How to look & feel 15 years younger: David Sinclair, Ph.D. | mbg Podcast

Welcome to the mindbodygreen podcast! Each week, host Jason Wachob, founder and co-CEO of mindbodygreen, engages in open, honest conversations with the people shaping the world of well-being. Today’s featured guest is David Sinclair, Ph.D., a longevity expert and Harvard geneticist.
“I’ve been getting younger for the past decade, and the biggest impact has been the change in my eating habits," he says. In this episode, Sinclair and Wachob discuss our 2022 Wellness Trend of making longevity easier and more accessible, plus:
- How the science of longevity has updated in the past year
- How to make sure your body absorbs resveratrol
- The power of rest for living longer
- How to practice hot-cold therapy at home
- Why avocados are a top longevity food
Enjoy this episode! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [e-mail].
ABOUT mbg:
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[@BarsandNightclubsAU]

I have watched 99% of David sinclair interviews and this is by and far the best...

[@annemccarron2281]

I am in the process of watching any I can. This is a great interview.

[@mag4926]

David Sinclair is a good and conscientious man who cares about the welfare of the people.❤ We should all appreciate that. Something like this cannot be taken for granted. I think we are very privileged to be part of a small group of people who already know and use more about longevity than most other people. That's a great gift!🙂

[@jlvandat69]

I'm not sure what impresses me more about these two gentlemen, the excellent information or the generous spirit from which it was delivered. Many, many thanks.

[@cashmunydray35]

😂😂😂😑👍👍

[@kristinabeck2174]

Another important key to health is to do a protocol to target parasites. They are treated and tested for in most countries. Not in the U.S. I overcame hypothyroidism and fatty liver disease. My bloodwork keeps improving and I got off of alot of prescription medication. Nutrition and exercise combined with the right supplements can do wonders but we also have to eliminate pathogens in our bodies

[@raiderkeno]

I definitely turned back time. Been fasting for maybe 15 years. For those that want to try it took me a while to get used to not eating. I was the type if I didn’t eat within an hour or so after being awake I didn’t feel good. Now I do 1-36 hour, 5-20 hours and 16x8 every week. I am 51 and always get late 30’s when people guess my age. I also work full body twice a week. Serious workouts. I love it mainly because I love a big meal when I eat.

[@dollyvandenbrink5211]

Thanks so much David!

[@cindydeas192]

I'm glad to hear you say that it's never too late to start! Wellness is a lifelong journey!

[@robertkuiper1423]

Very much appreciate your loving energy David. Love to meet you some day to give you a hug!

[@heyyou9839]

25 years ago, I bought my dad a book, call “how to live well beyond 100” by an Australian author. Longevity books have peppered my shelf for over a decade, but David apparently invented every concept.

[@normanbell-br7nf]

you live in Australia hey you ? - I'm in Scotland if it makes any diffo

[@christoffernilsen747]

28:12 Avocado was the 1st, brussels sprout (with a bit of garlic, salt and pepper) was the 3rd, cantaloupe was the 4th and blueberries was the 5th. He also mentions nuts, like cashews and brazil nuts. But what was the 2nd?

[@TheJaymeCannon]

I think he meant to say really good quality olive oil

[@Schutzmassnahmen]

Cehsews are to much lectins

[@christoffernilsen747]

@@Schutzmassnahmen Nothing wrong with lectins.

[@Schutzmassnahmen]

@@christoffernilsen747 look in dr gundry videos i get stomic pain and bloating so hard

[@xtian384]

With all these researches I am sure that in a couple years the world will be filled with absolutely healthy, strong, youthful, immortal mice.

[@beenageo]

Let it be so!!

[@thevcountdown9824]

lol

[@normanbell-br7nf]

orange juice on mice is nice

[@xtian384]

@@normanbell-br7nf piperepettenusa piperepettepan

[@heyyou9839]

😂😂😂😂😂

[@adnanbuyungnasutionpartner7577]

Wow, I hear many beneficial things here, thank youu

[@micron1983]

I am following many KZbinrs that are doing meat or plant-based diets, and I noticed that both groups of people claim that are healthier than before, and both look fit which means they both lost fat, but... those who are doing meat-based diets look younger and healthier than those doing the plant-based diets.

