A Harvard Geneticist Is Extending Human Lifespan: David Sinclair, PhD | Rich Roll Podcast

Thanks for watching! Read all about David Sinclair, PhD here 👉🏼bit.ly/richroll498A
David Sinclair PhD is a biologist and Professor of Genetics at Harvard Medical School, co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging and author of the New York Times bestseller "Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To".
Picking up where our first podcast left off (RRP #436), this conversation further explores the science behind extending human lifespan.
Enjoy!
✌🏼🌱 - Rich
EPISODE 498 AUDIO PODCAST
Blog & Show Notes: bit.ly/richroll498A
EPISODE 436: DAVID SINCLAIR
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DAVID SINCLAIR, PhD
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LIFESPAN BOOK
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Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist at large. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
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[@elvay6847]

Such a brilliant, humble and well spoken man.

[@belindamayson8670]

Thank you Dr Sinclair,you give me hope in my age and condition.🙏🙏🙏

[@andrewclancy2511]

Maybe you could get David Sinclair on a 4 month rotation? The field is fascinating, and it's moving so fast I can hardly keep up.

[@Danuxsy]

You can't keep up? I'm afraid aging already has you.

[@DS-eu2ww]

Sinclair has been spewing his same exact recipe for years now And hes made no progress on his own regime for years -its the same. Its not accepted by mainstream yet.

[@DS-eu2ww]

@Paul Caruso haha You're right, it's going slower than molasses in January. Not much different in 3 yrs.

[@MNhockeydude35]

@@DS-eu2ww because his research sucks...

[@jonjones8029]

@@MNhockeydude35 Show us yours and we'll compare. As I thought. PhD world respected scientist out of Harvard Vs you two dickheads in a comments section.

[@charlesx1957]

Have been learning to eat right, intermittent fasting, joined Genesis gym to exercise, sauna, 3 minutes of cold shower and biting on a towel so I don't scream out! Lol the cold does get easier after 30 seconds. Lost 40 lb since August, 20 or 30 more pounds to go, total lifestyle change thanks to David Sinclair

[@INsange]

Good luck with implementing the advice and improving your health! I wish you well!

[@scottbucc]

@Zeek Banistor references? I suppose you can have opinion. Sinclair has more than that...

[@MelvilleG]

@Zeek Banistor Yes, I think I can agree with you. It is too early to dash headlong into this new body-abusing routine. Too little research done for such radical self-execution.

[@Grox44]

Congrats man!

[@iamsavest1470]

What is Genesis gym?

[@MelvilleG]

A very rare case when I enjoy both the guest and the host. Appropriate questions, amazing answers, genuinely warm atmosphere, no annoying interruptions. Top notch podcast. Kudos to both Rich and Dave.

[@arsplastiques]

Okay, I have avoided talks about age as a disease precisely because media coverage has always made them sound ridiculous, but I respect Rich Roll and Dr. Huberman, and I saw Sinclair was a guest on both, so I gave a listen, and what a disservice media does to this topic! I'm profoundly appreciative of the podcast platform, the willingness of scientists to get out of their labs and talk about their work in a place where the average citizen can listen, and the availability of immensely useful, helpful, and informative content. This and other talks are incredible.

[@timteller1400]

1:03 Laird Hamilton morning pool workout (not Wim Hof) 6:30 Ray Cronise 8:28 Hormesis - get out of your comfort zone 9:46 Food - Resveratrol polyphenol - dense, colored, "stressed" plants better than white watery vegetables from greenhouse 13:30 organic foods 14:06 Laird Hamilton 15:01 "Exercise - eating less" paradigm shift - PNC 1 - NAD 16:16 NAD & Sirtuins - the penis

[@eem2562]

Pianist?

[@uknown124124]

@@eem2562 lol no penis!

[@rui-9-cs315]

thanks

[@zafrat5727]

Lol! It is the Pianist not Penis. Too funny though😆

[@Michael-gi5th]

Do you or anyone else think that fasting without any fluids will be even more effective than just fasting with fluids? If its all about putting the body in a stressed state, having fluids would give the body a false sense of being full therefore not having as big of an effect as having no fluids

[@mikeross2959]

Dr. Sinclair is always an absolute pleasure to listen to - the science, the experiences and the future.

