol

[@Fremmy]

Hyaluronic acid combined with retinol/retinoid while using sun cream with minimum spf 50 every day will do wonders for your skin.

[@SergiyMichael]

lol

[@supernice_auto]

Sunblock causes cancer

[@cosmichealth3907]

Lol...sunscreen

[@lolerie]

​​@@cosmichealth3907photoaging is a very key problem here

[@jacobcuva7231]

Hey Dr Brad! Could you please do one on reversing grey hair? Thank you

[@gamblinguru33]

Reduce stress, catalase, copper, Fo-ti, NMN, photobiomodulation

[@roba.8907]

@@gamblinguru33 Thank you! I’ve read supplementing with NAC and Glycine boosts intracellular levels of Glutathione. You’re obviously very knowledgeable and wondering if you think there’s any potential benefits to taking those as well?

[@Diana-mu9vd]

maybe spermadine nac and ubiquinol

[@eldictator1]

High possibility, glutathione reduces oxidative stress and increases catalase

[@stevebelzer4758]

Black hair dye !

[@franciscachesca]

Great video, love that the info is brought as short content Don't want to watch hours of explanation

[@ruchisistu8918]

I have been supplementing with hyaluronic acid from past one year. Worked great for my skin and joints 👍

[@enalo6261]

Within 30 days my knee stopped making a sound.

[@gooddaymate1171]

What brand and dosage do you have? Is it High Molecular Weight? If not, it can feed cancer cells.

[@kathleen9456]

@@enalo6261 mine still sound like bubble wrap so maybe I’m not taking enough

[@enalo6261]

@@kathleen9456 could also depend on the injury, mine wasn't that severe,I took 600 mg a day.

[@amirhamza7610]

What age?

[@fivestar5897]

glad to be back to the science

[@dekyor9547]

How convenient the same company you use for supplements made a huge donation to your study

[@BeingEmilie]

The owners of that company in the UK are also far right wing politicians. Representatives in their area for UKIP. I stopped buying anything from the company since I found that out. A quick Google will confirm that. The owner and his father.

[@SergiyMichael]

ah that is why!! seemed fishy from the start

[@evelynross6144]

Excellent content

[@MypronounIsKing]

I love your content you’ve gained a subscriber

[@biggrex]

Yeah, but for the first study where they put something on the skin, even if you simply apply common duct tape to a wrinkle overnight, once you take off the tape in the morning, you will have the appearance of removed wrinkles for about an hour. So, if they measured right after they took off the thing, the results are virtually without merit. They were even measuring with it on, so not sure how they can ensure it did not reduce the wrinkles itself.

[@EliasKlemedsson]

I believe that the "thing" they put on acts as a mold. As far as I can assume that is what they scanned and translated into 3d.

[@BobbyIronsights]

Double blind means that the same measurements were taken from both people who took the supplements and people who took sugar pills.

[@amirhamza7610]

in love with this topic

[@AngelaSenn]

I received my HMWHA today from do not age! I am so excited to start using it! Thank you for this video!

[@pandorasbox1658]

Topical hyaluronic acid does have a great temporary effect if applied to moist skin. Rub water on your face, then HA and watch those wrinkles plump out. It will also give your skin a glowing, shiny appearance.

[@stevebelzer4758]

Muriatic Acid or sodium phosphate applied directly to wet skin , is WAY more effective than HA once the flames subside the outcome is amazing

[@nyamoonshadow3259]

Agreed! I do this every morning and I'm always amazed and relieved by the wrinkle-reversing results.

[@anneb5603]

I 'll try this. Thanks

[@Sophos1964]

How “temporary” are the effects using that method?

[@pandorasbox1658]

@@Sophos1964 after you wash I suppose…☺️

[@Codydoggy]

My supplement list is as long as my arm already watching KZbin 😀

[@sandrap4188]

I've also gone done the KZbin Drs. recommended supplements rabbit hole & cant get out. Very expensive without really seeing any improvements. Plus now showing positive blood on my UA results so will now be weaning myself off pills & trying to just eat the right foods.

