How I Found My Health “Super Unlock” After 20 Years of Research and 20,000 Genes Tested

Each person has one to six highly unique unlocks that will only work for them, and this is how to find them.
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[@rramonlugo1]

I appreciate the work you are doing. Nevertheless, we have to deal with the reality that the majority of folks in the US have no access to these tests, and subsequent analyses, unless they pay out of pocket, an impossible task for the vast majority of Americans. You're describing doing something that should be normal care, and maybe one day, if we don't blow ourselves up, it will be available to all. And maybe if we change the world we live in for the better, these 1-6 built in deficiencies, won't have the opportunity to express themselves. In the meanwhile, your work is extremely important and I wish you the best.

[@Steve.Orland]

Very well articulated. This is probably what we are all thinking; our passion for health and optimizing nutrition is fulfilled by Chris’ work, intelligence and ambition but it’s compromised by these financial and logistical obstacles. Tough nut to crack

[@Sarahizahhsum]

I keep thinking this. How many thousands of dollars have I spent to get well that could've been easily mainlined if just doctors didn't lie through their teeth 24/7.

[@liio3824]

as you are mentioning his tests, could you give me some hints which atp/mito panels and which whole genome he uses? being a researcher, I am absolutely enthusiastic about his ideas and I think I could do it myself. but it would be best to start with the right inputs. And I wish there would be a forum or reddit group or search, where we could discuss.

[@JennieTurton]

Innovation often launches at a higher price point until someone figures out how to optimize and scale it. That is definitely coming with this via AI. First steps must be taken though.

[@user-yl7kl7sl1g]

Us poor people can use journaling. Add/Remove foods from the diet then record how you feel.

[@EONutrition]

Makes a lot of sense, and you look very well! You might like the book "Genetic Entropy" by John Sanford I wonder whether most of the people who become dependent on mega-dose thiamine (or any other nutrient, for that matter) for normal function simply have mild inborn errors of metabolism, which simply haven't been identified via common genetic panels.

[@chrismasterjohn]

Thanks! Yes I think it is obvious that they do.

[@1truthseeking8]

Just after 11:11 begins the KEY statement to review:

[@tommygallant4512]

You look noticeably healthier. Good stuff.

[@blackbandit1290]

What you are talking about is the 'real' promise of mapping the human genome back in the 1980's, 1990's and what we missed when President Clinton 'released' the genome map in 2020. The promise that everyone could be cured of most, if not all, issues/diseases that lie hidden in their genomes. Great work Chris!

[@lostieaddict]

As someone with epilepsy and who suffers from paralysis, it is good to have access to these videos! THANK YOU.

[@SOULARFLAIR]

🤯 "Synergistic heterozygocity". Well that's a 𝗰𝗼𝗺𝗽𝗹𝗲𝘁𝗲𝗹𝘆 different angle to genetics than I was taught at uni back in the 90's (ie, that being merely a carrier for something had absolutely nil health consequences).

[@rayquaza6791]

Retinoic acid use up your store of riboflavin,pantothenic acid and ATP ,It is therefore not surprising that you have higher needs of them when you eat animal liver, your CYP p450 enzymes that is needed for retinoic acid metabolism and clearance are most certainly inhibited by your coffee consumption and previous exposure to glyphosate and this will make you even more sensitive to the accumulation of retinoic acid. Ni cause the inhibition of fatty acid oxidation makes me think that in reality it is your switch from a (vegan high nickel diet) to a diet lower in Ni but higher in b5 ,b2 and zinc that made the real difference.

[@rayquaza6791]

www.ncbi.nlm.nih.gov/pmc/articles/PMC4497870/

[@jirihutecka9020]

This could be another scenario for sure. It is funny how he thinks that he knows for sure what is going on in his body. It is laughable..

[@Skyandgrace]

Advanced Genomics testing is a game changer - I am seeing amazing results from this

[@RonaldKragnes]

@1:20 1) Eat a nutritious, largely whole-food diet with adequate macronutrients and micronutrients. 2) Maintain a healthy body composition. 3) Live an active lifestyle with healthy movement patterns and ample outdoor time. 4) Get outdoor sunshine in the morning. 5) Avoid artificial light at night. 6) Include exposure to fire. 7) Let bare skin touch the Earth. 8) Experience transitions between hot and cold. 9) Ensure quality sleep. 10) Take manageable bites of life. 11) Foster positive relationships and maintain a positive outlook. 12) Be mindful of avoiding excessive exposure to toxins.

[@BacknRC]

Thank you.

[@simonjeppesen9484]

What a beautiful summary you give in the beginning on what it means to live a healthy life. Make this into a motto or something and play it at the beginning of your videos I would love that! Also you look healthier now than I think I have ever seen before.