[@gatesroyale]

Dr sinclair

[@carolscabinas]

Restoring vision? Awesome! The government should be throwing money at this research. Incredible fantastic work.

[@tbobbobs7606]

Governments don't care about human beings. They are essentially A.I.s with no real intelligence. I don't understand why people expect them to do anything positive. You wouldn't put SkyNet in charge of your life and it arguably has a real intelligence. All you need to do is take responsibility for your life and everyone does the same. People however don't like to take responsibility for their lives and *choose* to rely on things like governments and then wonder why they commit so many atrocities.

[@carolscabinas]

@@tbobbobs7606Yes. Unfortunately that is true about governments.

[@SpaceCadet4Jesus]

@Zeek Banistor Get Em Zeek!! By the way, did you know you are brilliant, humble and well spoken?

[@tenminutetokyo2643]

Carol Cullen The govt works for big pharma and big med and their only interest is to keep everyone sick. There is no profit in cures, only in chronic treatment.

[@carolscabinas]

@@tenminutetokyo2643 I know, true and everyone knows that arguement. But I only have one eye decent vision so any medical advancement is a glimmer of hope for me. In the last 100 years medical knowledge and technology has improved enormously and people are treated and have survived many things that they would have died from in the old days.

[@debstayblessed9549]

Dr. Sinclair, a humble genius. His sincerity to use his passion for science to help humanity is so inspiring! I also appreciate him keeping something so complex simple. Translating the science to make it pratical and doable e g. IF, excerise etc. Thank you !

[@IResonateWithU]

I love the diversity on your show Rich! I especially like the topics of ethics and motivation in there, inspiring. Keep us posted on this guy for sure!!!

[@rogerinkeywest]

What an awesome time I had listening to this, it is just like 2 friends talking, so honest and casual. Thanks both of you.

[@conorpaulpurcell3403]

Great work being done here. Ever thankful for the existence of such curious and inspiring people.

[@Kobe29261]

Love where the field is moving, turns out if you eat food grown under poor to moderately stressed conditions, occasionally endure physiological stress such as homelessness in the cold and finally subject yourself to sub-severe states of starvation you are well on your way to longevity. I'll pass this on to my Dad next time he tells me I need to make more money!

[@rogerinkeywest]

lol

[@ronalonzo3976]

Love your podcast and im very glad you had Dr Sinclair on your show...im 59 years old and been a health nut pretty much most of my life, ive been on Dr Sinclair's protocol of nmn, resveratrol, for only three weeks and what a huge difference i see happening in my daily physical abilities im feel incredible and it seems to be getting better every day....cant wait to see how i feel three months and a year from now... Dr David Sinclair is truly a pioneer in reversal of the aging process.....

[@jeanpeters2748]

What brand name of NMN and resveratrol do you take?

[@jennygentz3151]

Thank you so much for this conversation and all the work you put in!

[@katiemcghee9239]

I love to see how these two humans appreciate each other.

[@RobJenkinsDubTechno]

If you listen to your body when it whispers, you won’t have to hear it scream.

[@paulinafunfit4126]

Chillout Meditation Music Well said... 🙏 I’ve noted your quote 📝 Thank you for sharing 👌

[@CornerStaple]

Sometimes my body screams at me to eat junk

[@aniaskitiek4198]

elightement?? *_J^/.o^/.y o^/.f S^/.a^/.t^/.a^/.n o/r/,.g_*

[@tatkonateneryfie]

yeah- tell me who's body asking for less food and more stress? only intelectual and scientific approach - look at animals when they listen to theirs bodies in absence of restrictions

[@igot5onit423]

My body is a slut and I treat it as such.

[@alexanderalza5685]

Amazing episode! Amazing guest! Just finished a Lifespan book, AMAZING! :)

[@morake452]

Wow this podcast is everything. I love it. So informative, and sensible truth. I appreciate this one.

