Immunology - Antibody Somatic (VDJ) Recombination I

[@armandohasudungan]

📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓 youmakr.ai/test-playground/questionnaire/673d542d859b9c170836f2e0

[@rusticromeo]

Hi I am a Pathologist and I should say that that video is one of the best, clear and easy to learn video of somatic recombination I have ever seen. You must be so clear in your concepts to make something like this. Excellent work. Hats off to you.

[@isikaram6006]

Felt the same +1000 thanks a lot

[@thegahd]

its not "somatic recombination" that is something else entirely. It is antibody recombination, of the antibody Fc structure

[@macaroniwithoutcheese175]

I’ve been studying biology Olympiad tests, and my ability to ignore and unwillingness to learn the immune system so far has bit me in the butt hard right about 30 mins ago. Thanks for the video from 11 yrs later.

[@cravebaby11]

Just used this video for a presentation at University of Rochester School of Medicine, it's awesome! We wanted to point out one minor error for the sake of clarity - the big antibody, drawn at 2:17, has the structure of an IgG (with 3 constant regions). Armando is correct in stating that it is an IgM antibody, so the drawing should show 4 constant regions (with THREE constant regions before the hinge region, and 1 after the hinge region). Thanks! My class and my professor loved it!

[@033gauthamkesav7]

OMG....I don't have words to explain how beautifully you're explaining the whole stuffs...hats off..

[@mohammadadel3097]

Saving students since 2012. Armando Hasudungan.

[@ElYu-gn2dh]

1,5 hour lecture explained in 7min. Appreciate it man!

[@veramanelli9636]

I'm glad I've found such a clear presentation. Thanks to you I have now a chance to pass the next exam !

[@RudiSka]

3 years into my med lab science degree and Armando is still rescuing me!! Thanks for these excellent immunology videos.

[@rldnx1606]

Thank you so much for this video, I am a biomed student and I always found this topic so confusing

[@drcapt]

you saved my ass on med school immunology! thank you!

[@yoldw]

hi. im on med sch also. hows your med day ? nice to know you

[@ianolsen4260]

This has been great thank you. My prof introduces all the terms in an alphabet soup-like lecture, and you put it all together and make it make sense

[@Bradatimrkonja]

Also, thanks, your explanation made this MUCH easier to understand...everyone said immunology would be a breeze after biochem and cns. I got a 400 page book to learn in 2.5 weeks.

[@agnisuddhashaw2767]

Just wanna let u know that these videos are awesome and people like me are still using it and more students will keep using it forever

[@Mendoch]

got my inmuno final on friday if i pass i'm posting u on every single univerity group i know!!! thak you so much!!

[@andrewm2786]

did you pass

[@buqbooQ]

@@andrewm2786 did you pass?

[@andrewm2786]

@@buqbooQ yeah I'm an emergency medicine resident now thanks

[@buqbooQ]

@@andrewm2786 that’s great super proud of you doc!!

[@MsCleibson]

I love the fact that you use pictures and a flowchart. It's so difficult to just read it, some need to see it! Thank you from the visual learner.

[@armandohasudungan]

I will try to scan it one day, its a big piece of paper, so it needs orienting, cutting and editing. Will take a while. thanks

[@armandohasudungan]

Hey man, try watching it on massive screen with quality setting on 720p. And the printed version, I will try to upload picture next week:)

[@jenshu7]

The image is no longer there :(

[@sharinatisdale9539]

o m g you have no idea how much this saved my life

[@sanjuktaghosh8802]

May God bless you, for putting this complex stuff so simplistically.

[@Javerick137]

I like the way you present your explanation of the topic, so easy to follow, fast paced (in a good way) and succinct. Good job, man - I will be visiting here a lot more in prep for my mid-sem.

[@avocadomillennial530]

If I pass my immunology test it will solely be because of you!

[@jesssarah1123]

Thanks, this is great. The only thing is for VJ recombination of the light chain (around 6:30) you leave the leader segment in the complete spliced segment that makes up the final light chain.

[@Alireza.h.biology]

Excellent ❤ I'm a master degree student of genetic from Iran and I say hello to you🖐

[@giakolou2876]

Thank you, this is the best explanation ever. You are saving lives with these videos, I don’t know what I’d do without your explanations, (my lecturers are hmm useless sorry to say).Thank you infinite times. I’ll pass it forward.

[@armandohasudungan]

I really hope you pass!

[@BasicScienceSeries]

Hard work. Good video and great content.

[@abderrahmanedamiri7594]

A great video.. definitely had to rewind many times to understand some points. You talk alittle too fast for me 😂 but you saved my life

[@ninecalvo2870]

Em, Armando te quiero. Mil gracias.

[@ameera224]

This video and you are a masterpiece!! This was so helpful!! :) Thank you for taking the time out to educate the world!

[@Mendoch]

i passed!! got an 8 (out of 10) thanxs to you!!!!!! so very happy :) i shared you everywhere i know of lol

[@kkronschnabel]

I wish you could teach all my science classes! So helpful!

[@amerikaland]

thank you so much! been trying to figure out this bit about Ab diversity for so long. thanks for making it simple!