[@cameronborg8659]

Thank you so much for your efforts Chris. Really phenomenal insights. Keep up the great work!

[@rigaleb]

Considering this is not conventional medical advice and you are using genetic analysis providers that are not limited to the US, it would be fantastic if you could consult people that are not in the US, too.

[@Sarahizahhsum]

I think mine is lithium orotate and alpha gpc. I found them. 4 years of experimenting. ❤ Also, I knew that these "rare" disorders weren't so rare after all.

[@melissaclark7141]

What specifically resolved, if you don’t mind? I know a bit about each.

[@BabyTreasures]

@@melissaclark7141 she has a KZbin channel with a lot of information.

[@Sarahizahhsum]

@@melissaclark7141 I have a boatload of issues. But we will go off my diagnoses. ADHD, bipolar, schizophrenia, and borderline personality disorder. I have done the genetic testing the Dr talks about and have been working hard to isolate the exact genes that seem to be the cigarette in my wildfire.

[@lostieaddict]

Ahh, I love your channel @nutrigenomicsdecoded!!!

[@SM-lh2rm]

Excellent work - Ben Lynch’s work was a start for me, this is next level. Given the limited research on numerous gene variants including and especially synergistic hetergyz - is substantial non-researched inference required? Example - find a gene or genes with a lot of SNP’s (researched or not) and within the same pathways and hypothesize the interaction. I realize that nerds will scoff at this question given the numerous issues present in it - in the end, is guesswork required to connect the dots between SNP’s?

[@SkedgySky]

You mention taking riboflavin. Regular riboflavin or riboflavin 5 phosphate?

[@mandareendjes]

You're doing awesome work Chris!!! Thank you very much for all this in depth insight

[@carlcisc1706]

Do you do genetic testing. How do you sift through your raw genetic data. Are there reports that tell you what each gene does I.e. what chemical reaction it is involved in. Can you see homo vs heterozygous status.

[@1aliveandwell]

What is that clicking sound (related to you moving)? Maybe you could do a short vid for people not having a great ability to conecntration that hour (or much time to spend) by not repeating , but slimplfying (get to the point). Maybe put a few snps in or not.

[@gardeniainbloom812]

I appreciate you Chris. Have done for many years. Let me know when you've got the skinny on curing neuromyelitis optica and cancer.

[@chrismasterjohn]

Sorry can’t diagnose or treat diseases.

[@bannanaization]

Chris… what path would someone take in college/university to achieve knowledge/wisdom comparable to yours in order to pursue a similar career to yours?

[@alexisnannini2096]

Nutritional sciences/ biochemistry

[@jaimerr8826]

Hi ......i have fast Comt and slow Mao-A according to raw dna analyse. I take 20 mg Parnate. My question..is the Mao gene slow from parnate or is it just my genes. i have depression anxiety and more since i can remember..tnx

[@jorgeroman975]

Have your thyroid labs changed at all since you started the riboflavin? Maybe that Can account for the increased caloric intake while maintaining weight?

[@liio3824]

Who could give me a clue which atp/mitochondrial panel he recommends? And which full genome? judging from this video, these are the basic inputs for this type of analysis. I could already order them while on the waiting list. or, being a researcher, if he does not accept me, I would try hard to do it myself. I absolutely love his idea, but the entire thing takes a huge lot of time, add to that the waiting list, and I really want to start testing now, at least the basics.

[@LindaLugano]

Please please please! I have this same question too: which ATP / mito panel and which whole genome.

[@MichaelMerritt]

I saw some comments in his Substack mentioning nebula 100x WGS. And Dante Labs. But I’ve yet to see which company he suggests since the programs are changing.

[@liio3824]

@@MichaelMerritt Thanks!! and do you know what ATP/mito panel he uses? btw if you are interested, I have done for myself sthg similar as what he did and it boosted my thinking + energy wonderfully. It worked like this: 1. get the best ATP test available here (Europe). result: deficiency. 2. All ordinary vitamin test showed sufficiency. 3. buy a 30x WGS and get the Geneyx tool, which can be used for free if you or a friend of yours has an academic email. It takes weeks to learn but it's not difficult if you have scientific thinking 4. get every advanced test on metabolism e.g. vitamin metabolism 5. result: I was hetero for some genetic varians that are B6 responsive, and my B6 and my folate metabolism showed pecularities in a test by the most advanced lab here: IMD Berlin. 6. an improvements in thinking and energy that I could have never imagined... but now I would like to refine my approach (and resolve my nondiabetic small fiber neuropathy and my dependence on the ketogenic diet / inability to live normally with carbs) using his labs, In particular his ATP and mito panels that I was unable to find out online... of course I would love to get his help, but living in Europe and having issues that prevent me from traveling to the US he will give me the lowest priority in his waiting list... :-(

[@Always-xl9db]

He is using SequincingAI and Mitoswab Plus

[@Feirin332]

I so wish I could work with you but we're outside of the U.S., unfortunately. I just have a feeling that you could help me and my son. I have been suffering from Long Covid since 2020 but in reality I have been sick since before then and have had suboptimal energy my whole life. My 6-year old son has Asperger's and suffers from anxiety, ticks, sensory sensitivities, stomach aches and demand avoidance. Please let me know if there is any way you could help us. We are in South Africa.