[@nicholablakely2832]

Me too! I am enjoying the journey though so far ☺️

[@joaosilva-ji1ve]

Good multivatimin Omega 3 Magnesium if multi does not have. Collagen if you do sports or are more than 40/50. Creatine same thing. Good diet. This are the basics. Rest are extra.

[@janiceg7661]

Hi. Interesting. Does this work better than collagen? Thank you.

[@TheYopeydopeY]

What about liposomal HLA? Is there any benefit in taking it in that form? Great video!

[@ninjatoitle]

Very nice thanks for this

[@MatthewSmith-cp3hu]

thank you for listing the source links!

[@gitanjalinandan]

Keep going Dr S. Much appreciated

[@tberry79]

Thanks Doc!

[@hanihani8612]

Great info. Thank you.

[@Life-Inspired-Healing]

Excellent infromation Dr. Brad - clearly another one to explore further.

[@SilverFan21k]

Thanks for this. Interesting info and great video. 🧬

[@odeonhealingfrequencies2743]

FYI some people use microneedling devices with HA serums with excellent results

[@freepagan]

Thank you! Do you know how long the skin benefits continue after taking the supplements? Do the wrinkles come right back if you stop taking them?

[@gsomethingsomething2658]

Also interested, if anyone knows.

[@lolerie]

Well the decrease is not that big it's like 18%

[@makeadifference4all]

I am over 50 and have used La Roche-Posay hyaluronic acid serum on my face for a few months. (I have no connection to the company.) I have been pleased with the results in reducing fine wrinkles under my eyes but noticed no reduction in the deep forehead and "smile" wrinkles.

[@demonfedor3748]

You might try oral supplement and see if it helps more. Whatever brand that is available where you live. Can also add collagen peptides to the mix for extra benefit.

[@justinbischoff]

Thanks for the great info! I was wondering about baldness, do any treatments to prevent hair loss work?

[@cynthiahansen2341]

Watch huberman labs video today..4/10/23

[@roba.8907]

Yes, PRP treatments are very helpful to stop hair loss and promote regrowth. Also, red light laser therapy, topical or low dose oral Minoxidil, and Finasteride (in men). Finasteride has unwanted side effects but the others are very safe and often used in combination.

[@panagenesis2695]

How about Pycnogenol or Pine Bark Extract to promote the body's own production or Hyaluronic Acid, rather then just taking the latter?

[@stevebelzer4758]

wormwood and Elderberry combined with St Johns Wort with the enchantment “elementariouw!! Is highly effective . Griffendor

[@birdlover7776]

Good question

[@greenfield1944]

from a quick search: The organs of most livestock, including beef, lamb, pork, and poultry, contain high levels of hyaluronic acid. While a diet high in organ meats may provide plenty of hyaluronic acids

[@BrickMudge]

So grass-fed beef should probably be the main staple of our diet. The more, the better.

[@mcgeebag1]

Very interesting! I find it hard to find high M weight HA, does it go under any names? Also have you done a video on glycine supplementation?

[@gemnilvr]

Umary

[@johnolaoluwa]

Thank you, Brad, for this episode. It is both a gentle reminder and rebuke that I should remember to take my HA supplements. It is quite encouraging.

[@maxborn7400]

Beware of Hyaluronic Acid's possible side-effects: it seems to exacerbate pancreatic cancer DOI: 10.7554/eLife.62645 I have asked him to explain this issue, but he just deletes the comments without saying anything. This is troubling behaviour from a doctor.

[@johnolaoluwa]

@@maxborn7400 Hmmm, I think that problem resides with the LMW HA, don't you think?

