How to set-up a hydrogenation reaction using palladium on carbon and a hydrogen balloon

[@chromatogiraffery3104]

Very nice video, two comments; once punctured, septa are not terribly vacuum-tight, meaning under vacuum, atmospheric air could be sucked in through the puncture. If the volume of hydrogen is completely consumed by the reaction, the setup could generate a partial vacuum, which once again could lead to atmosphere ingress.

[@فاا-ي8غ]

Excellent work that deserves admiration ..... I love the miniature industrial processes that take place in the laboratory ..... Excellent work .. Excellent work ... Thank you very much

[@Moritz___]

Great explanation

[@laurentang890]

Hey, I was just wondering if you have to evacuate the air out of the flask and back-fill it with nitrogen if I were using a nickel catalyst? Does it effect the hydrogenation reaction or is it evacuated just because it reacts with the palladium? I'm doing a school lab investigation on finding the activation energy of hydrogenation, so I was just wondering if that step would be necessary for my experiment. Thanks!!

[@botondbolgar7449]

I’m watching you adding ethanol and the predissolved reactant and I have already two questions: how can be the ethanol dry and the reactant moisture/water or oxygen free if you’re adding it this way?

[@bekeneel]

I have a question, how much would a setup/lab cost if you would like to do hydrogenation "industrially"? It's because I have an idea for a product I'd like to create, synthesize like this and I wondered how much this would cost on average & the amount of substance one could "hydrogenate" at a time? Thanks

[@richardlyman2961]

Is the “product” a substituted amphetamine? 😐😐😐

[@brandonross6083]

Or phenethylamine? That alpha methyl doesn't make all the fun 😅

[@shawnio]

I like how you injected the hydrogen with the balloons and the syringe but shouldn't the space be flooded, I assume you just have to wait a lil longer for the correct amount of gas or equalization, just never seen it done like that, it was a good idea

[@wellcomecentreforanti-infe6171]

Hi there. not sure what you mean by "the space be flooded"? Let me know how we can help you with that bit.

[@shawnio]

@@wellcomecentreforanti-infe6171 you are vacating the air from the flask with hydrogen, making it a hydrogen rich enviroment, never seen someone do it with a syringe before, my comment was pretty rudimental

[@wellcomecentreforanti-infe6171]

@@shawnio Great!

[@黄蟮]

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[@黄蟮]

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[@brandonross6083]

NEVER use septa for hydrogenations. They will leak when pierced. That leak could blow atmospheric gases over your catalyst in a flammable solvent when you do the last purge. Then your flask can spontaneously disassemble with a ear drum destroying conclusive blast. You will kill your lab partner and wished you paid attention to this comment because now I'll tell you to ALWAYS use a 3 way vacuum adapter with the standard tapered glass joints. P.S. I've never been in a chemistry class. Not in highschool and definitely not in college. Even I know these things. That means there is no excuse for ignorance that leads to catastrophic events.

[@Indra.artist]

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[@wellcomecentreforanti-infe6171]

Have you tried resetting your browser?

[@黄蟮]

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