[@CryptoDrew]

Just when I needed a recent video about David Sinclair you got it. Thank you very much!

[@debwest7816]

Every time I listen to David Sinclair, I learn something.

[@laura7visionmission]

Absolutely fascinated by this science and data. Thank you so much.

[@Bajoli86]

The oldest people in the world (okinawa Japan) ate 850 grams of sweet potatoes per day (1949 study). It turns out to contain resveratrol-like compounds also comparable with pterostilbene-like compounds.

[@PatriciaRodriguez-dm7oc]

Thank you Rich this is fantastic!

[@javieroliveras344]

I just got this video. And already a David fan. I hate aging. I just turned 40 and not aging well. So thankful for your work.

[@cabolynn]

I always enjoy listening to David talk. I started my longevity lifestyle when I was 38 and I'm 60 now and plan on going well past 100. If anyone asks me for advice and what I am doing, staying active is so important and spending plenty of time in Nature. I also refuse to work an indoor desk job and work a job that is physically demanding and also allows me to spend plenty of time in the beautiful outdoors, even during the long and cold Michigan winters. Sleep in the cold too, window open during the winter months. I won't touch pharma drugs at all, but do take berberine. The list goes on and it's almost like having another full time job. Great show! One more crucial thing, I avoid PUFA's , staying with the good quality saturated fats.

[@elizabetherwin1315]

Starlight, what job do you do outside?

[@AvsFan32]

Starlight what’s Pufa

[@JezaGaia]

@@AvsFan32 Poly unsaturated Fats, so all fats made out of seeds, best fats are saturated ones so animal ones or coconut, otherwise fruit oils like avocado or olive are acceptable but all the others are very damaging.

[@AvsFan32]

JezaGaia thank you!

[@Docinaplane]

Starlight: Thank you! I've been lucky enough to make several lifestyle choices when I was younger that now are considered good ideas like IF, eating mostly a plant based diet, and being very active.

[@goldfishlover7997]

I'm new at all this, but am learning so much! PhD David Sinclair makes it so easier to help me understand. It's so fascinating!!

[@sox2613]

Hey Rich! Loved this podcast. Intense, inspirational and indeed something that has got me doing a bit more research. I would love to hear more about the research on intermittent fasting with women. I’ve seen a bit of research saying that women should be a bit more cautious. Maybe something you could get into on your next podcast with David Sinclair??? Would love to hear his perspective. Thanks of your endless efforts in making the world a better place, one amazing podcast at a time. Sincerely, Courtney

[@MrRichardolsen19]

Pure inspiration!!! 🙌🏻

[@lisengel2498]

I knew as three years old that I wanted to become an artist but I was born in the end of World War Two from a very young mother and was adopted from my grandmother that raised me and my mother as “ my sister” until I was 12 - then they told me my life story and why they wanted me to have an education - and I chose to study at the university getting a old in psycho physiology but combined it with art in a lit of ways and became an associate professor in bodymind techniques in theory and practices at the university of Copenhagen. When I retired I decided to go 100% into Art as a research into human experience as ways of creating relations with life 🙏for your kind and inspiring and informative conversation 🎶♥️🎵

[@spoudaois4535]

I wonder if mental challenges turn on longevity genes. I learned spanish last year, this year french. Got to keep learning!

[@ghizlanederkaoui1172]

I tried to leran spanish for a whole year I cant say a single word

[@spoudaois4535]

@@ghizlanederkaoui1172 there is a way using a technique called comprehensible input. I used a program called lingQ. Check out lingosteve on you tube

[@Sol-gl3nl]

there was a study showing that people who learn a 2nd language later in life have lower risk of dementia - it was hypothesised it was something to do with 'exercising' the brain, so neuro-degenerative diseases were less likely to happen.

[@RunToTheHills999]

@@Sol-gl3nl indeed, because you create more neuron connections, it's way harder for disseases such as dementia to affect you. So basically learning anything new will help, even if it's learning to fix your car or learning a new language

[@rogerinkeywest]

@@Sol-gl3nl Thanks for that, I will look, thanks again.