[@lazyb6091]

Omg this is just perfect... Just look at your drawing so clean and perfect 😀... I really want to make notes like this ❤️❤️❤️... Thanks for the video.

[@alhaeri1]

hen 720p was the highest quality :) good old days

[@RNcooley]

Overpriced med school education can be replaced by youtube videos. Thanks for making sense of this:)

[@258孙笑川-r2y]

thanks for helping me understand this process easily!

[@careleentoh3487]

Need more people so spread this video more

[@jameslongbui]

100x better than my lecture in grad. school

[@themrvims]

Splendid and TO THE POINT Explanation...very useful for basics and quick revision...

[@aashnakumari3497]

You just blew my mind❤️

[@sorayabadrie2180]

Omg this video was awesome!!!!!!

[@saketpandey3889]

Thank you so much sir very helpful 🙂❤️

[@mcatterall93]

yep, it's on his facebook page

[@arifdina9069]

Really helpful...thank you sir

[@AliSalman-ye9sq]

You are a hero!!

[@victoryj8595]

Your videos are really brilliant and helpful. Thanks !

[@toreassuremyheart.5252]

kzbin.info/www/bejne/poXIfGaXq9CVq9E

[@teallantern2814]

this guy is great. helped ridiculously

[@jata14]

Bless you this helped so much!

[@alessandroduse5645]

That was quite useful! Thank you so much!

[@rimshar.755]

This was amazing!!!!! Thank you so much!!!

[@emmam.2784]

Love this guy 💚

[@princerainier]

if i receive at least a B on my immuno test by watching youtube videos the night before, then i am going to completely lose faith in most bio professors. props on explaining fairly in depth material through simple and orderly depictions.

[@emilyaigner1646]

Great video!! So Helpful

[@mikeLmula]

You're amazing! Thanks for the video!!

[@roadtoaesthetics4253]

thank you very clearly explained.

[@abirnina7346]

thank you so much

[@munyaradzinyarugwe8769]

thank you soo much. this is golden !!!

[@lionsinescanor373]

Very helpful video!!

[@maryamalamodi9717]

amaaaaaziing, thank youu!!

[@msjalan]

during light chain recombination, at the last stage after intron removal, the J segment is removed as well so only V and C remains in the end product.

[@prerithprabhu8359]

Thank you very clear explanation

[@mohammedmonzurmorshed2896]

thank you so much for your effort...amazing

[@monaelwassefy166]

wonderful work i love it thank you

[@majda2992]

This is so helpful! Thankyou

[@brittophone6219]

Amazing job thx 🥺

[@NieceyWeesey]

This is so perfect! Thank you!!!!

[@kurtcurtis511]

Hi, This video is fantastic. Thank you!

[@mrsiddhartha6]

thank you. The video was really helpful!

[@piumiwickramasinghe6514]

really helpful video.

[@tonysantana6302]

HO, LEE, SHIT my bone click, my mouse clicks..... but nothing has ever clicked so hard in m life

[@yasmine_boutemine]

wonderful!! thanks so much

[@yasminechaimaa6856]

Thank uu so much it helped me a lot

[@Orius25]

You don't describe RAG1/RAG2, recombination signal sequences, the "turns" (12/23 rule), or the addition of nucleotides after splicing. Those are really important to this process.

[@matttzzz2]

Video starts at 0:34

[@myuniverse367]

Thank you

[@karkaspir2102]

God bless you

[@MaryamEemaAli-to3kc]

Thank you !!

[@jannat1583]

Thank you SO much!

[@CktopShoOter]

Thanks dude, you rock

[@sandeepkaur-nn6mb]

it was really helpful thankyou so much :)

[@jmonroy1973]

If this is an M antibody, should there be 4 constant regions without the hinge? I only see 3 constant regions in the final AB. I know this is a minor detail. BTW, amazing videos!! Clear and concise voice, talented artwork!!

[@xJustKeeepSwimmingx]

incredible!!!! thank you!!!!!

[@yusufcabuk66]

I'm not sure if you ment this but I guess after the dna recombination we still have a DNA which now is locked until class switch. After the recombined DNA is transkipted we get the RNA and splicing etc..

[@maxblack7778]

this video literally saved my soul but i do have one question. since an igm antibody has 4 constant regions, and the big antibody drawn in 5:01 only has 3, is that an error? Also, why was the second C region colored in with red... does it not participate as a constant region subunit, and thats why there were only 3 drawn in the antibody?

[@cattycatterson]

Thank you very much😊

[@sumblaateeq4009]

Amazing

[@ILOVEBGM888]

this is amazing!!

[@selmam9676]

Amazing !

[@GR-bt3et]

EXCELLENT!

[@RAyano]

Thank you so much!!!

[@hanaakhatib7098]

thank you so much

[@kaasjeklaas551]

Thank you!

[@kart6320000]

very nice presented but you showed DJ rearrangement in DNA and VDJ in RNA.please explain

[@Etrusco15]

well done

[@DuckODuckProductions]

Thank you sir.

[@hudafatima224]

It’s wrong to say somatic recombination occurs in B cells . It occurs in both b and T cells

[@rovcekrezi]

I love you!

[@danspitalnik]

Very useful.

[@HTo-zp9bt]

thank you so much ^-^