David Sinclair: Living to 120 and beyond | ABC Conversations Podcast

David Sinclair joins Richard Fidler on ABC Conversations
Discover more from ABC Conversations on the ABC listen app
ab.co/ABClisten
David Sinclair OAM is an Australian biologist based at Harvard University who is leading scientific fight against the inevitability of aging.
Dr Sinclair believes aging is a disease, and we can find a cure for it.
In the process, his lab has cured blindness in mice and has created tiny little brains out of human stem cells, which look like “little flesh-coloured peas”.
Further information | ab.co/Conversations
Lifespan is published by HarperCollins
Credits
Richard Fidler, Presenter
Carmel Rooney, Executive Producer
Meggie Morris, Producer
Broadcast 28 Feb 2022
#podcast #conversations
Subscribe ✅ and tap the notification bell 🔔 to be delivered Australian stories every day: ab.co/ABCAus-subscribe
Web: abc.net.au/
Facebook: / abc
Twitter: / abcaustralia
Instagram: / abcaustralia
_________________________________________
This is an official Australian Broadcasting Corporation KZbin channel. Contributions may be removed if they violate ABC's Online Conditions of Use www.abc.net.au/conditions.htm (Section 3).

[@grantjones8690]

82 now; two years I was in pretty good shape but starting to go downhill. Lifelong weight training but low fat, high sugar, alcohol, high carb, constant eating was taking it’s toll. Gradually switched to low carb, hi fat, time restricted eating, supplements. My body is undergoing a healing process, where everything is improving. I think that one is never too old to start significant rejuvenation.

[@LK-pc4sq]

Take a look at NMN and NAD supplements.

[@user-pi2oo2jh5d]

, 2:53

[@malsherbeeny]

You're building a real arc for humanity. Thank you Noah.. I mean David. I love your work, and you've truly become my life coach and mentor since I watched your videos on KZbin 6 months ago. May nature yield and bow to your clever mind.

[@sleepsmartsmashstress740]

You mentione Noah and David what about Moses and Goliath. Let us get the full cast before we make the movie.

[@starbettypink]

this is awesome ❤

[@psychobabbler]

Possibly the greatest Australian of all time

[@LK-pc4sq]

David is American

[@jozette-pierce]

Yikes, guys, he's both. We both get credit, along with his mom and dad.

[@Jessica-kk1cz]

Ugh. I want video. I don’t know why I want video, but I want video. These breakthroughs have been absolutely fascinating. I’ve been tracking Sinclair and similar scientists for 3 years now. Another good channel to watch is Modern Healthspan. Richard brings on all top scientists. Ignore the bransfieild guy - but everyone else has been excellent.

[@nimfabangay7318]

Very interesting....ty❤

[@Elasworld71]

Wow this is so interesting.

[@tomu4725]

Good video. Others like aubrey de grey think we have a 50% chance to extend our lives by 1 additional year each year within 15 years. Once at that point, we should pretty much live indefinitely unless we get hit by a car or something like that.

[@sleepsmartsmashstress740]

But the reality is we are going the other way, life expectancy of Americans keeps shrinking

[@secretname2670]

@@sleepsmartsmashstress740 not my problem they keep eating literal fried trash and drinking lead poisoned water

[@moseshorowitz4345]

Reminds me of an episode of The X Files, where a doctor treated ageing as an opportunistic disease. When Mulder and Scully meet him in the 1990s he looks identical to his pictures from the 1950s.

[@andreasneeb7448]

In the Interview Dr. Sinclair say that there will be a human study for glaukoma in 18 month. Could you please provide a contact to be part of this?

[@Elasworld71]

I wish I could look over your shoulder while you do all tge amazing stuff you do.

[@metaphysicalArtist]

@34:00 what is the present thereapy for Macular degeneration can NMN help stop or reverse the issue

[@rhuyisia8163]

I have nothing against looking young and living like forever! My problem is financial constraints! 😭

[@Robin_P_Patriot]

If you are healthy you don’t have to retire 😂

[@I8l]

@@Robin_P_Patriot if u are poor u probably cant afford the treatments that will allow you to live to 120

[@janemuses3031]

I agree with Dr Sinclair's viewpoint, which is better accepted in Asian countries, that the wisdom that comes from having lived life is to be valued. Ageism, especially in western culture perpetuates the belief that one is "over the hill" past a certain age. Why should age be a factor if one is fit, sound of mind, and can still be a productive member of society? With the diminishing birth rates in developed countries, this outdated mindset puts undue strain on the younger generation to support the older. I think it's a wonderful goal to try to live to 120, regardless of whether you actually achieve that because think about how much more you can achieve in that time. Instead of thinking you need to retire and be "put to pasture", you could be planning to start a totally new career if you choose to do so, go back to school or explore many new avenues of endeavor. This second stage in life, where you are past the responsibility of bringing up children, can be focused on self-development and trodding down the paths less traveled.