[@johnolaoluwa]

@@maxborn7400 Doesn't make an interesting read.... "Hyaluronic acid -- a polymer or long chain of sugars -- is great at attracting and retaining water. When a lot of it is present, pancreatic tumors become hyperdense, collapsing veins and blood flow. Lyssiotis says these tumors become very hard..... The lab's new work indicates that one way cells do this is by scavenging the hyaluronic acid itself. .... Hyaluronic acid doesn't only affect tumors by creating this density, which does make it difficult to treat," Lyssiotis said. "It is literally a chain of sugars. In retrospect, it makes good sense that the malignant cells are also feeding off hyaluronic acid."

[@Venutian5]

​@maxborn7400 thank you Max ! I was just about order this. You saved me from throwing away my money and from having to deal with this !

[@bgueberdenteich5206]

@@johnolaoluwa I am a little dumb, explain to me what LMW HA stands for? Thank you !

[@SkinCareLuver]

I'm using neocells hyaluronic acid serum

[@donotageteam]

Great video Brad! On the product page that you linked to people will find the TED Talk that our lead researcher, Professor Vera Gorbunova, did on hyaluronic acid and the importance of high molecular weight. Thank you!

[@AngelaSenn]

Yes, that is a great video!

[@robertlken2963]

An honest question: Does HA improve the bodies health, or just how the body looks? Most above 80 years would look younger by fixing/whitening their teeth, but that doesn't mean their healthspan is increased.

[@descai10]

It can reduce joint pain and eye dryness.

[@peterz53]

Another option may be to inhibit the enzyme which breaks down hyaluronic acid, hyaluronidase. If I recall correctly, a chemical in rosemary dose this. But have no clue about amounts needed and whether topical is helpful.

[@cosmichealth3907]

Rosmarinic acid....

[@N3dita]

@@cosmichealth3907I did a search. I can’t find any supplements with this in it. I don’t suppose rosemary extract is the same thing, right? 😅🙏🏼

[@kekoakaawa8879]

Anyone here use the do not age hyaluronic acid supplement daily? Have you seen a difference in your skin since taking it? Also- since it holds water molecules- has it caused you water weight gain/ water weight retention???

[@skinrepairaddict]

This is interesting. I've never looked at the studies. But I always see the difference when using them vs. when I don't.

[@WaVy5477]

Touching base on the cancer subject, recently scientists from the Institute of Cancer Research in London realized/discovered, because hyaluronic acid is a sugar based molecule, fuels cancer especially pancreatic cancer. Specifically talking about what naturally occurs in the body and supplement form. Aside from fueling tumors, It has been found to play a major role of the density of pancreatic cancer tumors and other types of cancer tumors making it harder to deliver cancer drugs to the tumor. Also, when glucose and other forms of sugar isn't available to provide energy, cancer feeds off Uridine-derived sugar from RNA rich foods, especially pancreatic cancer. It has been known for years that cancer feeds off sugar, all forms of sugar. When one form of sugar isn't available, cancer uses the next form for fuel. What took scientists so long to "realize" that? “If it'd been a snake it would have bit them!” Uridine, is found at different levels in meat including organ meat, seafood, fish, legumes, broccoli, spinach, mushrooms, tomatoes, asparagus, soybeans and soy-based products, whole grains, nuts and seeds, dairy products, beer, bakers, nutritional and brewers yeast. As far as hyaluronic acid goes, so far the molecular weight matters. High molecular weight is great for hydration, joint health, anti-inflammatory, anti-cancer, . It's the low and medium molecular weight hyaluronic acid that has great concern. This is a recent breakthrough for all types of cancer especially pancreatic cancer and breast cancer!

[@chip2881]

That sounds to me like nearly every food there? It’s easy to avoid processed sugars but not sure what sort of diet could remove uridine derived sugars, are any of those of much real concern?

[@WaVy5477]

@@chip2881 yes given the new breakthrough research (Uridine a nucleotide sugar fuels glucose-restricted pancreatic cancer) I talked about in the above comment. It's basically the metabolic Achilles' heel in pancreatic cancer. Sugar is sugar.