[@rainbowsky123]

Sounds a bit like Lyme

[@mercychesed4104]

Amelia it is possible to join Chris’ master pass forum for $20.00 a month where you can get extra information and even community discussion on how to address long COVID. My sons have nonverbal autism and everything I’ve learned through following Chris’ work has not only benefitted me but also relates to my children. Either way it seems that some people who have long COVID really benefit from Zinc and N Acetyl Cysteine supplementation. These are both supplements that help a certain subgroup of people on the autism spectrum. Of course the best thing is if you can identify the rare disease causing genes that you carry. But even if you can’t it’s still worth it to safely experiment with supplements after researching and determining what would seem helpful based on symptoms.

[@T.J]

Yes could be Lyme and coinfecfions or heavy metals or many other things

[@VanillaAttila]

I read something about long COVID being not a real thing. Maybe it's something else especially since you've had issues prior. If you've gotten the jab it's been shown to amplify any underlying issues. Either way gotta find the underlying issues. If Lyme could take one of the Lyme herb protocols for 3 months and see if you notice any improvement

[@rainbowsky123]

Or pandas/pans

[@1truthseeking8]

I am VERY interested in knowing that if someone really benefits for m glycine and NAC, and a half dozen other amino acids along with taking Hydrolyzed Collagen at double serving- is thier issue an app or o.s. issue? Achlorhydria seems to be a MAJOR issue in this case .... Any thoughts? EDIT: among "extensive" & severe food Intolerances is and intolerance to foods containing CITRIC ACID...(not sure if this is because Citric acid is now made from black mold species or if it is indicating an "o.s." level problem?? The reactions are extensive.

[@1truthseeking8]

I have Achlorhydria... what would one be the most impactful course to pursue?

[@Sarahizahhsum]

Not a medical professional. Disclaimer. 1. Zinc 2. B vitamins 3. Salt

[@ExcellentHealth]

So where does one order a whole genome sequencing test? What do you recommend?

[@erikahuxley]

He mentioned Dante's Lab.

[@ExcellentHealth]

@@erikahuxley Do you have experience with them?

[@erikahuxley]

@@ExcellentHealth No sorry.

[@sarahalvarez8058]

If you are no longer taking clients, who is a good person that can help us chronic sufferers? I have a few homozygous gene snps, some heterozygous, can’t tolerate msm, most supplements make my joints ache, TMG I struggle with. Told I’m high copper, not sure that’s true. I am hypothyroid and low B9, fixing B9. Lots of arthritis and inflammation. I need help please!

[@sarahalvarez8058]

I also have chronic muscle tension for almost 12 yrs

[@chrisbusby4395]

I just want Chris to finish his vitamin and mineral book I pre ordered about 3 years ago and gets promised to be finished, seems he’s too busy on everything else to finish it.

[@johan2380]

do you think your program or Tyler Panzner's DNA analysis would be best for me? Brain fog, chronic fatigue, low energy, low muscular strength. exc. I just want to get better

[@chrismasterjohn]

Can’t make health claims. I think everyone should get optimized.

[@johan2380]

@@chrismasterjohn I would like to get optimized with you. How can I move forward and book a consultation?

[@richardgabbrielli3328]

What textbook do you recommend for stuyding inborn errors of metabolism?

[@richardgabbrielli3328]

And how are you analysing your genome? Just looking up individual rs #s?

[@dh1147]

There’s a lot of nutrigenomics platforms out there such as Opus23

[@questingspangle]

Can this approach help with dominant genes or only recessive genes? Eg ADPKD?

[@starofmitra]

I'm curious about this also

[@GerardMenmalle]

hello Chris, I would like to listen to your video with French subtitles, however the subtitles are unavailable, unlike your other videos. Is this normal?

[@T.J]

Ils sont actifs de mon côté. En général KZbin met un certain temps avant d’ajouter des sous titres sur une vidéo qui vient d’être uploadée.

[@GerardMenmalle]

​@@T.Jsuper, merci, ça fait plaisir de voir que Chris est écouté en francophonie 😁

[@T.J]

@@GerardMenmalle Oui, il est vraiment intéressant ! En France pour ma part !