[@jdacasin]

I believe it

[@LindsayMach]

I'd be curious Dr. Sinclair's thoughts on earthing / grounding and the potential abilities that may have to health / anti-age the body.

[@David-sq2en]

what is that?

[@BJ-fu4zy]

@@David-sq2enbare feet on earth

[@jlvandat69]

👍👍Excellent interview. Thank you gentlemen. I wonder...... when it comes to speculating how many more years of life a certain generation may have as a result of current and future medical breakthroughs and improved lifestyles, could it be possible we're grossly UNDERESTIMATING those numbers? Said differently, perhaps the developments will progress at a much faster rate than most expect, causing humans who are currently in their 50's to potentially live to be 130+? Asking for a friend.......

[@MissChatterton]

What an amazing and interesting interview gosh I’m going to have to listen to it again so much to take in!

[@tube2211ification]

This interview was back in February how about putting it on KZbin when it’s put on the abc website.

[@SquatFull]

I would appreciate a response to Dr. Charles Brenner's Article "Sirtuins are not conserved longevity genes" Life Metabolism, Volume 1, Issue 2, October 2022, Pages 122-133.

[@sunmoon-84]

A question in regard to fasting or time restricted feeding. We are told for example we need 4700mg of potassium per day, that is just one of many recommendations to keep our body running efficiently. With time restricted feeding how do we make sure we meet those goals? Is it possible that our body doesn't actually run on a 24 hour clock and we don't need this daily? Or does digestion itself dictate our 'daily' nutritional requirements. I'm confused, any comments?

[@Layoorah]

When doing long fast you should be consuming electrolytes. It depends on you and your body how long you can safely go without potassium but if you are going to be doing a fast of 24+ hours or exercising while fasting 18+ hours I highly recommend electrolytes. You can find zero calorie fasting electrolytes online. Be careful choosing, check the labels.

[@defiscanner1927]

You need a half thumb sized piece of ginger, 2 kiwis and 1-2 lemons per day + green tea and black tea + a table spoon of honey. Also a nice salad with beetroot. That will keep you healthy

[@marynayna6327]

Get onto KZbin and start educating yourself on all the info on nutrition and fasting,I’ve been on a ketogenic lifestyle of eating now for over a year have lost 40 Kgs at 72 feel better than I have for decades,I also only eat once a day at lunch time,have lost my carb addiction and best of all feel happy. I recommend listening to Australian Dr Paul Mason, Sten Ekberg, Dr Becky Gillaspy, Dr Ken Barry.

[@carolinelewis952]

I use Lugals potassium drops and electrolyte drops.

[@tedwalford7615]

Regarding time-restricted eating, I'd think that dinner would be the meal to skip, not breakfast!

[@mirandapillsbury7885]

it's exiting but it is also sad because I do believe this will happen but every born before the 2000s will probably not live long enough to enjoy these breakthroughs. I'm a 1995 kid...I'm probably going to miss it by a hair....oh well

[@drblaneyphysics]

How can you retrieve lost information? Did I miss where the original info was saved? e.g...Which cell has the info and in what form. thank you [anyone] if you know.

[@BlackMamba-lt8oe]

No cell

[@deanmindock3680]

He did say that there is a copy that contains all the original information but I didn't catch its name/location. He said that that copy was a "big deal". AFAIK, it must stored within a cell, likely in the nuclease.

[@I8l]

u could take a blood sample and freeze it just incase you want younger dna available if it ever matters. maybe it will maybe it wont

[@alex_rogan]

Take a look into what hes trying to do with NMN and his proprietary blend and how he’s attempting to control the supply now that it’s been banned.

[@monag.769]

Nobody tries to control anything here

[@sandybayes]

I just bought some. Not banned.

[@GOBEF3]

Once Sinclair hits 100 we be delighted to consider his thoughts on his next 20 ... not a minute before.

[@enkibumbu]

Cosmic irony would never allow it.