[@jameslay6505]

Great work, Dr! It would be great if you could mention the efficacy of sodium hyaluronate! You know, for the plant eaters ;-)

[@lachatnoir1127]

Always inferior. Bioavailability being the main problem

[@premyslkouril1794]

Dr. Stanfield, what about liposomal hyaluronic acid ? Recently there have been new products on the market which have liposomal delivery. Does it make sense or is it a waste of money ?

[@msagoo29]

My skin at 42 looks fantastic with Vichy mineral 89 HA serum, Topicals do work, and I notice instant plumping and smoothing, skin looks and feels great.

[@t1mmytiger]

Profhilo has been a game changer

[@slobodanfuletic9465]

Chondroitin and Glucosamine and Hyaluronan are winning combo

[@bgueberdenteich5206]

chondroitin and glucosamine have been proven (clinically not to be effective). Save your money.

[@MatthewSmith-cp3hu]

how was the Hyaluronic Acid taken? i theorize that dissolving it it water is the best i also theorize that dissolving with Collagen and Gelatin will make it better

[@popothebright]

I honestly don't know what Brad is talking about. There are several studies that have shown that HA serum can be absorbed into the deeper layers of the dermis, can increase cellular turnover, and can reduce wrinkles. It also moisturises and it smooths by removing the outer layer of the epidermis. The results are noticeable.

[@lilbaejing7185]

Sources pls?

[@JohnnyTravel68]

Incredible how it changed your hair color as well.

[@poolahpot]

where is this hyaluronic acid derived from??

[@MRSTEEL15]

What is the Regimen for this Product? TY

[@lotfibouhedjeur]

What about HA with microneedling? Will that help it penetrate deep into the skin?

[@stevebelzer4758]

VIVACE RF is the gold standard with PRP platelets replacement using SELPHYL cavalrymen carbonate

[@lotfibouhedjeur]

@@stevebelzer4758 Doesn't RF damage facial fat?

[@Always-xl9db]

RF would only effect fat if you choose deeper setting. 1mm would not even reach it

[@stevebelzer4758]

@@lotfibouhedjeur RF promotes the growth of new collagen doesn’t destroy the fat cells BUT it may melt fillers already in place

[@stevebelzer4758]

@@Always-xl9db correct - for example EMWCUPT NEO specifically targets abdominal fat cells with RF causing fat cell walls to break and be destroyed while not affecting lean muscle tissue

[@invinsiblekent9603]

Can you talk about restoring hair color what supplements to take and what would help

[@gemnilvr]

umary brand is a good choice too

[@MISSIONCAT11]

This is a welcome message because of many unsubstantiated H.Acid messages seen on the internet, other than at this site. Re: reaching deeper layers of skin. Castor oil is reputed to be a general cathartic. When applied to the skin, castor oil is said to penetrate through the skin completely and then drive various detritus toward the nearest lymph duct, effectively cleaning the skin and the subcutaneous layers. If true, could castor oil behave as a carrier and drive H. Acid into subcutaneous layer ? Cleopatra was said to have used castor oil, and they say she was a beautiful Egyptian Queen with many suitors. Edgar claims to have cured many conditions with castor oil between 1900 and 1943, including scleroderma, a lethal skin condition.

[@Always-xl9db]

Just dilute it in dmso oil, which will def carry it through the skin if thats the goal

[@MISSIONCAT11]

@@Always-xl9db Thanks for that input. I stopped using DMSO due to a reported incident in an ER where the entire ER staff was disabled and I think one nurse died. The patient was on DMSO, and when oxygen was administered, a nerve gas was released by the patient's body that poisoned the entire air in the ER (emergency room). Google: "WILL DMSO AND OXYGEN FORM A POISONOUS GAS IN THE ER" (DMSO + oxygen in blood)

[@masher1042]

How about taking more Hyaluronic acid rich foods? Soy foods such as tofu, soy chunks, soy milk and citrus fruits such as oranges, lemons, limes, and grapefruits contain the most hyaluronic acid. Also, tuber vegetables such as potatoes and sweet potatoes, and green leafy vegetables are excellent sources of hyaluronic acid.

