How mitochondrial diseases are inherited

In this video, Professor Rob Lue explains how mitochondrial diseases are inherited and discusses the threshold effect and its implications for mitochondrial disease inheritance.
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Sign-up for the course “Cell Biology: Mitochondria” on edX: www.edx.org/co...
The cell is a powerful case study to help us explore the functional logic of living systems. All organisms, from single-celled algae to complex multicellular organisms like us, are made up of cells. In this course, you will learn the how and why of biology by exploring the function of the molecular components of cells, and how these cellular components are organized in a complex hierarchy.
This course is designed to explore the fundamentals of cell biology. The overarching goal is for learners to understand, from a human-centered perspective, that cells are evolving ensembles of macromolecules that in turn form complex communities in tissues, organs, and multicellular organisms.
We will focus, in particular, on the mitochondrion, the organelle that powers the cell. In this context, we will look at the processes of cell metabolism. Finally, we will examine the F1F0 ATP synthase, the molecular machine that is responsible for the synthesis of most of the ATP that your cells require to do work. To underscore the importance of cell biology to our lives, we will address questions of development and disease and implications of science in society.
By the end of four weeks, we hope learners will have a deep intuition for the functional logic of a cell. Together we will ask how do things work within a cell, why do they work the way they do, and how are we impacted?
Join us as we explore the extraordinary and wonderfully dynamic world of the cell.
What you'll learn:
How the internal structure and organization of a cell provides an understanding of how and why a cell works
The role mitochondria play in the cell and why it is important for a cell to make ATP
How cells metabolize food to provide the molecules necessary for mitochondrial function
How the structure of the F1F0 ATP synthase leads to the production of ATP
What experimental techniques are used to investigate mitochondrial structure and function in the laboratory
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[@HarvardOnline]

Learn more in our free online course, “Cell Biology: Mitochondria”: harvardx.link/pwnt

[@sawayakichizuru6667]

This may sound stupid but the part where I don’t understand is that when primordial germ cells divide into oocytes, how exactly are mitochondria distributed? Why is it that when primordial germ cell has 20 mitochondria, why do oocytes have only 10 mitochondria each? Aren’t they supposed to have also 20 each?

[@colejohnson4941]

@@sawayakichizuru6667 I believe they start with ~10, which divide into ~20.

[@waggieoreilly5714]

Brilliant

[@mr.mustache4743]

Thank you so much for allowing us access to this information. It has always been my dream to study at either MIT or Harvard, and I hope to one day take the micro master's credentials after my bachelor's degree and get into a master's program and then into medicine or law.

[@kc7339]

Recently diagnosed Pimary. Thanks for sharing

[@NeonsStyleHD]

Fascinating series of videos. Watched them all. Not sure if the playlist is in the right order.

[@mr.mustache4743]

I agree, =] learned a lot here.

[@funkystyle7249]

I would love to be in his class. edit: I am late. RIP Dr Lue you were a wonderful teacher.

[@realleftover]

Did he die fr???

[@Leen-ih8ql]

Thank you. Soo much, Could you please give an example of a maternal inheritance and a multifactorial inheritance trait or disease in cats?

[@طيبةيونساحمدحسن]

great dr thank u alot

[@Inthought-hj8vr]

Thank you, sir.

[@noone-ks6fv]

Can you please answer how this disease is related to modification of mandelian inheritance? Please 🙏🥺

[@FullTimePatient37]

But my mum died from cancer in her early 30s how can I know..I have so many diseases 😢😢😢

[@Ari-fg9ue]

this is heteroplasmy right?

[@mhmdhaarismhmdhaaris4352]

Well explain

[@noel5544]

Tnx a lot sir

[@Nurse_Nonso8300]

why does mitochondrial genes inherited only from the mother?

[@daily_motivational.]

only the nucleous of the sperm enter the ovocytes and the nucleous does not have mitochondrias

[@humanoid4338]

Rip :(