[@sleepsmartsmashstress740]

A more accurate manner of stating what is being referred to as slowing the aging or putting the foot on the brake paddle is to take the foot of the accelerator. All that is needed is to stop the pro-death habits of gluttony, being sedentary, partying, smoking, binge drinking, street drugs the list is long and known to all of us but who is stopping.

[@jeremywvarietyofviewpoints3104]

It's interesting how he eats less but his body adapts to not feel hungry.

[@Journeyman-Fixit]

I started using IF in 2019, I feel so much better doing it I can't ever go back to the old three meals a day again.

[@zegikniet9999]

what aboud taking nmn?

[@burnoutminion]

The thought of living to 80 makes me feel instantly depressed

[@yodidabhutia7935]

👍

[@gloriagolemboski4515]

What’s your opinion with Strotium and calcium.

[@jdacasin]

Im only on Dr sinclair style just 3 years ago

[@darshuetube]

What do you think about the work of Dr Michael Levin? Bioelectric?

[@jdacasin]

I am 59 years old now

[@olivergeoffreyblakely7623]

If you listen to other experts.. on the subject, they have said NAD or NMN the supplement is nowhere close to progressive exercise, primarily V02 Max.

[@Dan-uf2vh]

I was falling into lethargy a year ago even with over a decade of exercise. NMN turned that around bigtime. It depends on what is going on with the metabolism and how much each person needs to boost NAD+ chain. I suppose mine was very poor.

[@neerajmehta4993]

@@Dan-uf2vh do you recommend this to a person with less than normal health but no major health issues. In other words, a person either 6.7 A1C or 150/80 BP etc.

[@squamish4244]

I did NAD intravenously (they really need to study this method of delivery, because it is much more bioavailable than as a supplement) for addiction problems, and it had a huge effect on my joint and muscle pain and, for the next few weeks, my stamina and flexibility. Really remarkable. And I noticed this change at age 40, so for someone older whose natural levels are much lower than mine...

[@squamish4244]

@@neerajmehta4993 Yes. See my comment.

[@lisagothier7477]

@@Dan-uf2vh what nmn do you take?

[@nmambuehnawe3324]

Living to 120yrs is normal. Can the scientists increase longitivity to 300yrs??

[@jimsmart6940]

If they can get you to 120, technology will be such that you can probably get to 300 or whatever age you want

[@megabaneen8057]

I want 🍬 candy

[@enkibumbu]

Yes, but it costs 2 billion dollars.

[@enkibumbu]

Guy's an investor and director in the companies who make the supplements he recommends.

[@sandybayes]

Not when he begin taking the regime.

[@greywolf850]

Show me the 120 guy that followed this protocol… meanwhile we had a 114 year old AZ man who loved that long just eating biblical foods like honey, cinnamon, real fruit and vegetables, olive oil, garlic … research already exists on how live into your 100s

[@monag.769]

So with Davids discoveries we will live much longer😊

[@secretname2670]

But david also advises on eating normal, vegetarian leaning diet with fish and some olive oil , honey and exercise. Bible is right about a lot of things for some reason. I don't know why or how but a lot of christian basis for life has impressively good results. Don't overeat, don't be gluttonous, don't feel anger or hatred, try to be compassionate, work fairly but don't burn yourself out for no reason are all great life advice.

[@dapawap]

I will make it to 120 & have 120 years of problems!…..😢😅😊

[@ranghashalatr142]

Some people say live life forever you say live 120 what about on news

[@tarannumrahman5522]

How to stay young like 20 years old body for as long as we live

[@phillebedev4300]

The universe is the mind and we are all one and spiritually immortal. To be biologically immortal being perpetually healthy and youthful should be the easiest thing to do. Just know that it is possible.

[@squamish4244]

If we realize #1, we don't need #2. Although living long enough to guarantee that your spiritual practices pay off to realize #1 would be nice :)

[@sleepsmartsmashstress740]

Were longevity to become a public reality then global poverty would revert the trend and people would begin to die sooner from homelessness starvation lack of healthcare etc., so the dream of longevity is only for the superwealthy and those with a doctorate etc. and mostly a fantasy.

[@heyyou9839]

He’s got his strengths but take him with a grain of salt - see his resveratrol controversy

[@iguanaamphibioustruck7352]

There is no place in our society for over 80. What do we do with another 40 years. Iguana (87)

[@erikacsizmadia2863]

What do you WANT to do?

[@groia2104]

Good point though…

[@deanmindock3680]

You have to motivate yourself. Do the things that interest you and make you feel happy and content.