[@Furmily]

I agree, get it from food, that way it is safe and absorbed. Not made in some lab goodness knows where, and goodness knows how it is created, chemically changed during the proceses etc. Stick to nature wherever possible to ensure safety.

[@vicz8899]

Wouldn't hurt. But you might have to eat an abundance of those foods to get a meaningful amount, and miss out on other nutrients needed for healthy skin.

[@BrickMudge]

Plant-based foods are toxic, especially ultra processed plant-based foods. Soy is probably the worst plant of them all, right up there with gluten in terms of things that are not fit for human consumption. Instead, eat lots of grass-fed beef and pasture-raised eggs. Problem solved.

[@1947froggy]

I take HA powder mixed in a smoothie daily & HA knee injections, The Knee injections are 100% effective, been getting for several years (OA in the knees & elsewhere). The powder in the smoothie turns to a gel before I drink it. Is it still going to be "digested & absorbed"? Also taking collagen. 76 YO skin looks younger.

[@RynaxAlien]

Choose vegan hyaluronic acid produced by the bacteria. Can solution be used on skin when microneedling?

[@TheZahra110]

How about HA injectable moisturisers and fillers? Are they safe and do they work?

[@marikleinen1189]

At 3:16, the Japanese company name that you pronounced was not correctly spoken. You pronounce it Kew ( like a long Q) and pie part of its pronounciation is say long sound of P. Now, you got the Japanese tounge to say "Kewpie" properly. 😘 By the way, the Kewpie Corporation is well known company for the Japanese mayonnaise. I bumped into some German ladies who were going crazy in buying their mayonnaise in Germany 🇩🇪. I asked them what they like about the product among rest of other mayonnaise production makers out of curiosity. They told me that the Japanese mayonnaise from the Kewpie has more eggs and the flavor wasn't oily in compared to other mayonnaise available at local German supermarkets. In short, people who live outside of Japan can find such mayonnaise definitely at Japanese supermarket try out this , and I am pretty sure that you could find it at Asian stores. Anyway, I better listen to your presentation further on the hyalronan relieves wrinkles... 😎🥳👍❤️ You know that is also good for your eyes, in case you haven't looked into other subject areas of specialists' studies. Thank you doctor! I am going to check out on the hyaluronan details in-depth. We got so much to learn about the unknowns... 😋 But, for scientific research studies, perhaps your ways of pronounciation may be also correct in serving the purposes of encryption and decode of such encrypting method of understanding. I find it simply 😎 cool.

[@robertvondarth1730]

The great skin hack that I use is taking 5 g all in one day to front load Hylaurronic acid . The effects on skin appearance is tr dramatic the next day

[@mitzvot1018]

What brand did you buy? Thank you

[@mimimoon6082]

Great video Dr. Brad! I'm taking the HA from DNA and my nails look great! ❤

[@SergiyMichael]

ye my sneakers shine!

[@mieses]

you meant from DONOTAGE WEBSITE RIGHT??

[@JosePerez-pn3ke]

How can I figure out the molecular weight of a supplement?

[@Rottimail]

It only works in a humid climate. If you live in a sonoran desert (as I do), it will do nothing for your skin because there's no moisture in the air to draw on.

[@C2C.]

That's for the topical form. The oral supplements work internally.

[@lolodee3528]

Topical and ingested give two completely different effects. I see it, as I live in a high humidity climate. Eating it is way more effective.

[@ggoodwin9408]

Brad is actually 50 years old.

[@andreigheorghe3135]

We hope HA will help with anti aging!

[@diannaflutes]

I like it when products allow reviews on their websites. I see no reviews online about the Donotage product. Since it is not a well known brand, I am nervous about trusting it.

[@charliekaiser482]

I get my NMN from DoNotAge and it works fine. 😊

[@diannaflutes]

@@charliekaiser482 It would be nice to see reviews on the HA.

[@delindasmith5993]

Blending Castrol oil and hyaluronic acid together will take the hyaluronic acid deeper into the skin cell.