[@timendrizzi2180]

Vegans seem to be militaristic as well!

[@heyyou9839]

Vegan v. carnivorous- it’s about what you REMOVE from the diet: processed carbs, rancid fats, sugars

[@klevykids]

I think it's about fat consumption. " Good " fats promote healthy skin and youthful hormone profile. I think a lot of vegetarians eat too many carbs, and I agree with the comment above

[@mariagargioni3269]

Thankyou for thinking of us that we are not able to affort the this. You are a wonderful human. Love the interview.👍♥️

[@anetteccarlstrom4528]

Great Interview! Thank You!

[@walterbishop3668]

Thanks for the calm interview

[@Bronte866]

“I know it sounds crazy but I’m at Harvard so people take me more seriously.” Sounds good to me, Dave! I’m all over it!

[@saralouise-bo2rm]

David Sinclair is A1 I believe in what his saying have faith

[@mybobalu2]

Thank you David! The difficulty of distributing good nutritional information and practice to the wider population has always bothered me. Making healthy food user and kid friendly can be a major challenge.

[@ZacharyTech7]

I do 7000 - 12000 steps all at once ( in one session), however don't move but maybe 3000 steps the rest of the day at work. I am addicted to walking / jogging due to my high functioning autism, usually do this daily then am sedentary at work on a desk for the rest of the day. I regularly fast 18 - 20 hours a day. I also was born with ToF heart condition repaired at birth. When I was younger I used to think and feel immortal, so now I focus on bio hacking so I can be. Most of my family already lives to age 85+ even with some cancers in the family. I started doing this stuff naturally around age 22. I also only eat clean foods unless I hang out with family, who orders like a couple times a week.

[@valeriehopebennett]

LOVE IT . Thank you.excellent wow finally this has become for all, as A health education BENEFIT, to make A better living on planet earth.. DR DAVID SINCLAIR IS A GREAT HEALTH EDUCATOR THANKS FOR the WONDERFUL SERVICES FOR ALL OF US..i am most grateful

[@aaliyahlee1265]

You cannot wholly reverse aging-it's a normal part of life. However, you may be able to slow it down and help prevent age-related diseases by adopting a healthy lifestyle. That includes habits like eating a healthy diet, wearing sunscreen every day, and exercising. Especially for us women, we tend to look more stressed and weaker as we age. Everything appears to speed up in our perceptions as we get older. Your body needs all the help it can get. So, for me, I take Nicotinamide Mononucleotide (Vitruvin Nutrition 500mg) every morning with a protein drink and some Greek yogurt. It has radically changed everything. All sorts of problems have mostly disappeared. I have lots of energy. My vision is better, aches and pain are almost gone, and my mental clarity is pretty well. At 75, that’s not shabby.

[@RamataKAhn]

No, you can reverse it and it's not a normal part of life.

[@leroybrown9143]

@@RamataKAhn no, you cannot, i think a sharp minded, septuagenarian would know far better than a person who may never even see 70 years. What could you possibly possess that supercedes the wisdom and experience of her years, hopes and wishes. There is no such thing as "anti aging," its a myth everyone desperately wants to be a reality. At best what one can do is be youthful FOR ONE'S AGE. To be a youthful 45, but 45 is 45 and 60 is 60. 60 is not, and never will be, " the new 30." One of the reasons we are self-decieved is because almost all of us engages in behaviors that greatly accelerate aging, drinking, smoking, indiscriminate sex, poor sleeping, contenting over meaningless things, etc. When, if ever, one grows wise enough to moderate those behaviors we then label the effects of that moderation, "age reversal." But it's nonsemse, as all you've done was stop aging faster than your true age and start aging in line with your true age. But you're still your true age no matter what, nd you're a fool if you dont know it. You've reversed nothing. Almost everyone that claims anti aging to be a reality is going gray, has thinning or receding hair, and wrinkles (and almost surely shrinking in stature), why haven't those processes been arrested and gone into reversal or at least remission in those individuals, including the guy featured in this video. Unless he's 70 he does not appear 15 years younger than his age, if that's David Sinclair he isn't yet 55 years old and neither man had the appearance of a peraon in their 30s.