[@vegains]

so interesting! Cant wait for part 3 🤓

[@Vrin137]

Fantastic podcast! Thank you!!

[@stainlesssteal]

Thank you David for your hard work...

[@Adventureye]

So, so fascinating!

[@georginab6995]

A great interview. Such interesting information that really makes one think twice about one’s lifestyle.

[@JEKYLLHYDE123]

Such a Shame I did not listen earlier to your podcasts, catching up for lost time now. Thank you.

[@davidbakino617]

That smile in the last few minutes tells it all. That something ground-breaking is about to happen that he can't YET reveal. He was clearly hinting at the idea that he already knows how to keep us eternally young but it's as if he couldn't affirm it flat-out, because of colleagues critics and losing his reputation. Am I the only one to think that ?

[@SpaceCadet4Jesus]

Yes.

[@kathleenlynch1961]

Agree. He knows the science and has been using himself as evidence that his theory is most likely on target. The doubters and critics obviously force him to lay low.

[@rustycovey4607]

1:22:22 When, I got to 6th grade, I was miles behind the starting line. I had to learn what they learned in the 1st grade and do 6th grade work, by 7th grade, I had pretty much caught up and in the 8th grade, the Decision making teach asked us what we wanted to do with our lives and I had heard about architecture. And during 8th grade, I designed a building. It was several stories and it had four wings, the elevators were on the outside of the building at the center between each wing. Lets go back to 5th grade, just like 4th grade the teachers didn't know what to do with me, but, assign me to the next grade, well in 5th grade I saw spelling words, which at this time I didn't even know how to read nor did I know the ABCs, yet, the next day. I was able to write the words down from what I saw in my head. Lets jump to 7th grade, I'm in track and my friend wants to race me, and after a couple of minutes of him doing stretching, we raced and I barely beat him. Now, lets look at what happened in basketball. Within ten seconds coach gives us directions. Not enough time to process what I'm about to do. The kid beside me is the fastest kid in school, he breaks records at track events. Coach blows his whistle and I don't see the kid beside me, because, I've outrun him to get the ball. My point is this. We don't want to get caught up in what we ca do and can't do. We don;t want to process anything. We want to just let it happen. Once, you understand that there is no such thing as failure or success. And you can live in the calm, joyful state. You will begin to use everything that makes us very different fro any other species on this planet.

[@keqinyangmuseum6183]

Excellent information!

[@kasia5237]

great conversation!

[@Sara-lf4fb]

I've changed my eating window to be about 11am - 3pm, and yes, it is hard for the first week or two, but I've been eating this way for almost two years now and I am never hungry at night so it's super easy. It's been life changing as far as my energy level, physical health and overall outlook and attitude. I sleep better, and I eat mostly plant-based. I'm 47, 120 lbs and on zero medications with blood work that looks great. I feel so much younger, better than I did in my twenties! I'll have to read Dr. Sinclair's book to find out about these compounds he speaks of! lol

[@conocimientocritico9270]

Do you eat fruits?

[@Sara-lf4fb]

@@conocimientocritico9270 oh yes, they are packed full of disease and cancer fighting nutrients and fiber so I eat at least two pieces/servings a day, especially berries. I throw in ground flaxseed, chia seed, walnuts or any nut or seed into my berries (and sometimes both into my oatmeal), or I put fruit on my daily greens or blend in my smoothies, or I just eat just the piece of fresh fruit. Super yummy!

[@conocimientocritico9270]

@@Sara-lf4fb, oh yeah, I love fruits too. I had some doubts about it taking into acccount their glicemic index. I eat mangoes despite Its glucemic index because It's delicious, sorry for my bad english, I'm learning It. I have Sinclair's book in digital version. It's a little difficult for me to undestand It, but I'm trying to read It anyways. I can send It to you If you want to. 🙂

[@Sara-lf4fb]

@@conocimientocritico9270 I have it now, thank you! My blood sugar workups all look great eating mostly a whole food plant based diet which includes a lot of fruit. I think the fiber in the fruit is what helps slow down the absorption of the simple sugars found in fruit.

