How Magic Mushrooms Work in the Brain | The Neuroscience of Psilocybin

**Checkout My Free Neuroplasticity PDF Here: the-psychedelic-scientist.ck.... **
In honour of our wonderful fungal comrades and the fact that 9/20 was this past weekend (9/20 is the magic mushroom version of cannabis' 4/20), here's a video going over all the main brain imaging findings with psilocybin (the active compound in magic mushrooms) over the past decade.
The video should be accessible to all, but if you have zero background in brain networks or the default mode network, I highly recommend watching my video 'fMRI Brain Networks in 10 minutes' prior to this one. Enjoy!
Don't forget to follow me on social media for all the latest updates:
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More info about the host:
Manesh Girn is a Neuroscience PhD student at McGill University and has been lead or co-author on over a dozen scientific publications and book chapters on topics including psychedelics, meditation, daydreaming, and brain networks.
Manesh currently has ongoing collaborations with Robin Carhart-Harris and others at the Imperial College Center for Psychedelic Research and is investigating the brain changes underlying psilocybin, LSD, and DMT.
/ mgirnneuro
www.researchgate.net/profile/...

[@connorbullock1669]

Just got off my first shroom trip and omg if you are able too it’s essential that you try them it changes your whole viewpoint on life in a positive way

[@acoatl8454]

For a few weeks, then you go back to being the same crappy person you were.

[@nunisthathigh4825]

@@acoatl8454 if you don't act upon your awareness and continue the same unenlightened patterns (mass alcohol consumption, media addiction, codependency) that the magic mushrooms were informing you against, then sure.

[@grantmorgan432]

No I agree you need to keep having decent trips at least every a few months at least 3 - 5 dried grams possibly more depending on which shrooms you eating

[@dare_he_is]

@@acoatl8454 It does sound like you fell into your old patterns and habits that the shrooms showed you. Everything takes work and discipline. It’s up to you to make the decision and take control of the mindset you had after your trip. Happiness takes work, remaining optimistic and positive take work.

[@Rob76kim]

Is there a TRUSTED place where you can buy them online?

[@fluxo_musical]

I haven't found anything quite like your channel on youtube, despite the fact that learning more about the correlation between neurology and psychedelics (and probably also -"therapy") seems to me absolutely fundamental for anyone researching on the nature of consciousness. Fantastic work, please, for the sake of us all, keep on doing it.

[@galenballentine3529]

Thank you for these high-quality summaries of the latest psychedelic neuroscience research -- very informative and helpful. I would love it if you also posted a link to the papers or their DOI #s

[@stevenr123456]

I feel very connected, but when it’s gone so is feeling connected

[@tedrajames9725]

subscribed!! this is exactly the field I want to dig deeper into and i’m so glad i found your channel. great explanations and best of luck with your studies!

[@joe_blo45]

i was going to reply the same thing ahaha!

[@djeevan4133]

Great work man. It was interesting to hear about the different points of contention between research facilities. Looking forward to hearning more in the future. Thank you!

[@ThePsychedelicScientist]

cheers brother!

[@peterbuknicz3993]

Great job! Keep up the great work.

[@gurmeharsingh1485]

puts things into perspective.

[@DananWhiddon]

Thank you! I just found your channel and I love your videos!

[@ThePsychedelicScientist]

Thank you for watching!!

[@srijeetm]

Accessible but not superficial should be the tagline for this channel

[@ThePsychedelicScientist]

🙌

[@Zuperduperboi2]

Liked and subscribed. Exactly what I was looking for 🤠

[@ThePsychedelicScientist]

Awesome to hear

[@haileemorrison4704]

Great info. Please slow down though.

[@ironjon2081]

I have been working with the medicines in the way of the old medicine men to try an help myself. Figuring out I’m on the autistic spectrum, along with other mental issues, I am now conducting a study on how the medicines are helpin broth cognitive ability, create new patterns and routines in my life. I am taking an intro to neuroscience offered thru Harvard now, and will be pursuing more knowledge in the molecular biology studies to learn how to understand what the researchers are finding out to make my own medicines. Thank you for your information!

[@universoulstrength7343]

Through great video thank you!

[@haichin13]

Thoughts on Manoj Doss + Hopkins group recent findings about Salvia with regards to DMN, REBUS? I think a video about that would be very useful. Hope you managed to get that stain out :)

[@ThePsychedelicScientist]

Haa! Damn, that stain was haunting me... I was hoping nobody would be attentive enough to notice hahaha. Yeah! I saw that. My next video will be a discussion of the DMN and psychedelics, and then after that I'm gonna invite Manoj to chat with me podcast style.

[@NicholasEymann]

Good info thanks 🙏

[@evanarents968]

why does the DMN become less active when it is dense with serotonin 2A receptors and psychedelics are agonists there? awesome videos, thank you!

[@zeynepbuyukkeser9637]

Very informative. Thank you so much for the video!

