Introduction to mitochondrial disease

[@HarvardOnline]

Learn more in our free online course, “Cell Biology: Mitochondria”: harvardx.link/pwnt

[@wtfhowbizarre1946]

Got anything on MELAS syndrome? mtDNA A3243G?

[@margueriteoreilly2168]

I love Cellular Biology Belfast Ireland 🇮🇪 Michondria is key to good health

[@SusanStrong-l7r]

So much of what males are selected for is in the mitochondria

[@gregorysagegreene]

Why is it that a person such as this, who has created and narrated so many informative videos as this one, and as a researcher and public educationalist has done so much to promote interest in this field - an area which could ultimately lead to disease eradication and longevity advancement - had to expire so damn early?! I have been on a personal and amateur exploration of intra-cellular organic micro-machinery over the past year, and Lue's animated videos have a level of sophistication that make learning a complex subject easy without a textbook or even a knowledge of basic chemistry. If you are interested in the question of 'what is life' then I highly recommend anything that he and Harvard have put out. So, hurry up and get on with this progress, all you scientists! I feel we are so short-changed by those of us so brilliant that they have to depart with their star from us so early. Robert Lue was just 56, yet I am only 59. Thankyou, and RIP Professor Lue, for your shine. 💜

[@NeonsStyleHD]

Wow. My mind has been opened even further on this series. Love it. More please!

[@BushCampingTools]

Great video. I once was working on mitochondrial dysfunction focusing on some particular enzymes- came across this vi by chance as i'm teaching my son about the etc and other mitochondrial stuff.

[@GlynWilliams1950]

Great lecture and very interesting.

[@GeorgePickup]

This video is so interesting & informative as I have a friend whose daughter died aged 2 last year. It is very easily explained for the lay person. Thank you so much. 3:10

[@briansmith9439]

All drugs have to be analyzed for the damage to the mitochondria they cause (all drugs are damaging to a greater or lesser extent). When the mitochondrial toxicity is known, this informs the manufacturer what other drugs they can be taken with and which ones are contraindicated. Specific tissues are affected differently by different drugs: mitochondria destruction in nerves causes peripheral neuropathy; in the liver, it will cause elevated cholesterol levels; myopathy in muscle cells; anemia in RBCs. etc.

[@MissBlueEyeliner]

6 minutes of what my neurologist hasn’t told me in 6 years.

[@briseboy]

School is recommended.

[@عزالدين-م5ك]

Sigh! Hope you are in good health 💝💝💝

[@raplopez4258]

Best animation of all Animations, closest to real life.

[@friedchicken1]

3:51 this guy had all A++ in school except for coloring class

[@ohkay7418]

Friend has this. His cuz. Mothers sister son just died of als and ftd. Same age as him 75. Didn't grow up with stand out problems. Low muscle tone poor growth and cognitive problems

[@moonoom764]

Ciprofloxacin messes up mitochondria! and most of the times women are given it for UTIs. This might be a major contributor

[@Asuthoshi]

Thank you so much for your excellent renditions

[@catmom1322]

You're terrific, Dr Lue!

[@margueriteoreilly2168]

Robert lue is a fantastic Professor Belfast Ireland 🇮🇪 😎

[@kimwilliams3026]

I’ve sporadic adult onset not inherited mitochondrial myopathy .....how does that work

[@gloriafulton2000]

wonderful topics and very good explainations,great job ...god bless

[@tadmarshall2739]

The book Power, Sex, Suicide by Nick Lane says that mitochondria basically MUST all match in mtDNA within an individual or disaster ensues. Dr. Lue seems to paint a different picture with his color-coded mitochondria. Am I misunderstanding this?

[@sunithiranya1357]

Is diabetes also caused by inefficient mitochondrias ? Or inefficient glycolysis which will reduce the glucose utilization in the cells which will make the cell resist further intake of glucose inside the cell. As excessive sugar in side the cell is more harmful it is not absorbed from the blood ,there by raising blood glucose level, which is called diabetes

[@teddybearroosevelt1847]

No, type II diabetes is caused by too great of a production of insulin over long periods of time as a result of which cells become resistant to it.

[@Horse237]

Hyperbaric Oxygen Therapy increases mitochondria functioning. People over 50 can almost always benefit from HBOT.

[@vnpoker]

thank you for the lesson

[@wtfhowbizarre1946]

Doesn't the number of Mitochondria per cell vary from 10''s to 1,000's of Mitochondria depending the energy needs of the individual cell? At what homeoplasmy raitio of mutant Mitochondria to normal Mitochondria in vital organ cells do the vital organs die?

[@joeexworkingpoortaxpayer4652]

7

[@stephanberkoff2679]

The incredible design of this system is unfortunately breaking down and researchers are making great progress in how to correct this deterioration. Thank the Lord you scientists are putting in such on going hard work in research!

[@mohammedal-hammadi5085]

Oh thank you really, very good information

[@cintifitz]

high cudos to Rob Lue; very well done.

[@louiseobrien1119]

Every defect he spoke of my son had until he pasked away at 3 yrs old. Had no energy had seizures could not hold his head or arms could not speak or do things ur muscles usually do for u...

[@asand3440]

The same with my grandson. He ppl passed away three weeks ago at age 2 years 9 months.

[@mrniceguy4277]

They do so so much more than just producing ATP :)

[@GmanSach]

What else does mitochondria do that UUU are aware of?

[@mrniceguy4277]

@@GmanSach They are involved in an apoptosis pathway, which is critical for the organism to stay healthy. Or, in the immune system they help to generate reactive oxygen species which helps to kill pathogens :)

[@GmanSach]

@@mrniceguy4277 amazing. This has led to some great reads for me. Thank UUU so much!

[@waikienlim3562]

基因需要吸收细胞散发出的什么体质才能滋养生长得到更加强大的保健功效。。。

[@ALASKAOO7]

complimenti per il video e grazie

[@krishnaarora3587]

6 minutes I doesn't learned this in 6 minutes I was mind-blowing

[@kimwilliams3026]

I thought new research showed you could inherit mitochondrial disease from father as well?

[@rmrz34pink]

Yes, but more research is needed, scishow has a video about it.

[@Distillations21]

did anyone hear about the team that might of found that mutations are made and sperm also contributes mitochondrial dna , if this is true this could change alot about mitochondrial diseases

[@kimwilliams3026]

Mk yes I e seen on tv research stated that although rarer than maternally inherent mutations, paternal is possible

[@beatricenovac9326]

I have now low pregnenolone because mitochondrial damage after cipro

[@cathytilford388]

Wow, that's important info!

[@Johnnyredtail]

Where did these cell get there energy from before the intrusion of the bacterium?

[@aileexquis3206]

Procaryotic cells.

[@beautifulcrazy]

Interesting

[@darkblade1170]

I found a qr code to this video at meow wolf

[@jamesgordon8867]

Millions of years is a narrative

[@sayedelghairb8640]

Glory be to Allah Almighty who gave everything its creation and then guided it. Glory be to Allah 🙏🤲🏻❤️

[@turgidbanana]

😂

[@xportz9781]

🤲🤲

[@bradhilton2283]

WHAT IF WE CREATED AFTERMARKET MITOCHONDRIA VIA SYNTHETIC BIOLOGY AND SOLD THEM AS A PRODUCT ON THE BLACK MARKET FOR MEGA BUCKS?

[@donnagjoka2587]

Hmm of course mother's it's what we are ..but with out father(sperm)who ever it's ..we also do not exist..did you sow your body how it's ?....and did you accept to your body experiment..with out agreement? ..and Howard ..have name but not good science..thx 😊