[@conocimientocritico9270]

@@Sara-lf4fb, yes, the fiber plays a huge role reducing the glucemic index in fruits. I will continue eating them. 👍🙂

[@keqinyangmuseum6183]

Excellent points!!

[@tenminutetokyo2643]

That exact flight attendant thing happened to me on a 12 hour transpacific flight and she couldn’t believe I didn’t eat for 12 hours. Also see the book “The Miracle of Fasting” by the late Paul Bragg.

[@sueharrison6718]

Ten Minute Tokyo 2 Me too. They kept asking me if I wanted something. Definitely helped with jet lag.

[@brookstorm9789]

In considering aging, the older we get the more connected to the cosmos , one hopes ,and it's generative energy. We run on light as well as electricity. My Aunt and Uncle, each left a year apart, at 94 years, decided exactly the day they would leave without a medical emergency.Clearly they understood capacities not there earlier in life. Imagine as we get older, getting less dense and more illuminated. .There must be a physiology that combines matter and light. Thank you for the most profound and humanist presentation . Dr. Sinclair, in his humble brilliance gives hope. Best wishes Brook

[@knowens3]

Low glycemic index foods are a win for me, I also agree with eating less meals. Another great cast, thank you!

[@TorbLlorts]

you should change to low fat foods ;) okinawa population still the longest living and they eat high glucemic index foods such as sweet potatoes.

[@knowens3]

@@TorbLlorts Sweet potatos are on the low glycemic index list of foods.

[@TorbLlorts]

@@knowens3 what about carrots.

[@TorbLlorts]

@@knowens3 and all fruits basically..

[@TorbLlorts]

@@knowens3 TLDR: the only glycemic index you have to care about is from processed foods. But fats: care about all oils and animal fat.

[@johnsmith6072]

Excellent presentation

[@Boygayagaya]

The sad thing about getting old is that after accumulating so much knowledge and wisdom all through the years, you die. The next generation will then have to relearn what you have learned. What Dr Sinclair is doing will allow the world to be run by very very wise leaders, who can make the best decisions to make the world a better place to live

[@romanawilson3373]

This was really great! Thank you for this episode. I am excited to hear more!

[@MrYoubet]

two really great people

[@jeanpeters2748]

Yes. Getting out of your comfort zone, feel the cold, get out from under the electric blanket. Watch the movie "My Dinner With Andre"

[@valeriehopebennett]

thank you we certainly need this success longer life is waiting for rhank you both for hope.

[@MG.50]

I encountered "billboard shaming" in 1974 on the BART (Bay Area Rapid Transit) platform while waiting for a train. It was a no smoking area, and I was having a cigarette. The overhead electronic info sign cleared and said, "Hey, you. No smoking on the platform." I looked around and pointed at my chest, and the sign changed to, "Yeah, you." Realizing I must be on camera and in a real time "conversation" with some BART employee, probably security, I extinguished and disposed of my cigarette. Sign changed to "Thanks". Many years later I got a major laugh at Steve Martin in the movie _LA Story_ conversing with a godlike highway info sign.

[@LithaMoonSong]

So amazing, I really appreciate you both. I'm 55 and I work out daily (cuz mood) eat vegan and try to just be happy. I look years younger, I don't take hormone therapy , but I do take resveratrol.. :D

[@LithaMoonSong]

@Matt Cipollonenot twenty lol

[@PssupplementreviewsbyPete]

I have never even CS:GO flick shot as fast as clicking on a new David Sinclair content. I'm like an immortal puppy following this stuff into perpetuity.

[@samsung2699]

Love this guy,

[@user-gl9iz1bp1r]

Mindset - get rid of the old narratives and bring in the new. Thank you, David and Rich, for a new narrative.

[@rustycovey4607]

I wear a bicycle helmet, simply because, I get impulses to do crazy things on my bike rides. Listen to Dr. Daniel Amen's talks on concussions.