[@melissaclark7141]

Been trying the high dose Riboflavin for severe fatigue for a month, as discussed in another video.

[@r-type4945]

How did it work out for you?

[@juntjoonunya9216]

And?

[@nikolaussoundso]

Does the form matter? riboflavin'5-phosphat is much more expensive than just "riboflavin"

[@melissaclark7141]

It was hard to say the result. I need to be more consistent. I started carnivore, from keto, at the same time. I got a bad flu bug and became inconsistent last month.

[@dooftnuocca7286]

Yeah, figured as much. If you don't already have a WIP to develop an automated system for diagnosing, based on scenario matching genes, perhaps you should. I don't know if Joe's efforts will get to that level of complexity.

[@mganim4]

How do I become your client?. I need help! Help

[@VanillaAttila]

Can you share the following that youve found?? 1. two rare, riboflavin-responsive mutations in the ACAD9 gene 2. an assortment of genetic assaults on the mitochondrial respiratory chain

[@1truthseeking8]

Fascinating... 37:09 Biotinidase deficiency / Biotin recycling deficiency ... Not sure understand this entirely, as my initial thought qould be: "okay, so I need to supplement with MORE Biotin". ...which if I understand the analogy he referred to the biotin is being a problem with "the app" ..so therefore fixing it with More Biotin is fixing it at the correct level/app level since that-is-in-this-situation THE: problem-level.

[@TrojiteQ]

Bro you are an fnig legend. This is like bioahacking 2.0, i allways thoght just do 23 and me and thats it.

[@billb5732]

Holy crap. An hour to say about one paragraph of content. The rest is an advertisement for consulting service. While I don't doubt Dr Masterjohn's ability as a consultant, I didn't before I wasted an hour listening to this.

[@kerrmcclure5787]

What was the one paragraph of content?

[@1truthseeking8]

What was the timestamp?

[@billb5732]

lol. You guys are funny. I was giving credit to the observation that synergistic mutations occur, that they cause mysterious problems, and are not normally looked for. It makes complete sense, and nobody else is talking about it. So that part is interesting. If you want to actually DO something about it, then you have to sign up for the program. I have no doubt that the program is terrific. I just didn't need an hour-long sales pitch to sell me on it.

[@1truthseeking8]

​@@billb5732so you ARE sold on it then? ...as I am wondering if there are "six" ...then could I not simply arrive at which of the six I have;(if any) by supplementing TOWARDS each one at a time and then nothing my physical improvement of symptoms?

[@tohopes]

heh i skipped the vid and read his blog post and the comments here instead.

[@johnc5893]

Cutting down a tree with a microtome. To pretend we are all somewhat flawed somewhere without addressing all of the basic issues is not a prescription for health. The number of pathways, metabolic and otherwise, are so complex not to mention all the different ways of epigenetic modifications. Thinking that a few genes will be the key seems to be hubris... respectfully ... IMHO.

[@chrismasterjohn]

The profound complexity you speak of leads to an average effect of being average which means it drives what everyone shares in common as the path to health. This is not a claim that all of health is about a few genes. It is that most of the idiosyncratic portion of health is.

[@johnc5893]

@@chrismasterjohn Understood. Don't get me wrong; I love pushing things to the next level. I don't know how much I believe in the validity of the genetic component. Have you looked at any of Michael Levin's work? You might enjoy it.

[@johan2380]

Can someone post a TLRL recap on this under this comment please?

[@MichaelMerritt]

Whole genome sequencing could possibly explain health issues that are otherwise ignored or unknown by medical professionals. Most people have at least 1 or more mutation or defects that could cause health issues now or later in life. You can hire him to review your whole genome sequence raw data and help him optimize your wellness and debug your “os”.

[@nikolaussoundso]

Strategene essentially started and advertises this. They built a gen map that includes all enzymes and claim to include all SNPs with scientifically backed evidence to be relevant. Though it should be obvious that they make it too simple, that a lot of individually relevant SNPs simply do not reach significance, because most people can overcome those singular defects. What we need is a much broader, detailed extension of the strategene enzyme maps built with Chris' and others knowledge.

[@zigzag8162]

Do you know approximately how long we'll be on the waitlist before hearing back?

[@andrewzapapvigna-evolveyou1470]

500 👍

[@AlwaysAudacity]

25:37 That's what I always do. 😂

[@LolIGuess123]

Guy spends 60% of video talking about nothing but what the video is potentially almost about to reveal possibly maybe

[@chrismasterjohn]

It’s a free preview.

[@paulpellico3797]

so...do everything they told you to do in kindergarten! but then...there's life. or GOD, as some say. if (either) wants to take you, "pack your bags, they've come to take you home"...as the song states.