[@thevcountdown9824]

Men age better in your eyes? Wow, reading comments like these in the year 2023, unbeliveable. I know a lot of men who age horribly. This are comments people made 50 years ago. You should not only focus on living longer but also on widening your horizont.

[@severosedillo2890]

​@@thevcountdown9824Remember - men have better bone density and musculature than woman.

[@swarm6697]

Same here I'm not 70s but 50s but it's made a huge difference

[@orioles1971]

I take a tablespoon of of excellent EVOO with my supplements and don’t believe that ends my fast. Thanks for all the great information.

[@lvciddd.]

Thank you lvciddd

[@sherrychaudhry935]

I’ve been listening to you since 2020. Retired and non employees elders need you to provide a list of products, company’s and actual supplements you would take yourself.

[@sherrychaudhry935]

Please tell me how you feel about Ozempic as I’m taking it for last 6 months. Feel amazing and helps me with intermitted fasting .

[@lisengel2498]

As Always Inspiring - fir movement/ exercise I would add dance impro and yoga dance - and I just love whole grain saucer dough rye bread ( 2-3 peace’s per day) - one question what did you say as your second food choice? I heard 1) avocado 2) ? Was it the gluten free, fresh bread??? 3) sprouts pan fried with garlic, a bit of salt & Peber 4) cantaloupe and blueberries, 5 ) variety of nuts cashews, Brazil as snacks 🎵🍀🎶💚🐸🙏

[@ResponseDigitalMedia]

Not to second guess the brilliance of David Sinclair, but if eating a meat based diet brings an abundance of energy, strength and vitality, how is this burning out? Isn’t the best predictor of future health, current health?

[@JolicoeurAbear]

oh and I forgot, whether one is a meat eater or not fasting is highly important

[@JakeRichardsong]

Interesting, I think it's possible that 'sugar is not a treat', and that the treat is probably longevity and health.

[@shirleypeterson6393]

I can not har what the second food that he dips bread in? Can someone help me please. 😮

[@DiAna-im1vv]

Whats the second

[@teganchappell8501]

I just want David Sinclair to come out publicly about this FDA ban on over the counter NMN. If he’s not attached to the ban or the FDA then can he help with the appeals to keep it on the market?

[@lizmallen3461]

How much AKG is he recommending?

[@VeggieSushi]

My Avocado tree and Is going to take care of me 🥲

[@valery4872]

I.F. works! I have lost all the wrinkles on my face in one year. Also great research and results!

[@beenageo]

Happy to hear that. I have just started intermittent fasting

[@arrobax6053]

How much and how long IF?

[@user-dz9mo2lz2k]

nice soft focus lens to hide wrinkles

[@BillEarl]

Meat is inflammatory he says. Have read a million comments on carnivore sites were people are saying it has had just the opposite effect on them. All of the many ex vegans interviewed on those sites talk about the serious inflammation that diet gave them.

[@Schutzmassnahmen]

Clove essential oil is full of phenomenal polyphenols I take it with organic linseed oil and blackseedoil

[@normanbell-br7nf]

good for emergency toothache relief oil of cloves

[@SquatFull]

I would appreciate a response to Dr. Charles Brenner's Article "Sirtuins are not conserved longevity genes" Life Metabolism, Volume 1, Issue 2, October 2022, Pages 122-133.

[@heyyou9839]

He’s pretty brilliant but doesn’t endorse Sinclair’s “scientific method” and this is a red flag for Sinclair

[@jdcl3446]

What was the second food he said? The edits weren't too great

[@eirigh_suas]

I find it easier to eat breakfast and early lunch and not eat til the following day

[@sbrink1]

Why drug versus food or components?

[@luckydogcrypto]

What's he dipping the bread into? You skipped past what he said??

[@TheRomanPilgriminPerson]

What is the 2nd food that David mentions in his top 5 food list?

[@Schutzmassnahmen]

I think Olive

[@heyyou9839]

Olive oil - have it with sourdough

[@heyyou9839]

Pretty sure, there was heaps of research about the benefits of the polyphenols of red wine before, and since DS and I started drinking red wine because of a book called the red wine diet which actually said was Vera troll is not what it’s claimed to be. His resveratrol study has been debunked as artefactual.