[@cronoukie]

Can someone sum up the key points that will help me live longer? - eat stressed plants - switch up exercising which includes not exercising every day - buy synthetics that were created by his team via clinical trials - anything else? anything above need to be correct. let's live long together guys and circulate those positive big thumbs up

[@samantha-kemp-therapy]

Fascinating

[@azmrhaze]

1:30:00 - 1:40:00 This is a good summary in my opinion.

[@lizmarinelli5703]

Thanks for that ref saves time

[@sidmichael1158]

Thanks

[@sethseth9059]

I was expecting to hear "Never gonna give you up" at some time but I see its Rich Roll and not Rick Roll.

[@leleiskindofcool]

We need a video of you doing that workout, Rich!

[@dlbdlb3919]

David, I was told this many years ago … "In the realm of complexity there exist a thread of simplicity"

[@slothsarecool]

super interesting!

[@ingenium7135]

1:01:10 "At eighty he has no aches and pains" And here I am 22 and feel like I am dying :/ I just want to feel good and have no pain :(

[@tenminutetokyo2643]

Ingenium Stop eating the garbage food.

[@aabbb4150]

@@tenminutetokyo2643 fast food should be banned

[@tenminutetokyo2643]

@@aabbb4150 agreed. It’s full of poisonous chemicals and other stuff you don’t want to know about and is the cause of most of America’s health problems today.

[@tenminutetokyo2643]

Eat all raw vegetables for a year and no processed food. No soda either. And exercise. Sweating is also critically important as it clears built up toxins in the body. Also cut all sugars. I mean ALL of it. In a few months you will see a noticeable improvement.

[@aabbb4150]

@@tenminutetokyo2643 yes sir. i have high cholesterol and I'm only 22

[@nicolaybastos]

Great talks, I went back and listened to 436 first. I get so confused, though. Sinclair says essentially the opposite of Dr. Greger, advocating substituting coffee for breakfast in an attempt to skip meals, when Greger says front load your calories and eat a really big breakfast. And then we're not supposed to eat at night, but what about those of us who are night owls and also work evenings? All I know is whole food plant-based eating is for sure the way to go lol.

[@JamieNelson.]

I am a night owle and I skipp breakfast an feel well.

[@nicolaybastos]

@@JamieNelson. me too!

[@goodgravy3047]

Grey hair related to ageing has been mentioned twice. Can you please expound on the cause of hair turning grey?

[@kabbalahscribe]

How can you learn the best amount of NAD that is optimum? Packaging for NAD products say 300 units but I believe I have heard you say it doesn’t have any marked significance unless you take 600-1000 units. Please advise if possible. Thank you!

[@MzelleRI64]

I am not sure which M98 micronized resveratrol brand to buy. Can anyone recommend one they prefer?

[@birage9885]

Early on he talks about a little bit of stress being good, so that is maybe why ozone therapy could be a possible useful anti-aging tool, amongst other things.

[@rustycovey4607]

As I listen, I'm going to be making comments. On the topic of drowning, at age 6 a near drowning, came this close to taking my life. When, my mother got to the pool, she heard someone say to the pool manager, You need to stop, the boys not going to make it. I can only suppose that when he saw my mother. He had to try again. "I have to try one more time" When, I read a newspaper from 1967, it did point out that Stanley did try for a long time to revive me. Four days later, I'm released from the hospital. The near drowning has erased my memory and has reset my mental state back to that of a new born in some ways and an 18 month old in other ways. Let me put it like this. I would spend the next almost 40 years, living 90% of my mental activity living in the present moment. The first 12 ears of my life, I didn't have the kind of specific connections one uses to know that they exist. I lived without the use of a mind, to the point that the word "I" or me simply didn't exist, every second of the day was lived fully in the now. If, I experienced a painful, hurtful situation, or a pleasant, wonderful situation. There was no holding on to it or ever reflecting back on it. And this to a degree stayed with me into my last 30s.

[@mariaarbuzova5149]

This is fascinating! What about now?

[@rdance3]

I'm homozygous for the NAMPT risk allel. Apparently, it occurs in less than 1% of the population. I know that NAMPT, in the NAD salvage pathway, converts nicotinimide to NMN. So does supplementing with NMN fix the potential problem or is there something else to do? I have also been taking resveratrol.