[@patrickodonnell3270]

Is it effective to get your HA through bone broth protein?

[@zhenfu1101]

What do you think about nuemi

[@sweetestsna1]

Can you talk about vitamin patch and research on those? Iron deficiency generated this curiosity in me. I hate taking pills

[@Vgallo]

The Hylauronic acid that you recommended gave me really bad 😢anxiety. Why would that be?

[@dvdmon]

This is off-topic, but I've been hearing stuff about a supplement called "Shilajit" and I was hoping to get your take on it, perhaps in an upcoming video if you're open to doing some quick research on it, if you haven't already. Thanks!

[@iva11200]

Life extension brand has Ubiquinol+shilajit. Its their most popular product (and overall best on the market imho). Try it… two birds w/ one stone

[@simpleman7203]

Idk, doc it seems like you actually started to have sponsored vid from companies and it is impossible to see how genuine you're, there is a huge conflict of interest. I think you gotta do ads very ethically or you might lose credibility and don't even notice it yourself. I tell it with all kindness and gratitude for your work, don't get me wrong.

[@DrBradStanfield]

Thanks for the comment. I think my track record of stopping NMN, fistein, and quercetin (all sold by DoNotAge) speaks for itself, no?

[@Always-xl9db]

I agree, it would be much better without mentioning any brands at all. People can find out themselves if they need.

[@thankyou5093]

❤Can you do a video on FEMALE Hair loss and regrowth follicles PLEASE 🎉

[@deathandrebirth-y8x]

take biotin

[@thankyou5093]

@@deathandrebirth-y8x have done the research. Not entirely true. Rosemary is best

[@deathandrebirth-y8x]

@@thankyou5093 did it work?

[@thankyou5093]

@@deathandrebirth-y8x Don believe so

[@deathandrebirth-y8x]

@@thankyou5093 did you try biotin?

[@Jemolian]

I wonder how does Tremella compares to the hyaluronic acid

[@FJano12]

Reverse grey hair too?

[@PassionPno]

Grey hair cannot be reversed. A

[@BlackMamba-lt8oe]

@@giannidiolosa8804 what is catalase

[@123ChrisG]

@@BlackMamba-lt8oe catalase is an enzyme which prevents a buildup of hydrogen peroxide in the hair follicles which bleaches hairs grey. This is the same mechanism which causes vitiligo of the skin.

[@FJano12]

@@123ChrisG Never heard of it.. Is it safe and effective? Dr should make a video on it.

[@seekingthemiddleway4048]

@@PassionPno I reversed mine though.

[@Tygerleini]

Hello, I have a question. Do you store a lot of water and cause it to float? I take hyaluronic acid capsules and it seems to me that my legs are fuller and so is my stomach. Very best regards 

[@thomasackley2532]

Doc, 1st, You claim that the 2017 study used both LMWHA and HMWHA appears false. By the definitions, shown later in your presentation, of LMWHA (of less than or equal to 50kDa) and HMWHA (of greater than or equal to 1000 kDa or simply 1Mda) the higher molecular weight HA used in the 2017 study had a value of 300 kDa so is neither LMWHA (below 50 kDa) nor HMWHA (above 1000 kDA) . I'd say ,based upon the 2 definitions that 300kDA is "Medium MWHA". 2nd, your claim that HA was found to be good for osteoarthritis of the knee is, at best, in doubt. The study you cited, appears to be from: "The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain" An 8-week randomized double-blind placebo-controlled trial - Wang, Shyu-Jye MDa,b,∗; Wang, Ya-Hui MDc; Huang, Liang-Chen MD. For which they used a combination of liquid LMWHA with glucosamine and chondroitin. in their discussion they say and I quote, "Yet, it is of importance to note that the oral liquid supplement in our study is a combination of low molecular weight HA with molecular weight between 5 × 104 and 5 × 105 Da, glucosamine, and chondroitin sulfate. As the supplement contains glucosamine and chondroitin which are usually consumed as chondro-protective agents,[25] the potential effects of ingredients other than HA on knee OA symptom relief cannot be denied." I watched the TED talk associated with the HMWHA like you use from Do Not AGE. I believe the Ted Talk presenter may have something to her proposal that the naked mole rats long lifespan may be related to HMWHA and I believe that shar-pei dogs extremely low incidence of cancer might be related to HMWHA (1MDa or above). You seem to be making a point that LMWHA may help against skin wrinkles, I doubt that anyone has a problem buying that. But why do you mention HMWHA at all. And mention arthritis that may just be responding to glucosamine and chondroitin, a commonly used treatment for joint problems? And even if the arthritis thing is, at all, associated with HA, its LMWHA. This presentation is very confusing and misleading and makes me wonder about your association with that "DO NOT AGE" company influencing the quality and even the veracity of your presentations. I will continue to watch your presentations as I do believe I have learned some things from some of your presentations. However, my faith in you credibility has been severely shaken by this (and a few other presentations that I did not comment on). Early on you gave me the impression that you were a highly ethical, if idealistic, intelligent young man interested in the longevity space... however you appear to be getting influenced by the AMA, sponsers and perhaps other interests. I still like you, but I feel obliged to bring this up.