[@kennethmarquis6307]

blueberries, avocados, salmon, cantalope and nuts

[@heyyou9839]

Vegan v. carnivorous- it’s about what you REMOVE from the diet: processed carbs, rancid fats, sugars

[@CaptainBlaine]

I’ve personally been doing carnivore for a couple of months now. I honestly believe that this guy hasn’t done a lot of research on meat-based diets. There is a lot of info that contradicts what he said about it. Not to mention I haven’t felt this good in a very long time. Maybe ever. No pharmaceuticals anymore and I’ve dropped a lot of weight and will continue to do so. I have more energy than ever and I actually enjoy working out. Plants are not necessarily your friend. They are often extremely inflammatory and have a lot of chemicals that people can be sensitive to.

[@samanthawright6266]

I agree I felt straight up ill on a vegan diet even with supplementation… I feel healthy and full of energy eating meat again! Night and day.

[@annemccarron2281]

"This guy" has spent the last 30 years doing research on diet & longevity!

[@CaptainBlaine]

@@annemccarron2281 what’s your point? He’s still a guy, and still has blind spots.

[@arrobax6053]

A little bit of méat it s ok !but not a lot ..it s highly inflammatory ..everything is in moderation, a small quantity of meat once a day covers the body's needs

[@klevykids]

Not protecting red meat because it's usually corn- fed, therefore containing inflammatory omega-6, vs grassfed contains anti-inflammatory omega-3. But i cannot believe he said" red meat raises cholesterol ", that was a lie revealed many years ago. 😂

[@goobfilmcast4239]

Feeling 15 years younger.....I could just do with that.

[@heyyou9839]

Serena being the new woman…

[@OverlordGaming101]

anyone wanna be internet hero and make this 35min into fast summary in comments please like what to do for etc for long life.

[@JolicoeurAbear]

the progress in finding effective supplements and perhaps even gene therapies is here but so many are starting way behind with their health. the way people eat and drink. will supplements do much for obese persons with all the health issues associated with that? vegan is better than the "normal" diet but so much nutrition is lost from not getting animal protein and fat and organs and bone broth/marrow. unfortunately it has become too political. removing carbs and grains and increasing animal fat and olive oil fat has turned my health completely around, lost 40 pounds (and keeping it off) all biomarkers and bloodwork are perfect. too bad that meat has been demonized for decades. need studies on health conscious meat eaters who exercise and who don't eat buns and pasta and pie and drink soda, that combination with meat is of course bad. there is a bias toward vegans because they are health conscious.

[@orioles1971]

I don’t think they see the difference between regular raised meats and pastured raised meats. So if you eat meats make sure they are pastured raised.

[@jodyjackson5475]

Vegans are well intentioned but grossly misguided Davids interview with Paul Saladino was an interesting one with regard to that topic

[@carolinelewis952]

I only eat beef, butter, bacon, and eggs- lost 20 pounds since late December. No more IBS, weekly migraines, vertigo, or arthritis pain. I will keep this up forever!

[@iamnature4101]

you can't ship to Quebec, Canada, lol! Get your act together, contact me and I'll be your supplier from here!

[@JakeRichardsong]

8 years from AKG? Just one supplement?

[@xtian384]

Too much filter Dr Sinclair!

[@carolynwilson7736]

The background distracts from the message too

[@kennethmarquis6307]

I got.scarpenia without eating

[@carolinelewis952]

David just said thst a doctor told him to eat less meat. Did he really look at proper research???

[@jesusmerchanreina5069]

he lost me at vegan and low fat

[@lvciddd.]

Sunscreen ages you l lvciddd

[@vickyjohnson6919]

They missed broccoli sprouts.

[@alloneperiod6234]

He looks like he has that Vaseline style that older women who wanted to look younger would have on the screen. He’s definitely not for me, he’s a money maker My take: Dhea (15-25), pregnenolone and a little bit of progesterone. Niacinamide, 30 mg zinc, 3 mg copper. Absolutely no polyunsaturated, have sugar…

[@kennethmarquis6307]

What about normal craping

[@nina549]

I live in italy my sister lives in Spain ,why americans talk so much about Mediterranean diet. 1- they hardly eat vegs. Only what is in season. 2- eat red meat and cured meats almost exclusibly. 3- eat fry potatoes with every thing.-4 drink lots of coffee and cookies or breads for breakfast...never a protein.-5 fry fry fry everything. Please stop recommending these before you travel in europe. Yes they use olive oil i 😵‍💫give you that. And yes, they think that drinking water is an american fad.