[@hombrealagua]

Hello Rich, I'm thinking... What if you do interviews with this kind of people sticking to Endurance benefits?... for us endurance athletes that follow you. Just to know what we have and what we lack, in terms of longevity, nutrition, strength, health in general. Thanks!

[@bryinthe6197]

I was told my great grandmother would hammer a few copper spikes in the dirt at the base of her orange tree to make the fruit sweeter.

[@walker2837]

Great interview. But how do I not go directly to page 304?

[@DrSiddiqui]

Awesome.

[@ilnezija]

He just has described ordinary rutine of Russian baths when people rolling in snow after hot bath and soak in icy rivers while the temperature is 15-20 degree Celsium (it's very cold for anglo saxons)

[@XX-qi5eu]

And that's why the average Russian lives to 66.

[@youngpower24]

Laird’s coffee creamers are absolutely fantastic. Highly recommend the unsweetened options!

[@realestatesantafenmjudy2116]

Working on a less expensive way to do the age testing? It would be so nice to have NMN at a less expensive price so everyone who wants can use it. Loving Cozumel scuba diving in my retirement, and loving Resveratrol, it’s made me feel wonderful... Wanting more enjoyment time !

[@sidmichael1158]

No time stamp? Can anyone summarize this?

[@scottk1525]

Part of me is really excited about all this research. Another part of me thinks: if all these 'stressors' that allegedly turn on survival genes and extend lifespan really worked as advertised, then wouldn't the golden age of human longevity have been during the caveman/tribal/state of nature eras, during which all of these stressors were present most of the time? I understand that disease, war, violence, and environmental conditions significantly reduced the *average* lifespan of such civilizations, but still, wouldn't there be some evidence of cavemen, or Native Americans (or what have you) typically living to be centenarians in the absence of environmentally caused death? For instance, if hunger and cold exposure actually had profound longevity benefits, wouldn't ancient civilizations living in cold regions have showed the greatest longevity, once corrected for environmental mortality?

[@lucaskazama878]

38:00 oLIVE OIL 42:50 - sinthetized resveratrol vs food resveratrol

[@neilsant1194]

Dr. Sinclair is good scientist as he mentioning or giving credits to those who work for him & help him on his researchs...

[@tamika2656]

I just love you both!😍

[@666theninja]

I always wonder about the rare genetic condition called Progeria that makes kids age fast, and Why there has never been a human with a rare genetic condition that they do not age at all. Seems unfair life has not thrown that in the mix.

[@curtseed11]

@666 for all those who claim entropy/free radicals & UV and DNA mutations is what causes ageing and there is nothing we can do about it I point out Progeria and that it seems to be mostly a pre programmed gene cause of ageing. I agree with how unfair how Progeria can speed up age tremendously but not the opposite. Well is that what we must do then? Try to study Progeria more and see if there is any info on my that is caused? Sinclair can add age to mice. If they can do that perhaps we can take ageing away. I think we have the capacity to redevelop what was once developed in all of us and what will infinitely work on every single one of our offspring. If we study germ cells more then that will get us closer too since those are cells that never age nor die. I dont want to live forever I just want to live on my own terms and less on what other says is the best way to live and die. Unfortunately most of us would rather escape this boring ass captivity already and the fear extending the inevitable especially when it has sucked for so long as it is. I think as long as we remain just as youthful as we all once were then after living decades like that we will change our tune no matter how boring it is.

[@666theninja]

@@curtseed11 Progeria might hold a key in reversing Ageing I think, I am no expert on the Subject, maybe worth looking at.

[@swisstrader]

He keeps saying pianist and I keep thinking he’s saying something else😂 🍆😂

[@nathanwilber3345]

Believe it or not, the correct pronunciation is actually 'pee-nist'.

[@patriot20000]

Honey, grow up.

[@swisstrader]

Patricia Diekroger aw! You are simply no fun!!

[@thekeystone7963]

NYC Entrepreneur get your head out of the gutter..