[@Censz]

The video is just an ad for his product.

[@Censz]

Product placement + clickbait thumbnail already red flags

[@mauromendez195]

Please DR, make a video of white hair reversal...

[@august4633]

That’s pretty much impossible unless the greying is due to some severe deficiency. It’s most likely just due to aging which you can’t do much about. At least not after the fact.

[@RotPhalkun]

ACE + HA Takes back 10-20 years younger. Buy bulk mix your own.

[@slobodanfuletic9465]

What is ACE?

[@jerrycapodilupo9195]

❤ If it's absorbed in the Cecum when taken orally....then it can take up to 12 hours to be absorbed...yet it says it can take minutes to an hour (at most)...so what's the answer ???

[@dilbydoe4868]

Any research on exfoliating?

[@hiimjean]

Hi! Are Hyaluronic Acid supplements Keto-friendly? I'm eyeing the NowFoods and Youtheory 100mg Hyaluronic Acid supplements but I'm not sure if they're keto.

[@paulharrisonadventuregearm5457]

I wouldn't worry about 100mg ..it's practically insignificant

[@lolerie]

You need 200

[@adamandsteve13]

what about HA creams? okay, I guess it is the same as with serums

[@EasternRomeOrthodoxy]

Oh yeah? Well Dr Dray said it's great for skin!

[@tatianaa.3694]

​​@@EasternRomeOrthodoxy She actually said it is great for the top layers of the skin and the improvment is temporary meaning while you are using it

[@EasternRomeOrthodoxy]

@Xana Everyone says that she's the reliable one compared to the frauds. She's a dermatologist so she's the Bible on skin, and Dr. Stanfield is the Bible on inside biology. Who says it has to be absorbed the way Dr. Stanfield says it does in order for it to work?

[@EasternRomeOrthodoxy]

@Xana I do both - inside and outside

[@EasternRomeOrthodoxy]

@@tatianaa.3694 Yes, I know, so that's a good enough reason to use it as a night cream as well as the Retinol cream, as I do

[@rotiwokeman]

I'm 31, is it worth taking this yet?

[@cyclist5000]

Is this best taken with food or on an empty stomach?

[@SergiyMichael]

empty head

[@axelris]

apply topical or consume supplement ? which is better is there a difference?

[@pierrejeanes]

Sir what is hyaluronic acid

[@MichaelAmen316]

What about how to naturally fix Ulcerative colitis?

[@fpvsushi8590]

Spending my money on stuff that hopefully extends lifespan + health span is a no brainer for me. Most people, including me, spend money to have fun. But you can't have fun if your health is sh*t or your dead lol. My goal: have as much fun as possible for as long as possible. Therefor it makes total sense to buy stuff like this.

[@thomasmueller2319]

200mg is good, but when i upped it to 400mg per day my skin looks even better now!!!