[@normanbell-br7nf]

is he vegan or vulcan

[@metalgamedog]

longevity'? cinema filters only🤦🏼‍♂️

[@user-sz5re8qv9t]

Cc

[@whoatethechocolate]

Wonder why Sinclair is eating low fat yogurt and not full fat plain?

[@planetaryPoem9]

Funnily enough, though a brainbox scientist, he doesn't seem to be well informed about the recent findings that there's no connection between heart disease and saturated fat and blood cholesterol. He says that he has a history of blood cholesterol and also uses statins, but if you see the research on statins, they have an incredibly low success rate in terms of cardio vascular health. See Dr Pradip Jamnadas about this.

[@Schutzmassnahmen]

I think the fat in yogurt is not as healthy like in olive oil

[@Top12Boardsport]

Who cares about the outside look. Only thing that matters is how you look inside your body.

[@arrobax6053]

What is Inside the body it s reflecting outside the body and in the Face also

[@Top12Boardsport]

@@arrobax6053 just not true, ask people working with elderly. Body outside can look nice but inside is a mess and the other way around.

[@kunverjihirani276]

He’s finally become vegan! Yay! 🥳

[@zettcompact8586]

Could anyone tell us how does it feel being a 14 year older to feel 15 years younger? 😆

[@normanbell-br7nf]

not even made it to a womb with a view

[@peterwc333]

Why would David Sinclair, an eminent longevity scientist, take the lead from Serena Poon for ANY of his dietary decisions?! Google her name, she's a celebrity chef, low credibility (but very spiritual! ;)) Shocking that David would reduce meat and dairy based upon her suggestion!

[@miracoli16]

It's a fact that dairy and meat aren't healthy, above all if you want to live longer.

[@hermanharper4594]

He knows best what works for him . Based on his on work and education. He just sharing information for it or leave it.

[@waynerichardson1051]

​@@miracoli16 no it's not!! Not at all!!

[@heyyou9839]

He had an affair with her and left his wife for her. Something is off about her - on his IG he practically worships her and looks at her with this weird leering and she is detached. I suspect she reinvigorated his well… That side of his life, which flags away when you’re married with three kids.

[@heyyou9839]

Grey hair has nothing to do with premature aging

[@arrobax6053]

Yes

[@alloneperiod6234]

Bs with the plant based🙄 He’s so shady in saying it’s just a fact. That’s def a red flag. Especially cause we’re all supposed to be eating crickets and bugs. And cow farts make them a global warming threat👿

[@nickhyder9141]

I think David's secret is putting vaseline on his camera lense.

[@tnt01]

lol

[@normanbell-br7nf]

@@tnt01 ky jelly

[@vssrivas1]

Very poor moderator , non impressive n not sharp while asking question.

[@prawdziwaapiterapia]

Sounds like bullshit.

[@davidjordan2011]

You're welcome to think what you want, but Sinclair *does* base his ideas on quantitative, repeatable evidence.

[@annitabaladron4754]

Pedro Blessings to you and your family from Miami Florida. But I'm ashamed that you made this comment about DR. Sinclair. Hi is a Harvart University Professor . You should read his book my 3 daughters 1 son are in F. I. U. University of Miami Florida and they say he is one of the Best. Please before you write a comment think first . Dr.. SINCLAIR is the BEST.

[@marillavanbeuren8572]

your words and attitude perhaps assures your lifespan will not be one that David knows so well. good luck

[@prawdziwaapiterapia]

You never know. :)

[@davidjordan2011]

@@prawdziwaapiterapia Your statement is vague and of uncertain meaning. *What*, exactly does one "never know"? If David Sinclair bases his recommendations on verifiable facts and repeatable scientific experiments, his ideas are more "knowable" than vague deprecation.