[@bradsuarez2683]

@@thekeystone7963 Believe it or not you can actually appreciate the amazing scientific discoveries of our time whilst still having a good chuckle at a pronunciation you're not used to.

[@Grox44]

So metformin can effect muscle? Does berberine effect muscle and make it harder to gain and keep muscle?

[@mooinabc1]

Will krill oil work with restvertrol?

[@famzini4424]

I just had an idea as I was listening to this. How about many people after they retire they become teachers? Teach their life wisdom and experience and all kind of subjects?

[@Ayan-bp4dq]

1:41:34 NR vs NMN

[@TheASMRlogs]

Wouldn't signaling the body that food may be scarce shift it into storage mode? Store alll the fats, etc?

[@SCORP1ONF1RE]

@Paul Caruso I feel your pain Paul

[@cwstars]

@Paul Caruso are you the same Paul I used to know as a kid in oakland?

[@thoralder4963]

Funny, no mention concerning the gut microbiome , Which I think would be one of the greatest contributors to lifespan and Health span. Although I think Laird Hamilton seems amazing, it seems to glorify the punishment of a sauna being 260°, I’m pretty sure health benefits could be achieved at more bearable temperatures, I also wonder why people that obviously have the money like Laird or Anthony Robbins, don’t invest in a cryotherapy chamber, where you can get down to -260° in a safe and controlled environment with less shock to your body

[@AvsFan32]

I would love it if they talked about the different types of stress.

[@benzhao6321]

They're saying, all kinds of stress, hungry, cold, heat, workout, will effect the same longevity gene.

[@AvsFan32]

Ben Zhao thanks I realize that about elemental things and workouts. Was thinking more about money job marriage etc.

[@benzhao6321]

@@AvsFan32 yes, money, the more, the, better

[@benzhao6321]

@@AvsFan32 oh, I'm poor too.

[@benzhao6321]

@@AvsFan32 If I have enough money, probably I won't do fasting anymore 😂

[@daposevvg]

Yes, that's right lard has 20 percent less saturated fat than butter; it's also higher in monounsaturated fats, which are good for cardiovascular health. Lard is also rich in oleic acid, the same fatty acid that is in olive oil and praised for its health benefits. ... Necessary for immunity and general health

[@XX-qi5eu]

Lard is 47% mono, and 41% saturated fat, artery clogging saturated fat. Lard will shorten your life. Saying it's 20% less saturated than butter is misguided.

[@chekkov2142]

What is the maximum age achievable by rejuvenating? 30 years old, 20 years old or less?

[@Andrew650913]

How about sunlight and circadian rhythm? Would that help?

[@mariellagutierrez2853]

Yes, this is indeed interesting discovery. My uncle decided to try a NAD Revival Supplement after knowing about this research from Sinclair :)

[@ModernHealthspan]

Hi, does anyone have the link to the paper that Dr. Sinclair mentions at about 37:00 where he says Olive Oil has a compound similar to the endogenous activator? I did a google but could not find it. Thanks!

[@ModernHealthspan]

OK, I found it in an old tweet from Dr. Sinclair. www.cell.com/molecular-cell/fulltext/S1097-2765(19)30894-9

[@GeoffreyDean33]

@@ModernHealthspan I'd sure like to understand what David said about Olive Oil. Did he say it was also an endogenous activator? The link is not even a little helpful to me.

[@ModernHealthspan]

@@GeoffreyDean33 I do not have access to the full paper but looking at the paper and listening to what Dr. Sinclair says: when we fast the body breaks down fats from our fat stores. This process releases Monounsaturated fatty acids (MUFAs) which in turn activate SIRT1. These are the endogenous activators. He says that olive oil has MUFAs and explicitly that oleic acid, which is present in olive oil was shown as an activator of SIRT1 so this mimics the endogenous activator.

[@lee0399]

@@ModernHealthspan layman's terms please

[@ModernHealthspan]

@@lee0399 So note that this is just my understanding: you can get the benefits of resveratrol either from fasting or from taking olive oil as they both activate the same process in the body.

[@feemcdonald4423]

If there are ever trials in Australia I would love to participate