[@asmrclipps]

Immortal humans have walked the earth for centuries. Didn't you know?

[@David-sq2en]

how to become one?

[@ameliaramos5225]

Sorry..but why that so vague definition of deseasses? Thought that health was the constant on.our lives and illness was the exceptional events...

[@Alice_Walker]

Cool story but how the heck do I fund an extra twenty years of retirement???

[@dapawap]

And all those extra years of problems & challenges! No one escapes them!

[@David-sq2en]

maybe learn how to save and then how to invest?

[@mcnchse]

I want to live to 120 in my 20 year old body, not old, frail, deteriorating, and can't go anywhere.

[@lekiwatcher]

nmn banned, why David, WHY?

[@alex_rogan]

So he can then sell his proprietary blend

[@kantoquad]

@@alex_rogan Had such respect for the man. He talked like he cared, but now only a few who will be able to afford his version many only be able to afford it. He seems to only care about the rich, and only if they pay me

[@I8l]

@@kantoquad if you really think about it.. its a good thing. Why have chinese companies make money off of nmn. He can pump the price a little and its just that much more capital to be re-invested in research.

[@FreemonSandlewould]

Geebus this was slooooooooow

[@jmd1743]

It would be pretty revolutionary for women who desire both a family and career. If you could live to the age of 300 then then what would be the problem with having kids and then REALLY focusing on your schooling in your mid 40s once the kids move out? As a women you'll feel accomplished with the whole child business and by the time you start schooling your eggs would have begun to run out. Women would be able to have their cake & eat it all.

[@dapawap]

We don’t need any more kids in this world! The world is way way over populated!

[@jimsmart6940]

If we can live to 300, technology will probably be there for men to have kids as well.

[@Hippy2021]

Living healthy is Nice. Living to 120 to see all people around you and your loved ones disappear? I don't want to live alone . Go along with nature. Sickness is a concern, Not the length of time to live

[@jeremywvarietyofviewpoints3104]

What if others live long too?

[@David-sq2en]

I'm 40 and already see this happened... so...

[@johnnyq4260]

The onus is on him to live to 120 to prove his theories.

[@David-sq2en]

what if... he already did?

[@monag.769]

I prefer to follow his example. If he‘s right l don‘t want to waste time waiting for it to happen;-)

[@L.J.01]

Saying cancer will kill everyone if they live long enough is based on what exactly? 😂

[@dapawap]

Valder Longo says if we stop the IGF1 mostly in animal products we won’t get various diseases & cancers 🥳🥳🥳

[@fullerexplanations7872]

I think Elon Musk needs to get involved with this also at some level. NeuraLink can help in some capacity but there are other avenues he can help boost to help get these developments faster

[@David-sq2en]

please no

[@sandybayes]

Musk has said he doesn't want to live longer.

[@yavuzyazir9132]

i will give an example to mr. Sinclair from totally different and negative perspective so that i hope he undwerstands what his work may do to the world. Dear David, imagine there is one nice hospital in a particular place which can hold and cure up to 1000 patients. and suddenylly, you start adding more pesticides and chemicals to the soil, where that community is fed from and as a result, number of patients start significantlly increase... now tell me Mr. Sinclair, suppose you cant extend the existing hospital, how do you think that hospital will respond to that situation? Meaning, how our already depleted and contaminated soil with lots of chemicals can produce enough and clean food if you extend avarege Joe's life 5-7 years resulting rapid increase in world population?

[@RJ-is9ko]

Better have the retirement funds for that

[@David-sq2en]

you can use time to make money... that is never the problem. the problem have always being to use the money to buy time.

[@malcolmwhitehead7225]

What about population growth. Do you cut down even stop breeding for years? MW

[@David-sq2en]

sadistically speaking yes. the trend is that as people live longer they have less kids.

[@farinshore8900]

No thank you.

[@ebrelus7687]

You won't reach 120 with pharmacology while not eating human species proper diet with meat, eggs, fish and natural milk/dairy. Ancient Etiopians would laugh him out.

[@sandybayes]

Please read some recent studies.

[@squamish4244]

And those medieval people wore out and died younger due to malnutrition and gruelling hard work. We should only get 'kind of' medieval :P

[@AbdulRehman-ch5cp]

i want to connect to ABC Australia (team) on email

[@MrCharlesdick]

If you use a transgene expressing those 3 Yamanaka factors, and include telomerase reverse transccriptase, might the result be even more better?

[@DeSoccerRefMan]

telomerase reverse transccriptase?