[@mrs_Mccoy]

I bought some psilocybin from a online store

[@mrs_Mccoy]

From trip_mycologist

[@mrs_Mccoy]

I N I N S T A G R A M

[@zengmeiw8359]

Hello Manesh. Thanks a lot for the video. I really enjoyed it. I’m exploring this amazing area and your video really helps me organize a clearer roadmap from what I read. Would you be interested in an episode about a few proposed models such as entropic brain,REBUS etc. and related interesting concept such as predictive coding ？just thinking it might be good complementary to this episode :)

[@ThePsychedelicScientist]

Thank you Zengmei, really glad you enjoyed the video. Yes I certainly plan on doing videos on each of those in the near future! I'm caught up in a busy stretch in my life right now, but within the next couple months I'll have videos on those topics for sure :)

[@HelloThere-xs8ss]

This makes sense since the frontal cortex is closely related to the ego.

[@granderondeproductions3286]

So... in other words, we're barely just scratching the surface on understanding its full capabilities from the 5ha2a receptor to various parts of the brain that you mentioned.

[@olivierbrunelle672]

Great vid

[@JessiEce1]

Great video, thanks!! I have a question regarding the hippocampus' function. Since the variance increases and the hippocampus becomes more dynamic in the psychedelic state, does it form 'new memories' combining our emotions and feelings due to our set and setting? OR, does it gain deeper and faster access to 'already existing memories' in our unconscious? The reason I asked this is that some people believe that they saw themselves in different bodies, almost like a 'past-life' memory. I try to see the science behind it?

[@ThePsychedelicScientist]

This is a really good question! The short answer is that we don't know. But I can speculate based on past work. The idea prevalent in past research with psychedelics (especially in Robin Carthart-Harris' Entropic Brain Theory) is that the hippocampus is typically being constrained in normal consciousness. Basically the brain only allows limited set of memories/thoughts to emerge (based on how relevant/important they are, etc.). But then when in a psychedelic state, the connections which constrain the hippocampus are reduced and it becomes much more dynamic and entropic, leading to all sorts of memories pouring into consciousness. At the same time, this dynamic and entropic activity could also be combining past memories in a variety of ways as well (hence the crazy, non-sensical imagery that you can experience, which often blends together various things you've previously perceived). So I would say both of the things you suggested are possible. As for 'past life experiences', I feel like a lot of the time these are a result of an imaginative reconstruction where you're combining past experiences and your sense of self into what seems to be a real past experience. But who knows :)

[@xBLACKOUT19]

Nice video!

[@zachdancy5828]

As a guy that has been on opiates (methadone) for 12 years for pain and have worked myself down to 10 mgs from 150mgs to come off, do you believe this treatment would yield positive results? Thank you.

[@SwatiSharma-li8nt]

Great channel! Would love to hear you discuss some of the neurobiological effects of micro-dosing on creativity and cognitive enhancement if you are into it :)

[@ThePsychedelicScientist]

Thanks! Yes, I will definitely do a microdosing vid in the near future

[@TirsaTalks]

yes! id love to hear more about that too :)

[@RaoulDuke3030]

Not that it’s of importance given the context, I feel there has been understated that psilocybin is a prodrug for psilocin. Psilocin is the chemical interacting with the brain, but that’s mainly for stoichiometry people, still understated.

[@marisacabanpons4877]

It could work wonderfully with addictions!

[@johnny_baccarat5150]

I'm curious to why you never mentioned the amygdala. From what I've researched blood flow is slowed going to the amygdala causing less anxiety and depression. Is this true?

[@ThePsychedelicScientist]

Yes, there is some research suggesting that after psilocybin-assisted therapy there is less resting blood flow in the amygdala and this might be (one of many factors) related to depression reductions. But that effect is very likely not due to psilocybin alone - but the whole treatment, which includes extensive supportive psychotherapy. In this video I was focusing on research relating to the experience induced by psilocybin - not the long term effects of psilocybin therapy

[@yass8483]

I would like to know how this diagram was made 5:00

[@Iammarlonbrown]

Hey man my mom had a stroke about 2 years ago and it affected the right side of her Brain... when she tried the magic mushrooms she felt nothing is something being blocked?

[@kenishahammond3935]

How many grams was it?

[@Iammarlonbrown]

Kenisha Hammond about 1.8 ish

[@tnijoo5109]

This is very interesting. I hope someone answers.

[@GodsnameisBobRoss]

❤️

[@bluesquirrel2472]

Do you have any sources on how the psychedelics work?

[@JC-bt4cg]

I'll refer you to this mate online I do purchase from he's relatable..

[@JC-bt4cg]

He's on telegram as,

[@JC-bt4cg]

MyCodree

[@ironhead9507]

Have you ever heard of it not having any effect on someone

[@774game]

Are you dhar mann?

[@Nevermore093]

talk too fast bro... i didn't get anything out of this... try a power point presentation

[@Shroom_Wurld..on...instagram]

He's got the best stuff and ships too 🤞🤞👆👆👆⬆️✅✅